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Original Articles

Countercurrent Chromatographic Separation of Biotic Compounds with Extremely Hydrophilic Organic‐Aqueous Two‐Phase Solvent Systems and Organic‐Aqueous Three‐Phase Solvent Systems

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Pages 733-750 | Received 30 Oct 2005, Accepted 29 Nov 2005, Published online: 06 Feb 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Tian Han, Xueli Cao, Hairun Pei & Chen Fan. (2023) Overview of Solvent System Selection Strategies for Countercurrent Chromatography. Separation & Purification Reviews 52:4, pages 305-325.
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Jinzhi Wan, Guili Liu, Xinjun Xu, Chunyan Xie, Wenjing Ding & Jun Xu. (2014) SIMPLEX OPTIMIZATION FOR ALOE-EMODIN SEPARATION AND PURIFICATION USING AQUEOUS DOUBLE-PHASE EXTRACTION SYSTEM. Journal of Liquid Chromatography & Related Technologies 37:5, pages 653-663.
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Kazufusa Shinomiya, Heran Li, Susumu Kitanaka & Yoichiro Ito. (2009) Countercurrent Chromatographic Separation of Lipophilic Ascorbic Acid Derivatives and Extract from Kadsura coccinea Using Hydrophobic Organic-Aqueous Two-Phase Solvent Systems. Journal of Liquid Chromatography & Related Technologies 32:16, pages 2361-2371.
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Articles from other publishers (35)

Kazufusa Shinomiya, Hiroshi Iijima & Yoichiro Ito. (2023) Countercurrent chromatography as a frontier tool to discover new mechanical roles in liquid–liquid phase separation of cellular biomolecules. Biomedical Chromatography 37:7.
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Aline Gomes Lopes, Ricardo Moreira Borges, Stefan Kuhn, Rafael Garrett & Fernanda das Neves Costa. (2022) Combining high-speed countercurrent chromatography three-phase solvent system with electrospray ionization-mass spectrometry and nuclear magnetic resonance to profile the unconventional food plant Syzygium malaccense. Journal of Chromatography A 1677, pages 463211.
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Jun‐Xian Jing, Xiao Sun, Ning‐Li Wang, Dong Pei, Duo‐Long Di & Xin‐Yi Huang. (2022) Comprehensive separation of a wide variety of compounds from olive leaves by counter‐current chromatography with three‐phase solvent system. Journal of Separation Science 45:11, pages 1942-1951.
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Jun‐Xian Jing, Dong Pei, Duo‐Long Di & Xin‐Yi Huang. (2021) Role of three‐phase solvent system in the counter‐current chromatography. Journal of Separation Science 45:1, pages 338-346.
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Zhenshan Chen, Zhenhua Tian, Yaowen Zhang, Xiaoming Wang, Jinqi Xu, Yunlun Li, Haiqiang Jiang & Benzheng Su. (2021) Separation of chemical constituents in Bidens pilosa Linn. var. radiata Sch. Bip. by elution‐extrusion counter‐current chromatography using two new three‐phase solvent systems . Journal of Separation Science 44:19, pages 3540-3550.
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Fernanda das Neves Costa, Gerold Jerz, Peter Hewitson, Fabiana de Souza Figueiredo & Svetlana Ignatova. (2021) Laguncularia racemosa Phenolics Profiling by Three-Phase Solvent System Step-Gradient Using High-Performance Countercurrent Chromatography with Off-Line Electrospray Mass-Spectrometry Detection. Molecules 26:8, pages 2284.
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Walter Vetter, Marco Müller, Michael Englert & Simon Hammann. 2020. Liquid-Phase Extraction. Liquid-Phase Extraction 289 325 .
Leslie Brown, Martyn J. Earle, Manuela A. Gilea, Natalia V. Plechkova & Kenneth R. Seddon. 2020. Commercial Applications of Ionic Liquids. Commercial Applications of Ionic Liquids 167 189 .
Dan Liu, Xinxin Liu & Xiaozhe Zhang. (2019) Preparative isolation of caffeoylquinic acid isomers from Kuding tea by salt‐containing aqueous two‐phase extraction and purification by high‐speed countercurrent chromatography. SEPARATION SCIENCE PLUS 2:5, pages 170-177.
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Yanjuan Liu, Pengqun Kuang, Shaofen Guo, Qing Sun, Tao Xue & Haigang Li. (2018) An overview of recent progress in solvent systems, additives and modifiers of counter current chromatography. New Journal of Chemistry 42:9, pages 6584-6600.
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Leslie Brown, Martyn J. Earle, Manuela A. Gîlea, Natalia V. Plechkova & Kenneth R. Seddon. (2017) Ionic Liquid–Liquid Chromatography: A New General Purpose Separation Methodology. Topics in Current Chemistry 375:5.
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David P. Ward, Peter Hewitson, Max Cárdenas-Fernández, Charlotte Hamley-Bennett, Alba Díaz-Rodríguez, Nathalie Douillet, Joseph P. Adams, David J. Leak, Svetlana Ignatova & Gary J. Lye. (2017) Centrifugal partition chromatography in a biorefinery context: Optimisation and scale-up of monosaccharide fractionation from hydrolysed sugar beet pulp. Journal of Chromatography A 1497, pages 56-63.
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Leslie Brown, Martyn J. Earle, Manuela A. Gîlea, Natalia V. Plechkova & Kenneth R. Seddon. (2017) Ionic Liquid–Liquid Separations Using Countercurrent Chromatography: A New General-Purpose Separation Methodology. Australian Journal of Chemistry 70:8, pages 923.
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Dan Liu, Zhilai Hong, Mingzhe Gao, Zhixin Wang, Ming Gu, Xiaozhe Zhang & Hongbin Xiao. (2016) Polarity, selectivity and performance of hydrophilic organic/salt-containing aqueous two-phase system on counter-current chromatography for polar compounds. Journal of Chromatography A 1448, pages 49-57.
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Go Morikawa, Chihiro Suzuka, Atsushi Shoji, Yoichi Shibusawa & Akio Yanagida. (2016) High-throughput determination of octanol/water partition coefficients using a shake-flask method and novel two-phase solvent system. Journal of Pharmaceutical and Biomedical Analysis 117, pages 338-344.
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Fazuo Wang, Ru Li, Lijuan Long, Xinpeng Tian, Zhihui Xiao, Si Zhang & Hao Yin. (2015) A Three-Phase Solvent System in High-Speed Counter-Current Chromatographic for the Separation and Purification of Bioactive Constituents from Acanthus ilicifolius. Chromatographia 78:21-22, pages 1401-1407.
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David P. Ward, Max Cárdenas-Fernández, Peter Hewitson, Svetlana Ignatova & Gary J. Lye. (2015) Centrifugal partition chromatography in a biorefinery context: Separation of monosaccharides from hydrolysed sugar beet pulp. Journal of Chromatography A 1411, pages 84-91.
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J. Brent Friesen, James B. McAlpine, Shao-Nong Chen & Guido F. Pauli. (2015) Countercurrent Separation of Natural Products: An Update. Journal of Natural Products 78:7, pages 1765-1796.
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Yanjuan Liu, Xiaofen Chen, JunXi Liu & Duolong Di. (2015) Three-phase solvent systems for the comprehensive separation of a wide variety of compounds from Dicranostigma leptopodum by high-speed counter-current chromatography . Journal of Separation Science 38:12, pages 2038-2045.
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Xiaoyi Wu, Zhimao Chao, Chun Wang & Li Yu. (2015) Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio. Journal of Chromatography A 1384, pages 107-114.
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Shengqiang Tong, Yoichiro Ito & Ying Ma. (2014) Enantioseparation of dl -tryptophan by spiral tube assembly counter-current chromatography and evaluation of mass transfer rate for enantiomers. Journal of Chromatography A 1374, pages 77-84.
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Dan Liu, Xiaowei Zou, Mingzhe Gao, Ming Gu & Hongbin Xiao. (2014) Hydrophilic organic/salt-containing aqueous two-phase solvent system for counter-current chromatography: A novel technique for separation of polar compounds. Journal of Chromatography A 1356, pages 157-162.
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Kazufusa Shinomiya, Kazuki Sato, Kazunori Yoshida, Koji Tokura, Hiroshi Maruyama, Kazuhiro Yanagidaira & Yoichiro Ito. (2013) Partition efficiencies of newly fabricated universal high-speed counter-current chromatograph for separation of two different types of sugar derivatives with organic–aqueous two-phase solvent systems. Journal of Chromatography A 1322, pages 74-80.
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Hao Yin, Si Zhang, Lijuan Long, Hang Yin, Xinpeng Tian, Xiongming Luo, Haihan Nan & Sha He. (2013) The separation of flavonoids from Pongamia pinnata using combination columns in high-speed counter-current chromatography with a three-phase solvent system. Journal of Chromatography A 1315, pages 80-85.
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Mahmoud Hamzaoui, Jean‐Hugues Renault, Jean‐Marc Nuzillard, Romain Reynaud & Jane Hubert. (2013) Stepwise Elution of a Three‐phase Solvent System in Centrifugal Partition Extraction: A New Strategy for the Fractionation and Phytochemical Screening of a Crude Bark Extract. Phytochemical Analysis 24:4, pages 367-373.
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Ian Sutherland, Peter Hewitson, Rick Siebers, Remco van den Heuvel, Lillian Arbenz, Joachim Kinkel & Derek Fisher. (2011) Scale-up of protein purifications using aqueous two-phase systems: Comparing multilayer toroidal coil chromatography with centrifugal partition chromatography. Journal of Chromatography A 1218:32, pages 5527-5530.
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Yoichi Shibusawa, Atsushi Shoji, Chihiro Suzuka, Akio Yanagida & Yoichiro Ito. (2010) Counter-current chromatographic separation of nucleic acid constituents with a hydrophilic solvent system. Journal of Chromatography A 1217:20, pages 3457-3460.
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A. Berthod, M.J. Ruiz-Ángel & S. Carda-Broch. (2009) Countercurrent chromatography: People and applications. Journal of Chromatography A 1216:19, pages 4206-4217.
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Guido F. Pauli, Samuel M. Pro & J. Brent Friesen. (2008) Countercurrent Separation of Natural Products. Journal of Natural Products 71:8, pages 1489-1508.
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Atsushi Shoji, Akio Yanagida, Heisaburo Shindo, Yoichiro Ito & Yoichi Shibusawa. (2007) Counter-current chromatographic estimation of hydrophobicity of Z-(cis) and E-(trans) enalapril and kinetics of cis/trans isomerization. Journal of Chromatography A 1157:1-2, pages 101-107.
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Akio Yanagida, Yutaka Yamakawa, Ryoko Noji, Ako Oda, Heisaburo Shindo, Yoichiro Ito & Yoichi Shibusawa. (2007) Comprehensive separation of secondary metabolites in natural products by high-speed counter-current chromatography using a three-phase solvent system. Journal of Chromatography A 1151:1-2, pages 74-81.
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Kazufusa Shinomiya, Hiroko Kobayashi, Norio Inokuchi, Koji Kobayashi, Hisashi Oshima, Susumu Kitanaka, Kazuhiro Yanagidaira, Haruo Sasaki, Minoru Muto, Michiharu Okano & Yoichiro Ito. (2007) New small-scale cross-axis coil planet centrifuge. Journal of Chromatography A 1151:1-2, pages 91-98.
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J. Brent Friesen & Guido F. Pauli. (2007) Rational development of solvent system families in counter-current chromatography. Journal of Chromatography A 1151:1-2, pages 51-59.
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Maria Jose Ruiz-Angel, Veronica Pino, Samuel Carda-Broch & Alain Berthod. (2007) Solvent systems for countercurrent chromatography: An aqueous two phase liquid system based on a room temperature ionic liquid. Journal of Chromatography A 1151:1-2, pages 65-73.
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Yoichi Shibusawa, Yutaka Yamakawa, Ryoko Noji, Akio Yanagida, Heisaburo Shindo & Yoichiro Ito. (2006) Three-phase solvent systems for comprehensive separation of a wide variety of compounds by high-speed counter-current chromatography. Journal of Chromatography A 1133:1-2, pages 119-125.
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