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Journal of Receptors and Signal Transduction Volume 38, 2018 - Issue 3
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Research Article

Designing of enzyme inhibitors based on active site specificity: lessons from methyl gallate and its lipoxygenase inhibitory profile

Sharanya C. S.Inter University Centre for Bioscience and Department of Biotechnology & Microbiology, Kannur University, ThalasseryCampus, Palayad, IndiaView further author information
,
Arun K. G.Inter University Centre for Bioscience and Department of Biotechnology & Microbiology, Kannur University, ThalasseryCampus, Palayad, IndiaView further author information
,
Vijaytha V.Inter University Centre for Bioscience and Department of Biotechnology & Microbiology, Kannur University, ThalasseryCampus, Palayad, IndiaView further author information
,
Sabu A.Inter University Centre for Bioscience and Department of Biotechnology & Microbiology, Kannur University, ThalasseryCampus, Palayad, IndiaView further author information
&
Haridas M.Inter University Centre for Bioscience and Department of Biotechnology & Microbiology, Kannur University, ThalasseryCampus, Palayad, IndiaCorrespondence[email protected]
View further author information
Pages 256-265 | Received 23 Mar 2018, Accepted 10 May 2018, Published online: 30 May 2018

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Goverdhan Lanka, Revanth Bathula, Mahendar Dasari, Sravanthi Nakkala, Manan Bhargavi, Gururaj Somadi & Sarita Rajender Potlapally. (2019) Structure-based identification of potential novel inhibitors targeting FAM3B (PANDER) causing type 2 diabetes mellitus through virtual screening. Journal of Receptors and Signal Transduction 39:3, pages 253-263.
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Articles from other publishers (6)

Pimsumon Jiamboonsri, Chatchakorn Eurtivong & Sompit Wanwong. (2023) Assessing the Potential of Gallic Acid and Methyl Gallate to Enhance the Efficacy of β-Lactam Antibiotics against Methicillin-Resistant Staphylococcus aureus by Targeting β-Lactamase: In Silico and In Vitro Studies. Antibiotics 12:11, pages 1622.
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C.S. Sharanya, J. Abhithaj, K.G. Arun, Koti Reddy Eeda, Vignesh Bhat, E.J. Variyar, A. Sabu & M. Haridas. (2023) Lipoxygenase inhibitory synthetic derivatives of methyl gallate regulate gene expressions of COX-2 and cytokines to reduce animal model arthritis. Scientific Reports 13:1.
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Rashmi Sahu, Prashant Kumar Gupta, Amit Mishra & Awanish Kumar. (2022) Ayurveda and in silico Approach: A Challenging Proficient Confluence for Better Development of Effective Traditional Medicine Spotlighting Network Pharmacology. Chinese Journal of Integrative Medicine 29:5, pages 470-480.
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Yue Li, Bin Shen, Cunxian Lv, Xinyi Zhu, Qiqige Naren, Dong Xu, He Chen & Fengmiao Wu. (2023) Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression. International Immunopharmacology 114, pages 109489.
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Bo-Im Ryu & Ki-Tae Kim. (2022) Antioxidant activity and protective effect of methyl gallate against t-BHP induced oxidative stress through inhibiting ROS production. Food Science and Biotechnology 31:8, pages 1063-1072.
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Luana Barbosa Correa, Leonardo Noboru Seito, Marília F. Manchope, Waldiceu A. VerriJrJr, Thiago Mattar Cunha, Maria G. Henriques & Elaine Cruz Rosas. (2020) Methyl gallate attenuates inflammation induced by Toll-like receptor ligands by inhibiting MAPK and NF-Κb signaling pathways. Inflammation Research 69:12, pages 1257-1270.
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