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Journal of Liquid Chromatography Volume 18, 1995 - Issue 20: Clinical Analyses
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Original Articles

Simultaneous Measurement of Flurbiprofen, Ibuprofen, and Ketoprofen Enantiomer Concentrations in Plasma Using L-Leucinamide as the Chiral Coupling Component

F. Péhourcq Department of Pharmacology, EA 525, University of Bordeaux II, 33076, Bordeaux, Cedex, France
,
F. Lagrange Department of Pharmacology, EA 525, University of Bordeaux II, 33076, Bordeaux, Cedex, France
,
L. Labat Department of Pharmacology, EA 525, University of Bordeaux II, 33076, Bordeaux, Cedex, France
&
B. Bannwarth Department of Pharmacology, EA 525, University of Bordeaux II, 33076, Bordeaux, Cedex, France
Pages 3969-3979 | Received 24 Apr 1995, Accepted 26 May 1995, Published online: 23 Sep 2006

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N.H. Hashim, S. Shafie & S.J. Khan. (2010) Enantiomeric fraction as an indicator of pharmaceutical biotransformation during wastewater treatment and in the environment – a review. Environmental Technology 31:12, pages 1349-1370.
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Articles from other publishers (26)

Primal Sharma, Swati Guttikar, Gajendra Solanki, Daxesh P Patel & Pranav S Shrivastav. (2012) Determination of ( S )-(+)- and ( R )-(-)-ibuprofen enantiomers in human plasma after chiral precolumn derivatization by reversed-phase LC–ESI-MS/MS . Bioanalysis 4:24, pages 2909-2927.
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Patrícia Valderrama & Ronei Jesus Poppi. (2011) Second order standard addition method and fluorescence spectroscopy in the quantification of ibuprofen enantiomers in biological fluids. Chemometrics and Intelligent Laboratory Systems 106:2, pages 160-165.
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M.-J. Paik, D. T. Nguyen, I. S. Cho, S. Lee & K.-R. Kim. (2006) Measurement and Identification of (R)- and (S)-6-O-Desmethylnaproxen Enantiomers as Diastereomeric O-Ethoxycarbonyl/(R)-(+)-1-Phenylethylamides in Urine by GC and GC-MS. Chromatographia 63:11-12, pages 623-628.
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Man-Jeong Paik & Kyoung-Rae Kim. (2004) Optical purity determination of (S)-lbuprofen in tablets by achiral gas chromatography. Archives of Pharmacal Research 27:8, pages 820-824.
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Franciszek K. Główka & Marta Karaźniewicz. (2004) High performance capillary electrophoresis for determination of the enantiomers of 2-arylpropionic acid derivatives in human serum. Journal of Pharmaceutical and Biomedical Analysis 35:4, pages 807-816.
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F. Péhourcq, M. Matoga, C. Jarry & B. Bannwarth. (2003) HPLC microdetermination of flurbiprofen enantiomers in plasma with a glycopeptide‐type chiral stationary phase column. Biomedical Chromatography 18:5, pages 330-334.
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Man-Jeong Paik, Yoonsuk Lee, Junichi Goto & Kyoung-Rae Kim. (2004) Chiral discrimination of multiple profens as diastereomeric (R)-(+)-1-phenylethylamides by achiral dual-column gas chromatography. Journal of Chromatography B 803:2, pages 257-265.
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Fabienne Pehourcq, Myriam Matoga & Bernard Bannwarth. (2004) Diffusion of arylpropionate non-steroidal anti-inflammatory drugs into the cerebrospinal fluid: a quantitative structure-activity relationship approach. Fundamental and Clinical Pharmacology 18:1, pages 65-70.
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Pierina Sueli Bonato, Maria Perpetua F.M Del Lama & Roberto de Carvalho. (2003) Enantioselective determination of ibuprofen in plasma by high-performance liquid chromatography–electrospray mass spectrometry. Journal of Chromatography B 796:2, pages 413-420.
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Ramesh Mullangi, Ming Yao & Nuggehally R. Srinivas. (2003) Resolution of enantiomers of ketoprofen by HPLC: a review. Biomedical Chromatography 17:7, pages 423-434.
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M.A. Solinı́s, Y. de la Cruz, R.M. Hernández, A.R. Gascón, B. Calvo & J.L. Pedraz. (2002) Release of ketoprofen enantiomers from HPMC K100M matrices—diffusion studies. International Journal of Pharmaceutics 239:1-2, pages 61-68.
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M Matoga, F Péhourcq, F Lagrange, F Fawaz & B Bannwarth. (2002) Influence of a polymeric formulation of ketoprofen on its diffusion into cerebrospinal fluid in rats. Journal of Pharmaceutical and Biomedical Analysis 27:6, pages 881-888.
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B. K. Patel, J. Valentova & A. J. Hutt. (2002) Chromatographic separation and enantiomeric resolution of flurbiprofen and its major metabolites. Chromatographia 55:3-4, pages 135-142.
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M. Angeles Solinís, Yaimy de la Cruz, Begoña Calvo, Rosa M. Hernández, Alicia R. Gascón, Isabel Goñi, M. Dolores Gurruchaga & José Luis Pedraz. (2002) Release of salbutamol sulphate and ketoprofen enantiomers from matrices containing HPMC and cellulose derivatives. Chirality 14:10, pages 806-813.
Crossref
F Lagrange, T Fabre, F Péhourcq, A Durandeau & B Bannwarth. (2001) In vitro distribution of ketoprofen enantiomers in articular tissues of osteoarthritic patients. Journal of Pharmaceutical and Biomedical Analysis 26:5-6, pages 717-723.
Crossref
F. Péhourcq, C. Jarry & B. Bannwarth. (2001) Chiral resolution of flurbiprofen and ketoprofen enantiomers by HPLC on a glycopeptide-type column chiral stationary phase. Biomedical Chromatography 15:3, pages 217-222.
Crossref
Keith J. Duff. 2007. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry.
Fabrice Lagrange, Fabienne Péhourcq, Myriam Matoga & Bernard Bannwarth. (2000) Binding of ketoprofen enantiomers in various human albumin preparations. Journal of Pharmaceutical and Biomedical Analysis 23:5, pages 793-802.
Crossref
Thomas H. Eichhold, Ruth E. Bailey, Suzanne L. Tanguay & Steven H. Hoke. (2000) Determination of (R)- and (S)-ketoprofen in human plasma by liquid chromatography/tandem mass spectrometry following automated solid-phase extraction in the 96-well format. Journal of Mass Spectrometry 35:4, pages 504-511.
Crossref
A.I Gasco-Lopez, R Izquierdo-Hornillos & A Jimenez. (1999) LC method development for ibuprophen and validation in different pharmaceuticals. Journal of Pharmaceutical and Biomedical Analysis 21:1, pages 143-149.
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R. Bhushan & G. Thuku Thiongo. (1999) Direct enantiomeric resolution of some 2-arylpropionic acids using (−)-brucine-impregnated thin-layer chromatography. Biomedical Chromatography 13:4, pages 276-278.
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B. Bannwarth, F. Lagrange, F. Péhourcq, B. Llanas & J. L. Demarquez. (1999) (S)-ketoprofen accumulation in premature neonates with renal failure who were exposed to the racemate during pregnancy. British Journal of Clinical Pharmacology 47:4, pages 459-460.
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Ravi Bhushan & J�rgen Martens. (1998) Resolution of enantiomers of ibuprofen by liquid chromatography: a review. Biomedical Chromatography 12:6, pages 309-316.
Crossref
F Lagrange, F Pehourcq, B Bannwarth, JJ Leng & MC Saux. (2009) Passage of S ‐(+)‐ and R ‐(‐)‐ketoprofen across the human isolated perfused placenta . Fundamental & Clinical Pharmacology 12:3, pages 286-291.
Crossref
Laurence Deschamps-Labat, Fabienne Péhourcq, Maryline Jagou & Bernard Bannwarth. (1997) Relationship between lipophilicity and binding to human serum albumin of arylpropionic acid non-steroidal anti-inflammatory drugs. Journal of Pharmaceutical and Biomedical Analysis 16:2, pages 223-229.
Crossref
S. C. Tan, S. H. D. Jackson, C. G. Swift & A. J. Hutt. (1997) Enantiospecific analysis of ibuprofen by high performance liquid chromatography: Determination of free and total drug enantiomer concentrations in serum and urine. Chromatographia 46:1-2, pages 23-32.
Crossref

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