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Original Articles

Rasagiline-encapsulated chitosan-coated PLGA nanoparticles targeted to the brain in the treatment of parkinson's disease

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Sagar R. Pardeshi, Aniket Nikam, Priyanka Chandak, Vijaya Mandale, Jitendra B. Naik & Prabhanjan S. Giram. (2023) Recent advances in PLGA based nanocarriers for drug delivery system: a state of the art review. International Journal of Polymeric Materials and Polymeric Biomaterials 72:1, pages 49-78.
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Yan Zhao, Fang Lu, Yue Zhang, Meiling Zhang, Yusheng Zhao, Juan Luo, Hui Kong & Huihua Qu. (2021) Water-Soluble Carbon Dots in Cigarette Mainstream Smoke: Their Properties and the Behavioural, Neuroendocrinological, and Neurotransmitter Changes They Induce in Mice. International Journal of Nanomedicine 16, pages 2203-2217.
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Niyaz Ahmad, Rizwan Ahmad, Mortaja Zaki Almakhamel, Khalid Ansari, Mohd Amir, Wasim Ahmad, Abuzer Ali & Farhan Jalees Ahmad. (2020) RETRACTED ARTICLE: A comparative pulmonary pharmacokinetic study of budesonide using polymeric nanoparticles targeted to the lungs in treatment of asthma. Artificial Cells, Nanomedicine, and Biotechnology 48:1, pages 749-762.
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Niyaz Ahmad, Abeer M. Al-Subaie, Rizwan Ahmad, Sonali Sharma, Md Aftab Alam, Mohammad Ashafaq, Rehan Abdur Rub & Farhan Jalees Ahmad. (2019) RETRACTED ARTICLE: Brain-targeted glycyrrhizic-acid-loaded surface decorated nanoparticles for treatment of cerebral ischaemia and its toxicity assessment. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 475-490.
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Saleha Rehman, Bushra Nabi, Ameeduzzafar Zafar, Sanjula Baboota & Javed Ali. (2019) Intranasal delivery of mucoadhesive nanocarriers: a viable option for Parkinson’s disease treatment?. Expert Opinion on Drug Delivery 16:12, pages 1355-1366.
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Shengnan Tang, Aiping Wang, Xiuju Yan, Liuxiang Chu, Xiucheng Yang, Yina Song, Kaoxiang Sun, Xin Yu, Rongxia Liu, Zimei Wu & Peng Xue. (2019) Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease. Drug Delivery 26:1, pages 700-707.
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Articles from other publishers (47)

Sharayu Govardhane & Pravin Shende. (2023) Zinc–Phthalocyanine Loaded PLGA–PVA–Chitosan Nanosystem for the Enhancement of Antidiabetic Activity. Molecular Pharmaceutics.
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Dnyandev Gadhave, Mural Quadros, Akanksha R. Ugale, Mimansa Goyal & Vivek Gupta. (2023) A Nanoemulgel for Nose-to-Brain delivery of Quetiapine – QbD-Enabled formulation development & in-vitro characterization. International Journal of Pharmaceutics 648, pages 123566.
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Ikram Hasan, Shubham Roy, Bing Guo & Chunqi Chang. (2023) Parkinson's Disease: Current Status, Diagnosis, and Treatment Using Nanomedicines. Advanced Therapeutics 6:9.
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Donia M. Hassan, Amal H. El-Kamel, Eman A. Allam, Basant A. Bakr & Asmaa A. Ashour. (2023) Chitosan-coated nanostructured lipid carriers for effective brain delivery of Tanshinone IIA in Parkinson’s disease: interplay between nuclear factor-kappa β and cathepsin B. Drug Delivery and Translational Research.
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Mohd Faiyaz Khan, Niyaz Ahmad, Faisal K. Alkholifi, Zabih Ullah, Sadaf Farooqui, Nazia Khan, Mohammed Saifuddin Khalid, Mir Naiman Ali & Hajera Tabassum. (2023) A Novel UHPLC-MS/MS-Based Bioanalytical Method Developed for S-Allyl Cysteine in the Establishment of a Comparative Pharmacokinetic Study. Separations 10:8, pages 423.
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Niyaz Ahmad, Mohammed Saifuddin Khalid, Ayman Makki Al Ramadhan, Mohammed Zaki Alaradi, Mohammed Riyad Al Hammad, Khalid Ansari, Yousef D. Alqurashi, Mohd Faiyaz Khan, Ahmed A. Albassam, Mohammad Javed Ansari, Sultan Akhtar & Mubah Dilshad. (2022) Preparation of melatonin novel-mucoadhesive nanoemulsion used in the treatment of depression. Polymer Bulletin 80:7, pages 8093-8132.
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Paramita Saha, Himanshu Kathuria & Murali Monohar Pandey. (2023) Intranasal nanotherapeutics for brain targeting and clinical studies in Parkinson's disease. Journal of Controlled Release 358, pages 293-318.
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Rania Awad, Avi Avital & Alejandro Sosnik. (2023) Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders. Acta Pharmaceutica Sinica B 13:5, pages 1866-1886.
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Mohamed Mahmoud Ali, Raguia Aly Shoukri & Carol Yousry. (2022) Thin film hydration versus modified spraying technique to fabricate intranasal spanlastic nanovesicles for rasagiline mesylate brain delivery: Characterization, statistical optimization, and in vivo pharmacokinetic evaluation. Drug Delivery and Translational Research 13:4, pages 1153-1168.
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Surbhi Sharma & Shweta Dang. (2023) Nanocarrier-Based Drug Delivery to Brain: Interventions of Surface Modification. Current Neuropharmacology 21:3, pages 517-535.
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Dharmendra K. Khatri, Kumari Preeti, Shivraj Tonape, Sheoshree Bhattacharjee, Monica Patel, Saurabh Shah, Pankaj K. Singh, Saurabh Srivastava, Dalapathi Gugulothu, Lalitkumar Vora & Shashi B. Singh. (2023) Nanotechnological Advances for Nose to Brain Delivery of Therapeutics to Improve the Parkinson Therapy. Current Neuropharmacology 21:3, pages 493-516.
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Heba F. Salem, Adel A. Ali, Yasmine K. Rabea, Fatma I. Abo El-Ela & Rasha A. Khallaf. (2023) Optimization and Appraisal of Chitosan-Grafted PLGA Nanoparticles for Boosting Pharmacokinetic and Pharmacodynamic Effect of Duloxetine HCl Using Box-Benkhen Design. Journal of Pharmaceutical Sciences 112:2, pages 544-561.
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Anjali Bhosale, Gajanan Paul, Farhan Mazahir & A.K. Yadav. (2023) Theoretical and applied concepts of nanocarriers for the treatment of Parkinson's diseases. OpenNano 9, pages 100111.
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Ahmed Hafez Mousa & Salwa Agha Mohammad. (2022) Potential role of chitosan, PLGA and iron oxide nanoparticles in Parkinson’s disease therapy. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 58:1.
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Rania M. Hathout & Eman M. El-Marakby. (2022) Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers. Bioengineering 9:11, pages 647.
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Subashini Raman, Arshad Ali Khan & Syed Mahmood. (2022) Nose to brain delivery of selegiline loaded PLGA/lipid nanoparticles: Synthesis, characterisation and brain pharmacokinetics evaluation. Journal of Drug Delivery Science and Technology 77, pages 103923.
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Mohammed H. Elkomy, Adel A. Ali & Hussein M. Eid. (2022) Chitosan on the surface of nanoparticles for enhanced drug delivery: A comprehensive review. Journal of Controlled Release 351, pages 923-940.
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Saeem Ahmad, Iram Khan, Jayamanti Pandit, Nasr A. Emad, Shahnaj Bano, Khalid Imtiyaz Dar, M. Moshahid Alam Rizvi, Mohd Danish Ansari, Mohd. Aqil & Yasmin Sultana. (2022) Brain targeted delivery of carmustine using chitosan coated nanoparticles via nasal route for glioblastoma treatment. International Journal of Biological Macromolecules 221, pages 435-445.
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Niyaz Ahmad, Mohammed Jameel Abdulrahman Al-Ghamdi, Hani Saleh M. Alnajjad, Basaam Basim A. Al Omar, Mohd Faiyaz Khan, Ziyad Saeed Almalki, Ahmed A. Albassam, Zabih Ullah, Mohammed Saifuddin Khalid & Kamran Ashraf. (2022) A comparative brain Toxico-Pharmacokinetics study of a developed tannic acid nanoparticles in the treatment of epilepsy. Journal of Drug Delivery Science and Technology 76, pages 103772.
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Miguel Pinto, Vera Silva, Sandra Barreiro, Renata Silva, Fernando Remião, Fernanda Borges & Carlos Fernandes. (2022) Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform. Ageing Research Reviews 79, pages 101658.
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Violet V. Sheffey, Emily B. Siew, Eden E. L. Tanner & Omolola Eniola‐Adefeso. (2022) PLGA's Plight and the Role of Stealth Surface Modification Strategies in Its Use for Intravenous Particulate Drug Delivery. Advanced Healthcare Materials 11:8, pages 2101536.
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Francisca Espinoza, Walther Ide, Natalia Saldivia & Diego Zelada. 2022. Polymeric Biomaterials for Healthcare Applications. Polymeric Biomaterials for Healthcare Applications 369 402 .
Mohammed H. Elkomy, Rasha A. Khallaf, Mohamed O. Mahmoud, Raghda R. S. Hussein, Asmaa M. El-Kalaawy, Abdel-Razik H. Abdel-Razik & Heba M. Aboud. (2021) Intratracheally Inhalable Nifedipine-Loaded Chitosan-PLGA Nanocomposites as a Promising Nanoplatform for Lung Targeting: Snowballed Protection via Regulation of TGF-β/β-Catenin Pathway in Bleomycin-Induced Pulmonary Fibrosis. Pharmaceuticals 14:12, pages 1225.
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Ezgi Saylam, Yigit Akkaya, Elif Ilhan, Sumeyye Cesur, Ece Guler, Ali Sahin, Muhammmet Emin Cam, Nazmi Ekren, Faik Nuzhet Oktar, Oguzhan Gunduz, Denisa Ficai & Anton Ficai. (2021) Levodopa-Loaded 3D-Printed Poly (Lactic) Acid/Chitosan Neural Tissue Scaffold as a Promising Drug Delivery System for the Treatment of Parkinson’s Disease. Applied Sciences 11:22, pages 10727.
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Claudia Riccardi, Filomena Napolitano, Daniela Montesarchio, Simone Sampaolo & Mariarosa Anna Beatrice Melone. (2021) Nanoparticle-Guided Brain Drug Delivery: Expanding the Therapeutic Approach to Neurodegenerative Diseases. Pharmaceutics 13:11, pages 1897.
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Javad Sharifi-Rad, Cristina Quispe, Monica Butnariu, Lia Sanda Rotariu, Oksana Sytar, Simona Sestito, Simona Rapposelli, Muhammad Akram, Mehwish Iqbal, Akash Krishna, Nanjangud Venkatesh Anil Kumar, Susana S. Braga, Susana M. Cardoso, Karolina Jafernik, Halina Ekiert, Natália Cruz-Martins, Agnieszka Szopa, Marcelo Villagran, Lorena Mardones, Miquel Martorell, Anca Oana Docea & Daniela Calina. (2021) Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment. Cancer Cell International 21:1.
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Abdifetah Ibrahim Omar, Tullayakorn Plengsuriyakarn, Chuda Chittasupho & Kesara Na‐Bangchang. (2020) Enhanced oral bioavailability and biodistribution of atractylodin encapsulated in PLGA nanoparticle in cholangiocarcinoma. Clinical and Experimental Pharmacology and Physiology 48:3, pages 318-328.
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Imane M. Higazy, Azza A. Mahmoud, Mahmoud M. Ghorab & Hussein O. Ammar. (2021) Development and evaluation of polyvinyl alcohol stabilized polylactide-co-caprolactone-based nanoparticles for brain delivery. Journal of Drug Delivery Science and Technology 61, pages 102274.
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Niyaz Ahmad, Rizwan Ahmad, Mohd Amir, Md Aftab Alam, Mortaja Zaki Almakhamel, Abuzer Ali, Ayaz Ahmad & Kamran Ashraf. (2021) Ischemic brain treated with 6-gingerol loaded mucoadhesive nanoemulsion via intranasal delivery and their comparative pharmacokinetic effect in brain. Journal of Drug Delivery Science and Technology 61, pages 102130.
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Ikram Ahmad, Hina Tabassum, Farwa Batool Shamsi, Saad Maroof Saeed, Awais Ahmad & Shahid Hussain. 2021. Nanomedicine Manufacturing and Applications. Nanomedicine Manufacturing and Applications 173 191 .
Manuela Curcio, Giuseppe Cirillo, Jourdin R. C. Rouaen, Federica Saletta, Fiore Pasquale Nicoletta, Orazio Vittorio & Francesca Iemma. (2020) Natural Polysaccharide Carriers in Brain Delivery: Challenge and Perspective. Pharmaceutics 12:12, pages 1183.
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Niyaz Ahmad, Rizwan Ahmad, Sadiq Al Qatifi, Mahdi Alessa, Hassan Al Hajji & Md Sarafroz. (2020) A bioanalytical UHPLC based method used for the quantification of Thymoquinone-loaded-PLGA-nanoparticles in the treatment of epilepsy. BMC Chemistry 14:1.
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Nikhil R. Bali & Pramod S. Salve. (2020) Impact of rasagiline nanoparticles on brain targeting efficiency via gellan gum based transdermal patch: A nanotheranostic perspective for Parkinsonism. International Journal of Biological Macromolecules 164, pages 1006-1024.
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Yujun Zeng, Zhiqian Li, Hongyan Zhu, Zhongwei Gu, Hu Zhang & Kui Luo. (2020) Recent Advances in Nanomedicines for Multiple Sclerosis Therapy. ACS Applied Bio Materials 3:10, pages 6571-6597.
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Niyaz Ahmad, Rizwan Ahmad, Ridha Abdullah Alrasheed, Hassan Mohammed Ali Almatar, Abdullah Sami Al-Ramadan, Taysser Mohammed Buheazah, Hussain Salman AlHomoud, Hassan Ali Al-Nasif & Md Aftab Alam. (2020) A Chitosan-PLGA based catechin hydrate nanoparticles used in targeting of lungs and cancer treatment. Saudi Journal of Biological Sciences 27:9, pages 2344-2357.
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Yung-Chih Kuo & Rajendiran Rajesh. (2020) Particulate systems for improving therapeutic efficacy of pharmaceuticals against central nervous system-related diseases. Journal of the Taiwan Institute of Chemical Engineers 114, pages 12-23.
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Shrestha Sharma, Syed Arman Rabbani, Jasjeet K Narang, Faheem Hyder Pottoo, Javed Ali, Shobhit Kumar & Sanjula Baboota. (2020) Role of Rutin Nanoemulsion in Ameliorating Oxidative Stress: Pharmacokinetic and Pharmacodynamics Studies. Chemistry and Physics of Lipids 228, pages 104890.
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Niyaz Ahmad, Rizwan Ahmad, Ridha Alrasheed, Hassan Almatar, Abdullah Al-Ramadan, Mohd Amir & Md Sarafroz. (2020) Quantification and Evaluations of Catechin Hydrate Polymeric Nanoparticles Used in Brain Targeting for the Treatment of Epilepsy. Pharmaceutics 12:3, pages 203.
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Niyaz Ahmad, Rizwan Ahmad, Farhan Jalees Ahmad, Wasim Ahmad, Md Aftab Alam, Mohd Amir & Abuzer Ali. (2020) Poloxamer-chitosan-based Naringenin nanoformulation used in brain targeting for the treatment of cerebral ischemia. Saudi Journal of Biological Sciences 27:1, pages 500-517.
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Iman M. Higazy. (2020) Brain targeting stealth lipomers of combined antiepileptic-anti-inflammatory drugs as alternative therapy for conventional anti-Parkinson’s. Saudi Pharmaceutical Journal 28:1, pages 33-57.
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Jiayuan Shen, Qi Jia, Xuhua Huang, Guangzhe Yao, Wenjuan Ma, Yanxu Chang, Huizi Ouyang & Jun He. (2019) Study on Pharmacokinetic and Bioavailability of Tamarixetin after Intravenous and Oral Administration to Rats. Evidence-Based Complementary and Alternative Medicine 2019, pages 1-7.
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