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Redox Report
Communications in Free Radical Research
Volume 1, 1995 - Issue 4
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Original Articles

Lethal hydrogen peroxide toxicity involves lysosomal iron-catalyzed reactions with membrane damage

, , &
Pages 267-277 | Accepted 09 Feb 1995, Published online: 13 Jul 2016

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Read on this site (16)

Enayatollah Seydi, Mohsen Fatahi, Parvaneh Naserzadeh & Jalal Pourahmad. (2019) The effects of para-phenylenediamine (PPD) on the skin fibroblast cells. Xenobiotica 49:10, pages 1143-1148.
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Apostolos Sioutas, Linda K Vainikka, Magnus Kentson, Sören Dam-Larsen, Urban Wennerström, Petra Jacobson & Hans Lennart Persson. (2017) Oxidant-induced autophagy and ferritin degradation contribute to epithelial–mesenchymal transition through lysosomal iron. Journal of Inflammation Research 10, pages 29-39.
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Jianqing Li, Guang Yang, Shaopeng Wang, Liping Jiang, Xiaofang Liu, Chengyan Geng, Laifu Zhong & Min Chen. (2012) The protective effects of hydroxytyrosol against ortho-phenylphenol-induced DNA damage in HepG2 cells. Toxicology Mechanisms and Methods 22:6, pages 432-437.
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H Lennart Persson & Des R Richardson. (2005) Iron-binding drugs targeted to lysosomes: a potential strategy to treat inflammatory lung disorders. Expert Opinion on Investigational Drugs 14:8, pages 997-1008.
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H.L. Persson, A.I. Svensson & U.T. Brunk. (2001) -Lipoic acid and -lipoamide prevent oxidant-induced lysosomal rupture and apoptosis. Redox Report 6:5, pages 327-334.
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U.T. Brunk, J. Neuzil & J.W. Eaton. (2001) Lysosomal involvement in apoptosis. Redox Report 6:2, pages 91-97.
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Wei Li, Xi Ming Yuan & Ulf T. Brunk. (1998) OxLDL-induced macrophage cytotoxicity is mediated by lysosomal rupture and modified by intralysosomal redox-active iron. Free Radical Research 29:5, pages 389-398.
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Brett Garner, Karin Roberg & Ulf T. Brunk. (1998) Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress. Free Radical Research 29:2, pages 103-114.
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H. B. Hellquist, I. Svensson & U. T. Brunk. (1997) Oxidant-induced apoptosis: a consequence of lethal lysosomal leak?. Redox Report 3:1, pages 65-70.
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Brett Garner, Wei Li, Karin Roberg & Ulf T. Brunk. (1997) On the Cytoprotective Role of Ferritin in Macrophages and its Ability to Enhance Lysosomal Stability. Free Radical Research 27:5, pages 487-500.
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H. Zhang, B. Olejnicka, K. Öllinger & U. T. Brunk. (1996) Starvation-induced autophagocytosis enhances the susceptibility of insulinoma cells to oxidative stress. Redox Report 2:4, pages 235-247.
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X. M. Yuan, A. G. Olsson & U. T. Brunk. (1996) Macrophage erythrophagocytosis and iron exocytosis. Redox Report 2:1, pages 9-17.
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Articles from other publishers (49)

Chunjun Zhan, Xiaowei Li, Yankun Yang, Jens Nielsen, Zhonghu Bai & Yun Chen. (2021) Strategies and challenges with the microbial conversion of methanol to high‐value chemicals. Biotechnology and Bioengineering 118:10, pages 3655-3668.
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Jie Liu, Zhen-Ni Guo, Xiu-Li Yan, Shuo Huang, Jia-Xin Ren, Yun Luo & Yi Yang. (2020) Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke. Frontiers in Cellular Neuroscience 14.
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Rashid Jahangirnejad, Mehdi Goudarzi, Heibatullah Kalantari, Hossein Najafzadeh & Mohsen Rezaei. (2020) Subcellular Organelle Toxicity Caused by Arsenic Nanoparticles in Isolated Rat Hepatocytes. The International Journal of Occupational and Environmental Medicine 11:1, pages 41-52.
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Kamyar Zahedi, Sharon Barone & Manoocher Soleimani. (2019) Polyamine Catabolism in Acute Kidney Injury. International Journal of Molecular Sciences 20:19, pages 4790.
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Shabnam Rahimi, Parvaneh Naserzadeh, Zahra Mousavi, Khadijeh Ashtari, Enayatollah Seydi & Jalal Pourahmad. (2019) Nickel oxide nanoparticles exert selective toxicity on skin mitochondria and lysosomes isolated from the mouse model of melanoma. Journal of Biochemical and Molecular Toxicology 33:9.
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Kamyar Zahedi, Sharon Barone, Christina Destefano-Shields, Marybeth Brooks, Tracy Murray-Stewart, Matthew Dunworth, Weimin Li, Joanne R. Doherty, Mark A. Hall, Roger D. Smith, John L. Cleveland, Robert A. Casero & Manoocher Soleimani. (2017) Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury. PLOS ONE 12:9, pages e0184570.
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Carsten Berndt, Tino Kurz, Markus Selenius, Aristi P. Fernandes, Margareta R. Edgren & Ulf T. Brunk. (2010) Chelation of lysosomal iron protects against ionizing radiation. Biochemical Journal 432:2, pages 295-301.
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Jalal Pourahmad, Peter J. O?Brien, Katie Chan & Ataollah Shakouri. (2008) Tetramethylphenylenediamine-induced hepatocyte cytotoxicity caused by lysosomal labilisation and redox cycling with oxygen activation. Chemico-Biological Interactions 172:1, pages 39-47.
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Jae-Hyuck Choi, Dong-Hoon Kim, In-Jin Yun, Jun-Hee Chang, Boe-Gwun Chun & Sang-Hyun Choi. (2007) Zaprinast inhibits hydrogen peroxide-induced lysosomal destabilization and cell death in astrocytes. European Journal of Pharmacology 571:2-3, pages 106-115.
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Lori Emert-Sedlak, Sanjeev Shangary, Asaf Rabinovitz, Michelle B. Miranda, Scott M. Delach & Daniel E. Johnson. (2005) Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death . Molecular Cancer Therapeutics 4:5, pages 733-742.
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W. Ibrahim, U.‐S. Lee & C. K. Chow. (2004) Endotoxin increases hepatic susceptibility to lipid peroxidation: A possible role of iron. Journal of Biochemical and Molecular Toxicology 18:1, pages 23-29.
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A-C Johansson, H Steen, K Öllinger & K Roberg. (2003) Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine. Cell Death & Differentiation 10:11, pages 1253-1259.
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Jalal Pourahmad, Peter J O?Brien, Farzaneh Jokar & Bahram Daraei. (2003) Carcinogenic metal induced sites of reactive oxygen species formation in hepatocytes. Toxicology in Vitro 17:5-6, pages 803-810.
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Israel Alonso-Pozos, Ana Maria Rosales-Torres, Alejandro ?valos-Rodr??guez, Marcela Vergara-Onofre & Adolfo Rosado-Garc??a. (2003) Mechanism of granulosa cell death during follicular atresia depends on follicular size. Theriogenology 60:6, pages 1071-1081.
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M. P. Cajaraville, L. Hauser, G. Carvalho, K. Hylland, I. Olabarrieta, A. J. Lawrence, D. Lowe & A. Goksøyr. 2003. Effects of Pollution on Fish. Effects of Pollution on Fish 14 82 .
Anthony K.F Liou, Robert S Clark, David C Henshall, Xiao-Ming Yin & Jun Chen. (2003) To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways. Progress in Neurobiology 69:2, pages 103-142.
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Dong-Hee Choi, Dong-Hoon Kim, Yun-Gyu Park, Boe-Gwun Chun & Sang-Hyun Choi. (2002) Protective effects of rilmenidine and AGN 192403 on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. Free Radical Biology and Medicine 33:10, pages 1321-1333.
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Or Kakhlon & Z.Ioav Cabantchik. (2002) The labile iron pool: characterization, measurement, and participation in cellular processes1 1This article is part of a series of reviews on ?Iron and Cellular Redox Status.? The full list of papers may be found on the homepage of the journal.. Free Radical Biology and Medicine 33:8, pages 1037-1046.
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Maciej A. Pszczolkowski, Luis F. Matos, Ruth Brown & John J. Brown. (2002) Feeding and Development of <I>Cydia pomonella</I> (Lepidoptera: Tortricidae) Larvae on Apple Leaves. Annals of the Entomological Society of America 95:5, pages 603-607.
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John W Eaton & Mingwei Qian. (2002) Molecular bases of cellular iron toxicity12 1Guest Editor: Mario Comporti 2This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal.. Free Radical Biology and Medicine 32:9, pages 833-840.
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Sang-Hyun Choi, Dong-Hee Choi, Jeong-Jin Lee, Moon-Sung Park & Boe-Gwun Chun. (2002) Imidazoline drugs stabilize lysosomes and inhibit oxidative cytotoxicity in astrocytes. Free Radical Biology and Medicine 32:5, pages 394-405.
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Ming Zhao, John W. Eaton & Ulf T. Brunk. (2001) Bcl‐2 phosphorylation is required for inhibition of oxidative stress‐induced lysosomal leak and ensuing apoptosis. FEBS Letters 509:3, pages 405-412.
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Katarı́na Horáková, Andrea Šovčı́ková, Zuzana Seemannová, Dagmar Syrová, Katarı́na Bušányová, Zuzana Drobná & Miroslav Ferenčı́k. (2001) Detection of drug-induced, superoxide-mediated cell damage and its prevention by antioxidants. Free Radical Biology and Medicine 30:6, pages 650-664.
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Karin Roberg. (2001) Relocalization of Cathepsin D and Cytochrome c Early in Apoptosis Revealed by Immunoelectron Microscopy. Laboratory Investigation 81:2, pages 149-158.
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Jalal Pourahmad, Sumsullah Khan & Peter J. O’Brien. 2001. Biological Reactive Intermediates VI. Biological Reactive Intermediates VI 261 265 .
Jalal Pourahmad & Peter J. O’Brien. 2001. Biological Reactive Intermediates VI. Biological Reactive Intermediates VI 203 207 .
Ming Zhao, John W. Eaton & Ulf T. Brunk. (2000) Protection against oxidant‐mediated lysosomal rupture: a new anti‐apoptotic activity of Bcl‐2?. FEBS Letters 485:2-3, pages 104-108.
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DE Johnson. (2000) Noncaspase proteases in apoptosis. Leukemia 14:9, pages 1695-1703.
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Xi Ming Yuan, Wei Li, Ulf T Brunk, Helge Dalen, Yi Hsin Chang & Alex Sevanian. (2000) Lysosomal destabilization during macrophage damage induced by cholesterol oxidation products. Free Radical Biology and Medicine 28:2, pages 208-218.
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Karin Öllinger. (2000) Inhibition of Cathepsin D Prevents Free-Radical-Induced Apoptosis in Rat Cardiomyocytes. Archives of Biochemistry and Biophysics 373:2, pages 346-351.
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Karin Roberg, Uno Johansson & Karin Öllinger. (1999) Lysosomal release of Cathepsin D precedes relocation of Cytochrome C and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress. Free Radical Biology and Medicine 27:11-12, pages 1228-1237.
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Alexei Terman, Helge Dalen & Ulf T Brunk. (1999) Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation?. Experimental Gerontology 34:8, pages 943-957.
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Ho Jung, Eun Young Lee & Sang Ik Lee. (1999) Age-related changes in ultrastructural features of cathepsin B- and D-containing neurons in rat cerebral cortex. Brain Research 844:1-2, pages 43-54.
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Beata T. OlejnickaArne AnderssonBjörn TyrbergHelge DalenUlf T. Brunk. (1999) β -Cells, Oxidative Stress, Lysosomal Stability, and Apoptotic/Necrotic Cell Death . Antioxidants & Redox Signaling 1:3, pages 305-315.
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Alexei Terman, Nicklas Abrahamsson & Ulf T Brunk. (1999) Ceroid/Lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress. Experimental Gerontology 34:6, pages 755-770.
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Beata T. Olejnicka, Helge Dalen & Ulf T. Brunk. (2009) Minute oxidative stress is sufficient to induce apoptotic death of NIT‐1 insulinoma cells. APMIS 107:7-12, pages 747-761.
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Ulf T. Brunk. 1999. Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease. Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease 57 66 .
Rumi Ishisaka, Toshihiko Utsumi, Munehisa Yabuki, Tomoko Kanno, Takashi Furuno, Masayasu Inoue & Kozo Utsumi. (1998) Activation of caspase-3-like protease by digitonin-treated lysosomes. FEBS Letters 435:2-3, pages 233-236.
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G. Pagano, L.G. Korkina, U.T. Brunk, L. Chessa, P. Degan, D. del Principe, F.J. Kelly, W. Malorni, F. Pallardó, C. Pasquier, I. Scovassi, A. Zatterale & C. Franceschi. (1998) Congenital disorders sharing oxidative stress and cancer proneness as phenotypic hallmarks: prospects for joint research in pharmacology. Medical Hypotheses 51:3, pages 253-266.
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Karin Roberg & Karin Öllinger. (2016) A Pre-embedding Technique for Immunocytochemical Visualization of Cathepsin D in Cultured Cells Subjected to Oxidative Stress. Journal of Histochemistry & Cytochemistry 46:3, pages 411-418.
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Wei LiXi Ming YuanAnders G. OlssonUlf T. Brunk. (1998) Uptake of Oxidized LDL by Macrophages Results in Partial Lysosomal Enzyme Inactivation and Relocation. Arteriosclerosis, Thrombosis, and Vascular Biology 18:2, pages 177-184.
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Mosaad A M Abou-Seif. (2016) Vanadium-Mediated Oxidation of NADH is Enhanced by Aluminium and Inhibited by Vitamin E and Some Copper (II) Complexes. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 34:6, pages 645-650.
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Karin Öllinger & Karin Roberg. (1997) Nutrient Deprivation of Cultured Rat Hepatocytes Increases the Desferrioxamine-available Iron Pool and Augments the Sensitivity to Hydrogen Peroxide. Journal of Biological Chemistry 272:38, pages 23707-23711.
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Xi Ming Yuan, Wei Li, Anders G Olsson & Ulf T Brunk. (1997) The toxicity to macrophages of oxidized low-density lipoprotein is mediated through lysosomal damage. Atherosclerosis 133:2, pages 153-161.
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BEATA T. OLEJNICKA, KARIN ÖLLINGER & ULF T. BRUNK. (2009) A short exposure to a high‐glucose milieu stabilizes the acidic vacuolar apparatus of insulinoma cells in culture to ensuing oxidative stress. APMIS 105:7-12, pages 689-698.
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Ulf T Brunk, Helge Dalen, Karin Roberg & Henrik B Hellquist. (1997) Photo-Oxidative Disruption of Lysosomal Membranes Causes Apoptosis of Cultured Human Fibroblasts. Free Radical Biology and Medicine 23:4, pages 616-626.
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Ulf Wihlmark, Anders Wrigstad, Karin Roberg, Sven Erik G Nilsson & Ulf T Brunk. (1997) Lipofuscin Accumulation in Cultured Retinal Pigment Epithelial Cells Causes Enhanced Sensitivity to Blue Light Irradiation. Free Radical Biology and Medicine 22:7, pages 1229-1234.
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Ulf T. Brunk, Hong Zhang, Helge Dalen & Karin Öllinger. (1995) Exposure of cells to nonlethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization. Free Radical Biology and Medicine 19:6, pages 813-822.
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Karin Öllinger & Ulf T. Brunk. (1995) Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Radical Biology and Medicine 19:5, pages 565-574.
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