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Original Articles

A Validated High-Performance Liquid Chromatographic Method for the Determination Of Paracetamol and Its Major Metabolites in Urine

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Pages 3257-3268 | Received 24 Mar 1995, Accepted 02 Apr 1995, Published online: 23 Sep 2006

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Samy Emara, Tsutomu Masujima, Ghada Hadad, Maha Kamal, Hala ZaaZaa & Mohamed Abdel Kawi. (2013) A RAPID, SENSITIVE, AND ENVIRONMENTALLY FRIENDLY ON-LINE SOLID PHASE EXTRACTION USING PROTEIN-COATED μ-BONDAPAK CYANIDE SILICA PRECOLUMN FOR CHROMATOGRAPHIC DETERMINATION OF PARACETAMOL IN HUMAN SERUM. Journal of Liquid Chromatography & Related Technologies 36:10, pages 1297-1311.
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M.V. N. Kumar Talluri, MukeshK. Bairwa, H.H. Theja Dugga & R. Srinivas. (2012) DEVELOPMENT AND VALIDATION OF RP-HPLC AND ULTRAVIOLET SPECTROPHOTOMETRIC METHODS OF ANALYSIS FOR SIMULTANEOUS DETERMINATION OF PARACETAMOL AND LORNOXICAM IN PHARMACEUTICAL DOSAGE FORMS. Journal of Liquid Chromatography & Related Technologies 35:1, pages 129-140.
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Articles from other publishers (24)

Ibrahim A. Naguib, Meral Majed, Maram Albogami, Maram Alshehri, Aseel Bukhari, Hadeel Alshabani, Izzeddin Alsalahat & Heba-Alla H. Abd-ElSalam. (2023) Greenness Assessment of HPLC Analytical Methods with Common Detectors for Assay of Paracetamol and Related Materials in Drug Products and Biological Fluids. Separations 10:5, pages 283.
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Xiqian Zhang, Ruina Li, Wenya Hu, Jin Zeng, Xuehua Jiang & Ling Wang. (2018) A reliable LC-MS/MS method for the quantification of N -acetyl- p -benzoquinoneimine, acetaminophen glutathione and acetaminophen glucuronide in mouse plasma, liver and kidney: Method validation and application to a pharmacokinetic study . Biomedical Chromatography 32:11, pages e4331.
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Mohsen Behpour, Sayed Mehdi Ghoreishi & Ebrahim Honarmand. (2010) A Gold Nanoparticle-Modified Carbon Paste Electrode as a Sensor for Simultaneous Determination of Acetaminophen and Atenolol. International Journal of Electrochemical Science 5:12, pages 1922-1933.
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Hao Zou, Shouhong Gao, Wansheng Chen, Yanqiang Zhong, Xuetao Jiang & Yuanying Pei. (2008) Simultaneous Quantitation of Paracetamol, Pseudoephedrine and Chlorpheniramine in Dog Plasma by LC-MS-MS. Chromatographia 68:3-4, pages 251-257.
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Qiongfeng Liao, Zhiyong Xie, Biyan Pan, Chenchen Zhu, Meicun Yao, Xinjun Xu & Jinzhi Wan. (2008) LC–MS–MS Simultaneous Determination of Paracetamol, Pseudoephedrine and Chlorpheniramine in Human Plasma: Application to a Pharmacokinetic Study. Chromatographia 67:9-10, pages 687-694.
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Thomas Kraemer & Hans H. Maurer. 2008. Forensic Science. Forensic Science 319 356 .
A.S. El-Shahawy, S.M. Ahmed & N.Kh. Sayed. (2007) INDO/SCF-CI calculations and structural spectroscopic studies of some complexes of 4-hydroxyacetanilide. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 66:1, pages 143-152.
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M. Espinosa Bosch, A.J. Ruiz Sánchez, F. Sánchez Rojas & C. Bosch Ojeda. (2006) Determination of paracetamol: Historical evolution. Journal of Pharmaceutical and Biomedical Analysis 42:3, pages 291-321.
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Shulin Zhao, Wenling Bai, Hongyan Yuan & Dan Xiao. (2006) Detection of paracetamol by capillary electrophoresis with chemiluminescence detection. Analytica Chimica Acta 559:2, pages 195-199.
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Hayati Filik, İzzet Şener, Sema Demirci Cekiç, Emine Kiliç & Reşat Apak. (2006) Spectrophotometric Determination of Paracetamol in Urine with Tetrahydroxycalix[4]arene as a Coupling Reagent and Preconcentration with Triton X-114 Using Cloud Point Extraction. CHEMICAL & PHARMACEUTICAL BULLETIN Chemical and Pharmaceutical Bulletin 54:6, pages 891-896.
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Romina Kaushik, Barry Levine & William R. LaCourse. (2006) A brief review: HPLC methods to directly detect drug glucuronides in biological matrices (Part I). Analytica Chimica Acta 556:2, pages 255-266.
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Chunli Xu & Baoxin Li. (2004) Spectrophotometric determination of paracetamol with microwave assisted alkaline hydrolysis. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 60:8-9, pages 1861-1864.
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F Priego-Capote & M.D Luque de Castro. (2003) Ultrasound-assisted continuous liquid–liquid extraction without phase separation and hydrolysis of paracetamol in suppositories. Analytica Chimica Acta 489:2, pages 223-232.
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M.V Vertzoni, H.A Archontaki & P Galanopoulou. (2003) Development and optimization of a reversed-phase high-performance liquid chromatographic method for the determination of acetaminophen and its major metabolites in rabbit plasma and urine after a toxic dose. Journal of Pharmaceutical and Biomedical Analysis 32:3, pages 487-493.
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P. Ortega-Barrales, R. Padilla-Weigand & A. Molina-Díaz. (2002) Simultaneous Determination of Paracetamol and Caffeine by Flow Injection–Solid Phase Spectrometry Using C18 Silica Gel as a Sensing Support. Analytical Sciences 18:11, pages 1241-1246.
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Paula Schaiquevich, Ada Niselman & Modesto Rubio. (2002) Importance of entero‐salivary recirculation in paracetamol pharmacokinetics. Biopharmaceutics & Drug Disposition 23:6, pages 245-249.
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E.J Oliveira, D.G Watson & N.S Morton. (2002) A simple microanalytical technique for the determination of paracetamol and its main metabolites in blood spots. Journal of Pharmaceutical and Biomedical Analysis 29:5, pages 803-809.
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J. Meyer & U. Karst. (2001) Determination of paracetamol (acetaminophen) by HPLC with post-column enzymatic derivatization and fluorescence detection. Chromatographia 54:3-4, pages 163-167.
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M.J. Ayora Cañada, M.I. Pascual Reguera, A. Ruiz Medina, M.L. Fernández de Córdova & A. Molina Dı́az. (2000) Fast determination of paracetamol by using a very simple photometric flow-through sensing device. Journal of Pharmaceutical and Biomedical Analysis 22:1, pages 59-66.
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C Celma, J.A Allué, J Pruñonosa, C Peraire & R Obach. (2000) Simultaneous determination of paracetamol and chlorpheniramine in human plasma by liquid chromatography–tandem mass spectrometry. Journal of Chromatography A 870:1-2, pages 77-86.
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Thomas Kraemer & Hans H. Maurer. 2000. Forensic Science. Forensic Science 259 285 .
A. Ruiz Medina, M.L. Fernández de Córdova & A. Molina Dı́az. (1999) A very simple resolution of the mixture paracetamol and salicylamide by flow injection–solid phase spectrophotometry. Analytica Chimica Acta 394:2-3, pages 149-158.
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Colin T Bedford. (1998) Glucuronic acid conjugates. Journal of Chromatography B: Biomedical Sciences and Applications 717:1-2, pages 313-326.
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A. G. Goicoechea & J. L. Vila-Jato. (1998) Acetaminophen presystemic biotransformation vs bioavailability in therapeutical dosage range. European Journal of Drug Metabolism and Pharmacokinetics 23:2, pages 333-338.
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