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Journal of Receptors and Signal Transduction Volume 37, 2017 - Issue 2
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Research Article

Cholest-4-en-3-one attenuates TGF-β responsiveness by inducing TGF-β receptors degradation in Mv1Lu cells and colorectal adenocarcinoma cells

Chun-Lin ChenDepartment of Biological Sciences, National Sun Yat-Sen University, KaohsiungTaiwan, ROC; ;Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University and Academia Sinica, Kaohsiung, Taiwan, ROC; ;Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Correspondence[email protected]
,
Deng-Chyang WuCenter for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; ;Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC;
,
Min-Yun LiuTaiwan Ocean Research Institute, National Applied Research Laboratories, Kaohsiung, Taiwan, ROC;
,
Ming-Wei LinCenter for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; ;Department of Pharmacy, School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC;
,
Hung-Tu HuangDepartment of Biological Sciences, National Sun Yat-Sen University, KaohsiungTaiwan, ROC; ;Division of Pathology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC;
,
Yaw-Bin HuangDepartment of Biological Sciences, National Sun Yat-Sen University, KaohsiungTaiwan, ROC; ;Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; ;Taiwan Ocean Research Institute, National Applied Research Laboratories, Kaohsiung, Taiwan, ROC; ;Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC;
,
Li-Chai ChenDepartment of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, ROC; ;Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Taiwan, ROC;
,
Yu-Yu ChenDepartment of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, ROC;
,
Jih-Jung ChenDepartment of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, ROC; ;Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Taiwan, ROC; ;Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan
,
Pei-Hua YangDepartment of Biological Sciences, National Sun Yat-Sen University, KaohsiungTaiwan, ROC;
,
Yu-Chen KaoDepartment of Biological Sciences, National Sun Yat-Sen University, KaohsiungTaiwan, ROC;
&
Pei-Yu ChenDepartment of Biological Sciences, National Sun Yat-Sen University, KaohsiungTaiwan, ROC;
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Pages 189-199 | Received 16 Apr 2016, Accepted 05 Jun 2016, Published online: 12 Jul 2016

Citations (7)

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Read on this site (1)

Yan-Jie Cheng, Fan Fan, Zhong Zhang & Hai-jun Zhang. (2023) Lipid metabolism in malignant tumor brain metastasis: reprogramming and therapeutic potential. Expert Opinion on Therapeutic Targets 0:0, pages 1-18.
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Articles from other publishers (6)

Bofang Wang, Baohong Gu, Tao Zhang, Xuemei Li, Na Wang, Chenhui Ma, Lin Xiang, Yunpeng Wang, Lei Gao, Yang Yu, Kewei Song, Puyi He, Yueyan Wang, Jingyu Zhu & Hao Chen. (2023) Good or bad: Paradox of plasminogen activator inhibitor 1 (PAI-1) in digestive system tumors. Cancer Letters 559, pages 216117.
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Mussa Makran, Guadalupe Garcia-Llatas, Amparo Alegría & Antonio Cilla. (2023) Ethylcoprostanol modulates colorectal cancer cell proliferation and mitigates cytotoxicity of cholesterol metabolites in non-tumor colon cells. Food & Function.
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Cheng-Yi Huang, Chih-Ling Chung, Tsung-Hui Hu, Jih-Jung Chen, Pei-Feng Liu & Chun-Lin Chen. (2021) Recent progress in TGF-β inhibitors for cancer therapy. Biomedicine & Pharmacotherapy 134, pages 111046.
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Josiane Elia, Delphine Carbonnelle, Cédric Logé, Lucie Ory, Jean-Michel Huvelin, Mona Tannoury, Mona Diab-Assaf, Karina Petit & Hassan Nazih. (2019) 4-cholesten-3-one decreases breast cancer cell viability and alters membrane raft-localized EGFR expression by reducing lipogenesis and enhancing LXR-dependent cholesterol transporters. Lipids in Health and Disease 18:1.
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Chih-Ling Chung, Shun-Ban Tai, Tsung-Hui Hu, Jih-Jung Chen & Chun-Lin Chen. (2019) Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling. International Journal of Molecular Sciences 20:16, pages 3913.
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Shuang Liu, Huan Hou, Panpan Zhang, Yifan Wu, Xuanhong He, Hua Li & Nianlong Yan. (2018) Sphingomyelin synthase 1 regulates the epithelial‑to‑mesenchymal transition mediated by the TGF‑β/Smad pathway in MDA‑MB‑231 cells. Molecular Medicine Reports.
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