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Pharmaceutical Development and Technology Volume 11, 2006 - Issue 4
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Research Article

Bioavailability Enhancement of Poorly Water Soluble and Weakly Acidic New Chemical Entity with 2-Hydroxy Propyl-β-Cyclodextrin: Selection of Meglumine, a Polyhydroxy Base, as a Novel Ternary Component

S. Basavaraj Formulation Research Department, Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India
,
Vaibhav Sihorkar Formulation Research Department, Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India
,
T.R. Shantha Kumar Formulation Research Department, Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India
,
Prakash Sundaramurthi Formulation Research Department, Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India
,
Nuggehally R. Srinivas Formulation Research Department, Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India; Drug Metabolism and Pharmacokinetic Department, Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India; Drug Development, Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India
,
P. Venkatesh Drug Metabolism and Pharmacokinetic Department, Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India
,
Mullangi Ramesh Drug Metabolism and Pharmacokinetic Department, Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India
&
Sunil Kumar Singh Medicinal Chemistry, Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India
 show all
Pages 443-451 | Received 03 Oct 2005, Accepted 07 Jan 2006, Published online: 07 Oct 2008

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Alaa Y. Bazeed, Ebtessam A. Essa, Ahmed Nouh & Gamal M. El Maghraby. (2020) Co-processing of nateglinide with meglumine for enhanced dissolution rate: in vitro and in vivo evaluation. Drug Development and Industrial Pharmacy 46:10, pages 1676-1683.
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Vijay Gyanani, Basavaraj Siddalingappa & Guru V. Betageri. (2015) Evaluation of various processes for simultaneous complexation and granulation to incorporate drug–cyclodextrin complexes into solid dosage forms. Drug Development and Industrial Pharmacy 41:11, pages 1856-1863.
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Carolina Aloisio, Anselmo Gomes de Oliveira & Marcela Longhi. (2014) Characterization, inclusion mode, phase-solubility and in vitro release studies of inclusion binary complexes with cyclodextrins and meglumine using sulfamerazine as model drug. Drug Development and Industrial Pharmacy 40:7, pages 919-928.
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Yi Shi, William Porter, Thomas Merdan & Luk Chiu Li. (2009) Recent advances in intravenous delivery of poorly water-soluble compounds. Expert Opinion on Drug Delivery 6:12, pages 1261-1282.
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Articles from other publishers (10)

Xiaoshuang He, Yuanfeng Wei, Shiru Wang, Jianjun Zhang, Yuan Gao, Shuai Qian, Zunting Pang & Weili Heng. (2022) Improved Pharmaceutical Properties of Honokiol via Salification with Meglumine: an Exception to Oft-quoted ∆pKa Rule. Pharmaceutical Research 39:9, pages 2263-2276.
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Abbe Haser, Tu Cao, Joseph W. Lubach & Feng Zhang. (2018) In Situ Salt Formation during Melt Extrusion for Improved Chemical Stability and Dissolution Performance of a Meloxicam–Copovidone Amorphous Solid Dispersion . Molecular Pharmaceutics 15:3, pages 1226-1237.
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Abbe Haser, Siyuan Huang, Tony Listro, David White & Feng Zhang. (2017) An approach for chemical stability during melt extrusion of a drug substance with a high melting point. International Journal of Pharmaceutics 524:1-2, pages 55-64.
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Sumit S. Vakani, Apeksha Kajwe, Vasanti Suvarna & Atul P. Sherje. (2015) Influence of auxiliary agents on solubility and dissolution profile of repaglinide with hydroxypropyl-β-cyclodextrin: inclusion complex formation and its solid-state characterization. Journal of Inclusion Phenomena and Macrocyclic Chemistry 83:3-4, pages 239-250.
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Haiying Li, Lilan Ma, Xiaxia Li, Xin Cui, Wenzhi Yang, Shigang Shen & Mingmao Chen. (2015) A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique. European Journal of Pharmaceutical Sciences 77, pages 154-160.
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S Basavaraj & Guru V. Betageri. (2014) Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges. Acta Pharmaceutica Sinica B 4:1, pages 3-17.
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Mohd Aftab Alam, Fahad I. Al-Jenoobi & Abdullah M. Al-mohizea. (2013) Commercially bioavailable proprietary technologies and their marketed products. Drug Discovery Today 18:19-20, pages 936-949.
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Dan Wang, Haiyan Li, Jingkai Gu, Tao Guo, Shuo Yang, Zhen Guo, Xueju Zhang, Weifeng Zhu & Jiwen Zhang. (2013) Ternary system of dihydroartemisinin with hydroxypropyl-β-cyclodextrin and lecithin: Simultaneous enhancement of drug solubility and stability in aqueous solutions. Journal of Pharmaceutical and Biomedical Analysis 83, pages 141-148.
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Mayur Sangwai & Pradeep Vavia. (2013) Amorphous ternary cyclodextrin nanocomposites of telmisartan for oral drug delivery: Improved solubility and reduced pharmacokinetic variability. International Journal of Pharmaceutics 453:2, pages 423-432.
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Wei-Qin (Tony) Tong & Hong Wen. 2008. Water-Insoluble Drug Formulation, Second Edition. Water-Insoluble Drug Formulation, Second Edition 133 159 .

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