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Original Articles

Biokinetic Modeling and in Vitroin Vivo Extrapolations

Pages 242-252 | Published online: 21 Jun 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Chavy Chiang, Nadia Kashetsky, Aileen Feschuk, Anuk Burli, Rebecca Law & Howard Maibach. (2021) Efficacy of water-based skin decontamination of occupational chemicals using in vitro human skin models: a systematic review. Journal of Toxicology and Environmental Health, Part B 24:7, pages 337-353.
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Lina Thors, Elisabeth Wigenstam, Johanna Qvarnström & Anders Bucht. (2021) Efficient agent degradation within skin is important for decontamination of percutaneously exposed VX. Cutaneous and Ocular Toxicology 40:2, pages 95-102.
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David Rouquié, Marjoke Heneweer, Jane Botham, Hans Ketelslegers, Lauren Markell, Thomas Pfister, Winfried Steiling, Volker Strauss & Christa Hennes. (2015) Contribution of new technologies to characterization and prediction of adverse effects. Critical Reviews in Toxicology 45:2, pages 172-183.
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Arturo Anadón, María Aranzazu Martínez, Victor Castellano & María Rosa Martínez-Larrañaga. (2014) The role of in vitro methods as alternatives to animals in toxicity testing. Expert Opinion on Drug Metabolism & Toxicology 10:1, pages 67-79.
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Miyoung Yoon, Jerry L. Campbell, Melvin E. Andersen & Harvey J. Clewell. (2012) Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results. Critical Reviews in Toxicology 42:8, pages 633-652.
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Jochem Louisse, Miriam Verwei, Ruud A Woutersen, Bas J Blaauboer & Ivonne MCM Rietjens. (2012) Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation. Expert Opinion on Drug Metabolism & Toxicology 8:1, pages 11-27.
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Articles from other publishers (124)

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Daoyuan Yang, Hui Yang, Miaoying Shi, Xudong Jia, Haixia Sui, Zhaoping Liu & Yongning Wu. (2023) Advancing food safety risk assessment in China: development of new approach methodologies (NAMs). Frontiers in Toxicology 5.
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Daniel P. Russo, Lauren M. Aleksunes, Katy Goyak, Hua Qian & Hao Zhu. (2023) Integrating Concentration-Dependent Toxicity Data and Toxicokinetics To Inform Hepatotoxicity Response Pathways. Environmental Science & Technology 57:33, pages 12291-12301.
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Fabrice A. Müller, Marianna Stamou, Felix H. Englert, Ole Frenzel, Sabine Diedrich, Laura Suter-Dick, John F. Wambaugh & Shana J. Sturla. (2023) In vitro to in vivo extrapolation and high-content imaging for simultaneous characterization of chemically induced liver steatosis and markers of hepatotoxicity. Archives of Toxicology 97:6, pages 1701-1721.
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Kelly A Magurany, Xiaoqing Chang, Rebecca Clewell, Sandra Coecke, Esther Haugabrooks & Sue Marty. (2023) A pragmatic framework for the application of new approach methodologies in one health toxicological risk assessment. Toxicological Sciences 192:2, pages 155-177.
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Fanrong Zhao, Li Li, Penghui Lin, Yue Chen, Shipei Xing, Huili Du, Zheng Wang, Junjie Yang, Tao Huan, Cheng Long, Limao Zhang, Bin Wang & Mingliang Fang. (2023) HExpPredict: In Vivo Exposure Prediction of Human Blood Exposome Using a Random Forest Model and Its Application in Chemical Risk Prioritization . Environmental Health Perspectives 131:3.
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Yuxuan Zhang, Minghua Zhu, Wenjia Liu, Zhiqiang Fu, Xuehua Li & Jingwen Chen. 2023. QSAR in Safety Evaluation and Risk Assessment. QSAR in Safety Evaluation and Risk Assessment 511 522 .
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Dunja Dimitrijevic, Eric Fabian, Beate Nicol, Dorothee Funk-Weyer & Robert Landsiedel. (2022) Toward Realistic Dosimetry In Vitro : Determining Effective Concentrations of Test Substances in Cell Culture and Their Prediction by an In Silico Mass Balance Model . Chemical Research in Toxicology 35:11, pages 1962-1973.
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Sherri Bloch, Jon A. Arnot, Nynke I. Kramer, James M. Armitage & Marc-André Verner. (2022) Dynamic Mass Balance Modeling for Chemical Distribution Over Time in In Vitro Systems With Repeated Dosing. Frontiers in Toxicology 4.
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Ans Punt, Jochem Louisse, Nicole Pinckaers, Eric Fabian & Bennard van Ravenzwaay. (2022) Predictive Performance of Next Generation Physiologically Based Kinetic (PBK) Model Predictions in Rats Based on In Vitro and In Silico Input Data . Toxicological Sciences 186:1, pages 18-28.
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Styliani Fragki, Rudolf Hoogenveen, Conny van Oostrom, Paul Schwillens, Aldert H. Piersma & Marco J. Zeilmaker. (2022) Integrating in vitro chemical transplacental passage into a generic PBK model: A QIVIVE approach. Toxicology 465, pages 153060.
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Kuldeep Rajpoot, Nimeet Desai, HariPriya Koppisetti, Muktika Tekade, Mukesh Chandra Sharma, Santosh Kumar Behera & Rakesh Kumar Tekade. 2022. Pharmacokinetics and Toxicokinetic Considerations. Pharmacokinetics and Toxicokinetic Considerations 357 383 .
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Yitong Liu. 2022. High-Throughput Screening Assays in Toxicology. High-Throughput Screening Assays in Toxicology 189 198 .
Bincy A. JohnDavid J. SloanTimothy C. JensenSreenivasa C. RamaiahgariPeter EndGabrielle E. ReshRandall E. McClelland. (2021) A Unidirectional 96-Well Fluidic Culture Platform for Upstream Cell Dosing with Subsequent Downstream Nonlinear and Ascending Exposure Gradients for Real-Time and Cell-Based Toxicity Screening Environments. Applied In Vitro Toxicology 7:4, pages 175-191.
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C. J. Borgert, C. Fuentes & L. D. Burgoon. (2021) Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety. Archives of Toxicology 95:12, pages 3651-3664.
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Sherry R. Black, John W. Nichols, Kellie A. Fay, Sharlene R. Matten & Scott G. Lynn. (2021) Evaluation and comparison of in vitro intrinsic clearance rates measured using cryopreserved hepatocytes from humans, rats, and rainbow trout. Toxicology 457, pages 152819.
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Ans Punt, Nicole Pinckaers, Ad Peijnenburg & Jochem Louisse. (2020) Development of a Web-Based Toolbox to Support Quantitative In-Vitro-to-In-Vivo Extrapolations (QIVIVE) within Nonanimal Testing Strategies. Chemical Research in Toxicology 34:2, pages 460-472.
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Sebastian Lungu-Mitea, Carolina Vogs, Gunnar Carlsson, Maximiliane Montag, Kim Frieberg, Agneta Oskarsson & Johan Lundqvist. (2020) Modeling Bioavailable Concentrations in Zebrafish Cell Lines and Embryos Increases the Correlation of Toxicity Potencies across Test Systems. Environmental Science & Technology 55:1, pages 447-457.
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Rozaini Abdullah, Sebastiaan Wesseling, Bert Spenkelink, Jochem Louisse, Ans Punt & Ivonne M.C.M. Rietjens. (2020) Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach. Journal of Applied Toxicology 40:12, pages 1647-1660.
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Prachi Pradeep, Grace Patlewicz, Robert Pearce, John Wambaugh, Barbara Wetmore & Richard Judson. (2020) Using chemical structure information to develop predictive models for in vitro toxicokinetic parameters to inform high-throughput risk-assessment. Computational Toxicology 16, pages 100136.
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Yitong Liu, Mapa S.T. Mapa & Robert L. Sprando. (2020) Liver toxicity of anthraquinones: A combined in vitro cytotoxicity and in silico reverse dosimetry evaluation. Food and Chemical Toxicology 140, pages 111313.
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Jose Zavala, Anastasia N. Freedman, John T. Szilagyi, Ilona Jaspers, John F. Wambaugh, Mark Higuchi & Julia E. Rager. (2020) New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing. International Journal of Environmental Research and Public Health 17:6, pages 2124.
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Miyoung Yoon, Gina Song, Harvey Clewell & Bas Blaauboer. 2019. Big Data in Predictive Toxicology. Big Data in Predictive Toxicology 331 358 .
Jeremy A. Leonard & Yu-Mei Tan. (2019) Tiered approaches for screening and prioritizing chemicals through integration of pharmacokinetics and exposure information with in vitro dose-response data. Computational Toxicology 12, pages 100101.
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Maciej A. PSZCZOLKOWSKI. (2017) Pharmacological analysis of the feeding response of codling moth (Cydia pomonella; Lepidoptera: Tortricidae) neonates to bitter compounds. European Journal of Entomology 114, pages 500-506.
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Eberhard O. Voit. (2017) The best models of metabolism. WIREs Systems Biology and Medicine 9:6.
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Styliani Fragki, Aldert H. Piersma, Emiel Rorije & Marco J. Zeilmaker. (2017) In vitro to in vivo extrapolation of effective dosimetry in developmental toxicity testing: Application of a generic PBK modelling approach. Toxicology and Applied Pharmacology 332, pages 109-120.
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L. Thors, M. Koch, E. Wigenstam, B. Koch, L. Hägglund & A. Bucht. (2017) Comparison of skin decontamination efficacy of commercial decontamination products following exposure to VX on human skin. Chemico-Biological Interactions 273, pages 82-89.
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Marije Strikwold, Bert Spenkelink, Laura H. J. de Haan, Ruud A. Woutersen, Ans Punt & Ivonne M. C. M. Rietjens. (2016) Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols. Archives of Toxicology 91:5, pages 2119-2133.
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M. Mumtaz, P. Ruiz & Q. Zhang. 2017. Computational Systems Pharmacology and Toxicology. Computational Systems Pharmacology and Toxicology 191 208 .
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Andrew P. Worth & Grace Patlewicz. 2016. Validation of Alternative Methods for Toxicity Testing. Validation of Alternative Methods for Toxicity Testing 317 342 .
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