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Original Articles

OZONE-INDUCED LUNG INFLAMMATION AND MUCOSAL BARRIER DISRUPTION: TOXICOLOGY, MECHANISMS, AND IMPLICATIONS

Pages 31-86 | Published online: 30 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (26)

Termeh Kousha & Giuseppe Valacchi. (2015) The Air Quality Health Index and Emergency Department Visits for Urticaria in Windsor, Canada. Journal of Toxicology and Environmental Health, Part A 78:8, pages 524-533.
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Janice A. Dye, Allen D. Ledbetter, Mette C. Schladweiler, Daniel L. Costa & Urmila P. Kodavanti. (2015) Whole body plethysmography reveals differential ventilatory responses to ozone in rat models of cardiovascular disease. Inhalation Toxicology 27:sup1, pages 14-25.
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Joshua S. Barker, Zhongxin Wu, Dawn D. Hunter & Richard D. Dey. (2015) Ozone Exposure Initiates a Sequential Signaling Cascade in Airways Involving Interleukin-1Beta Release, Nerve Growth Factor Secretion, and Substance P Upregulation. Journal of Toxicology and Environmental Health, Part A 78:6, pages 397-407.
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Samantha J. Snow, Andrea De Vizcaya-Ruiz, Alvaro Osornio-Vargas, Ronald F. Thomas, Mette C. Schladweiler, John McGee & Urmila P. Kodavanti. (2014) The Effect of Composition, Size, and Solubility on Acute Pulmonary Injury in Rats Following Exposure to Mexico City Ambient Particulate Matter Samples. Journal of Toxicology and Environmental Health, Part A 77:19, pages 1164-1182.
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Saad Y Salim, Gilaad G Kaplan & Karen L Madsen. (2014) Air pollution effects on the gut microbiota. Gut Microbes 5:2, pages 215-219.
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Jitka Stilund Hansen, Gunnar Damgård Nielsen, Jorid Birkelund Sørli, Per Axel Clausen, Peder Wolkoff & Søren Thor Larsen. (2013) Adjuvant and Inflammatory Effects in Mice After Subchronic Inhalation of Allergen and Ozone-Initiated Limonene Reaction Products. Journal of Toxicology and Environmental Health, Part A 76:19, pages 1085-1095.
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Vanitha Bhoopalan, Sung Gu Han, Mrudang M. Shah, David M. Thomas & Deepak K. Bhalla. (2013) Tobacco smoke modulates ozone-induced toxicity in rat lungs and central nervous system. Inhalation Toxicology 25:1, pages 21-28.
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Stephanie A. Shore, Erin S. Williams, Lucas Chen, Leandro A.P. Benedito, David I. Kasahara & Ming Zhu. (2011) Impact of aging on pulmonary responses to acute ozone exposure in mice: role of TNFR1. Inhalation Toxicology 23:14, pages 878-888.
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Sung Gu Han, Vanitha Bhoopalan, Tolulola Akinbiyi, C. Gary Gairola & Deepak K. Bhalla. (2011) In Utero Tobacco Smoke Exposure Alters Pulmonary Responses of Newborn Rats to Ozone. Journal of Toxicology and Environmental Health, Part A 74:10, pages 668-677.
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Miriam E. Gerlofs-Nijland, Annike I. Totlandsdal, Evren Kilinç, A. John F. Boere, Paul H.B. Fokkens, Daan L.A.C Leseman, Constantinos Sioutas, Per E. Schwarze, Henri M. Spronk, Patrick W.F. Hadoke, Mark R. Miller & Flemming R. Cassee. (2010) Pulmonary and cardiovascular effects of traffic-related particulate matter: 4-week exposure of rats to roadside and diesel engine exhaust particles. Inhalation Toxicology 22:14, pages 1162-1173.
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S⊘ren T. Larsen, Shigeki Matsubara, Glen McConville, Steen S. Poulsen & Erwin W. Gelfand. (2010) Ozone Increases Airway Hyperreactivity and Mucus Hyperproduction in Mice Previously Exposed to Allergen. Journal of Toxicology and Environmental Health, Part A 73:11, pages 738-747.
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Ismael Lares-Asseff, Gabriela Fernandez Saavedra, Alejandra Toledo, Martha Sosa Macías, Francisco Bradley & Javier Espinosa. (2009) Effects of ozone exposure on the oxidative capacity for drug biotransformation in Wistar rats. Toxicological & Environmental Chemistry 91:4, pages 707-716.
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DeepakK. Bhalla, Fusao Hirata, ArunK. Rishi & C. Gary Gairola. (2009) Cigarette Smoke, Inflammation, and Lung Injury: A Mechanistic Perspective. Journal of Toxicology and Environmental Health, Part B 12:1, pages 45-64.
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Ming-Fen Cheng, Shu-Chen Ho, Hui-Fen Chiu, Trong-Neng Wu, Pei-Shih Chen & Chun-Yuh Yang. (2008) Consequences of Exposure to Asian Dust Storm Events on Daily Pneumonia Hospital Admissions in Taipei, Taiwan. Journal of Toxicology and Environmental Health, Part A 71:19, pages 1295-1299.
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Sung Gu Han, Rodney Andrews, C. Gary Gairola & Deepak K. Bhalla. (2008) Acute Pulmonary Effects of Combined Exposure to Carbon Nanotubes and Ozone in Mice. Inhalation Toxicology 20:4, pages 391-398.
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GaryL. Ginsberg, Bahman Asgharian, JuliaS. Kimbell, JamesS. Ultman & AnnieM. Jarabek. (2007) Modeling Approaches for Estimating the Dosimetry of Inhaled Toxicants in Children. Journal of Toxicology and Environmental Health, Part A 71:3, pages 166-195.
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Chun-Yuh Yang, Chih-Cheng Chen, Chi-Yu Chen & Hsin-Wei Kuo. (2007) Air Pollution and Hospital Admissions for Asthma in a Subtropical City: Taipei, Taiwan. Journal of Toxicology and Environmental Health, Part A 70:2, pages 111-117.
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Rentian Feng, Wei He, Hirotomo Ochi & Vincent Castranova. (2006) Ozone Exposure Impairs Antigen-Specific Immunity but Activates IL-7-Induced Proliferation of CD4−CD8− Thymocytes in Balb/c Mice. Journal of Toxicology and Environmental Health, Part A 69:16, pages 1511-1526.
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L. J. Huffman, C. M. Beighley, D. G. Frazer, W. G. McKinney & D. W. Porter. (2006) Increased Susceptibility of Hyperthyroid Rats to Ozone: Early Events and Mechanisms. Journal of Toxicology and Environmental Health, Part A 69:6, pages 465-479.
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L. Nikasinovic, I. Momas & N. Seta. (2003) Nasal Epithelial and Inflammatory Response to Ozone Exposure: A Review of Laboratory-Based Studies Published Since 1985. Journal of Toxicology and Environmental Health, Part B 6:5, pages 521-568.
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Mitchell Cohen, Maureen Sisco, Kathy Baker, Darlene Bowser, Lung-Chi Chen & Richard Schlesinger. (2003) Impact of Coexposure to Ozone on the Carcinogenic Potential of Inhaled Chromium. I. Effects on Retention and on Extra- and Intracellular Distribution. Journal of Toxicology and Environmental Health, Part A 66:1, pages 39-55.
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Roberto Bono, Enzo Scursatone, Tiziana Schilirò & Giorgio Gilli. (2003) Ambient Air Levels and Occupational Exposure to Benzene, Toluene, and Xylenes in Northwestern Italy. Journal of Toxicology and Environmental Health, Part A 66:6, pages 519-531.
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Hélène Desqueyroux, Jean-Claude Pujet, Michel Prosper, Yvon Le Moullec & Isabelle Momas. (2002) Effects of Air Pollution on Adults with Chronic Obstructive Pulmonary Disease. Archives of Environmental Health: An International Journal 57:6, pages 554-560.
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Michael P. DeLorme, Hui Yang, Constance Elbon-Copp, Xiufeng Gao, Holly Barraclough-Mitchell & David J. P. Bassett. (2002) Hyperresponsive Airways Correlate with Lung Tissue Inflammatory Cell Changes in Ozone-Exposed Rats. Journal of Toxicology and Environmental Health, Part A 65:19, pages 1453-1470.
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Kaoru Hamada, Carroll-Ann Goldsmith, Yasue Suzaki, Alejandra Goldman & Lester Kobzik. (2002) AIRWAY HYPERRESPONSIVENESS CAUSED BY AEROSOL EXPOSURE TO RESIDUAL OIL FLY ASH LEACHATE IN MICE. Journal of Toxicology and Environmental Health, Part A 65:18, pages 1351-1365.
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David Bassett, Constance Elbon-Copp, Sherrie Otterbein, Holly Barraclough-Mitchell, Michael Delorme & Hui Yang. (2001) INFLAMMATORY CELL AVAILABILITY AFFECTS OZONE-INDUCED LUNG DAMAGE. Journal of Toxicology and Environmental Health, Part A 64:7, pages 547-565.
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E. Van Miert, X. Dumont & A. Bernard. (2005) CC16 as a marker of lung epithelial hyperpermeability in an acute model of rats exposed to mainstream cigarette smoke. Toxicology Letters 159:2, pages 115-123.
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Christophe Soulage, David Perrin, Jean-Marie Cottet-Emard, Jacqueline Pequignot, Yvette Dalmaz & Jean-Marc Pequignot. (2004) Central and peripheral changes in catecholamine biosynthesis and turnover in rats after a short period of ozone exposure. Neurochemistry International 45:7, pages 979-986.
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Jürgen Pauluhn. (2004) Pulmonary irritant potency of polyisocyanate aerosols in rats: comparative assessment of irritant threshold concentrations by bronchoalveolar lavage. Journal of Applied Toxicology 24:3, pages 247-17.
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William J. Mautz. (2003) Exercising animal models in inhalation toxicology: interactions with ozone and formaldehyde. Environmental Research 92:1, pages 14-26.
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