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Education And Practice

qSOFA Has Poor Sensitivity for Prehospital Identification of Severe Sepsis and Septic Shock

Pages 489-497 | Received 21 Aug 2016, Accepted 15 Dec 2016, Published online: 25 Jan 2017

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Rae Denise Oanesa, Tom Wen-Han Su & Alexandra Weissman. (2023) Evidence for Use of Validated Sepsis Screening Tools in the Prehospital Population: A Scoping Review. Prehospital Emergency Care 0:0, pages 1-9.
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Francisco Martín-Rodríguez, Ancor Sanz-García, Elena Medina-Lozano, Miguel Ángel Castro Villamor, Virginia Carbajosa Rodríguez, Carlos del Pozo Vegas, Laura Natividad Fadrique Millán, Guillermo Ortega Rabbione, José Luis Martín-Conty & Raúl López-Izquierdo. (2021) The Value of Prehospital Early Warning Scores to Predict in - Hospital Clinical Deterioration: A Multicenter, Observational Base-Ambulance Study. Prehospital Emergency Care 25:5, pages 597-606.
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Chen Feng, Paul Griffin, Shravan Kethireddy & Yajun Mei. (2021) A boosting inspired personalized threshold method for sepsis screening. Journal of Applied Statistics 48:1, pages 154-175.
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Robert Liu, Ninad S. Chaudhary, Donald M. Yealy, David T. Huang & Henry E. Wang. (2020) Emergency Medical Services Care and Sepsis Trajectories. Prehospital Emergency Care 24:6, pages 733-740.
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Colin A. Graham, Ling Yan Leung, Ronson Sze Long Lo, Chun Yu Yeung, Suet Yi Chan & Kevin Kei Ching Hung. (2020) NEWS and qSIRS superior to qSOFA in the prediction of 30-day mortality in emergency department patients in Hong Kong. Annals of Medicine 52:7, pages 403-412.
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Daniel J. Lane, Steve Lin & Damon C. Scales. (2020) Classification versus Prediction of Mortality Risk using the SIRS and qSOFA Scores in Patients with Infection Transported by Paramedics. Prehospital Emergency Care 24:2, pages 282-289.
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Sriram Ramgopal, Robert J. Sepanski, Remle P. Crowe, Masashi Okubo, Clifton W. Callaway & Christian Martin‐Gill. (2023) Correlation of vital sign centiles with in‐hospital outcomes among adults encountered by emergency medical services. Academic Emergency Medicine.
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Khandaker Reajul Islam, Johayra Prithula, Jaya Kumar, Toh Leong Tan, Mamun Bin Ibne Reaz, Md. Shaheenur Islam Sumon & Muhammad E. H. Chowdhury. (2023) Machine Learning-Based Early Prediction of Sepsis Using Electronic Health Records: A Systematic Review. Journal of Clinical Medicine 12:17, pages 5658.
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Romain Jouffroy, Basile Gilbert, Jean Pierre Tourtier, Emmanuel Bloch-Laine, Patrick Ecollan, Josiane Boularan, Vincent Bounes, Benoit Vivien & Papa Gueye. (2023) Prehospital pulse pressure and mortality of septic shock patients cared for by a mobile intensive care unit. BMC Emergency Medicine 23:1.
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Agnes Olander, Henrik Andersson, Annelie J. Sundler, Magnus Andersson Hagiwara & Anders Bremer. (2023) The onset of sepsis as experienced by patients and family members: A qualitative interview study. Journal of Clinical Nursing.
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Xuesong Wang, Zhe Guo, Yan Chai, Ziyi Wang, Haiyan Liao, Ziwen Wang & Zhong Wang. (2023) Application Prospect of the SOFA Score and Related Modification Research Progress in Sepsis. Journal of Clinical Medicine 12:10, pages 3493.
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Ayaka Saito, Itsuki Osawa, Junichiro Shibata, Tomohiro Sonoo, Kensuke Nakamura & Tadahiro Goto. (2023) The prognostic utility of prehospital qSOFA in addition to emergency department qSOFA for sepsis in patients with suspected infection: A retrospective cohort study. PLOS ONE 18:2, pages e0282148.
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Agnes Olander, Carl Magnusson, Annelie J. Sundler, Anders Bremer, Henrik Andersson, Johan Herlitz, Christer Axelsson & Magnus Andersson Hagiwara. (2023) Prediction of the Risk of Sepsis by Using Analysis of Plasma Glucose and Serum Lactate in Ambulance Services: A Prospective Study. Prehospital and Disaster Medicine, pages 1-8.
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Wolfgang Bauer, Noa Galtung, Iris von Wunsch-Rolshoven Teruel, Johannes Dickescheid, Konrad Reinhart & Rajan Somasundaram. (2023) Screening auf Sepsis in der Notfallmedizin – qSOFA ist uns nicht genugScreening for sepsis in emergency medicine—qSOFA is just not enough. Notfall + Rettungsmedizin.
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Jaechul Yoon, Dohern Kym, Jun Hur, Yong Suk Cho, Wook Chun & Dogeon Yoon. (2023) Validation of Sepsis-3 using survival analysis and clinical evaluation of quick SOFA, SIRS, and burn-specific SIRS for sepsis in burn patients with suspected infection. PLOS ONE 18:1, pages e0276597.
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Romain Jouffroy, Basile Gilbert, Léa Thomas, Emmanuel Bloch-Laine, Patrick Ecollan, Josiane Boularan, Vincent Bounes, Benoit Vivien & Papa-Ngalgou Gueye. (2022) Association between prehospital shock index variation and 28-day mortality among patients with septic shock. BMC Emergency Medicine 22:1.
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Sriram Ramgopal, Christopher M Horvat & Mark D Adler. (2022) Varying Estimates of Sepsis among Adults Presenting to US Emergency Departments: Estimates from a National Dataset from 2002-2018. Journal of Intensive Care Medicine 37:11, pages 1451-1459.
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Amith Sreekanth, Ankit Jain, Souradeep Dutta, Gomathi Shankar & Nagarajan Raj Kumar. (2022) Accuracy of Quick Sequential Organ Failure Assessment Score & Systemic Inflammatory Response Syndrome Criteria in Predicting Adverse Outcomes in Emergency Surgical Patients With Suspected Sepsis: A Prospective Observational Study. Cureus.
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Enrico Brunetti, Gianluca Isaia, Gianluca Rinaldi, Tiziana Brambati, Davide De Vito, Giuliano Ronco & Mario Bo. (2022) Comparison of Diagnostic Accuracies of qSOFA, NEWS, and MEWS to Identify Sepsis in Older Inpatients With Suspected Infection. Journal of the American Medical Directors Association 23:5, pages 865-871.e2.
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Francisco Martín-Rodríguez, Laura Melero-Guijarro, Guillermo J. Ortega, Ancor Sanz-García, Teresa de la Torre de Dios, Jesús Álvarez Manzanares, José L. Martín-Conty, Miguel A. Castro Villamor, Juan F. Delgado Benito & Raúl López-Izquierdo. (2022) Combination of Prehospital NT-proBNP with qSOFA and NEWS to Predict Sepsis and Sepsis-Related Mortality. Disease Markers 2022, pages 1-13.
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Steve Goodacre, Ben Thomas, Michael Smyth & Jon M Dickson. (2021) Should prehospital early warning scores be used to identify which patients need urgent treatment for sepsis?. BMJ, pages n2432.
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R. Phillip DellingerMitchell M. LevyChrista A. SchorrSean R. Townsend. (2021) 50 Years of Sepsis Investigation/Enlightenment Among Adults—The Long and Winding Road. Critical Care Medicine 49:10, pages 1606-1625.
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Myrto Bolanaki, Martin Möckel, Johannes Winning, Michael Bauer, Konrad Reinhart, Angelika Stacke, Peter Hajdu & Anna Slagman. (2021) Diagnostic Performance of Procalcitonin for the Early Identification of Sepsis in Patients with Elevated qSOFA Score at Emergency Admission. Journal of Clinical Medicine 10:17, pages 3869.
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Romain Jouffroy, Teddy Léguillier, Basile Gilbert, Jean Pierre Tourtier, Emmanuel Bloch-Laine, Patrick Ecollan, Vincent Bounes, Josiane Boularan, Papa Gueye-Ngalgou, Valérie Nivet-Antoine, Jean-Louis Beaudeux & Benoit Vivien. (2021) Prehospital lactate clearance is associated with reduced mortality in patients with septic shock. The American Journal of Emergency Medicine 46, pages 367-373.
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Sang Yun Kim, Seon Hee Woo, Woon Jeong Lee, Dae Hee Kim, Seung Hwan Seol, June Young Lee, Sikyoung Jeong, Sanghyun Park, Kyungman Cha & Chun Song Youn. (2020) The qSOFA score combined with the initial red cell distribution width as a useful predictor of 30 day mortality among older adults with infection in an emergency department. Aging Clinical and Experimental Research 33:6, pages 1619-1625.
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Vibe S. Mikkelsen, Mads Christian Tofte Gregers, Ulrik Stenz Justesen, Jens Schierbeck & Søren Mikkelsen. (2021) Pre‐hospital antibiotic therapy preceded by blood cultures in a physician‐manned mobile emergency care unit. Acta Anaesthesiologica Scandinavica 65:4, pages 540-548.
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Dongdong Zhang, Changchang Yin, Katherine M. Hunold, Xiaoqian Jiang, Jeffrey M. Caterino & Ping Zhang. (2021) An interpretable deep-learning model for early prediction of sepsis in the emergency department. Patterns 2:2, pages 100196.
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Tomoya Hirose, Yusuke Katayama, Hiroshi Ogura, Yutaka Umemura, Tetsuhisa Kitamura, Yasuaki Mizushima & Takeshi Shimazu. (2021) Relationship between the prehospital quick Sequential Organ Failure Assessment and prognosis in patients with sepsis or suspected sepsis: a population‐based ORION registry. Acute Medicine & Surgery 8:1.
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Monika Loritz, Hans-Jörg Busch, Thomas Helbing & Katrin Fink. (2020) Prospective evaluation of the quickSOFA score as a screening for sepsis in the emergency department. Internal and Emergency Medicine 15:4, pages 685-693.
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Michael A. Smyth, Daniel Gallacher, Peter K. Kimani, Mark Ragoo, Matthew Ward & Gavin D. Perkins. (2019) Derivation and internal validation of the screening to enhance prehospital identification of sepsis (SEPSIS) score in adults on arrival at the emergency department. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 27:1.
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Agnes Olander, Henrik Andersson, Annelie J. Sundler, Anders Bremer, Lars Ljungström & Magnus Andersson Hagiwara. (2019) Prehospital characteristics among patients with sepsis: a comparison between patients with or without adverse outcome. BMC Emergency Medicine 19:1.
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Daniel J. Silcock, Alasdair R. Corfield, Harry Staines & Kevin D. Rooney. (2019) Superior performance of National Early Warning Score compared with quick Sepsis-related Organ Failure Assessment Score in predicting adverse outcomes: a retrospective observational study of patients in the prehospital setting. European Journal of Emergency Medicine 26:6, pages 433-439.
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S. Casu, D. Häske, F. Herbstreit & P.-M. Rath. (2019) Management der Sepsis: Erstantibiose bereits im Rettungs- und NotarztdienstManagement of sepsis: initial antibiotic treatment already by the emergency medical personnel. Notfall + Rettungsmedizin 22:8, pages 704-708.
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Velma Herwanto, Amith Shetty, Marek Nalos, Mandira Chakraborty, Anthony McLean, Guy D. Eslick & Benjamin Tang. (2019) Accuracy of Quick Sequential Organ Failure Assessment Score to Predict Sepsis Mortality in 121 Studies Including 1,716,017 Individuals. Critical Care Explorations 1:9, pages e0043.
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Vijay Anand, Zilu Zhang, Sameer S. Kadri, Michael Klompas & Chanu Rhee. (2019) Epidemiology of Quick Sequential Organ Failure Assessment Criteria in Undifferentiated Patients and Association With Suspected Infection and Sepsis. Chest 156:2, pages 289-297.
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Bo-Sun Shim, Young-Hoon Yoon, Jung-Youn Kim, Young-Duck Cho, Sung-Jun Park, Eu-Sun Lee & Sung-Hyuk Choi. (2019) Clinical Value of Whole Blood Procalcitonin Using Point of Care Testing, Quick Sequential Organ Failure Assessment Score, C-Reactive Protein and Lactate in Emergency Department Patients with Suspected Infection. Journal of Clinical Medicine 8:6, pages 833.
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A. V. Sazhin, G. B. Ivakhov, E. A. Stradymov & V. A. Petukhov. (2019) Surgical treatment of perforated gastric and duodenum ulcers complicated by diffuse peritonitis: prediction factors (part 2). Endoskopicheskaya khirurgiya 25:4, pages 46.
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Christopher R Yee, Niven R Narain, Viatcheslav R Akmaev & Vijetha Vemulapalli. (2019) A Data-Driven Approach to Predicting Septic Shock in the Intensive Care Unit. Biomedical Informatics Insights 11, pages 117822261988514.
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Shahin Gaini, Mette Marie Relster, Court Pedersen & Isik Somuncu Johansen. (2019) Prediction of 28-days mortality with sequential organ failure assessment (SOFA), quick SOFA (qSOFA) and systemic inflammatory response syndrome (SIRS) — A retrospective study of medical patients with acute infectious disease. International Journal of Infectious Diseases 78, pages 1-7.
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Jae-Uk Song, Cheol Kyung Sin, Hye Kyeong Park, Sung Ryul Shim & Jonghoo Lee. (2018) Performance of the quick Sequential (sepsis-related) Organ Failure Assessment score as a prognostic tool in infected patients outside the intensive care unit: a systematic review and meta-analysis. Critical Care 22:1.
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Yun Tae Jung, Jiyeon Jeon, Jung Yun Park, Myung Jun Kim, Seung Hwan Lee & Jae Gil Lee. (2018) Addition of lactic acid levels improves the accuracy of quick sequential organ failure assessment in predicting mortality in surgical patients with complicated intra-abdominal infections: a retrospective study. World Journal of Emergency Surgery 13:1.
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Oliver C. RedfernGary B. SmithDavid R. PrytherchPaul MeredithMatthew Inada-KimPaul E. Schmidt. (2018) A Comparison of the Quick Sequential (Sepsis-Related) Organ Failure Assessment Score and the National Early Warning Score in Non-ICU Patients With/Without Infection. Critical Care Medicine 46:12, pages 1923-1933.
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Yong Soo Cho, Byeong Jo Chun & Jeong Mi Moon. (2018) The qSOFA Score: A Simple and Accurate Predictor of Outcome in Patients with Glyphosate Herbicide Poisoning. Basic & Clinical Pharmacology & Toxicology 123:5, pages 615-621.
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S. Maitra, A. Som & S. Bhattacharjee. (2018) Accuracy of quick Sequential Organ Failure Assessment (qSOFA) score and systemic inflammatory response syndrome (SIRS) criteria for predicting mortality in hospitalized patients with suspected infection: a meta-analysis of observational studies. Clinical Microbiology and Infection 24:11, pages 1123-1129.
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Brit Long & Michael D. April. (2018) Are qSOFA Criteria Better Than the Systemic Inflammatory Response Syndrome Criteria for Diagnosing Sepsis and Predicting Inhospital Mortality?. Annals of Emergency Medicine 72:4, pages 470-472.
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Silvia Spoto, Eleonora Cella, Marina de Cesaris, Luciana Locorriere, Silvia Mazzaroppi, Edoardo Nobile, Arcangela M. Lanotte, Lucia Pedicino, Marta Fogolari, Sebastiano Costantino, Giordano Dicuonzo, Massimo Ciccozzi & Silvia Angeletti. (2018) Procalcitonin and MR-Proadrenomedullin Combination with SOFA and qSOFA Scores for Sepsis Diagnosis and Prognosis: A Diagnostic Algorithm. Shock 50:1, pages 44-52.
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Philip D. Sloane, Kimberly Ward, David J. Weber, Christine E. Kistler, Benjamin Brown, Katherine Davis & Sheryl Zimmerman. (2018) Can Sepsis Be Detected in the Nursing Home Prior to the Need for Hospital Transfer?. Journal of the American Medical Directors Association 19:6, pages 492-496.e1.
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Kei Hayashida, Yutaka Kondo, Toru Hifumi, Junya Shimazaki, Yasutaka Oda, Shinichiro Shiraishi, Tatsuma Fukuda, Junichi Sasaki & Keiki Shimizu. (2018) A novel early risk assessment tool for detecting clinical outcomes in patients with heat-related illness (J-ERATO score): Development and validation in independent cohorts in Japan. PLOS ONE 13:5, pages e0197032.
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Sung Yeon Hwang, Ik Joon Jo, Se Uk Lee, Tae Rim Lee, Hee Yoon, Won Chul Cha, Min Seob Sim & Tae Gun Shin. (2018) Low Accuracy of Positive qSOFA Criteria for Predicting 28-Day Mortality in Critically Ill Septic Patients During the Early Period After Emergency Department Presentation. Annals of Emergency Medicine 71:1, pages 1-9.e2.
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Selin Tusgul, Pierre-Nicolas Carron, Bertrand Yersin, Thierry Calandra & Fabrice Dami. (2017) Low sensitivity of qSOFA, SIRS criteria and sepsis definition to identify infected patients at risk of complication in the prehospital setting and at the emergency department triage. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 25:1.
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Åsa Askim, Florentin Moser, Lise T. Gustad, Helga Stene, Maren Gundersen, Bjørn Olav Åsvold, Jostein Dale, Lars Petter Bjørnsen, Jan Kristian Damås & Erik Solligård. (2017) Poor performance of quick-SOFA (qSOFA) score in predicting severe sepsis and mortality – a prospective study of patients admitted with infection to the emergency department. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 25:1.
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Amith Shetty, Stephen PJ MacDonald, Julian M Williams, John van Bockxmeer, Bas de Groot, Laura M Esteve Cuevas, Annemieke Ansems, Malcolm Green, Kelly Thompson, Harvey Lander, Jaimi Greenslade, Simon Finfer & Jonathan Iredell. (2017) Lactate ≥2 mmol/L plus qSOFA improves utility over qSOFA alone in emergency department patients presenting with suspected sepsis. Emergency Medicine Australasia 29:6, pages 626-634.
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