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Pharmaceutical Development and Technology Volume 24, 2019 - Issue 6
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Research Article

Evaluation of anti-inflammatory impact of dexamethasone-loaded PCL-PEG-PCL micelles on endotoxin-induced uveitis in rabbits

Mitra Alami-MilaniDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; ;Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Correspondence[email protected] [email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0003-4247-9681View further author information
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Parvin Zakeri-MilaniLiver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; ;Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3243-587XView further author information
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Hadi ValizadehDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; ;Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; ORCID Iconhttp://orcid.org/0000-0003-4157-6279View further author information
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Shahram SattariNikookari Ophthalmology Center, Tabriz University of Medical Sciences, Tabriz, Iran; View further author information
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Sara SalatinStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; ;Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, IranView further author information
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Mitra JelvehgariDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; ;Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Correspondence[email protected] [email protected] [email protected]
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Pages 680-688 | Received 16 Aug 2018, Accepted 23 Jan 2019, Published online: 20 Mar 2019

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Mitra Alami-Milani, Parvin Zakeri-Milani, Hadi Valizadeh, Marzieh Fathi, Sara Salatin, Roya Salehi & Mitra Jelvehgari. (2020) PLA–PCL–PEG–PCL–PLA based micelles for improving the ocular permeability of dexamethasone: development, characterization, and in vitro evaluation. Pharmaceutical Development and Technology 25:6, pages 704-719.
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Sara Salatin, Farzaneh Lotfipour & Mitra Jelvehgari. (2020) Preparation and characterization of a novel thermosensitive and bioadhesive cephalexin nanohydrogel: a promising platform for topical antibacterial delivery. Expert Opinion on Drug Delivery 17:6, pages 881-893.
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Sara Salatin, Farzaneh Lotfipour & Mitra Jelvehgari. (2019) A brief overview on nano-sized materials used in the topical treatment of skin and soft tissue bacterial infections. Expert Opinion on Drug Delivery 16:12, pages 1313-1331.
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Articles from other publishers (26)

Ziyad Binkhathlan, Raisuddin Ali, Abdullah H. Alomrani, Mohd Abul Kalam, Aws Alshamsan & Afsaneh Lavasanifar. (2023) Role of Polymeric Micelles in Ocular Drug Delivery: An Overview of Decades of Research. Molecular Pharmaceutics 20:11, pages 5359-5382.
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Jing Wei, Jinyu Mu, Yong Tang, Dalian Qin, Junguo Duan & Anguo Wu. (2023) Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy. Journal of Nanobiotechnology 21:1.
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Kevin Y. Wu, Kenneth Tan, Dania Akbar, Mazen Y. Choulakian & Simon D. Tran. (2023) A New Era in Ocular Therapeutics: Advanced Drug Delivery Systems for Uveitis and Neuro-Ophthalmologic Conditions. Pharmaceutics 15:7, pages 1952.
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Mahmoud Mostafa, Adel Al Fatease, Raid G. Alany & Hamdy Abdelkader. (2023) Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye Diseases. Pharmaceutics 15:6, pages 1746.
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Daniel Hawthorne, Ananth Pannala, Susan Sandeman & Andrew Lloyd. (2022) Sustained and targeted delivery of hydrophilic drug compounds: A review of existing and novel technologies from bench to bedside. Journal of Drug Delivery Science and Technology 78, pages 103936.
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Raquel da Ana, Joel Fonseca, Jacek Karczewski, Amélia M. Silva, Aleksandra Zielińska & Eliana B. Souto. (2022) Lipid-Based Nanoparticulate Systems for the Ocular Delivery of Bioactives with Anti-Inflammatory Properties. International Journal of Molecular Sciences 23:20, pages 12102.
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Saeed Sadigh-Eteghad, Shahriar Shahi, Javad Mahmoudi, Afsaneh Farjami, Ahad Bazmani, Behrooz Naghili, Solmaz Maleki Dizaj & Sara Salatin. (2022) Application of Nano-based Drug Loading Systems in the Treatment of Neurological Infections: An Updated Review. Current Pharmaceutical Design 28:28, pages 2330-2342.
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Mehdi Farhoudi, Saeed Sadigh-Eteghad, Javad Mahmoudi, Afsaneh Farjami, Mohammad Mahmoudian & Sara Salatin. (2022) The Therapeutic Benefits of Intravenously Administrated Nanoparticles in Stroke and Age-related Neurodegenerative Diseases. Current Pharmaceutical Design 28:24, pages 1985-2000.
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Bjorn John Stephen, Ankit Chokriwal, Madan Mohan Sharma, Devendra Jain, Juhi Saxena, Harshdeep Dhaliwal, Vikram Sharma, Rajeev Mishra, Ramandeep Kaur & Abhijeet Singh. (2022) Dexamethasone encapsulated PLGA nanoparticles for the treatment of neuroinflammation. Bioinspired, Biomimetic and Nanobiomaterials 11:2, pages 72-85.
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Vijay Sagar Madamsetty, Reza Mohammadinejad, Ilona Uzieliene, Noushin Nabavi, Ali Dehshahri, Jomarien García-Couce, Shima Tavakol, Saeid Moghassemi, Arezoo Dadashzadeh, Pooyan Makvandi, Abbas Pardakhty, Abbas Aghaei Afshar & Ali Seyfoddin. (2022) Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery Systems. ACS Biomaterials Science & Engineering 8:5, pages 1763-1790.
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Sara Salatin, Ahad Bazmani, Shahriar Shahi, Behrooz Naghili, Mohammad Yousef Memar & Solmaz Maleki Dizaj. (2022) Antimicrobial Benefits of Flavonoids and their Nanoformulations. Current Pharmaceutical Design 28:17, pages 1419-1432.
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Sara Salatin, Mitra Alami-Milani, Hamit Cilvegar, Saber Fereidouni, Maryam Maghsoodi, Farnaz Monajemzadeh & Mitra Jelvehgari. (2022) Development and characterization of bilayered tablets of diazepam for oral drug delivery: design, optimization and in vitro evaluation . Therapeutic Delivery 13:4, pages 221-231.
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Sara Salatin, Mina Tarzamani, Afsaneh Farjami & Mitra Jelvehgari. (2022) Development and characterization of a novel mucoadhesive sol-gel suppository of sumatriptan: design, optimization, in vitro  and ex vivo evaluation for rectal drug delivery . Therapeutic Delivery 13:2, pages 95-108.
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Emine Kahraman, M. Ezgi Durgun, Sevgi Güngör & Yıldız Özsoy. 2022. Polymeric Micelles for Drug Delivery. Polymeric Micelles for Drug Delivery 115 143 .
Alexander Vaneev, Victoria Tikhomirova, Natalia Chesnokova, Ekaterina Popova, Olga Beznos, Olga Kost & Natalia Klyachko. (2021) Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye. International Journal of Molecular Sciences 22:22, pages 12368.
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Afsaneh Farjami, Sara Salatin, Samira Jafari, Mohammad Mahmoudian & Mitra Jelvehgari. (2021) The Factors Determining the Skin Penetration and Cellular Uptake of Nanocarriers: New Hope for Clinical Development. Current Pharmaceutical Design 27:42, pages 4315-4329.
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Farzaneh Lotfipour, Shahriar Shahi, Afsaneh Farjami, Sara Salatin, Mohammad Mahmoudian & Solmaz Maleki Dizaj. (2021) Safety and Toxicity Issues of Therapeutically Used Nanoparticles from the Oral Route. BioMed Research International 2021, pages 1-14.
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Mitra Alami-Milani, Sara Salatin, Elaheh Nasiri & Mitra Jelvehgari. (2021) Preparation and optimization of fast disintegrating tablets of isosorbide dinitrate using lyophilization method for oral drug delivery. Therapeutic Delivery 12:7, pages 523-538.
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Mitra Alami-Milani, Sara Salatin, Farzaneh Sharifi Rayeni & Mitra Jelvehgari. (2021) Preparation and in vitro evaluation of thermosensitive and mucoadhesive hydrogels for intranasal delivery of phenobarbital sodium . Therapeutic Delivery 12:6, pages 461-475.
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Maryam Saadat, Farid Mostafaei, Somaye Mahdinloo, Mahdieh Abdi, Fahimeh Zahednezhad, Parvin Zakeri-Milani & Hadi Valizadeh. (2021) Drug delivery of pH-Sensitive nanoparticles into the liver cancer cells. Journal of Drug Delivery Science and Technology 63, pages 102557.
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Madhusudan B Kulkarni, K Velmurugan, Enaganti Prasanth, Khairunnisa Amreen, Jayabalan Nirmal & Sanket Goel. (2021) Smartphone enabled miniaturized temperature controller platform to synthesize NiO/CuO nanoparticles for electrochemical sensing and nanomicelles for ocular drug delivery applications. Biomedical Microdevices 23:2.
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Sara Salatin, Raziyeh Asadi & Mitra Jelvehgari. (2021) Development and characterization of sublingual films for enhanced bioavailability of selegiline hydrochloride. Therapeutic Delivery 12:2, pages 159-174.
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Qingqing Li, Jingwen Weng, Si Nga Wong, Wai Yip Thomas Lee & Shing Fung Chow. (2020) Nanoparticulate Drug Delivery to the Retina. Molecular Pharmaceutics 18:2, pages 506-521.
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Yun-Chu Chen, Sheryhan F. Gad, Dhawal Chobisa, Yongzhe Li & Yoon Yeo. (2021) Local drug delivery systems for inflammatory diseases: Status quo, challenges, and opportunities. Journal of Controlled Release 330, pages 438-460.
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Mayara Rodrigues Brandão De Paiva, Daniel Vítor Vasconcelos-Santos, Lorena Carla Vieira, Sílvia Ligório Fialho & Armando Silva-Cunha. (2021) Sirolimus-Loaded Intravitreal Implant for Effective Treatment of Experimental Uveitis. AAPS PharmSciTech 22:1.
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Meltem Ezgi DurgunSevgi GüngörYıldız Özsoy. (2020) Micelles: Promising Ocular Drug Carriers for Anterior and Posterior Segment Diseases. Journal of Ocular Pharmacology and Therapeutics 36:6, pages 323-341.
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