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Human and Ecological Risk Assessment: An International Journal Volume 13, 2007 - Issue 6
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Workshop Report

Use of In Vitro Absorption, Distribution, Metabolism, and Excretion (ADME) Data in Bioaccumulation Assessments for Fish

John Nichols National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, MN, USA
,
Susan Erhardt Toxicology, Environmental Research and Consulting, Dow Chemical Company, Midland, MI, USA
,
Scott Dyer Central Product Safety, Procter and Gamble Company, Cincinnati, OH, USA
,
Margaret James Department of Medicinal Chemistry, University of Florida, Gainesville, FL, USA
,
Margo Moore Department of Biological Sciences, Simon Fraser University, Burnaby, BC, Canada
,
Kathleen Plotzke Health and Environmental Sciences, Dow Corning Corporation, Midland, MI, USA
,
Helmut Segner Centre for Fish and Wildlife Health, University of Bern, Bern, Switzerland
,
Irvin Schultz Battelle, Pacific Northwest National Laboratory-Marine Research Operations, Sequim, WA, USA
,
Karluss Thomas ILSI Health and Environmental Sciences Institute, Washington, DC, USA
,
Luba Vasiluk Department of Land Resource Science, University of Guelph, Guelph, ON, Canada
&
Annie Weisbrod Central Product Safety, Procter and Gamble Company, Cincinnati, OH, USA
 show all
Pages 1164-1191 | Received 27 Mar 2007, Accepted 01 Apr 2007, Published online: 07 Nov 2007

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John W. Nichols, Patrick N. Fitzsimmons, Alex D. Hoffman & Kameron Wong. (2023) In Vitro–In Vivo Extrapolation of Hepatic Biotransformation Data for Fish. III. An In‐depth Case Study with Pyrene. Environmental Toxicology and Chemistry 42:7, pages 1501-1515.
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Ina Bischof, Jon A. Arnot, Heinrich Jürling, Georg Knipschild, Christian Schlechtriem, Anna Schauerte & Helmut Segner. (2022) In vitro biotransformation assays using fish liver cells: Comparing rainbow trout and carp hepatocytes. Frontiers in Toxicology 4.
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Anton Ribbenstedt, James M. Armitage, Felix Günther, Jon A. Arnot, Steven T. J. Droge & Michael S. McLachlan. (2022) In Vivo Bioconcentration of 10 Anionic Surfactants in Rainbow Trout Explained by In Vitro Data on Partitioning and S9 Clearance . Environmental Science & Technology 56:10, pages 6305-6314.
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Elisabeth Dohmann Chang, Raewyn M. Town, Stewart F. Owen, Christer Hogstrand & Nic R. Bury. (2021) Effect of Water pH on the Uptake of Acidic (Ibuprofen) and Basic (Propranolol) Drugs in a Fish Gill Cell Culture Model. Environmental Science & Technology 55:10, pages 6848-6856.
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Jakub Maculewicz, Klaudia Świacka, Dorota Kowalska, Piotr Stepnowski, Stefan Stolte & Joanna Dołżonek. (2020) In vitro methods for predicting the bioconcentration of xenobiotics in aquatic organisms. Science of The Total Environment 739, pages 140261.
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Verena Kosfeld, Qiuguo Fu, Ina Ebersbach, Dana Esser, Anna Schauerte, Ina Bischof, Juliane Hollender & Christian Schlechtriem. (2020) Comparison of Alternative Methods for Bioaccumulation Assessment: Scope and Limitations of In Vitro Depletion Assays with Rainbow Trout and Bioconcentration Tests in the Freshwater Amphipod Hyalella azteca . Environmental Toxicology and Chemistry 39:9, pages 1813-1825.
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John Weeks, Patrick Guiney & Karla Johanning. (2020) In vitro and in vivo metabolic stability of various fragrance materials and insect repellent in rainbow trout ( Oncorhynchus mykiss ) . Journal of Applied Toxicology 40:6, pages 763-779.
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Toshiyuki Katagi. (2020) <i>In vitro</i> metabolism of pesticides and industrial chemicals in fish. Journal of Pesticide Science 45:1, pages 1-15.
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Junho Jeon & Juliane Hollender. (2019) In vitro biotransformation of pharmaceuticals and pesticides by trout liver S9 in the presence and absence of carbamazepine. Ecotoxicology and Environmental Safety 183, pages 109513.
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Marco E. Franco & Ramon Lavado. (2019) Applicability of in vitro methods in evaluating the biotransformation of polycyclic aromatic hydrocarbons (PAHs) in fish: Advances and challenges. Science of The Total Environment 671, pages 685-695.
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Elisabeth D. Chang, Christer Hogstrand, Thomas H. Miller, Stewart F. Owen & Nic R. Bury. (2018) The Use of Molecular Descriptors To Model Pharmaceutical Uptake by a Fish Primary Gill Cell Culture Epithelium. Environmental Science & Technology 53:3, pages 1576-1584.
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Monika Nendza, Ralph Kühne, Anna Lombardo, Sebastian Strempel & Gerrit Schüürmann. (2018) PBT assessment under REACH: Screening for low aquatic bioaccumulation with QSAR classifications based on physicochemical properties to replace BCF in vivo testing on fish. Science of The Total Environment 616-617, pages 97-106.
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Jon A. Arnot, Sascha Pawlowski & Samantha Champ. (2018) A weight-of-evidence approach for the bioaccumulation assessment of triclosan in aquatic species. Science of The Total Environment 618, pages 1506-1518.
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Edward Schram, Johan W Schrama, Tobias van Kooten, Christiaan J A F Kwadijk, Harm Kampen, Jan W van de Heul, Johan A J Verreth & Albertinka J Murk. (2018) Experimental validation of geosmin uptake in rainbow trout, Oncorhynchus mykiss (Waldbaum) suggests biotransformation . Aquaculture Research 49:2, pages 668-675.
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Laura M. Langan, Silvia Arossa, Stewart F. Owen & Awadhesh N. Jha. (2018) Assessing the impact of benzo[ a ]pyrene with the in vitro fish gut model: An integrated approach for eco-genotoxicological studies. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 826, pages 53-64.
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Kellie A. Fay, Patrick N. Fitzsimmons, Alex D. Hoffman & John W. Nichols. (2017) Comparison of trout hepatocytes and liver S9 fractions as in vitro models for predicting hepatic clearance in fish. Environmental Toxicology and Chemistry 36:2, pages 463-471.
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Matthew G. Baron, Kate S. Mintram, Stewart F. Owen, Malcolm J. Hetheridge, A. John Moody, Wendy M. Purcell, Simon K. Jackson & Awadhesh N. Jha. (2017) Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance. PLOS ONE 12:1, pages e0168837.
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Jaeshin Kim, Frank A.P.C. Gobas, Jon A. Arnot, David E. Powell, Rita M. Seston & Kent B. Woodburn. (2016) Evaluating the roles of biotransformation, spatial concentration differences, organism home range, and field sampling design on trophic magnification factors. Science of The Total Environment 551-552, pages 438-451.
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Robert Hoke, Duane Huggett, Sandra Brasfield, Becky Brown, Michelle Embry, Anne Fairbrother, Michelle Kivi, Miriam Leon Paumen, Ryan Prosser, Dan Salvito & Rick Scroggins. (2015) Review of laboratory‐based terrestrial bioaccumulation assessment approaches for organic chemicals: Current status and future possibilities. Integrated Environmental Assessment and Management 12:1, pages 109-122.
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Adam Abelkop, John Graham & Todd Royer. 2015. Persistent, Bioaccumulative, and Toxic (PBT) Chemicals. Persistent, Bioaccumulative, and Toxic (PBT) Chemicals 29 64 .
Helmut Segner. (2015) In Vitro Methodologies in Ecotoxicological Hazard Assessment: The Case of Bioaccumulation Testing for Fish . Alternatives to Laboratory Animals 43:2, pages P14-P16.
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Neus Rodriguez-Sanchez, Mark Timothy David Cronin, Adam Lillicrap, Judith Clare Madden, Przemyslaw Piechota & Knut Erik Tollefsen. (2014) Development of a list of reference chemicals for evaluating alternative methods to in vivo fish bioaccumulation tests. Environmental Toxicology and Chemistry 33:12, pages 2740-2752.
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Till Luckenbach, Stephan Fischer & Armin Sturm. (2014) Current advances on ABC drug transporters in fish. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 165, pages 28-52.
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John W. Nichols, Alex D. Hoffman, Thomas L. ter Laak & Patrick N. Fitzsimmons. (2013) Hepatic Clearance of 6 Polycyclic Aromatic Hydrocarbons by Isolated Perfused Trout Livers: Prediction From In Vitro Clearance by Liver S9 Fractions. Toxicological Sciences 136:2, pages 359-372.
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Kristin A. Connors, Bowen Du, Patrick N. Fitzsimmons, Alex D. Hoffman, C. Kevin Chambliss, John W. Nichols & Bryan W. Brooks. (2013) Comparative pharmaceutical metabolism by rainbow trout ( Oncorhynchus mykiss ) liver S9 fractions . Environmental Toxicology and Chemistry 32:8, pages 1810-1818.
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Karla Johanning, Gregg Hancock, Beate Escher, Adebayo Adekola, Mary Jo Bernhard, Christina Cowan‐Ellsberry, Jeanne Domoradzki, Scott Dyer, Curtis Eickhoff, Michelle EmbrySusan Erhardt, Patrick Fitzsimmons, Marlies Halder, James Hill, Dustin Holden, Rebecca Johnson, Sibylle Rutishauser, Helmut Segner, Irvin Schultz & John Nichols. (2012) Assessment of Metabolic Stability Using the Rainbow Trout ( Oncorhynchus mykiss ) Liver S9 Fraction . Current Protocols in Toxicology 53:1.
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Keith R Solomon & Mark Hanson. 2010. Handbook of Green Chemistry. Handbook of Green Chemistry.
Eva M. Webster & David A. Ellis. (2012) Estimating chemical biotransformation rates from food web concentrations. Chemosphere 87:4, pages 404-412.
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John W. Nichols, Alex D. Hoffman & Patrick N. Fitzsimmons. (2009) Optimization of an isolated perfused rainbow trout liver model: Clearance studies with 7-ethoxycoumarin. Aquatic Toxicology 95:3, pages 182-194.
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Scott D. Dyer, Mary Jo Bernhard, Christina Cowan-Ellsberry, Elisabeth Perdu-Durand, Susanne Demmerle & Jean-Pierre Cravedi. (2009) In vitro biotransformation of surfactants in fish. Part II – Alcohol ethoxylate (C16EO8) and alcohol ethoxylate sulfate (C14EO2S) to estimate bioconcentration potential. Chemosphere 76:7, pages 989-998.
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Christina E. Cowan-Ellsberry, Scott D. Dyer, Susan Erhardt, Mary Jo Bernhard, Amy L. Roe, Martin E. Dowty & Annie V. Weisbrod. (2008) Approach for extrapolating in vitro metabolism data to refine bioconcentration factor estimates. Chemosphere 70:10, pages 1804-1817.
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