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Journal of Liquid Chromatography & Related Technologies Volume 21, 1998 - Issue 14
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Original Articles

Development and Validation of a Stability-Indicating HPLC Method for the Determination of Tobramycin and Its Related Substances in an Ophthalmic Suspension

H Russ Bausch and Lomb Pharmaceuticals, Inc, Research & Development, Hidden River, Parkway, Tampa, FL 33637
,
D. McCleary Bausch and Lomb Pharmaceuticals, Inc, Research & Development, Hidden River, Parkway, Tampa, FL 33637
,
R. Katimy Bausch and Lomb Pharmaceuticals, Inc, Research & Development, Hidden River, Parkway, Tampa, FL 33637
,
J.L Montana Bausch and Lomb Pharmaceuticals, Inc, Research & Development, Hidden River, Parkway, Tampa, FL 33637
,
R.B Miller Bausch and Lomb Pharmaceuticals, Inc, Research & Development, Hidden River, Parkway, Tampa, FL 33637
,
R. Krishnamoorthy Bausch and Lomb Pharmaceuticals, Inc, Research & Development, Hidden River, Parkway, Tampa, FL 33637
&
C. W. Davis Bausch and Lomb Pharmaceuticals, Inc, Research & Development, Hidden River, Parkway, Tampa, FL 33637
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Pages 2165-2181 | Received 12 Dec 1997, Accepted 20 Jan 1998, Published online: 20 Aug 2006

Citations (34)

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Nirav Patel, Vaishali Thakkar, Viral Metalia, Lalji Baldaniya, Tejal Gandhi & Mukesh Gohel. (2016) Formulation and development of ophthalmic in situ gel for the treatment ocular inflammation and infection using application of quality by design concept. Drug Development and Industrial Pharmacy 42:9, pages 1406-1423.
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Mehmet Gokhan Caglayan & Feyyaz Onur. (2014) Silver Nanoparticle Based Analysis of Aminoglycosides. Spectroscopy Letters 47:10, pages 771-780.
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Articles from other publishers (32)

Mokhtar M. Mabrouk, Suzan M. Soliman, Heba M. El-Agizy & Fotouh R. Mansour. (2022) A highly sensitive pre-column derivatization method for fluorescence detection of tobramycin using 2-naphthalenesulfonyl chloride as a derivatizing agent. Discover Chemical Engineering 2:1.
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Chelsea R. Thorn, Zlatko Kopecki, Anthony Wignall, Anita Kral, Clive A. Prestidge & Nicky Thomas. (2022) Liquid crystal nanoparticle platform for increased efficacy of cationic antimicrobials against biofilm infections. Nanomedicine: Nanotechnology, Biology and Medicine 42, pages 102536.
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Chelsea R. Thorn, Anthony Wignall, Zlatko Kopecki, Anita Kral, Clive A. Prestidge & Nicky Thomas. (2022) Liquid Crystal Nanoparticles Enhance Tobramycin Efficacy in a Murine Model of Pseudomonas aeruginosa Biofilm Wound Infection . ACS Infectious Diseases 8:4, pages 841-854.
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Nusaiba.K. Al-nemrawi, Rami Q. Alkhatib, Hadeel Ayyad & Nid''A Alshraiedeh. (2022) Formulation and characterization of tobramycin-chitosan nanoparticles coated with zinc oxide nanoparticles. Saudi Pharmaceutical Journal 30:4, pages 454-461.
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Chelsea R. Thorn, Deepa Raju, Ira Lacdao, Stephanie Gilbert, Piyanka Sivarajah, P. Lynne Howell, Clive A. Prestidge & Nicky Thomas. (2021) Protective Liquid Crystal Nanoparticles for Targeted Delivery of PslG: A Biofilm Dispersing Enzyme. ACS Infectious Diseases 7:8, pages 2102-2115.
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Chelsea R. Thorn, Cristiane de Souza Carvalho‐Wodarz, Justus C. Horstmann, Claus‐Michael Lehr, Clive A. Prestidge & Nicky Thomas. (2021) Tobramycin Liquid Crystal Nanoparticles Eradicate Cystic Fibrosis‐Related Pseudomonas aeruginosa Biofilms . Small 17:24.
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Tathyanne da Silva Medeiros, Eduardo Costa Pinto, Lucio Mendes Cabral & Valeria Pereira de Sousa. (2021) Tobramycin: A review of detectors used in analytical approaches for drug substance, its impurities and in pharmaceutical formulation. Microchemical Journal 160, pages 105658.
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Vajra Badha, Rex Moore, John Heffernan, Paulo Castaneda, Alex McLaren & Derek Overstreet. (2019) Determination of Tobramycin and Vancomycin Exposure Required to Eradicate Biofilms on Muscle and Bone Tissue In Vitro. Journal of Bone and Joint Infection 4:1, pages 1-9.
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Nusaiba Al-Nemrawi, Nid’’A Alshraiedeh, Aref Zayed & Bashar Altaani. (2018) Low Molecular Weight Chitosan-Coated PLGA Nanoparticles for Pulmonary Delivery of Tobramycin for Cystic Fibrosis. Pharmaceuticals 11:1, pages 28.
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Corina Pfeifer, Georg Fassauer, Hagen Gerecke, Thomas Jira, Yvonne Remane, Roberto Frontini, Jonathan Byrne & Robert Reinhardt. (2015) Purity determination of amphotericin B, colistin sulfate and tobramycin sulfate in a hydrophilic suspension by HPLC. Journal of Chromatography B 990, pages 7-14.
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Hellen S. Santos, Gabriela M. de França, Eric C. Romani, Dunieskys G. Larrudé, Alessandra L.M.C. da Cunha, Ricardo Q. Aucélio & Andrea R. da Silva. (2014) Selective determination of tobramycin in the presence of streptomycin through the visible light effect on surface plasmon resonance of gold nanoparticles. Microchemical Journal 116, pages 206-215.
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D. Shou, Y. Dong, L. Shen, R. Wu, Y. Zhang, C. Zhang & Y. Zhu. (2013) Rapid Quantification of Tobramycin and Vancomycin by UPLC-TQD and Application to Osteomyelitis Patient Samples. Journal of Chromatographic Science 52:6, pages 501-507.
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Serife Evrim Kepekci Tekkeli, Armağan Önal & A.Olcay Sağırlı. (2014) Spectrofluorimetric determination of tobramycin in human serum and pharmaceutical preparations by derivatization with fluorescamine. Luminescence 29:1, pages 87-91.
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Liang Zhu & Jingkang Wang. (2013) Fast determination of tobramycin by reversed-phase ion-pair high performance liquid chromatography with a refractive index detector. Frontiers of Chemical Science and Engineering 7:3, pages 322-328.
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Vicky Manyanga, Ehab Elkady, Jos Hoogmartens & Erwin Adams. (2013) Improved reversed phase liquid chromatographic method with pulsed electrochemical detection for tobramycin in bulk and pharmaceutical formulation. Journal of Pharmaceutical Analysis 3:3, pages 161-167.
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Mohamed Nouri El-Attug, Jos Hoogmartens, Erwin Adams & Ann Van Schepdael. (2012) Optimization of capillary electrophoresis method with contactless conductivity detection for the analysis of tobramycin and its related substances. Journal of Pharmaceutical and Biomedical Analysis 58, pages 49-57.
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Shun He, Qiyou Chen, Yan Sun, Yuncong Zhu, Laixin Luo, Jianqiang Li & Yongsong Cao. (2011) Determination of tobramycin in soil by HPLC with ultrasonic-assisted extraction and solid-phase extraction. Journal of Chromatography B 879:13-14, pages 901-907.
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I. Clarot, I. Storme-Paris, P. Chaminade, O. Estevenon, A. Nicolas & A. Rieutord. (2009) Simultaneous quantitation of tobramycin and colistin sulphate by HPLC with evaporative light scattering detection. Journal of Pharmaceutical and Biomedical Analysis 50:1, pages 64-67.
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B. Li, A. Van Schepdael, J. Hoogmartens & E. Adams. (2009) Characterization of impurities in tobramycin by liquid chromatography–mass spectrometry. Journal of Chromatography A 1216:18, pages 3941-3945.
Crossref
Neil D. Danielson, Patricia A. Gallagher & James J. Bao. 2007. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry.
Michele Xuemei Guo, Loren Wrisley & Eshwar Maygoo. (2006) Measurement of tobramycin by reversed-phase high-performance liquid chromatography with mass spectrometry detection. Analytica Chimica Acta 571:1, pages 12-16.
Crossref
Nan Sun, Wei-Min Mo, Zhen-Lu Shen & Bao-Xiang Hu. (2005) Adsorptive stripping voltammetric technique for the rapid determination of tobramycin on the hanging mercury electrode. Journal of Pharmaceutical and Biomedical Analysis 38:2, pages 256-262.
Crossref
Nikolaos C. Megoulas & Michael A. Koupparis. (2005) Development and validation of a novel HPLC/ELSD method for the direct determination of tobramycin in pharmaceuticals, plasma, and urine. Analytical and Bioanalytical Chemistry 382:2, pages 290-296.
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Humphrey Fonge, Eliangiringa Kaale, Cindy Govaerts, Koenraad Desmet, Ann Van Schepdael & Jos Hoogmartens. (2004) Bioanalysis of tobramycin for therapeutic drug monitoring by solid-phase extraction and capillary zone electrophoresis. Journal of Chromatography B 810:2, pages 313-318.
Crossref
R. Nageswara Rao & V. Nagaraju. (2003) An overview of the recent trends in development of HPLC methods for determination of impurities in drugs. Journal of Pharmaceutical and Biomedical Analysis 33:3, pages 335-377.
Crossref
Chia-Hsien Feng, Shun-Jin Lin, Hsin-Lung Wu & Su-Hwei Chen. (2002) Trace analysis of tobramycin in human plasma by derivatization and high-performance liquid chromatography with ultraviolet detection. Journal of Chromatography B 780:2, pages 349-354.
Crossref
Shalini Joshi. (2002) HPLC separation of antibiotics present in formulated and unformulated samples. Journal of Pharmaceutical and Biomedical Analysis 28:5, pages 795-809.
Crossref
R. K. Gilpin & L. A. Pachla. (2001) Pharmaceuticals and Related Drugs. Analytical Chemistry 73:12, pages 2805-2816.
Crossref
Neil D. Danielson, Patricia A. Gallagher & James J. Bao. 2007. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry.
J Szúnyog, E Adams, E Roets & J Hoogmartens. (2000) Analysis of tobramycin by liquid chromatography with pulsed electrochemical detection. Journal of Pharmaceutical and Biomedical Analysis 23:5, pages 891-896.
Crossref
David A Stead. (2000) Current methodologies for the analysis of aminoglycosides. Journal of Chromatography B: Biomedical Sciences and Applications 747:1-2, pages 69-93.
Crossref
Ann van schepdael, Erwin Adams, Eugène Roets & Jos Hoogmatens. 2000. Identification and Determination of Impurities in Drugs. Identification and Determination of Impurities in Drugs 684 711 .

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