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Original Articles

Noncholinesterase Effects Induced by Organophosphate Pesticides and their Relationship to Cognitive Processes: Implication for the Action of Acylpeptide Hydrolase

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Pages 623-630 | Published online: 28 Nov 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Carol J. Burns, Laura J. McIntosh, Pamela J. Mink, Anne M. Jurek & Abby A. Li. (2013) Pesticide Exposure and Neurodevelopmental Outcomes: Review of the Epidemiologic and Animal Studies. Journal of Toxicology and Environmental Health, Part B 16:3-4, pages 127-283.
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Sarah Mackenzie Ross, I. C. McManus, Virginia Harrison & Oliver Mason. (2013) Neurobehavioral problems following low-level exposure to organophosphate pesticides: a systematic and meta-analytic review. Critical Reviews in Toxicology 43:1, pages 21-44.
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Christopher D. Ruark, C. Eric Hack, Peter J. Robinson & Jeffery M. Gearhart. (2010) Quantitative Structure–Activity Relationships for Organophosphates Binding to Trypsin and Chymotrypsin. Journal of Toxicology and Environmental Health, Part A 74:1, pages 1-23.
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Articles from other publishers (37)

Bhadriraju Subramanyam, Manivannan Selladurai, Ryan Olson, Joe Taft & Sam Hanni. (2023) Evaluation of dichlorvos pest strips in shipping containers holding soybeans: Effectiveness against immature stages of Plodia interpunctella (Hübner) (Lepidoptera: Pyralidae). Journal of Stored Products Research 103, pages 102155.
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Jonathan Burdon, Lygia Therese Budnik, Xaver Baur, Gerard Hageman, C. Vyvyan Howard, Jordi Roig, Leonie Coxon, Clement E. Furlong, David Gee, Tristan Loraine, Alvin V. TerryJr.Jr., John Midavaine, Hannes Petersen, Denis Bron, Colin L. Soskolne & Susan Michaelis. (2023) Health consequences of exposure to aircraft contaminated air and fume events: a narrative review and medical protocol for the investigation of exposed aircrew and passengers. Environmental Health 22:1.
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Enye Linus Anderson, Saka Olusola Stephen, Onoriode Andrew Udi, Ebeye Abimbola Oladunni & Igbigbi Patrick Sunday. (2023) Investigating the effect of Mimosa Pudica on dichlorvos induced hippocampal neurodegeneration in mice. Phytomedicine Plus 3:1, pages 100393.
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Milan Jokanović, Patrik Oleksak & Kamil Kuca. (2023) Multiple neurological effects associated with exposure to organophosphorus pesticides in man. Toxicology 484, pages 153407.
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Igor S.A. Felippe, Claudia J.T. Müller, Luciana M. Passamani, Ana P. Abdala, Julian F.R. Paton & Karla N. Sampaio. (2022) Patterns of cardio-respiratory motor outputs during acute and subacute exposure to chlorpyrifos in an ex-vivo in situ preparation in rats. Toxicology and Applied Pharmacology 436, pages 115862.
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Marcos Francos. 2023. Impact of Agriculture on Soil Degradation I. Impact of Agriculture on Soil Degradation I 129 151 .
Muriel Ramírez-Santana, Liliana Zúñiga-Venegas, Sebastián Corral, Nel Roeleveld, Hans Groenewoud, Koos van der Velden, Paul T.J. Scheepers & Floria Pancetti. (2020) Association between cholinesterase's inhibition and cognitive impairment: A basis for prevention policies of environmental pollution by organophosphate and carbamate pesticides in Chile. Environmental Research 186, pages 109539.
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Vivian S. Lin, Regan F. Volk, Adrian J. DeLeon, Lindsey N. Anderson, Samuel O. Purvine, Anil K. Shukla, Hans C. Bernstein, Jordan N. Smith & Aaron T. Wright. (2019) Structure Dependent Determination of Organophosphate Targets in Mammalian Tissues Using Activity-Based Protein Profiling. Chemical Research in Toxicology 33:2, pages 414-425.
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Samir F. de A. Cavalcante, Alessandro B. C. Simas & Kamil Kuča. (2019) Nerve Agents’ Surrogates: Invaluable Tools for Development of Acetylcholinesterase Reactivators. Current Organic Chemistry 23:14, pages 1539-1559.
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Li Pang, Junlan Liu, Wei Li, Yan Xia & Jihong Xing. (2019) Serum ubiquitin C‐terminal hydrolase L1 predicts cognitive impairment in patients with acute organophosphorus pesticide poisoning. Journal of Clinical Laboratory Analysis 33:7.
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Theodore A. Slotkin, Samantha Skavicus, Ashley Ko, Edward D. Levin & Frederic J. Seidler. (2019) Perinatal diazinon exposure compromises the development of acetylcholine and serotonin systems. Toxicology 424, pages 152240.
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S. J. Sudharshan, Subasri Subramaniyan, Greeshma Satheeshan & Madhu Dyavaiah. (2019) Astaxanthin supplementation reduces dichlorvos-induced cytotoxicity in Saccharomyces cerevisiae. 3 Biotech 9:3.
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Milan Jokanović. (2018) Neurotoxic effects of organophosphorus pesticides and possible association with neurodegenerative diseases in man: A review. Toxicology 410, pages 125-131.
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Todd J. Zurlinden & Brad Reisfeld. (2018) A Novel Method for the Development of Environmental Public Health Indicators and Benchmark Dose Estimation Using a Health-Based End Point for Chlorpyrifos. Environmental Health Perspectives 126:4.
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Danielle Hagstrom, Siqi Zhang, Alicia Ho, Eileen S. Tsai, Zoran Radić, Aryo Jahromi, Kelson J. Kaj, Yingtian He, Palmer Taylor & Eva-Maria S. Collins. (2017) Planarian cholinesterase: molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity. Archives of Toxicology 92:3, pages 1161-1176.
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Gianna Palmieri, Ennio Cocca, Marta Gogliettino, Roberta Valentino, Menotti Ruvo, Gloria Cristofano, Antonella Angiolillo, Marco Balestrieri, Mosè Rossi & Alfonso Di Costanzo. (2017) Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer’s Disease: A Sign of Defective Proteostasis?. Journal of Alzheimer's Disease 60:3, pages 1097-1106.
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Danielle Hagstrom, Hideto Hirokawa, Limin Zhang, Zoran Radic, Palmer Taylor & Eva-Maria S. Collins. (2016) Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation. Archives of Toxicology 91:8, pages 2837-2847.
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Pia Basaure, Fiona Peris-Sampedro, Maria Cabré, Ingrid Reverte & Maria Teresa Colomina. (2017) Two cholinesterase inhibitors trigger dissimilar effects on behavior and body weight in C57BL/6 mice: The case of chlorpyrifos and rivastigmine. Behavioural Brain Research 318, pages 1-11.
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Luminita Marutescu & Mariana Carmen Chifiriuc. 2017. New Pesticides and Soil Sensors. New Pesticides and Soil Sensors 393 435 .
Ping Fu, Wei Sun & Ze Zhang. (2016) Molecular cloning, expression and characterization of acylpeptide hydrolase in the silkworm, Bombyx mori. Gene 580:1, pages 8-16.
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Muriel Ramírez-Santana, Liliana Zúñiga, Sebastián Corral, Rodrigo Sandoval, Paul TJ Scheepers, Koos Van der Velden, Nel Roeleveld & Floria Pancetti. (2015) Assessing biomarkers and neuropsychological outcomes in rural populations exposed to organophosphate pesticides in Chile – study design and protocol. BMC Public Health 15:1.
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Judith Anderson. (2015) Commentary on: de Ree H, et al. “Health risk assessment of exposure to tricresyl phosphates (TCPs) in aircraft: A commentary” [Neurotoxicology (2014), http://dx.doi.org/10.1016/j.neuro.2014.08.011]. NeuroToxicology 46, pages 165-166.
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Monika Meyer-Baron, Guido Knapp, Michael Schäper & Christoph van Thriel. (2015) Meta-analysis on occupational exposure to pesticides – Neurobehavioral impact and dose–response relationships. Environmental Research 136, pages 234-245.
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Russell L. Carr, Casey A. Graves, Lee C. Mangum, Carole A. Nail & Matthew K. Ross. (2014) Low level chlorpyrifos exposure increases anandamide accumulation in juvenile rat brain in the absence of brain cholinesterase inhibition. NeuroToxicology 43, pages 82-89.
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Caridad López-Granero, Diana Cardona, Estela Giménez, Rafael Lozano, José Barril, Michael Aschner, Fernando Sánchez-Santed & Fernando Cañadas. (2014) Comparative study on short- and long-term behavioral consequences of organophosphate exposure: Relationship to AChE mRNA expression. NeuroToxicology 40, pages 57-64.
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Ramesh C. Gupta & Dejan Milatovic. 2014. Biomarkers in Toxicology. Biomarkers in Toxicology 389 407 .
Caridad López-Granero, Diana Cardona, Estela Giménez, Rafael Lozano, José Barril, Fernando Sánchez-Santed & Fernando Cañadas. (2013) Chronic dietary exposure to chlorpyrifos causes behavioral impairments, low activity of brain membrane-bound acetylcholinesterase, and increased brain acetylcholinesterase-R mRNA. Toxicology 308, pages 41-49.
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Judit Marsillach, Lucio G. Costa & Clement E. Furlong. (2013) Protein adducts as biomarkers of exposure to organophosphorus compounds. Toxicology 307, pages 46-54.
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Paula E. Goines & Paul Ashwood. (2013) Cytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment. Neurotoxicology and Teratology 36, pages 67-81.
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Paul E. Baker, Toby B. Cole, Megan Cartwright, Stephanie M. Suzuki, Kenneth E. Thummel, Yvonne S. Lin, Aila L. Co, Allan E. Rettie, Jerry H. Kim & Clement E. Furlong. (2013) Identifying safer anti-wear triaryl phosphate additives for jet engine lubricants. Chemico-Biological Interactions 203:1, pages 257-264.
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Caridad López-Granero, Fernando Cañadas, Diana Cardona, Yingchun Yu, Estela Giménez, Rafael Lozano, Daiana Silva Avila, Michael Aschner & Fernando Sánchez-Santed. (2013) Chlorpyrifos-, Diisopropylphosphorofluoridate-, and Parathion-Induced Behavioral and Oxidative Stress Effects: Are They Mediated by Analogous Mechanisms of Action?. Toxicological Sciences 131:1, pages 206-216.
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Pamela J. Lein, Matthew R. Bonner, Fayssal M. Farahat, James R. Olson, Diane S. Rohlman, Richard A. Fenske, K. Matthew Lattal, Michael R. Lasarev, Kit Galvin, Taghreed M. Farahat & W. Kent Anger. (2012) Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos. NeuroToxicology 33:4, pages 660-668.
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Christopher N. Banks & Pamela J. Lein. (2012) A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation. NeuroToxicology 33:3, pages 575-584.
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Rodrigo Sandoval, Sebastián Navarro, Gonzalo García-Rojo, Rodrigo Calderón, Andrea Pedrero, Soledad Sandoval, Ursula Wyneken & Floria Pancetti. (2012) Synaptic localization of acylpeptide hydrolase in adult rat telencephalon. Neuroscience Letters 520:1, pages 98-103.
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Mansour Bayrami, Touraj Hashemi, Ali Akbar Malekirad, Hassan Ashayeri, Fardin Faraji & Mohammad Abdollahi. (2011) Electroencephalogram, cognitive state, psychological disorders, clinical symptom, and oxidative stress in horticulture farmers exposed to organophosphate pesticides. Toxicology and Industrial Health 28:1, pages 90-96.
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Diane S. Rohlman, W. Kent Anger & Pamela J. Lein. (2011) Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure. NeuroToxicology 32:2, pages 268-276.
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Miroslav Pohanka, Jana Zdarova Karasova, Kamil Musilek, Kamil Kuca & Jiri Kassa. (2009) Effect of five acetylcholinesterase reactivators on tabun‐intoxicated rats: induction of oxidative stress versus reactivation efficacy. Journal of Applied Toxicology 29:6, pages 483-488.
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