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Debate/Commentary

Modelling Bioaccumulation and Toxicity of Metal Mixtures

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Pages 266-289 | Published online: 17 Apr 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Bing Gong, Hao Qiu, Ana Romero-Freire, Cornelis A. M. Van Gestel & Erkai He. (2022) Incorporation of chemical and toxicological availability into metal mixture toxicity modeling: State of the art and future perspectives. Critical Reviews in Environmental Science and Technology 52:10, pages 1730-1772.
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Yamini Gopalapillai, Tereza Dan & Beverley Hale. (2019) Ni bioavailability in oat (Avena sativa) grown in naturally aged, Ni refinery-impacted agricultural soils. Human and Ecological Risk Assessment: An International Journal 25:6, pages 1422-1437.
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T. T. Yen Le & Willie J. G. M. Peijnenburg. (2017) Modelling toxicity of metal mixtures: A generalisation of new advanced methods, considering potential application to terrestrial ecosystems. Critical Reviews in Environmental Science and Technology 47:7, pages 409-454.
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U. Borgmann, J.E. Schroeder, L.A. Golding & D.G. Dixon. (2010) Models of Cadmium Accumulation and Toxicity to Hyalella azteca during 7- and 28-Day Exposures. Human and Ecological Risk Assessment: An International Journal 16:3, pages 560-587.
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PeterM. Chapman. (2008) Environmental Risks of Inorganic Metals and Metalloids: A Continuing, Evolving Scientific Odyssey. Human and Ecological Risk Assessment: An International Journal 14:1, pages 5-40.
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Articles from other publishers (54)

Yachen Liu, Hongjing Zhao, Kai Yin, Menghao Guo, Yu Wang, Dongxu Wang, Hui Zong & Mingwei Xing. (2022) The protective effect of Zn2+ on As3+ toxicity in common carp: Resistance to oxidative stress, inhibition of endoplasmic reticulum stress, apoptosis and autophagy. Aquaculture 546, pages 737375.
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Elise Morel, Lei Cui, William Zerges & Kevin J. Wilkinson. (2021) Mixtures of rare earth elements show antagonistic interactions in Chlamydomonas reinhardtii. Environmental Pollution 287, pages 117594.
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E. Tipping, S. Lofts & W. Keller. (2021) The use of WHAM-FTOX, parameterized with laboratory data, to simulate zooplankton species richness in acid- and metal- contaminated lakes. Aquatic Toxicology 231, pages 105708.
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Bing Gong, Erkai He, Bing Xia, Rongrong Ying, Willie J.G.M. Peijnenburg, Yang Liu & Hao Qiu. (2020) Bioavailability and phytotoxicity of rare earth metals to Triticum aestivum under various exposure scenarios. Ecotoxicology and Environmental Safety 205, pages 111346.
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Bing Gong, Erkai He, Hao Qiu, Cornelis A.M. Van Gestel, Ana Romero-Freire, Ling Zhao, Xiaoyun Xu & Xinde Cao. (2020) Interactions of arsenic, copper, and zinc in soil-plant system: Partition, uptake and phytotoxicity. Science of The Total Environment 745, pages 140926.
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D.J. Cain, M.-N. Croteau & C.C. Fuller. (2019) Competitive interactions among H, Cu, and Zn ions moderate aqueous uptake of Cu and Zn by an aquatic insect. Environmental Pollution 255, pages 113220.
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E. Tipping, A. Stockdale & S. Lofts. (2019) Systematic analysis of freshwater metal toxicity with WHAM-FTOX. Aquatic Toxicology 212, pages 128-137.
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Rebecca R. Philipps, Xiaoyu Xu, Robert B. Bringolf & Gary L. Mills. (2018) Evaluation of the DGT technique for predicting uptake of metal mixtures by fathead minnow ( Pimephales promelas) and yellow lampmussel ( Lampsilis cariosa ) . Environmental Toxicology and Chemistry 38:1, pages 61-70.
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Yusuf Saibu, Ankur Jamwal, Renfei Feng, Derek Peak & Som Niyogi. (2018) Distribution and speciation of zinc in the gills of rainbow trout ( Oncorhynchus mykiss ) during acute waterborne zinc exposure: Interactions with cadmium or copper. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 206-207, pages 23-31.
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Jianfeng Feng, Yongfei Gao, Yijun Ji & Lin Zhu. (2018) Quantifying the interactions among metal mixtures in toxicodynamic process with generalized linear model. Journal of Hazardous Materials 345, pages 97-106.
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Melissa K. Driessnack, Ankur Jamwal & Som Niyogi. (2017) Effects of chronic exposure to waterborne copper and nickel in binary mixture on tissue-specific metal accumulation and reproduction in fathead minnow (Pimephales promelas). Chemosphere 185, pages 964-974.
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Melissa K. Driessnack, Ankur Jamwal & Som Niyogi. (2017) Effects of chronic waterborne cadmium and zinc interactions on tissue-specific metal accumulation and reproduction in fathead minnow (Pimephales promelas). Ecotoxicology and Environmental Safety 140, pages 65-75.
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Yamini Gopalapillai & Beverley A. Hale. (2017) Internal versus External Dose for Describing Ternary Metal Mixture (Ni, Cu, Cd) Chronic Toxicity to Lemna minor . Environmental Science & Technology 51:9, pages 5233-5241.
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Aiju Liu, JinXin Li, Menghong Li, Xiao yin Niu & Jun Wang. (2017) Toxicity Assessment of Binary Metal Mixtures (Copper–Zinc) to Nitrification in Soilless Culture with the Extended Biotic Ligand Model. Archives of Environmental Contamination and Toxicology 72:2, pages 312-319.
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Leire Méndez-Fernández, Pilar Rodriguez & Maite Martínez-Madrid. 2017. Reviews of Environmental Contamination and Toxicology Volume 243. Reviews of Environmental Contamination and Toxicology Volume 243 149 172 .
Liske Versieren, Steffie Evers, Hamada AbdElgawad, Han Asard & Erik Smolders. (2017) Mixture toxicity of copper, cadmium, and zinc to barley seedlings is not explained by antioxidant and oxidative stress biomarkers. Environmental Toxicology and Chemistry 36:1, pages 220-230.
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Liske Versieren, Steffie Evers, Karel De Schamphelaere, Ronny Blust & Erik Smolders. (2016) Mixture toxicity and interactions of copper, nickel, cadmium, and zinc to barley at low effect levels: Something from nothing?. Environmental Toxicology and Chemistry 35:10, pages 2483-2492.
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Yongfei Gao, Jianfeng Feng, Feng Han & Lin Zhu. (2016) Application of biotic ligand and toxicokinetic–toxicodynamic modeling to predict the accumulation and toxicity of metal mixtures to zebrafish larvae. Environmental Pollution 213, pages 16-29.
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Melissa K. Driessnack, Amber L. Matthews, Jason C. Raine & Som Niyogi. (2016) Interactive effects of chronic waterborne copper and cadmium exposure on tissue-specific metal accumulation and reproduction in fathead minnow ( Pimephales promelas ). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 179, pages 165-173.
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M. Van Ginneken, M. De Jonge, L. Bervoets & R. Blust. (2015) Uptake and toxicity of Cd, Cu and Pb mixtures in the isopod Asellus aquaticus from waterborne exposure. Science of The Total Environment 537, pages 170-179.
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R. Redelstein, H. Zielke, D. Spira, U. Feiler, L. Erdinger, H. Zimmer, S. Wiseman, M. Hecker, J. P. Giesy, T.-B. Seiler & H. Hollert. (2015) Bioaccumulation and molecular effects of sediment-bound metals in zebrafish embryos. Environmental Science and Pollution Research 22:21, pages 16290-16304.
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Som Niyogi, Sunita R. Nadella & Chris M. Wood. (2015) Interactive effects of waterborne metals in binary mixtures on short-term gill–metal binding and ion uptake in rainbow trout (Oncorhynchus mykiss). Aquatic Toxicology 165, pages 109-119.
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Yvonne H. Clemow & Michael P. Wilkie. (2015) Effects of Pb plus Cd mixtures on toxicity, and internal electrolyte and osmotic balance in the rainbow trout (Oncorhynchus mykiss). Aquatic Toxicology 161, pages 176-188.
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Yuichi Iwasaki, Masashi Kamo & Wataru Naito. (2015) Testing an application of a biotic ligand model to predict acute toxicity of metal mixtures to rainbow trout. Environmental Toxicology and Chemistry 34:4, pages 754-760.
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Roula Flouty & Gaby Khalaf. (2015) Role of Cu and pb on Ni bioaccumulation by Chlamydomonas reinhardtii: Validation of the biotic ligand model in binary metal Mixtures. Ecotoxicology and Environmental Safety 113, pages 79-86.
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M. De Jonge, C. Belpaire, G. Van Thuyne, J. Breine & L. Bervoets. (2015) Temporal distribution of accumulated metal mixtures in two feral fish species and the relation with condition metrics and community structure. Environmental Pollution 197, pages 43-54.
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Erkai He, Jan Baas & Cornelis A.M. Van Gestel. (2015) Interaction between nickel and cobalt toxicity in Enchytraeus crypticus is due to competitive uptake . Environmental Toxicology and Chemistry 34:2, pages 328-337.
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Catherine E. Raptis, Ronnie Juraske & Stefanie Hellweg. (2014) Investigating the relationship between toxicity and organic sum-parameters in kraft mill effluents. Water Research 66, pages 180-189.
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Guang Yang, Qiao-Guo Tan, Lin Zhu & Kevin J. Wilkinson. (2014) The role of complexation and competition in the biouptake of europium by a unicellular alga. Environmental Toxicology and Chemistry 33:11, pages 2609-2615.
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Yang Liu, Martina G. Vijver & Willie J.G.M. Peijnenburg. (2014) Comparing three approaches in extending biotic ligand models to predict the toxicity of binary metal mixtures (Cu–Ni, Cu–Zn and Cu–Ag) to lettuce (Lactuca sativa L.). Chemosphere 112, pages 282-288.
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Liske Versieren, Elke Smets, Karel De Schamphelaere, Ronny Blust & Erik Smolders. (2014) Mixture toxicity of copper and zinc to barley at low level effects can be described by the Biotic Ligand Model. Plant and Soil 381:1-2, pages 131-142.
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Erkai He, Hao Qiu & Cornelis A.M. Van Gestel. (2014) Modelling uptake and toxicity of nickel in solution to Enchytraeus crypticus with biotic ligand model theory. Environmental Pollution 188, pages 17-26.
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Ekta Roy, Santanu Patra, Rashmi Madhuri & Prashant K. Sharma. (2014) Simultaneous determination of heavy metals in biological samples by a multiple-template imprinting technique: an electrochemical study. RSC Adv. 4:100, pages 56690-56700.
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Maarten De Jonge, Edward Tipping, Stephen Lofts, Lieven Bervoets & Ronny Blust. (2013) The use of invertebrate body burdens to predict ecological effects of metal mixtures in mining-impacted waters. Aquatic Toxicology 142-143, pages 294-302.
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E. Tipping & S. Lofts. (2013) Metal mixture toxicity to aquatic biota in laboratory experiments: Application of the WHAM-FTOX model. Aquatic Toxicology 142-143, pages 114-122.
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Jacob D. Ouellet, Monique G. Dubé & Som Niyogi. (2013) Influence of elevated alkalinity and natural organic matter (NOM) on tissue-specific metal accumulation and reproductive performance in fathead minnows during chronic, multi-trophic exposures to a metal mine effluent. Ecotoxicology and Environmental Safety 95, pages 104-112.
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Pauline Abboud & Kevin J. Wilkinson. (2013) Role of metal mixtures (Ca, Cu and Pb) on Cd bioaccumulation and phytochelatin production by Chlamydomonas reinhardtii. Environmental Pollution 179, pages 33-38.
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Rolf Altenburger, Thomas Backhaus, Wolfgang Boedeker, Michael Faust & Martin Scholze. (2013) Simplifying complexity: Mixture toxicity assessment in the last 20 years. Environmental Toxicology and Chemistry 32:8, pages 1685-1687.
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Warren P. Norwood, Uwe Borgmann & D. George Dixon. (2013) An effects addition model based on bioaccumulation of metals from exposure to mixtures of metals can predict chronic mortality in the aquatic invertebrate hyalella azteca . Environmental Toxicology and Chemistry 32:7, pages 1672-1681.
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Yamini Gopalapillai, Beverley Hale & Bernard Vigneault. (2013) Effect of major cations (Ca 2+ , Mg 2+ , Na + , K + ) and anions (SO 42−, Cl − , NO 3−) on Ni accumulation and toxicity in aquatic plant ( Lemna minor L.): Implications For Ni risk assessment . Environmental Toxicology and Chemistry 32:4, pages 810-821.
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Mayumi Seto, Shigeki Wada & Satoru Suzuki. (2013) The effect of zinc on aquatic microbial ecosystems and the degradation of dissolved organic matter. Chemosphere 90:3, pages 1091-1102.
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T.T. Yen Le, Martina G. Vijver, A. Jan Hendriks & Willie J.G.M. Peijnenburg. (2012) Modeling toxicity of binary metal mixtures (Cu 2+ –Ag + , Cu 2+ –Zn 2+ ) to lettuce, Lactuca sativa , with the biotic ligand model . Environmental Toxicology and Chemistry 32:1, pages 137-143.
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Anna R. Winter, Richard C. Playle, D. George Dixon, Uwe Borgmann & Michael P. Wilkie. (2012) Interactions of Pb and Cd mixtures in the presence or absence of natural organic matter with the fish gill. Ecotoxicology and Environmental Safety 83, pages 16-24.
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A. Bourgeault, C. Gourlay-Francé, S. Ayrault & M.-H. Tusseau-Vuillemin. (2012) Bioaccumulation of waterborne Ni in Dreissena polymorpha: A stable isotope experiment to assess the effect of zinc, calcium, and dissolved organic matter. Environmental Toxicology and Chemistry 31:4, pages 819-827.
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Farhan R. Khan, W. (Bill) Keller, Norman D. Yan, Paul G. Welsh, Chris M. Wood & James C. McGeer. (2012) Application of Biotic Ligand and Toxic Unit Modeling Approaches to Predict Improvements in Zooplankton Species Richness in Smelter-Damaged Lakes near Sudbury, Ontario. Environmental Science & Technology 46:3, pages 1641-1649.
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Yamini Gopalapillai, Bernard Vigneault & Beverley Hale. (2012) Effect of pH and environmental ligands on accumulation and toxicity of Ni2+ to Lemna minor. Environmental Chemistry 9:6, pages 547.
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A.J. Bartlett, Q. Rochfort, L.R. Brown & J. Marsalek. (2012) Causes of toxicity to Hyalella azteca in a stormwater management facility receiving highway runoff and snowmelt. Part I: Polycyclic aromatic hydrocarbons and metals. Science of The Total Environment 414, pages 227-237.
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Lisa A. Golding, Uwe Borgmann & D. George Dixon. (2011) Modeling chronic dietary cadmium bioaccumulation and toxicity from periphyton to Hyalella azteca. Environmental Toxicology and Chemistry 30:7, pages 1709-1720.
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Paul Paquin, Aaron Redman, Adam Ryan & Robert Santore. 2011. Homeostasis and Toxicology of Non-Essential Metals. Homeostasis and Toxicology of Non-Essential Metals 429 484 .
J.E. Schroeder, U. Borgmann & D.G. Dixon. (2010) Evaluation of the biotic ligand model to predict long-term toxicity of nickel to Hyalella azteca. Environmental Toxicology and Chemistry 29:11, pages 2498-2504.
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C.M. Hutchins, D.F. Simon, W. Zerges & K.J. Wilkinson. (2010) Transcriptomic signatures in Chlamydomonas reinhardtii as Cd biomarkers in metal mixtures. Aquatic Toxicology 100:1, pages 120-127.
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Wataru Naito, Masashi Kamo, Koji Tsushima & Yuichi Iwasaki. (2010) Exposure and risk assessment of zinc in Japanese surface waters. Science of The Total Environment 408:20, pages 4271-4284.
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Kouji Tsushima, Wataru Naito & Masashi Kamo. (2010) Assessing ecological risk of zinc in Japan using organism- and population-level species sensitivity distributions. Chemosphere 80:5, pages 563-569.
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Irina Komjarova & Ronny Blust. (2009) Multimetal Interactions between Cd, Cu, Ni, Pb, and Zn Uptake from Water in the Zebrafish Danio rerio . Environmental Science & Technology 43:19, pages 7225-7229.
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