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Pharmaceutical Development and Technology Volume 24, 2019 - Issue 1
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Research Article

Assessment of spatial heterogeneity in continuous twin screw wet granulation process using three-compartmental population balance model

Huolong LiuDepartment of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USA; View further author information
,
Shaun C. GalbraithDepartment of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USA; View further author information
,
Seo-Young ParkDepartment of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USA; View further author information
,
Bumjoon ChaDepartment of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USA; View further author information
,
Zhuangrong HuangDepartment of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USA; View further author information
,
Robert Frederick MeyerPharmaceutical Technology, Merck & Co., Inc, West Point, PA, USA; View further author information
,
Matthew H. FlammPharmaceutical Technology, Merck & Co., Inc, West Point, PA, USA; View further author information
,
Thomas O’ConnorFood and Drug Administration, Center for Drug Evaluation and Research, Office of Generics Drug, Silver Spring, MD, USAView further author information
,
Sau LeeFood and Drug Administration, Center for Drug Evaluation and Research, Office of Generics Drug, Silver Spring, MD, USAView further author information
&
Seongkyu YoonDepartment of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USA; Correspondence[email protected]
View further author information
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Pages 105-117 | Received 22 Apr 2017, Accepted 09 Jan 2018, Published online: 25 Jan 2018

Citations (14)

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Zhuangrong Huang, Shaun C. Galbraith, Bumjoon Cha, Huolong Liu, Seoyoung Park, Matthew H. Flamm, Matt Metzger, Anthony Tantuccio & Seongkyu Yoon. (2020) Effects of process parameters on tablet critical quality attributes in continuous direct compression: a case study of integrating data-driven statistical models and mechanistic compaction models. Pharmaceutical Development and Technology 25:10, pages 1204-1215.
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Articles from other publishers (13)

Ana Alejandra Barrera Jiménez, Kensaku Matsunami, Daan Van Hauwermeiren, Michiel Peeters, Fanny Stauffer, Eduardo dos Santos Schultz, Ashish Kumar, Thomas De Beer & Ingmar Nopens. (2023) Partial least squares regression to calculate population balance model parameters from material properties in continuous twin-screw wet granulation. International Journal of Pharmaceutics 640, pages 123040.
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Michiel Peeters, Ana Alejandra Barrera Jiménez, Kensaku Matsunami, Fanny Stauffer, Ingmar Nopens & Thomas De Beer. (2023) Evaluation of the influence of material properties and process parameters on granule porosity in twin-screw wet granulation. International Journal of Pharmaceutics 641, pages 123010.
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Adam C. Fisher, William Liu, Andreas Schick, Mahesh Ramanadham, Sharmista Chatterjee, Raphael Brykman, Sau L. Lee, Steven Kozlowski, Ashley B. Boam, Stelios C. Tsinontides & Michael Kopcha. (2022) An audit of pharmaceutical continuous manufacturing regulatory submissions and outcomes in the US. International Journal of Pharmaceutics 622, pages 121778.
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Bo Wang, Xinran Sun, Jia Xiang, Xu Guo, Zeneng Cheng, Wenjie Liu & Songwen Tan. (2022) A critical review on granulation of pharmaceuticals and excipients: Principle, analysis and typical applications. Powder Technology 401, pages 117329.
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Christoph Portier, Tamas Vigh, Giustino Di Pretoro, Jan Leys, Didier Klingeleers, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2021) Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying – A QbD approach. International Journal of Pharmaceutics: X 3, pages 100077.
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Li Ge Wang, John P. Morrissey, Dana Barrasso, David Slade, Sean Clifford, Gavin Reynolds, Jin Y. Ooi & James D. Litster. (2021) Model driven design for twin screw granulation using mechanistic-based population balance model. International Journal of Pharmaceutics 607, pages 120939.
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Ana Alejandra Barrera Jiménez, Daan Van Hauwermeiren, Michiel Peeters, Thomas De Beer & Ingmar Nopens. (2021) Improvement of a 1D Population Balance Model for Twin-Screw Wet Granulation by Using Identifiability Analysis. Pharmaceutics 13:5, pages 692.
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Huolong Liu, Robert Meyer, Matthew Flamm, Laura Wareham, Matthew Metzger, Anthony Tantuccio & Seongkyu Yoon. (2021) Optimization of Critical Quality Attributes in Tablet Film Coating and Design Space Determination Using Pilot-Scale Experimental Data. AAPS PharmSciTech 22:1.
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Hamza Y. Ismail, Mehakpreet Singh, Ahmad B. Albadarin & Gavin M. Walker. (2020) Complete two dimensional population balance modelling of wet granulation in twin screw. International Journal of Pharmaceutics 591, pages 120018.
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Christoph Portier, Charlotte De Vriendt, Tamas Vigh, Giustino Di Pretoro, Thomas De Beer, Chris Vervaet & Valérie Vanhoorne. (2020) Continuous twin screw granulation: Robustness of lactose/MCC-based formulations. International Journal of Pharmaceutics 588, pages 119756.
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S.C. Galbraith, S. Park, Z. Huang, H. Liu, R.F. Meyer, M. Metzger, M.H. Flamm, S. Hurley & S. Yoon. (2020) Linking process variables to residence time distribution in a hybrid flowsheet model for continuous direct compression. Chemical Engineering Research and Design 153, pages 85-95.
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Huolong Liu, Brendon Ricart, Courtney Stanton, Brandye Smith-Goettler, Luke Verdi, Thomas O'Connor, Sau Lee & Seongkyu Yoon. (2019) Design space determination and process optimization in at-scale continuous twin screw wet granulation. Computers & Chemical Engineering 125, pages 271-286.
Crossref
Kentaro Hayashi & Satoru Watano. (2019) Novel population balance model for granule aggregation and breakage in fluidized bed granulation and drying. Powder Technology 342, pages 664-675.
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