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Research Article

Mucoadhesive buccal film containing ornidazole and dexamethasone for oral ulcers: in vitro and in vivo studies

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Pages 118-126 | Received 05 Jun 2017, Accepted 10 Jan 2018, Published online: 25 Jan 2018

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Amresh Kumar, Pradeep Kumar Naik, Deepak Pradhan, Goutam Ghosh & Goutam Rath. (2020) Mucoadhesive formulations: innovations, merits, drawbacks, and future outlook. Pharmaceutical Development and Technology 25:7, pages 797-814.
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Soraia Pinto, Manuela E Pintado & Bruno Sarmento. (2020) In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems. Expert Opinion on Drug Delivery 17:1, pages 33-48.
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Yiyu Zeng, Yijun Gao, Liming He, Wenhui Ge, Junhui Liu, Yi Yu & Xiaoyan Xie. (2023) Multifunctional polysaccharide composited microneedle for oral ulcers healing. Materials Today Bio 22, pages 100782.
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Hao Chen, Xin Li, Ye Gong, Tianshi Bu, Xiangyu Wang & Hao Pan. (2023) Unidirectional drug release from 3D printed personalized buccal patches using FDM technology. International Journal of Pharmaceutics 645, pages 123382.
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Yu Tian, Jiangtao Lin, Hongshu Jing, Quan Wang, Zhihua Wu & Yourong Duan. (2023) Recent progress in orodispersible films‐mediated therapeutic applications: A review. MedComm – Biomaterials and Applications 2:2.
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Oana Mihaela Neagu, Timea Ghitea, Eleonora Marian, Laurian Vlase, Ana-Maria Vlase, Gabriela Ciavoi, Pálma Fehér, Annamária Pallag, Ildikó Bácskay, Dániel Nemes, Laura Grațiela Vicaș, Alin Teușdea & Tünde Jurca. (2023) Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos. Molecules 28:10, pages 4002.
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Haijun Fu, Jiayu Yang, Zongshan Shen, Yong Zhang, Shuhong Kuang, Lifeng Li, Zhengmei Lin & Xuetao Shi. (2023) Antibacterial, wet adhesive, and healing-promoting nanosheets for the treatment of oral ulcers. Biomaterials Science 11:9, pages 3214-3226.
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Dorota Kida, Tomasz Konopka, Kamil Jurczyszyn & Bożena Karolewicz. (2023) Technological Aspects and Evaluation Methods for Polymer Matrices as Dental Drug Carriers. Biomedicines 11:5, pages 1274.
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Shaolong He & Huiling Mu. (2023) Microenvironmental pH Modification in Buccal/Sublingual Dosage Forms for Systemic Drug Delivery. Pharmaceutics 15:2, pages 637.
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Paula de Freitas Rosa Remiro, Mariana Harue Taniguchi Nagahara, Rafael Abboud Azoubel, Michelle Franz-Montan, Marcos Akira d’Ávila & Ângela Maria Moraes. (2022) Polymeric Biomaterials for Topical Drug Delivery in the Oral Cavity: Advances on Devices and Manufacturing Technologies. Pharmaceutics 15:1, pages 12.
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Lewis Shipp, Fang Liu, Laxmi Kerai-Varsani & Tochukwu C. Okwuosa. (2022) Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation approaches. Journal of Controlled Release 352, pages 1071-1092.
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Yangqi Zhou, Menglong Wang, Chao Yan, Hui Liu & Deng-Guang Yu. (2022) Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers. Biomolecules 12:9, pages 1254.
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Tian Xu, Xue Yu, Jing Ji, Qi Shao, Ying Li, Ting Li, Hanfen Shi, Huiling Tian, Jiayang Sai, Chongyang Ma, Xueqian Wang, Fafeng Cheng & Qingguo Wang. (2022) Network pharmacology-based approach to evaluate the effect and predict the mechanism of Calculus bovis against oral ulcers. Pharmacological Research - Modern Chinese Medicine 3, pages 100098.
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Qurrat ul Ain Javed, Muhammad Ali Syed, Rabia Arshad, Abbas Rahdar, Muhammad Irfan, Syed Atif Raza, Gul Shahnaz, Sana Hanif & Ana M. Díez-Pascual. (2022) Evaluation and Optimization of Prolonged Release Mucoadhesive Tablets of Dexamethasone for Wound Healing: In Vitro–In Vivo Profiling in Healthy Volunteers. Pharmaceutics 14:4, pages 807.
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Sophia A. Ward, Roy N. Kirkwood, Yunmei Song, Sanjay Garg & Kate J. Plush. (2022) Effect of Dexamethasone and Route of Administration on Sow Farrowing Behaviours, Piglet Delivery and Litter Performance. Animals 12:7, pages 847.
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Sweta KambojRohit DuttRohit Kamboj. (2022) Orodispersible thin films: A Hodiernal Perspective in Drug Delivery System. Research Journal of Pharmacy and Technology, pages 447-457.
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Noha S. El-Salamouni & Amira Sayed Hanafy. (2021) Hyaluronic-benzydamine oromucosal films outperform conventional mouth rinse in ulcer healing. Journal of Drug Delivery Science and Technology 65, pages 102690.
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Joanna Potaś, Emilia Szymańska, Magdalena Wróblewska, Izabela Kurowska, Mateusz Maciejczyk, Anna Basa, Eliza Wolska, Agnieszka Zofia Wilczewska & Katarzyna Winnicka. (2021) Multilayer Films Based on Chitosan/Pectin Polyelectrolyte Complexes as Novel Platforms for Buccal Administration of Clotrimazole. Pharmaceutics 13:10, pages 1588.
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Shery Jacob, Anroop B. Nair, Sai H. S. Boddu, Bapi Gorain, Nagaraja Sreeharsha & Jigar Shah. (2021) An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems. Pharmaceutics 13:8, pages 1206.
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Dorota Kida, Aneta Zakrzewska, Jacek Zborowski, Małgorzata Szulc & Bożena Karolewicz. (2021) Polymer-Based Carriers in Dental Local Healing—Review and Future Challenges. Materials 14:14, pages 3948.
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Samaneh Alaei & Hamid Omidian. (2021) Mucoadhesion and Mechanical Assessment of Oral Films. European Journal of Pharmaceutical Sciences 159, pages 105727.
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Deepak Sharma & Rajeev Garg. (2020) Recent Developments and Potential of Mucoadhesive Buccal Drug Delivery System for Oro-mucosal Disorders. Current Dentistry 2:1, pages 12-28.
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Zheng Yang, Miaojuan Li, Lin Xiao, Zhiming Yi, Min Zhao & Shengjie Ma. (2020) Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis. Brazilian Journal of Medical and Biological Research 53:8.
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Nasrul Wathoni, Nia Yuniarsih, Arief Cahyanto & Muhctaridi Muhctaridi. (2019) α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis. Applied Sciences 9:23, pages 5235.
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Oluwatoyin A. Adeleke. (2019) Premium ethylcellulose polymer based architectures at work in drug delivery. International Journal of Pharmaceutics: X 1, pages 100023.
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Katarzyna Wasilewska & Katarzyna Winnicka. (2019) Ethylcellulose–A Pharmaceutical Excipient with Multidirectional Application in Drug Dosage Forms Development. Materials 12:20, pages 3386.
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Heliu Jiang, Xiang Yu, Rongzhen Fang, Zhimei Xiao & Yiguang Jin. (2019) 3D printed mold-based capsaicin candy for the treatment of oral ulcer. International Journal of Pharmaceutics 568, pages 118517.
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