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Journal of Liquid Chromatography & Related Technologies Volume 30, 2007 - Issue 2
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Original Articles

Retention Phenomena Induced by Large Volume Injection of Solvents Non‐Miscible with the Mobile Phase in Reversed‐Phase Liquid Chromatography

Andrei Medvedovici Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, RomaniaCorrespondence[email protected]
,
Vasile David Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, Romania
,
Victor David Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, Romania
&
Cristina Georgita LaborMed Pharma S.A., Bucharest, Romania
Pages 199-213 | Received 20 Sep 2006, Accepted 27 Oct 2006, Published online: 07 Feb 2007

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Stefan Udrescu, Iuliana Daniela Sora, Victor David & Andrei Medvedovici. (2009) LARGE VOLUME INJECTION OF HEXANE SOLUTIONS IN RPLC/UV TO ENHANCE ON SENSITIVITY OF THE ASSAY OF GINKGOLIC ACIDS IN GINGKO BILOBA STANDARDIZED EXTRACTS. Journal of Liquid Chromatography & Related Technologies 33:1, pages 133-149.
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Articles from other publishers (22)

Thiago Santana Novotny, Mychelle Alves Monteiro, Patrícia Condé de Lima, Soraya de Mendonça Ochs, Ricardo Luiz do Nascimento Maranho, Fernando Antônio Simas Vaz & Flávia Ferreira de Carvalho Marques. (2023) Thymol-Based Hydrophobic Deep Eutectic Solvents as a Green Approach for Screening Polar Nitrosamines in Sartans Pharmaceutical Products by Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction Combined with HPLC-DAD. Journal of Pharmaceutical Sciences 112:5, pages 1231-1245.
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Gino Groeneveld, Melissa N. Dunkle, Matthias Pursch, Edwin P.C. Mes, Peter J. Schoenmakers & Andrea F.G. Gargano. (2022) Investigation of the effects of solvent-mismatch and immiscibility in normal-phase × aqueous reversed-phase liquid chromatography. Journal of Chromatography A 1665, pages 462818.
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Serban Moldoveanu & Victor David. 2022. Essentials in Modern HPLC Separations. Essentials in Modern HPLC Separations 207 269 .
Serban C. Moldoveanu & Victor David. 2017. Selection of the HPLC Method in Chemical Analysis. Selection of the HPLC Method in Chemical Analysis 393 450 .
Edvin Caiali, Victor David, Hassan Y. Aboul-Enein & Serban C. Moldoveanu. (2016) Evaluation of the phase ratio for three C18 high performance liquid chromatographic columns. Journal of Chromatography A 1435, pages 85-91.
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Serban Moldoveanu & Victor David. (2015) Estimation of the phase ratio in reversed-phase high-performance liquid chromatography. Journal of Chromatography A 1381, pages 194-201.
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Paul Lazăr, Ştefan Udrescu, Florentin Tache, Florin Albu, Nelu Grinberg & Andrei Medvedovici. (2015) Revisiting large volume injection in non-miscible diluents: an on-line reversed phase supported liquid extraction/liquid chromatography scenario. Analytical Methods 7:1, pages 342-352.
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Victor David, Toma Galaon & Hassan Y. Aboul-Enein. (2014) Effects of large volume injection of aliphatic alcohols as sample diluents on the retention of low hydrophobic solutes in reversed-phase liquid chromatography. Journal of Chromatography A 1323, pages 115-122.
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Victor DavidMihaela Cheregi & Andrei Medvedovici. (2013) Alternative sample diluents in bioanalytical LC–MS. Bioanalysis 5:24, pages 3051-3061.
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Mihaela Cheregi, Florin Albu, Ştefan Udrescu, Nicoleta Răducanu & Andrei Medvedovici. (2013) Greener bioanalytical approach for LC/MS–MS assay of enalapril and enalaprilat in human plasma with total replacement of acetonitrile throughout all analytical stages. Journal of Chromatography B 927, pages 124-132.
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Florentin Tache, Stefan Udrescu, Florin Albu, Florina Micăle & Andrei Medvedovici. (2013) Greening pharmaceutical applications of liquid chromatography through using propylene carbonate–ethanol mixtures instead of acetonitrile as organic modifier in the mobile phases. Journal of Pharmaceutical and Biomedical Analysis 75, pages 230-238.
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T. Galaon, E. Bacalum, M. Cheregi & V. David. (2012) Retention Studies for Large Volume Injection of Aromatic Solvents on Phenyl-Silica Based Stationary Phase in RP-LC. Journal of Chromatographic Science 51:2, pages 166-172.
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Andrei Medvedovici, Stefan Udrescu & Victor David. (2012) Use of a green (bio) solvent – limonene – as extractant and immiscible diluent for large volume injection in the RPLC‐tandem MS assay of statins and related metabolites in human plasma. Biomedical Chromatography 27:1, pages 48-57.
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Costel Sârbu, Rodica Domnica Naşcu-Briciu, Dorina Casoni, Agata Kot-Wasik, Andrzej Wasik & Jacek Namieśnik. (2012) Chromatographic lipophilicity determination using large volume injections of the solvents non-miscible with the mobile phase. Journal of Chromatography A 1266, pages 53-60.
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Toma Galaon, Medeea Radulescu, Victor David & Andrei Medvedovici. (2012) Use of an immiscible diluent in ionic liquid / ion pair LC for the assay of an injectable analgesic. Open Chemistry 10:4, pages 1360-1368.
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Henrik Nordberg, Gunilla Jerndal & Richard A Thompson. (2011) Direct injection of lipophilic compounds in the organic phase from liquid–liquid extracted plasma samples onto a reversed-phase column. Bioanalysis 3:17, pages 1963-1973.
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Andrei Medvedovici, Stefan Udrescu, Florin Albu, Florentin Tache & Victor David. (2011) Large-volume injection of sample diluents not miscible with the mobile phase as an alternative approach in sample preparation for bioanalysis: an application for fenspiride bioequivalence. Bioanalysis 3:17, pages 1935-1947.
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Stefan Udrescu, Iulia Daniela Sora, Florin Albu, Victor David & Andrei Medvedovici. (2011) Large volume injection of 1-octanol as sample diluent in reversed phase liquid chromatography: Application in bioanalysis for assaying of indapamide in whole blood. Journal of Pharmaceutical and Biomedical Analysis 54:5, pages 1163-1172.
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Victor David, Toma Galaon, Edvin Caiali & Andrei Medvedovici. (2009) Competitional hydrophobicity driven separations under RP-LC mechanism: Application to sulfonylurea congeners. Journal of Separation Science 32:18, pages 3099-3106.
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Eric Loeser, Stanislaw Babiak & Patrick Drumm. (2009) Water-immiscible solvents as diluents in reversed-phase liquid chromatography. Journal of Chromatography A 1216:15, pages 3409-3412.
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Stefan Udrescu, Andrei Medvedovici & Victor David. (2008) Effect of large volume injection of hydrophobic solvents on the retention of less hydrophobic pharmaceutical solutes in RP-LC. Journal of Separation Science 31:16-17, pages 2939-2945.
Crossref
Min S. Chang, Qin Ji, Jun Zhang & Tawakol A. El‐Shourbagy. (2007) Historical review of sample preparation for chromatographic bioanalysis: pros and cons. Drug Development Research 68:3, pages 107-133.
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