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Research Article

Formulation and evaluation of in situ gelling system of dimenhydrinate for nasal administration

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Pages 240-248 | Received 07 Jul 2008, Accepted 14 Aug 2008, Published online: 01 Jun 2009

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Forouhe Zahir-Jouzdani, Julian Dominik Wolf, Fatemeh Atyabi & Andreas Bernkop-Schnürch. (2018) In situ gelling and mucoadhesive polymers: why do they need each other?. Expert Opinion on Drug Delivery 15:10, pages 1007-1019.
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Reena MP Singh, Anil Kumar & Kamla Pathak. (2013) Mucoadhesive in situ nasal gelling drug delivery systems for modulated drug delivery. Expert Opinion on Drug Delivery 10:1, pages 115-130.
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Hitendra S. Mahajan, Vinod Tyagi, Gopal Lohiya & Pankaj Nerkar. (2012) Thermally reversible xyloglucan gels as vehicles for nasal drug delivery. Drug Delivery 19:5, pages 270-276.
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Mahmoud H. Teaima, Doaa A. Helal, Jihad M. Alsofany, Mohamed A. El-Nabarawi & Mohamed Yasser. (2022) Ion-Triggered In Situ Gelling Intranasal Spray of Dronedarone Hydrochloride Nanocarriers: In Vitro Optimization and In Vivo Pharmacokinetic Appraisal. Pharmaceutics 14:11, pages 2405.
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Hitendra S Mahajan, Vikram D Jadhao & Sachin M Chandankar. (2022) Pullulan and Pluronic F-127 based in situ gel system for intranasal delivery: Development, in vitro and in vivo evaluation. Journal of Bioactive and Compatible Polymers 37:5, pages 406-418.
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Michał Rudko, Tomasz Urbaniak & Witold Musiał. (2021) Recent Developments in Ion-Sensitive Systems for Pharmaceutical Applications. Polymers 13:10, pages 1641.
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Mrunal Patil. 2021. Direct Nose-to-Brain Drug Delivery. Direct Nose-to-Brain Drug Delivery 115 156 .
Amrinder Singh, Shubham Thakur, Tushit Sharma, Manjot Kaur, Nikhil Shri Sahajpal, Rohan Aurora & Subheet Kumar Jain. (2020) Harmonious Biomaterials for Development of In situ Approaches for Locoregional Delivery of Anti-cancer Drugs: Current Trends. Current Medicinal Chemistry 27:21, pages 3463-3498.
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Kapil Khatri, Shikha Jain & Satish Shilpi. (2020) Nasal In-situ Gel: An Approach to Enhance Therapeutic Benefits of the Drug . Drug Delivery Letters 10:2, pages 85-95.
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Christina Leichner, Randi Angela Baus, Max Jelkmann, Melanie Plautz, Jan Barthelmes, Sarah Dünnhaupt & Andreas Bernkop-Schnürch. (2019) In vitro evaluation of a self-emulsifying drug delivery system (SEDDS) for nasal administration of dimenhydrinate. Drug Delivery and Translational Research 9:5, pages 945-955.
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Milan Milivojevic, Ivana Pajic-Lijakovic, Branko Bugarski, Amit Kumar Nayak & Md Saquib Hasnain. 2019. Natural Polysaccharides in Drug Delivery and Biomedical Applications. Natural Polysaccharides in Drug Delivery and Biomedical Applications 145 186 .
Karishma Khan, Mohd Aqil, Syed Sarim Imam, Abdul Ahad, Thasleem Moolakkadath, Yasmin Sultana & Mohd Mujeeb. (2018) Ursolic acid loaded intra nasal nano lipid vesicles for brain tumour: Formulation, optimization, in-vivo brain/plasma distribution study and histopathological assessment. Biomedicine & Pharmacotherapy 106, pages 1578-1585.
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Lawrence A. Trissel, Lisa D. Ashworth & Jay Ashworth. 2018. Trissel’s Stability of Compounded Formulations, 6e. Trissel’s Stability of Compounded Formulations, 6e.
Yingting Wang, Shulong Jiang, Hongli Wang & Haiyan Bie. (2017) A mucoadhesive, thermoreversible in situ nasal gel of geniposide for neurodegenerative diseases. PLOS ONE 12:12, pages e0189478.
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Sara S. Barakat, Maha Nasr, Rania F. Ahmed, Sabry S. Badawy & Samar Mansour. (2017) Intranasally administered in situ gelling nanocomposite system of dimenhydrinate: preparation, characterization and pharmacodynamic applicability in chemotherapy induced emesis model. Scientific Reports 7:1.
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Jifu Hao, Jing Zhao, Shupeng Zhang, Tiantian Tong, Qiannan Zhuang, Kai Jin, Wei Chen & Hua Tang. (2016) Fabrication of an ionic-sensitive in situ gel loaded with resveratrol nanosuspensions intended for direct nose-to-brain delivery. Colloids and Surfaces B: Biointerfaces 147, pages 376-386.
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Mohammed H. Mahdi, Barbara R. Conway & Alan M. Smith. (2015) Development of mucoadhesive sprayable gellan gum fluid gels. International Journal of Pharmaceutics 488:1-2, pages 12-19.
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P. H Patil, V. S Belgamwar, D. A Patel & S. J. Surana. (2013) FORMULATION AND IN-VITRO EVALUATION OF ZOLMITRIPTAN IN SITU GEL FOR NASAL ADMINISTRATION. INDIAN DRUGS 50:12, pages 54-58.
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Sachin Shivaji Kushare & Surendra G Gattani. (2013) Microwave-generated bionanocomposites for solubility and dissolution enhancement of poorly water-soluble drug glipizide: in-vitro and in-vivo studies. Journal of Pharmacy and Pharmacology 65:1, pages 79-93.
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Ana Serralheiro, Gilberto Alves & Amílcar Falcão. (2012) Bioanalysis of small-molecule drugs in nasal and paranasal tissues and secretions: Current status and perspectives. Open Chemistry 10:3, pages 686-702.
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Pankaj Padmakar Nerkar & Surendra Ganeshlal Gattani. (2011) Cress seed mucilage based buccal mucoadhesive gel of venlafaxine: in vivo, in vitro evaluation. Journal of Materials Science: Materials in Medicine 23:3, pages 771-779.
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