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Cytisine—from Ethomedical use to the Development as a Natural Alternative for Smoking Cessation

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Pages 151-160 | Published online: 15 Apr 2014

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Alena V. Koval’skaya, Polina R. Petrova, Dmitry O. Tsypyshev, Alexander N. Lobov & Inna P. Tsypysheva. (2022) Thionation of quinolizidine alkaloids and their derivatives via Lawesson’s reagent. Natural Product Research 36:14, pages 3538-3543.
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Inna Tsypysheva, Polina Petrova, Alena Koval’skaya, Alexander Lobov, Tatyana Sapozhnikova, Nina Makara, Svetlana Gabdrakhmanova & Felix Zarudii. (2021) Variation of spacer type and topology of phenyl moiety in 2-pyridone core of 4-oxo-3-N-methylcytisine; effect of synthesized compounds on rat’s behavior in conditioned passive avoidance reflex (CPAR) test. Natural Product Research 35:2, pages 207-215.
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Cecilia Gotti & Francesco Clementi. (2021) Cytisine and cytisine derivatives. More than smoking cessation aids. Pharmacological Research 170, pages 105700.
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Francisco Sánchez-Viesca & Reina Gómez. (2021) The Chemistry of van de Moer Test for Cytisine. Earthline Journal of Chemical Sciences, pages 15-22.
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Alessandro Sacchetti & Arianna Rossetti. (2021) Synthesis of Natural Compounds Based on the [3,7]‐Diazabicyclo[3.3.1]nonane (Bispidine) Core. European Journal of Organic Chemistry 2021:10, pages 1491-1507.
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Simon X. Lin, Maurice A. Curtis & Jonathan Sperry. (2020) Pyridine alkaloids with activity in the central nervous system. Bioorganic & Medicinal Chemistry 28:24, pages 115820.
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Gautam Nandita, KK Shivalingesh, Sharma Swati, Irshad Resham & Verma Satyaki. (2020) Evaluation of pharmacological and non–pharmacological methods of smoking cessation; A Review. Journal of Addiction Medicine and Therapeutic Science 6:1, pages 045-051.
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Piotr Tutka, Denis Vinnikov, Ryan J. Courtney & Neal L. Benowitz. (2019) Cytisine for nicotine addiction treatment: a review of pharmacology, therapeutics and an update of clinical trial evidence for smoking cessation. Addiction 114:11, pages 1951-1969.
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Nicola Bates. (2018) Poisonous plants part 2. Companion Animal 23:10, pages 558-568.
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Eric J. BuenzRob VerpoorteBrent A. Bauer. (2018) The Ethnopharmacologic Contribution to Bioprospecting Natural Products. Annual Review of Pharmacology and Toxicology 58:1, pages 509-530.
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Razika Touati, Sónia A.O. Santos, Sílvia M. Rocha, Kamel Belhamel & Armando J.D. Silvestre. (2015) Retama sphaerocarpa: An unexploited and rich source of alkaloids, unsaturated fatty acids and other valuable phytochemicals. Industrial Crops and Products 69, pages 238-243.
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Yu. V. Vakhitova, E. I. Farafontova, L. F. Zainullina, V. A. Vakhitov, I. P. Tsypysheva & M. S. Yunusov. (2015) Search for (-)-cytisine derivatives as potential inhibitors of NF-κB and STAT1. Russian Journal of Bioorganic Chemistry 41:3, pages 297-304.
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Irena Philipova, Georgi Stavrakov, Nikolay Vassilev, Rositsa Nikolova, Boris Shivachev & Vladimir Dimitrov. (2015) Cytisine as a scaffold for ortho-diphenylphosphinobenzenecarboxamide ligands for Pd-catalyzed asymmetric allylic alkylation. Journal of Organometallic Chemistry 778, pages 10-20.
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Alexander N. Shikov, Olga N. Pozharitskaya, Valery G. Makarov, Hildebert Wagner, Rob Verpoorte & Michael Heinrich. (2014) Medicinal Plants of the Russian Pharmacopoeia; their history and applications. Journal of Ethnopharmacology 154:3, pages 481-536.
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Jacques Rouden, Marie-Claire Lasne, Jérôme Blanchet & Jérôme Baudoux. (2013) (−)-Cytisine and Derivatives: Synthesis, Reactivity, and Applications. Chemical Reviews 114:1, pages 712-778.
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Patricia E. Grebenstein, Joseph L. Harp & Neil E. Rowland. (2013) The effects of noncontingent and self-administered cytisine on body weight and meal patterns in male Sprague–Dawley rats. Pharmacology Biochemistry and Behavior 110, pages 192-200.
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Edwin G. Pérez, Carolina Méndez-Gálvez & Bruce K. Cassels. (2012) Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors. Natural Product Reports 29:5, pages 555.
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Rumyana Simeonova, Vessela Vitcheva & Mitka Mitcheva. (2010) Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats. Interdisciplinary Toxicology 3:1, pages 21-25.
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Richard L. Bell, Bill J.A. EilerIIII, Jason B. Cook & Shafiqur Rahman. (2009) Nicotinic receptor ligands reduce ethanol intake by high alcohol–drinking HAD-2 rats. Alcohol 43:8, pages 581-592.
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