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Original Articles

Evaluation of the hazards of industrial exposure to tricresyl phosphate:a review and interpretation of the literature

Pages 281-300 | Published online: 30 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

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Mohamed B. Abou-Donia, Martha M. Abou-Donia, Eman M. ElMasry, Jean A. Monro & Michel F. A. Mulder. (2013) Autoantibodies to Nervous System-Specific Proteins Are Elevated in Sera of Flight Crew Members: Biomarkers for Nervous System Injury. Journal of Toxicology and Environmental Health, Part A 76:6, pages 363-380.
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Articles from other publishers (74)

Meng Li, Congcong Wang, Wanying Gui, Peng Wang, Jierong Chen, Shaoqi Zuo, Yanbin Zhao, Jiayin Dai & Kun Zhang. (2023) Developmental Toxicities in Zebrafish Embryos Exposed to Tri-o-cresyl Phosphate. Water 15:16, pages 2942.
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Jonathan Burdon, Lygia Therese Budnik, Xaver Baur, Gerard Hageman, C. Vyvyan Howard, Jordi Roig, Leonie Coxon, Clement E. Furlong, David Gee, Tristan Loraine, Alvin V. TerryJr.Jr., John Midavaine, Hannes Petersen, Denis Bron, Colin L. Soskolne & Susan Michaelis. (2023) Health consequences of exposure to aircraft contaminated air and fume events: a narrative review and medical protocol for the investigation of exposed aircrew and passengers. Environmental Health 22:1.
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Roshanak Amiri, Meera J. Bissram, Mahin Hashemihedeshi, Frank L. Dorman, David Megson & Karl J. Jobst. (2023) Differentiating Toxic and Nontoxic Tricresyl Phosphate Isomers Using Ion–Molecule Reactions with Oxygen. Journal of the American Society for Mass Spectrometry 34:4, pages 640-648.
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Ahmed I. Rushdi, B. R. T. Simoneit, L. Lijotra, A. Y. Bazeyad, R. Dumenden, A. H. El-Mubarak, M. A. Qurban & K. F. Al-Mutlaq. (2022) Phthalates, non-phthalates, polychlorinated biphenyls, and phenyl phosphates in atmospheric suspended particulate matter of Dhahran City, Saudi Arabia: levels and seasonal variation. International Journal of Environmental Science and Technology 20:4, pages 3561-3576.
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Jannik Peters & Nathan P. Staff. (2022) Update on Toxic Neuropathies. Current Treatment Options in Neurology 24:5, pages 203-216.
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Xiaotong Wang, Barbara F. Hales & Bernard Robaire. (2021) Effects of flame retardants on ovarian function. Reproductive Toxicology 102, pages 10-23.
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Hai-Yang Xu, Ying-Jian Sun, Yan-Yan Sun, Yi-Jun Wu, Ming-Yuan Xu, Li-Ping Chen & Li Zhu. (2021) Lapatinib alleviates TOCP-induced axonal damage in the spinal cord of mouse. Neuropharmacology 189, pages 108535.
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Pan Wang, Yi-Jun Wu & Man-Lian Sun. (2021) Decrease of an intracellular organic osmolyte contributes to the cytotoxicity of organophosphate in neuroblastoma cells in vitro. Toxicology 453, pages 152725.
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Qiang Deng, Lan Jiang, Liang Mao, Xiao‐Hua Song, Chu‐Qi He, Xiao‐Ling Li, Zhao‐Hui Zhang, Huai‐Cai Zeng, Jia‐xiang Chen & Ding‐Xin Long. (2020) The role of protein kinase C alpha in tri‐ortho‐cresyl phosphate‐induced autophagy in human neuroblastoma SK‐N‐SH cells. Journal of Applied Toxicology 40:11, pages 1480-1490.
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Shabana Siddique, Shelley A. Harris, Ivana Kosarac, Lidija Latifovic & Cariton Kubwabo. (2020) Urinary metabolites of organophosphate esters in women and their relationship with serum lipids: An exploratory analysis. Environmental Pollution 263, pages 114110.
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Pavel A. Melentev, Olga E. Agranovich & Svetlana V. Sarantseva. (2020) Human diseases associated with NTE gene. Ecological genetics 18:2, pages 229-242.
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Madeleine Böckers, Norbert W. Paul & Thomas Efferth. (2020) Organophosphate ester tri-o-cresyl phosphate interacts with estrogen receptor α in MCF-7 breast cancer cells promoting cancer growth. Toxicology and Applied Pharmacology 395, pages 114977.
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Chang Liu, Wenjuan Zhou, Zhaopei Li, Jun Ren, Xian Li, Shan Li, Qian Liu, Fuyong Song, Aijun Hao & Fuwu Wang. (2020) Melatonin Protects Neural Stem Cells Against Tri-Ortho-Cresyl Phosphate-Induced Autophagy. Frontiers in Molecular Neuroscience 13.
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Bei Yang, Xinlu Wang, Yilin Ma, Lei Yan, Yuan Ren, Dainan Yu, Bo Qiao, Xin Shen, Hui Liu, Dalei Zhang & Haibin Kuang. (2019) Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice. Environmental Toxicology 35:1, pages 97-107.
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Yu Wang, Cuiqin Zhang, Zhenyu Shen, Ruirui Kou, Keqin Xie & Fuyong Song. (2019) Activation of PINK1-Parkin-dependent mitophagy in Tri-ortho-cresyl phosphate-treated Neuro2a cells. Chemico-Biological Interactions 308, pages 70-79.
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Jinglei Wang, Wenli Ruan, Boshu Huang, Shuxin Shao, Dan Yang, Mengling Liu, Lin Zeng, Jie Wei & Jiaxiang Chen. (2019) Tri-ortho-cresyl phosphate induces autophagy of mouse ovarian granulosa cells. Reproduction 158:1, pages 61-69.
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Pan Wang, Min Yang, Lu Jiang & Yi-Jun Wu. (2019) A fungicide miconazole ameliorates tri-o-cresyl phosphate-induced demyelination through inhibition of ErbB/Akt pathway. Neuropharmacology 148, pages 31-39.
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Liaoliao Hu, Tingting Peng, Jian Huang, Tie Su, Ruichen Luo, Yuehui Zheng, Zhisheng Zhong, Peiling Yu, Kun Nie & Liping Zheng. (2019) Tri-ortho-cresyl phosphate (TOCP) induced ovarian failure in mice is related to the Hippo signaling pathway disruption. Reproductive Toxicology 83, pages 21-27.
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David Megson, Saeed Hajimirzaee, Aidan Doyle, Frank Cannon & Jean-Christophe Balouet. (2019) Investigating the potential for transisomerisation of trycresyl phosphate with a palladium catalyst and its implications for aircraft cabin air quality. Chemosphere 215, pages 532-534.
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Michael Odarczenko, Dhawal Thakare, Wenle Li, Ke Yang, Shijia Tang, Sai P. Venkateswaran, Nancy R. Sottos & Scott R. White. (2018) Self-Protecting Epoxy Coatings with Anticorrosion Microcapsules. ACS Omega 3:10, pages 14157-14164.
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Chao Li, Shanshan Zheng, Jingwen Chen, Hong-Bin Xie, Ya-Nan Zhang, Yuanhui Zhao & Zheng Du. (2018) Kinetics and mechanism of OH-initiated atmospheric oxidation of organophosphorus plasticizers: A computational study on tri-p-cresyl phosphate. Chemosphere 201, pages 557-563.
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Mingjun Deng, Dave T.F. Kuo, Qihang Wu, Ying Zhang, Xinyu Liu, Shengyu Liu, Xiaodong Hu, Bixian Mai, Zhineng Liu & Haozhi Zhang. (2018) Organophosphorus flame retardants and heavy metals in municipal landfill leachate treatment system in Guangzhou, China. Environmental Pollution 236, pages 137-145.
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Chao Li, Gaoliang Wei, Jingwen Chen, Yuanhui Zhao, Ya-Nan Zhang, Limin Su & Weichao Qin. (2018) Aqueous OH Radical Reaction Rate Constants for Organophosphorus Flame Retardants and Plasticizers: Experimental and Modeling Studies. Environmental Science & Technology 52:5, pages 2790-2799.
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Qiang Ding, Sui Fang, Xueqin Chen, Youxin Wang, Jian Li, Fuyun Tian, Xiang Xu, Bernard Attali, Xin Xie & Zhaobing Gao. (2017) TRPA1 channel mediates organophosphate-induced delayed neuropathy. Cell Discovery 3:1.
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Hai-Yang Xu, Pan Wang, Ying-Jian Sun, Lu Jiang, Ming-Yuan Xu & Yi-Jun Wu. (2016) Autophagy in Tri- o -cresyl Phosphate-Induced Delayed Neurotoxicity . Journal of Neuropathology & Experimental Neurology, pages nlw108.
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Xiaomei Liu, Linlin Xu, Jingcao Shen, Jinglei Wang, Wenli Ruan, Mei Yu & Jiaxiang Chen. (2016) Involvement of oxidative stress in tri-ortho–cresyl phosphate-induced autophagy of mouse Leydig TM3 cells in vitro. Reproductive Biology and Endocrinology 14:1.
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L. Xu, C. Long, J. Wang, M. Yu & J. Chen. (2016) Involvement of oxidative stress in tri-ortho-cresyl phosphate-induced liver injury in male mice. Human & Experimental Toxicology 35:10, pages 1093-1101.
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David Megson, Xavier Ortiz, Karl J. Jobst, Eric J. Reiner, Michel F.A. Mulder & Jean-Christophe Balouet. (2016) A comparison of fresh and used aircraft oil for the identification of toxic substances linked to aerotoxic syndrome. Chemosphere 158, pages 116-123.
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Lynne E. Pinkerton, Misty J. Hein, Barbara Grajewski & Freya Kamel. (2016) Mortality from neurodegenerative diseases in a cohort of US flight attendants. American Journal of Industrial Medicine 59:7, pages 532-537.
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Lin-Lin Xu, Meng-Ling Liu, Jing-Lei Wang, Mei Yu & Jia-Xiang Chen. (2016) Saligenin cyclic-o-tolyl phosphate (SCOTP) induces autophagy of rat spermatogonial stem cells. Reproductive Toxicology 60, pages 62-68.
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Peder Wolkoff, Derrick R. Crump & Paul T.C. Harrison. (2016) Pollutant exposures and health symptoms in aircrew and office workers: Is there a link?. Environment International 87, pages 74-84.
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Hester S. Hendriks & Remco H.S. Westerink. (2015) Neurotoxicity and risk assessment of brominated and alternative flame retardants. Neurotoxicology and Teratology 52, pages 248-269.
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Kang Liang, Yumin Niu, Yongguang Yin & Jingfu Liu. (2015) Evaluating the blank contamination and recovery of sample pretreatment procedures for analyzing organophosphorus flame retardants in waters. Journal of Environmental Sciences 34, pages 57-62.
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Jelle Reinen, Leyla Nematollahi, Alex Fidder, Nico P. E. Vermeulen, Daan Noort & Jan N. M. Commandeur. (2015) Characterization of Human Cytochrome P450s Involved in the Bioactivation of Tri- ortho -cresyl Phosphate (ToCP) . Chemical Research in Toxicology 28:4, pages 711-721.
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Meng-Ling Liu, Jing-Lei Wang, Jie Wei, Lin-Lin Xu, Mei Yu, Xiao-Mei Liu, Wen-Li Ruan & Jia-Xiang Chen. (2015) Tri-ortho-cresyl phosphate induces autophagy of rat spermatogonial stem cells. REPRODUCTION 149:2, pages 163-170.
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Jacob de Boer, Angel Antelo, Ike van der Veen, Sicco Brandsma & Nienke Lammertse. (2015) Tricresyl phosphate and the aerotoxic syndrome of flight crew members – Current gaps in knowledge. Chemosphere 119, pages S58-S61.
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Sufang Wang, Bin Wan, Lianying Zhang, Yu Yang & Liang-Hong Guo. (2014) In vitro inhibition of lysine decarboxylase activity by organophosphate esters. Biochemical Pharmacology 92:3, pages 506-516.
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Xiangying Zeng, Lixiong He, Shuxia Cao, Shengtao Ma, Zhiqiang Yu, Hongyan Gui, Guoying Sheng & Jiamo Fu. (2014) Occurrence and distribution of organophosphate flame retardants/plasticizers in wastewater treatment plant sludges from the Pearl River Delta, China. Environmental Toxicology and Chemistry 33:8, pages 1720-1725.
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Birgit Karin Schindler, Stephan Koslitz, Tobias Weiss, Horst Christoph Broding, Thomas Brüning & Jürgen Bünger. (2014) Exposure of aircraft maintenance technicians to organophosphates from hydraulic fluids and turbine oils: A pilot study. International Journal of Hygiene and Environmental Health 217:1, pages 34-37.
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Jia-Xiang Chen, Ying-Jian Sun, Pan Wang, Ding-Xin Long, Wei Li, Li Li & Yi-Jun Wu. (2013) Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth. Toxicology 310, pages 92-97.
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Shuxia Cao, Xiangying Zeng, Han Song, Huiru Li, Zhiqiang Yu, Guoying Sheng & Jiamo Fu. (2012) Levels and distributions of organophosphate flame retardants and plasticizers in sediment from Taihu Lake, China. Environmental Toxicology and Chemistry 31:7, pages 1478-1484.
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