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Review Article

Impact of Antimicrobial Agents on Human Intestinal Microflora

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Pages 218-237 | Published online: 14 Jul 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Marianne Lindgren, Sonja Löfmark, Charlotta Edlund, Pentti Huovinen & Jari Jalava. (2009) Prolonged impact of a one-week course of clindamycin on Enterococcus spp. in human normal microbiota. Scandinavian Journal of Infectious Diseases 41:3, pages 215-219.
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Fatemeh Rafii, John B Sutherland & Carl E Cerniglia. (2008) Effects of treatment with antimicrobial agents on the human colonic microflora. Therapeutics and Clinical Risk Management 4:6, pages 1343-1358.
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Diamantis P. Kofteridis, Elpis Mantadakis, Alexander D. Karatzanis, Constantinos A. Bourolias, Georgios Papazoglou, George A. Velegrakis & George Samonis. (2008) Non-Candida albicans Candida mediastinitis of odontogenic origin in a diabetic patient. Medical Mycology 46:4, pages 345-348.
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Sandrine Bourgeois, Antoun Laham, Madeleine Besnard, Antoine Andremont & Elias Fattal. (2005) In vitro and in vivo evaluation of pectin beads for the colon delivery of β-lactamases. Journal of Drug Targeting 13:5, pages 277-284.
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S. Maraki, A.N. Margioris, E. Orfanoudaki, Y. Tselentis, E. Koumantakis, D.P. Kontoyiannis, M. Rovithi & G. Samonis. (2003) Effects of Doxycycline, Metronidazole and their Combination on Candida species Colonization of the Human Oropharynx, Intestinal Lumen and Vagina. Journal of Chemotherapy 15:4, pages 369-373.
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G. Samonis, S. Maraki, N. Anatoliotakis, M. Anatoliotaki, H. Apostolakou, A. N. Margioris, Y. Tselentis & D. P. Kontoyiannis. (2002) Effects of erythromycin, clarithromycin, roxithromycin and azithromycin on murine gut colonization by Candida albicans. Medical Mycology 40:2, pages 139-142.
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P. Mangiarotti, C. Pizzini & V. Fanos. (2000) Antibiotic Prophylaxis in Children with Relapsing Urinary Tract Infections: Review. Journal of Chemotherapy 12:2, pages 115-123.
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Brigitta Kleessen, Eugenia Bezirtzoglou, Jaana Mättö. (2000) Culture-Based Knowledge on Biodiversity, Development and Stability of Human Gastrointestinal Microflora. Microbial Ecology in Health and Disease 12:2, pages 53-63.
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E. Bertazzoni Minelli & A. Benini. (1993) Effects of Six Antimicrobial Drugs on Rat Intestinal Flora: Is the Rat Model of Predictive Value in Clinical Practice?. Microbial Ecology in Health and Disease 6:2, pages 53-66.
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C. Edlund, B. Brismar, H. Sakamoto & C. E. Nord. (1993) Impact of Cefuroxime-axetil on the Normal Intestinal Microflora. Microbial Ecology in Health and Disease 6:4, pages 185-189.
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Bo Brismar, Charlotta Edlund & Carl ERIK Nord. (1991) Comparative effects of clarithromycin and erythromycin on the normal intestinal microflora. Scandinavian Journal of Infectious Diseases 23:5, pages 635-642.
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Carl Erik Nord, Anders Grahnen & Sven-Åke Eckernäs. (1991) Effect of loracarbef on the normal oropharyngeal and intestinal microflora. Scandinavian Journal of Infectious Diseases 23:2, pages 255-260.
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Articles from other publishers (44)

Abayeneh Girma. (2023) The effect of novel antimicrobial agents on the normal functioning of human intestinal microbiota: a systematic review. Frontiers in Gastroenterology 2.
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Monique R. Bidell, Manjunath (Amit) P. Pai & Thomas P. Lodise. (2020) Use of Oral Tetracyclines in the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia: A Literature Review on the Often-Overlooked Antibiotic Class. Antibiotics 9:12, pages 905.
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Theocharis Konstantinidis, Christina Tsigalou, Alexandros Karvelas, Elisavet Stavropoulou, Chrissoula Voidarou & Eugenia Bezirtzoglou. (2020) Effects of Antibiotics upon the Gut Microbiome: A Review of the Literature. Biomedicines 8:11, pages 502.
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R.K. Menon, D. Gopinath, K.Y. Li, Y.Y. Leung & M.G. Botelho. (2019) Does the use of amoxicillin/amoxicillin–clavulanic acid in third molar surgery reduce the risk of postoperative infection? A systematic review with meta-analysis. International Journal of Oral and Maxillofacial Surgery 48:2, pages 263-273.
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Peng Guo, Shun‑Wen Zhang, Jie Zhang, Jiang‑Tao Dong, Jiang‑Dong Wu, Su‑Tu Tang, Jun‑Ting Yang, Wan‑Jiang Zhang & Fang Wu. (2018) Effects of imipenem combined with low‑dose cyclophosphamide on the intestinal barrier in septic rats. Experimental and Therapeutic Medicine.
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Bryan Tungland. 2018. Human Microbiota in Health and Disease. Human Microbiota in Health and Disease 1 35 .
Joren De Smet, Siska Croubels, Patrick De Backer & Mathias Devreese. (2017) Effect of administration route and dose alteration on sulfadiazine-trimethoprim plasma and intestinal concentrations in pigs. International Journal of Antimicrobial Agents 50:6, pages 707-714.
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Femke de Velde, Brenda C. M. de Winter, Birgit C. P. Koch, Teun van Gelder & Johan W. Mouton. (2016) Non-linear absorption pharmacokinetics of amoxicillin: consequences for dosing regimens and clinical breakpoints. Journal of Antimicrobial Chemotherapy 71:10, pages 2909-2917.
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Pierre-Louis Toutain, Aude A. Ferran, Alain Bousquet-Melou, Ludovic Pelligand & Peter Lees. (2016) Veterinary Medicine Needs New Green Antimicrobial Drugs. Frontiers in Microbiology 7.
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Haley SandersonColin FrickerR. Stephen BrownAnna MajurySteven N. Liss. (2016) Antibiotic resistance genes as an emerging environmental contaminant. Environmental Reviews 24:2, pages 205-218.
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Mamun-Ur Rashid, Staffan Rosenborg, Georgios Panagiotidis, Karin Söderberg Löfdal, Andrej Weintraub & Carl Erik Nord. (2015) Ecological effect of ceftazidime/avibactam on the normal human intestinal microbiota. International Journal of Antimicrobial Agents 46:1, pages 60-65.
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Per Brandström & Sverker Hansson. (2014) Long-term, low-dose prophylaxis against urinary tract infections in young children. Pediatric Nephrology 30:3, pages 425-432.
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B. S. BARR, B. M. WALDRIDGE, P. R. MORRESEY, S. M. REED, C. CLARK, R. BELGRAVE, J. M. DONECKER & D. J. WEIGEL. (2012) Antimicrobial‐associated diarrhoea in three equine referral practices. Equine Veterinary Journal 45:2, pages 154-158.
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Caroline E. C. GoertzSalvatore FrascaJr.Jr., Gregory A. BohachDaniel F. CowanJohn D. BuckRichard A. FrenchSylvain De GuiseJennifer MarateaLynn HinckleyDarla EwaltPatrick M. SchlievertSheila M. KarstClaudia F. DeobaldDavid J. St. AubinJ. Lawrence Dunn. (2011) Brucella sp. vertebral osteomyelitis with intercurrent fatal Staphylococcus aureus toxigenic enteritis in a bottlenose dolphin ( Tursiops truncatus ) . Journal of Veterinary Diagnostic Investigation 23:4, pages 845-851.
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Belagihalli M. Srikanta, Mysore A. Harish Nayaka & Shylaja M. Dharmesh. (2011) Inhibition of Helicobacter pylori growth and its cytotoxicity by 2-hydroxy 4-methoxy benzaldehyde of Decalepis hamiltonii (Wight & Arn); a new functional attribute. Biochimie 93:4, pages 678-688.
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B. C. McGorum & R. S. Pirie. (2010) Antimicrobial associated diarrhoea in the horse. Part 1: Overview, pathogenesis and risk factors. Equine Veterinary Education 21:11, pages 610-616.
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Sandrine Bourgeois, Nicolas Tsapis, Helge Honnas, Antoine Andremont, Monjed Shakweh, Madeleine Besnard & Elias Fattal. (2008) Colonic Delivery of β‐Lactamases Does not Affect Amoxicillin Pharmacokinetics in Rats. Journal of Pharmaceutical Sciences 97:5, pages 1853-1863.
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Amnon Hoffman, Ehud Horwitz, Shmuel Hess, Ronit Cohen-Poradosu, Lilach Kleinberg, Anna Edelberg & Mervyn Shapiro. (2007) Implications on Emergence of Antimicrobial Resistance as a Critical Aspect in the Design of Oral Sustained Release Delivery Systems of Antimicrobials. Pharmaceutical Research 25:3, pages 667-671.
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Geert Huys, Tom Vanhoutte & Peter Vandamme. (2008) Application of Sequence-Dependent Electrophoresis Fingerprinting in Exploring Biodiversity and Population Dynamics of Human Intestinal Microbiota: What Can Be Revealed?. Interdisciplinary Perspectives on Infectious Diseases 2008, pages 1-26.
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Sandrine Bourgeois, Muriel Gernet, Dominique Pradeau, Antoine Andremont & Elias Fattal. (2006) Evaluation of critical formulation parameters influencing the bioactivity of β-lactamases entrapped in pectin beads. International Journal of Pharmaceutics 324:1, pages 2-9.
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Che-Yi Chou, Min-Tsung Kao, Huey-Liang Kuo, Jiung Shiun Liu, Yao-Lung Liu & Chiu-Ching Huang. (2020) Gram-Negative and Polymicrobial Peritonitis Are Associated with Subsequent Fungal Peritonitis in CAPD Patients. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 26:5, pages 607-608.
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T. Pellet, M. Gicquel-Bruneau, P. Sanders & M. Laurentie. (2006) Comparison of faecal and optimal growth conditions on in vitro pharmacodynamic activity of marbofloxacin against Escherichia coli. Research in Veterinary Science 80:3, pages 324-335.
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Richard J. Farrell, Lorraine Kyne & Ciarán P. Kelly. 2005. Inflammatory Bowel Disease: From Bench to Bedside. Inflammatory Bowel Disease: From Bench to Bedside 823 844 .
S.Steve Yan & Jeffrey M Gilbert. (2004) Antimicrobial drug delivery in food animals and microbial food safety concerns: an overview of in vitro and in vivo factors potentially affecting the animal gut microflora. Advanced Drug Delivery Reviews 56:10, pages 1497-1521.
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Dongeun Yong, Jong Hwa Yum, Kyungwon Lee, Yunsop Chong, Sung Hak Choi & Jae Keol Rhee. (2004) In Vitro Activities of DA-7867, a Novel Oxazolidinone, against Recent Clinical Isolates of Aerobic and Anaerobic Bacteria. Antimicrobial Agents and Chemotherapy 48:1, pages 352-357.
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Richard J. Farrell, Lorraine Kyne & Ciarán P. Kelly. 2003. Inflammatory Bowel Disease: From Bench to Bedside. Inflammatory Bowel Disease: From Bench to Bedside 823 844 .
Jonathan E Markowitz & Stig Bengmark. (2002) Probiotics in health and disease in the pediatric patient. Pediatric Clinics of North America 49:1, pages 127-141.
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Lorraine Kyne, Richard J. Farrell & Ciarán P. Kelly. (2001) Clostridium difficile. Gastroenterology Clinics of North America 30:3, pages 753-777.
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F. Vogel, H.R. Ochs, K. Wettich, S. Kaiich, I. Nihson-Ehle, I. Odenholt & C.E. Nord. (2001) Effect of step-down therapy of ceftriaxone plus loracarbef versus parenteral therapy of ceftriaxone on the intestinal microflora in patients with community-acquired pneumonia. Clinical Microbiology and Infection 7:7, pages 376-379.
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P. Richard, M. H. Delangle, F. Raffi, E. Espaze & H. Richet. (2001) Impact of Fluoroquinolone Administration on the Emergence of Fluoroquinolone-Resistant Gram-Negative Bacilli from Gastrointestinal Flora. Clinical Infectious Diseases 32:1, pages 162-166.
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Inger Adamsson, Carl Erik Nord, Per Lundquist, Svante Sjöstedt & Charlotta Edlund. (1999) Comparative effects of omeprazole, amoxycillin plus metronidazole versus omeprazole, clarithromycin plus metronidazole on the oral, gastric and intestinal microflora in Helicobacter pylori-infected patients. Journal of Antimicrobial Chemotherapy 44:5, pages 629-640.
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