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Original Articles

Countercurrent Chromatography (CCC) and its Versatile Application as an Industrial Purification & Production Process

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Pages 279-298 | Received 20 Mar 1997, Accepted 01 Jul 1997, Published online: 22 Aug 2006

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Read on this site (14)

María José Navas, Ana María Jiménez-Moreno, Julia Martín Bueno, Purificación Sáez-Plaza & AgustinG. Asuero. (2012) Analysis and Antioxidant Capacity of Anthocyanin Pigments. Part III: An Introduction to Sample Preparation and Extraction. Critical Reviews in Analytical Chemistry 42:4, pages 284-312.
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Gilda Guimarães Leitão, Samira Santos El‐Adji, Walédya Araújo Lopes de Melo, Suzana Guimarães Leitão & Les Brown. (2005) Separation of Free and Glycosylated Flavonoids from Siparuna guianensis by Gradient and Isocratic CCC. Journal of Liquid Chromatography & Related Technologies 28:12-13, pages 2041-2051.
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I. A. Sutherland, D. Hawes, R. van den Heuvel, L. Janaway & E. Tinnion. (2003) Resolution in CCC: The Effect of Operating Conditions and Phase System Properties on Scale‐Up. Journal of Liquid Chromatography & Related Technologies 26:9-10, pages 1475-1491.
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I. A. Sutherland, J. de Folter & P. Wood. (2003) Modelling CCC Using an Eluting Countercurrent Distribution Model. Journal of Liquid Chromatography & Related Technologies 26:9-10, pages 1449-1474.
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Philip L. Wood, David Hawes, Lee Janaway & Ian A. Sutherland. (2003) Determination of J‐Type Centrifuge Extra‐Coil Volume Using Stationary Phase Retentions at Differing Flow Rates. Journal of Liquid Chromatography & Related Technologies 26:9-10, pages 1417-1430.
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Philip L. Wood, David Hawes, Lee Janaway & Ian A. Sutherland. (2003) Stationary Phase Retention in CCC: Modelling the J‐Type Centrifuge as a Constant Pressure Drop Pump. Journal of Liquid Chromatography & Related Technologies 26:9-10, pages 1373-1396.
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Lee Janaway, David Hawes, Svetlana Ignatova, Philip Wood & Ian A. Sutherland. (2003) A New Small Coil‐Volume CCC Instrument for Direct Interfacing with MS. Journal of Liquid Chromatography & Related Technologies 26:9-10, pages 1345-1354.
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A. S. Graham, I. F. McConvey & P. Shering. (2001) AN EVALUATION OF THE PERFORMANCE OF A PREPARATIVE CCC MACHINE FOR THE SEPARATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT. Journal of Liquid Chromatography & Related Technologies 24:11-12, pages 1811-1825.
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I. A. Sutherland, Q. Du & P. Wood. (2001) THE RELATIONSHIP BETWEEN RETENTION, LINEAR FLOW, AND DENSITY DIFFERENCE IN COUNTERCURRENT CHROMATOGRAPHY. Journal of Liquid Chromatography & Related Technologies 24:11-12, pages 1669-1683.
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I. A. Sutherland, A. J. Booth, L. Brown, B. Kemp, H. Kidwell, D. Games, A. S. Graham, G. G. Guillon, D. Hawes, M. Hayes, L. Janaway, G. J. Lye, P. Massey, C. Preston, P. Shering, T. Shoulder, C. Strawson & P. Wood. (2001) INDUSTRIAL SCALE-UP OF COUNTERCURRENT CHROMATOGRAPHY. Journal of Liquid Chromatography & Related Technologies 24:11-12, pages 1533-1553.
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I. A. Sutherland, J. Muytjens, M. Prins & P. Wood. (2000) A NEW HYPOTHESIS ON PHASE DISTRIBUTION IN COUNTERCURRENT CHROMATOGRAPHY. Journal of Liquid Chromatography & Related Technologies 23:15, pages 2259-2276.
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Akira Tsuyoshi, Hiroaki Ogawa, Kenichi Akiba, Harutaka Hoshi & Eiichi Kitazume. (2000) HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY USING A SMALL COILED COLUMN. Journal of Liquid Chromatography & Related Technologies 23:13, pages 1995-2008.
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C. Viron, R. Pennanec, P. André & M. Lafosse. (2000) LARGE SCALE CENTRIFUGAL PARTITION CHROMATOGRAPHY IN PURIFICATION OF POLYPHENOLS FROM OROBANCHE RAPUM . Journal of Liquid Chromatography & Related Technologies 23:11, pages 1681-1688.
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Articles from other publishers (27)

Raena MorleyMirjana Minceva. (2021) Liquid–Liquid Chromatography: Current Design Approaches and Future Pathways. Annual Review of Chemical and Biomolecular Engineering 12:1, pages 495-518.
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Li Cheng, Kai Wan, Hao Liang & Qipeng Yuan. 2020. Glucosinolates: Properties, Recovery, and Applications. Glucosinolates: Properties, Recovery, and Applications 281 312 .
Marco Müller, Alexander Kröpfl & Walter Vetter. (2019) Identification of two α-tocodienol isomers in palm oil after countercurrent chromatographic enrichment. Analytical and Bioanalytical Chemistry 412:3, pages 795-802.
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Leslie Brown, Martyn J. Earle, Manuela A. Gilea, Natalia V. Plechkova & Kenneth R. Seddon. 2020. Commercial Applications of Ionic Liquids. Commercial Applications of Ionic Liquids 167 189 .
Simon Roehrer, Juergen Behr, Verena Stork, Mara Ramires, Guillaume Médard, Oliver Frank, Karin Kleigrewe, Thomas Hofmann & Mirjana Minceva. (2018) Xanthohumol C, a minor bioactive hop compound: Production, purification strategies and antimicrobial test. Journal of Chromatography B 1095, pages 39-49.
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Leslie Brown, Martyn J. Earle, Manuela A. Gîlea, Natalia V. Plechkova & Kenneth R. Seddon. (2017) Ionic Liquid–Liquid Chromatography: A New General Purpose Separation Methodology. Topics in Current Chemistry 375:5.
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Junfei Tao, Rongwei Yan, Leilei Zhao, Dongmei Wang & Xinjun Xu. (2017) Separation and purification of two taxanes and one xylosyl-containing taxane from Taxus wallichiana Zucc.: A comparison between high-speed countercurrent chromatography and reversed-phase flash chromatography . Journal of Separation Science 40:6, pages 1273-1282.
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Leslie Brown, Martyn J. Earle, Manuela A. Gîlea, Natalia V. Plechkova & Kenneth R. Seddon. (2017) Ionic Liquid–Liquid Separations Using Countercurrent Chromatography: A New General-Purpose Separation Methodology. Australian Journal of Chemistry 70:8, pages 923.
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A.E. Rodrigues, C. Pereira, M. Minceva, L.S. Pais, A.M. Ribeiro, A. Ribeiro, M. Silva, N. Graça & J.C. Santos. 2015. Simulated Moving Bed Technology. Simulated Moving Bed Technology 245 272 .
Krystyna Skalicka-Woźniak & Ian Garrard. (2014) Counter-current chromatography for the separation of terpenoids: a comprehensive review with respect to the solvent systems employed. Phytochemistry Reviews 13:2, pages 547-572.
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Da-Bing Ren, Zhao-Hui Yang, Yi-Zeng Liang, Qiong Ding, Chen Chen & Mei-Lan Ouyang. (2013) Correlation and prediction of partition coefficient using nonrandom two-liquid segment activity coefficient model for solvent system selection in counter-current chromatography separation. Journal of Chromatography A 1301, pages 10-18.
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Andrew Marston. 2012. Recent Advances in Polyphenol Research. Recent Advances in Polyphenol Research 287 309 .
Nazim Mekaoui, Karine Faure & Alain Berthod. (2012) Advances in countercurrent chromatography for protein separations. Bioanalysis 4:7, pages 833-844.
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Hacer Guzlek, Philip Leslie Wood & Lee Janaway. (2009) Performance comparison using the GUESS mixture to evaluate counter-current chromatography instruments. Journal of Chromatography A 1216:19, pages 4181-4186.
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Hao Liang, Cuijuan Li, Qipeng Yuan & Frank Vriesekoop. (2008) Application of High-Speed Countercurrent Chromatography for the Isolation of Sulforaphane from Broccoli Seed Meal. Journal of Agricultural and Food Chemistry 56:17, pages 7746-7749.
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Shihua Wu, Lu Yang, Yuan Gao, Xiaoyue Liu & Feiyan Liu. (2008) Multi-channel counter-current chromatography for high-throughput fractionation of natural products for drug discovery. Journal of Chromatography A 1180:1-2, pages 99-107.
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Svetlana Ignatova, Philip Wood, David Hawes, Lee Janaway, David Keay & Ian Sutherland. (2007) Feasibility of scaling from pilot to process scale. Journal of Chromatography A 1151:1-2, pages 20-24.
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Wolfgang Feger, Herbert Brandauer, Paulina Gabris & Herta Ziegler. (2006) Nonvolatiles of Commercial Lime and Grapefruit Oils Separated by High-Speed Countercurrent Chromatography. Journal of Agricultural and Food Chemistry 54:6, pages 2242-2252.
Crossref
Andrew Marston & Kurt Hostettmann. 2005. Flavonoids. Flavonoids 1 36 .
A.E. Kostanian, A. Berthod, S.N. Ignatova, T.A. Maryutina, B.Ya. Spivakov & I.A. Sutherland. (2004) Countercurrent chromatographic separation: a hydrodynamic approach developed for extraction columns. Journal of Chromatography A 1040:1, pages 63-72.
Crossref
A.J. Booth, I. A. Sutherland & G. J. Lye. (2003) Modeling the performance of pilot‐scale countercurrent chromatography: Scale‐up predictions and experimental verification of erythromycin separation. Biotechnology and Bioengineering 81:6, pages 640-649.
Crossref
Guy H. Harris. 2002. Countercurrent Chromatography - The Support-Free Liquid Stationary Phase. Countercurrent Chromatography - The Support-Free Liquid Stationary Phase 301 330 .
Ian A. Sutherland. 2002. Countercurrent Chromatography - The Support-Free Liquid Stationary Phase. Countercurrent Chromatography - The Support-Free Liquid Stationary Phase 159 176 .
Weizheng Wang-Fan, Ernst Küsters, Ching-Pong Mak & Ying Wang. (2001) Application of coil centrifugal counter-current chromatography to the separation of macrolide antibiotic analogues. Journal of Chromatography A 925:1-2, pages 139-149.
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Andreas Degenhardt, Ulrich H. Engelhardt, Andreas-Sascha Wendt & Peter Winterhalter. (2000) Isolation of Black Tea Pigments Using High-Speed Countercurrent Chromatography and Studies on Properties of Black Tea Polymers. Journal of Agricultural and Food Chemistry 48:11, pages 5200-5205.
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Ian A Sutherland. (2000) Relationship between retention, linear velocity and flow for counter-current chromatography. Journal of Chromatography A 886:1-2, pages 283-287.
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Gary J. Lye & John M. Woodley. (1999) Application of in situ product-removal techniques to biocatalytic processes. Trends in Biotechnology 17:10, pages 395-402.
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