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Redox Report
Communications in Free Radical Research
Volume 22, 2017 - Issue 2
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Review Articles

The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture

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Seyed Mostafa Nachvak, Maryam Shabanpur, Roghayeh Mostafai, Reza Heidari Moghaddam & Jalal Moludi. (2023) L-Carnitine supplementation reduces biomarkers of inflammatory and oxidative stress in patients with coronary artery disease: a randomised controlled trial. Archives of Physiology and Biochemistry 129:1, pages 61-68.
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Chan Li & Zhaoya Liu. (2021) Bioinformatic Analysis for Potential Biomarkers and Therapeutic Targets of T2DM-related MI. International Journal of General Medicine 14, pages 4337-4347.
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Jalal Soubhye, Pierre Van Antwerpen & François Dufrasne. (2020) A patent review of myeloperoxidase inhibitors for treating chronic inflammatory syndromes (focus on cardiovascular diseases, 2013-2019). Expert Opinion on Therapeutic Patents 30:8, pages 595-608.
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Thanat Chaikijurajai & W. H. Wilson Tang. (2020) Myeloperoxidase: a potential therapeutic target for coronary artery disease. Expert Opinion on Therapeutic Targets 24:7, pages 695-705.
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Abeer M. Rababa’h, Raghad W. Bsoul, Mohammad J. Alkhatatbeh, Karem H. Alzoubi & Omar F. Khabour. (2019) Waterpipe tobacco smoke distresses cardiovascular biomarkers in mice: alterations in protein expression of metalloproteinases, endothelin and myeloperoxidase. Inhalation Toxicology 31:3, pages 99-106.
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Articles from other publishers (113)

Jingjin Liu, Liwei Diao, Weiyi Xia, Xiaoyi Zeng, Wen Li, Jieru Zou, Tiansheng Liu, Xinli Pang & Yongshun Wang. (2023) Meteorin-like protein elevation post-exercise improved vascular inflammation among coronary artery disease patients by downregulating NLRP3 inflammasome activity. Aging.
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Elena O. DEZZANI. (2023) Chronic obstructive pulmonary disease and modern therapies. Gazzetta Medica Italiana Archivio per le Scienze Mediche 182:9.
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Angela Yan & Avrum I. Gotlieb. (2023) The microenvironment of the atheroma expresses phenotypes of plaque instability. Cardiovascular Pathology 67, pages 107572.
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Andrew Harper, Maike Chapel, Grace Hodgson, Krzysztof Malinowski, Imogen Yates, Michael Garle & Vera Ralevic. (2023) GYY4137, a hydrogen sulfide donor, protects against endothelial dysfunction in porcine coronary arteries exposed to myeloperoxidase and hypochlorous acid. Vascular Pharmacology 152, pages 107199.
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Tobias Harm, Dominik Rath, Klaus-Peter Kreisselmeier, Livia Baas, Carolin Prang, Sarah Gekeler, Stephen Schröder, Meinrad Paul Gawaz, Tobias Geisler, Iris Irmgard Müller & Karin Anne Lydia Müller. (2023) Thrombus architecture is influenced by the antiplatelet loading treatment in patients with acute myocardial infarction. Thrombosis Research 230, pages 45-54.
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Xiaofan Yang, Yupeng Ma, Xin Chen, Jingjing Zhu, Wenlong Xue & Ke Ning. (2023) Mechanisms of neutrophil extracellular trap in chronic inflammation of endothelium in atherosclerosis. Life Sciences 328, pages 121867.
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Min Hua, Wen-Ya Chen, Li-Hui Wang, Xiao-Hua Zou & Lun-Lin Mao. (2023) The value of serum Lp-PLA2 combined with MPO in the diagnosis of cerebral infarction caused by large artery atherosclerosis. Clinical Neurology and Neurosurgery 232, pages 107899.
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Yunfeng Yu, Manli Zhou, Xi Long, Shuang Yin, Gang Hu, Xinyu Yang, Weixiong Jian & Rong Yu. (2023) Study on the mechanism of action of colchicine in the treatment of coronary artery disease based on network pharmacology and molecular docking technology. Frontiers in Pharmacology 14.
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Rika Kawakami, Aloke V. Finn & Renu Virmani. (2023) Can Myeloperoxidase Identify High-Risk Plaques and Subjects Harboring Them?. JACC: Advances 2:3, pages 100313.
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James Nadel, Sergey Tumanov, Stephanie M.Y. Kong, Weiyu Chen, Nicola Giannotti, Vanathi Sivasubramaniam, Imran Rashid, Martin Ugander, Andrew Jabbour & Roland Stocker. (2023) Intraplaque Myeloperoxidase Activity as Biomarker of Unstable Atheroma and Adverse Clinical Outcomes in Human Atherosclerosis. JACC: Advances 2:3, pages 100310.
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Minying Wan, Yi Lu, Bin Mao, Shikai Yu, Peinan Ju, Kun Hu, Yawei Xu, Xiankai Li & Jianhui Zhuang. (2023) Immature neutrophil is associated with coronary plaque vulnerability based on optical coherence tomography analysis. International Journal of Cardiology 374, pages 89-93.
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Shigeki Kimura. (2023) Reliability of immature neutrophils in the risk stratification of acute coronary syndrome lesions. International Journal of Cardiology.
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Niv Vigder, Cacang Suarna, Leo Corcilius, James Nadel, Weiyu Chen, Richard Payne, Sergey Tumanov & Roland Stocker. (2023) An improved method for the detection of myeloperoxidase chlorinating activity in biological systems using the redox probe hydroethidine. Free Radical Biology and Medicine 195, pages 23-35.
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G. F. Bunenkova, S. P. Salikova, V. B. Grinevich & E. S. Ivanyuk. (2023) Role of myeloperoxidase in atrial fibrillation and ischemic heart disease. The Clinician 16:3, pages 18-24.
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Kozo TakeuchiKimiko KazumuraKaori Kuzawa, Yukiko HatanoMasashi NagaiMichitaka Naito. (2023) Effect of fat ingestion on postprandial oxidative status in healthy young women: a pilot study. Journal of Clinical Biochemistry and Nutrition.
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Kozo TakeuchiKimiko KazumuraAkihiro Yoshida, Tappei Furuta, Kazunori Hayashi, Masashi NagaiYukiko HatanoMichitaka Naito & Etsushi Matsushita. (2023) Comparison of the oxidative profiles before and after revascularization in peripheral arterial disease: a pilot study. Journal of Clinical Biochemistry and Nutrition 72:3, pages 278-288.
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Bjørn Edvard Seim, Margrethe Flesvig Holt, Aleksandra Ratajska, Annika Michelsen, Monica Myklebust Ringseth, Bente Evy Halvorsen, Mona Skjelland, John-Peder Escobar Kvitting, Runar Lundblad, Kirsten Krohg-Sørensen, Liv T. N. Osnes, Pål Aukrust, Benedicte Paus & Thor Ueland. (2022) Markers of extracellular matrix remodeling and systemic inflammation in patients with heritable thoracic aortic diseases. Frontiers in Cardiovascular Medicine 9.
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Nan Zhang, Xiahenazi Aiyasiding, Wen-jing Li, Hai-han Liao & Qi-zhu Tang. (2022) Neutrophil degranulation and myocardial infarction. Cell Communication and Signaling 20:1.
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Olusegun G. Adebayo, Wadioni Aduema, Adaku V. Iwueke, Jerome N. Asiwe, Ijeoma Onyeleonu, Ajirioghene E. Akpotu, Iheanyichukwu Wopara, Oluwakemi Rachael Adebayo, Ogechukwu G. Onuoha, Emeka Spiff Eleazar & Favour C. Onwuka. (2022) Treatment with Ginkgo biloba supplement modulates oxidative disturbances, inflammation and vascular functions in oxygen deprived hypothyroid mice: Involvement of endothelin‐1/NO signaling pathways . Journal of Food Biochemistry 46:12.
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Weiyu Chen, Sergey Tumanov, Stephanie M.Y. Kong, David Cheng, Erik Michaëlsson, André Bongers, Carl Power, Anita Ayer & Roland Stocker. (2022) Therapeutic inhibition of MPO stabilizes pre-existing high risk atherosclerotic plaque. Redox Biology 58, pages 102532.
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Qiujing Chen, Shuai Chen, Yang Dai, Xiaoqun Wang, Fenghua Ding, Ruiyan Zhang, Weifeng Shen, Wenbo Hu, Lin Lu & Wenqi Pan. (2022) Serum MPO levels and activities are associated with angiographic coronary atherosclerotic plaque progression in type 2 diabetic patients. BMC Cardiovascular Disorders 22:1.
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Alexander DupuyLining Arnold JuJoyce ChiuFreda H. Passam. (2022) Mechano-Redox Control of Integrins in Thromboinflammation. Antioxidants & Redox Signaling 37:13-15, pages 1072-1093.
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Scott E. Janus, Jamal Hajjari, Tarek Chami, Mohamad Karnib, Sadeer G Al-Kindi & Imran Rashid. (2022) Myeloperoxidase is Independently Associated with Incident Heart Failure in Patients with Coronary Artery Disease and Kidney Disease. Current Problems in Cardiology 47:11, pages 101080.
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Joey S. Lockhart & Ronen Sumagin. (2022) Non-Canonical Functions of Myeloperoxidase in Immune Regulation, Tissue Inflammation and Cancer. International Journal of Molecular Sciences 23:20, pages 12250.
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T. A. Sheshurina. (2022) Myeloperoxidase, troponin I and C-reactive protein in blood of patients before and after coronary artery bypass grafting. Medical alphabet:19, pages 18-21.
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Paulina Valadez-Cosmes, Sofia Raftopoulou, Zala Nikita Mihalic, Gunther Marsche & Julia Kargl. (2022) Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target. Pharmacology & Therapeutics 236, pages 108052.
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Sabina Andreea Leancă, Daniela Crișu, Antoniu Octavian Petriș, Irina Afrăsânie, Antonia Genes, Alexandru Dan Costache, Dan Nicolae Tesloianu & Irina Iuliana Costache. (2022) Left Ventricular Remodeling after Myocardial Infarction: From Physiopathology to Treatment. Life 12:8, pages 1111.
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Yuncong Shi, Huanji Zhang, Suli Huang, Li Yin, Feng Wang, Pei Luo & Hui Huang. (2022) Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials. Signal Transduction and Targeted Therapy 7:1.
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Juan A. Azcona, Samantha Tang, Elizabeth Berry, Frank F. Zhang, Radha Garvey, John R. Falck, Michal Laniado Schwartzman, Tao Yi, Thomas M. Jeitner & Austin M. Guo. (2022) Neutrophil-Derived Myeloperoxidase and Hypochlorous Acid Critically Contribute to 20-Hydroxyeicosatetraenoic Acid Increases that Drive Postischemic Angiogenesis. Journal of Pharmacology and Experimental Therapeutics 381:3, pages 204-216.
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Christian Frangie & Jalil Daher. (2022) Role of myeloperoxidase in inflammation and atherosclerosis (Review). Biomedical Reports 16:6.
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Muhammad Zeeshan, Sara Yousaf, Adeel Ahmed, Hina Bahadar, Usman Ali, Sidra Jabeen, Hassan ul Hussain, Hassan Mumtaz & Mohammad Hasan. (2022) Co-relation of Monocyte Count in High vs. Low Thrombus Burden ST-Segment Elevated Myocardial Infarction (STEMI) Patients Undergoing Primary Percutaneous Coronary Intervention. Cureus.
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Laura ACEVEDO-AGUILAR, Ivan LOZADA-MARTÍNEZ, Daniela TORRES-LLINÁS, Gustavo GAITAN-HERRERA & Luis MOSCOTE-SALAZAR. (2022) Myeloperoxidase: another predictor of cerebrovascular disease to consider. Journal of Neurosurgical Sciences 66:2.
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Nan Zhang, Jing-Xian Wang, Xiao-Yuan Wu, Yan Cui, Zhong-He Zou, Yin Liu & Jing Gao. (2022) Correlation Analysis of Plasma Myeloperoxidase Level With Global Registry of Acute Coronary Events Score and Prognosis in Patients With Acute Non-ST-Segment Elevation Myocardial Infarction. Frontiers in Medicine 9.
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Solaiman M. Al-hadlaq, Hanan A. Balto, Wail M. Hassan, Najat A. Marraiki & Afaf K. El-Ansary. (2022) Biomarkers of non-communicable chronic disease: an update on contemporary methods. PeerJ 10, pages e12977.
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Sheeba Varghese & Binitha Ponnamparambil Purushothaman. (2022) THE IMPACT OF BIOMARKERS FOR THE DIAGNOSIS AND PROGNOSIS OF MYOCARDIAL INFARCTION. INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, pages 45-47.
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Danielle Cristyane Kalva Borato, Carlos Augusto Kalva-Filho, Edneia Peres Machado, Cristiane Rickli Barbosa & José Carlos Rebuglio Vellosa. (2022) Effect of non-nucleoside reverse transcriptase inhibitors and protease inhibitors on serum levels of myeloperoxidase and C-reactive protein in HIV-infected individuals. Brazilian Journal of Pharmaceutical Sciences 58.
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Pooja Yadav, Nabendu Debnath, Ashish Tyagi & Ashok Kumar Yadav. 2022. Biosafety Assessment of Probiotic Potential. Biosafety Assessment of Probiotic Potential 379 387 .
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Clare L. Hawkins & Michael J. Davies. (2021) Role of myeloperoxidase and oxidant formation in the extracellular environment in inflammation-induced tissue damage. Free Radical Biology and Medicine 172, pages 633-651.
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Yulia Kargapolova, Simon Geißen, Ruiyuan Zheng, Stephan Baldus, Holger Winkels & Matti Adam. (2021) The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication. Antioxidants 10:4, pages 562.
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Johanne Poisson, Marion Tanguy & Pierre-Emmanuel Rautou. (2021) Microvésicules de globules rouges et vasospasmes artériels dans les syndromes myéloprolifératifs avec mutation JAK2 V617F . médecine/sciences 37:4, pages 329-331.
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Konstantina Flouda, John Mercer, Michael J. Davies & Clare L. Hawkins. (2021) Role of myeloperoxidase-derived oxidants in the induction of vascular smooth muscle cell damage. Free Radical Biology and Medicine 166, pages 165-177.
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Xibao Shi, Tianqi Zhu, Jun Ni & Ruiyan Zhang. (2021) The expression of myeloperoxidase in thrombi is associated with reduced heme oxygenase‐1 induction and worse left ventricular remodeling in patients with acute ST ‐elevation myocardial infarction . Clinical Cardiology 44:3, pages 357-363.
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Michael J. Davies. (2021) Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases. Pharmacology & Therapeutics 218, pages 107685.
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Michele Mariotti, Adelina Rogowska-Wrzesinska, Per Hägglund & Michael J. Davies. (2021) Cross-linking and modification of fibronectin by peroxynitrous acid: Mapping and quantification of damage provides a new model for domain interactions. Journal of Biological Chemistry 296, pages 100360.
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Jürgen Prasch, Eva Bernhart, Helga Reicher, Manfred Kollroser, Gerald N. Rechberger, Chintan N. Koyani, Christopher Trummer, Lavinia Rech, Peter P. Rainer, Astrid Hammer, Ernst Malle & Wolfgang Sattler. (2020) Myeloperoxidase-Derived 2-Chlorohexadecanal Is Generated in Mouse Heart during Endotoxemia and Induces Modification of Distinct Cardiomyocyte Protein Subsets In Vitro. International Journal of Molecular Sciences 21:23, pages 9235.
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Yu Tan, Shujun Yang, Runzhen Chen, Zhaoxue Sheng, Peng Zhou, Chen Liu, Hanjun Zhao, Li Song, Jiannan Li, Jinying Zhou, Yi Chen & Hongbing Yan. (2020) High Plasma Myeloperoxidase Is Associated with Plaque Erosion in Patients with ST-Segment Elevation Myocardial Infarction. Journal of Cardiovascular Translational Research 13:6, pages 908-915.
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V. S. Vasylchenko, L. V. Korol, O. B. Kuchmenko & N. M. Stepanova. (2020) The oxidative status in patients with chronic kidney disease. The Ukrainian Biochemical Journal 92:5, pages 70-77.
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Jürgen Arnhold. (2020) The Dual Role of Myeloperoxidase in Immune Response. International Journal of Molecular Sciences 21:21, pages 8057.
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Chaorui Guo, Michael J. Davies & Clare L. Hawkins. (2020) Role of thiocyanate in the modulation of myeloperoxidase-derived oxidant induced damage to macrophages. Redox Biology 36, pages 101666.
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Siriluck Vanichkitrungruang, Christine Y. Chuang, Clare L. Hawkins & Michael J. Davies. (2020) Myeloperoxidase-derived damage to human plasma fibronectin: Modulation by protein binding and thiocyanate ions (SCN−). Redox Biology 36, pages 101641.
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Michael J. DaviesClare L. Hawkins. (2020) The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease. Antioxidants & Redox Signaling 32:13, pages 957-981.
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Johanne Poisson, Marion Tanguy, Hortense Davy, Fatoumata Camara, Marie-Belle El Mdawar, Marouane Kheloufi, Tracy Dagher, Cécile Devue, Juliette Lasselin, Aurélie Plessier, Salma Merchant, Olivier Blanc-Brude, Michèle Souyri, Nathalie Mougenot, Florent Dingli, Damarys Loew, Stephane N. Hatem, Chloé James, Jean-Luc Villeval, Chantal M. Boulanger & Pierre-Emmanuel Rautou. (2020) Erythrocyte-derived microvesicles induce arterial spasms in JAK2V617F myeloproliferative neoplasm. Journal of Clinical Investigation 130:5, pages 2630-2643.
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Huan Cai, Christine Y. Chuang, Clare L. Hawkins & Michael J. Davies. (2020) Binding of myeloperoxidase to the extracellular matrix of smooth muscle cells and subsequent matrix modification. Scientific Reports 10:1.
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Junaida Osman, Shing Cheng Tan, Pey Yee Lee, Teck Yew Low & Rahman Jamal. (2019) Sudden Cardiac Death (SCD) – risk stratification and prediction with molecular biomarkers. Journal of Biomedical Science 26:1.
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Karli R. Reiding, Vojtech Franc, Minke G. Huitema, Elisabeth Brouwer, Peter Heeringa & Albert J.R. Heck. (2019) Neutrophil myeloperoxidase harbors distinct site-specific peculiarities in its glycosylation. Journal of Biological Chemistry 294:52, pages 20233-20245.
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Denise O. Schoeps, Simone Holzer, Fabiola I. Suano-Souza, Sonia Hix, Fernando L.A. Fonseca & Roseli O.S. Sarni. (2019) Myeloperoxidase as cardiovascular risk marker in pre-pubertal preterm children?. Nutrition, Metabolism and Cardiovascular Diseases 29:12, pages 1345-1352.
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V. Vasilchenko, O. Dunaevskaya, L. Korol, O. Kuchmenko & N. Stepanova. (2019) Activity 0f Lipoprotein-Associated Paraoxonase-1 Enzymes and Myeloperoxidase in Patients with Chronic Kidney Disease. Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 4:6, pages 321-328.
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Rotem Volkman, Tali Ben-Zur, Anat Kahana, Ben Zion Garty & Daniel Offen. (2019) Myeloperoxidase Deficiency Inhibits Cognitive Decline in the 5XFAD Mouse Model of Alzheimer’s Disease. Frontiers in Neuroscience 13.
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Robert Antoni Olek, Joanna Jolanta Samulak, Angelika Katarzyna Sawicka, Dace Hartmane, Solveiga Grinberga, Osvalds Pugovics & Wieslawa Lysiak-Szydlowska. (2019) Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women. Oxidative Medicine and Cellular Longevity 2019, pages 1-6.
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