Citations (24)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (1)
William T. McElroy. (2019) Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors: an updated patent review (2016-2018). Expert Opinion on Therapeutic Patents 29:4, pages 243-259.
Read now
Read now
Articles from other publishers (23)
Himanshu Yadav & Raj Kumar Shirumalla. (2023) Emerging trends in IRAK-4 kinase research. Molecular Biology Reports.
Crossref
Crossref
Yongjin Hao, Jin Wang, Jiawan Ma, Xiaoliang Yu, Zhanhui Li, Shuwei Wu, Sheng Tian, Haikuo Ma, Sudan He & Xiaohu Zhang. (2023) Design, synthesis, evaluation and optimization of potent IRAK4 inhibitors alleviating production of inflammatory cytokines in LPS-induced SIRS model. Bioorganic Chemistry, pages 106584.
Crossref
Crossref
Swapnil P. Bhujbal, Weijie He & Jung-Mi Hah. (2022) Design of Novel IRAK4 Inhibitors Using Molecular Docking, Dynamics Simulation and 3D-QSAR Studies. Molecules 27:19, pages 6307.
Crossref
Crossref
Linan Zhao, Le Fu, Guangping Li, Yan Shen, Yong Hu, Yan Chen & Yuanqiang Wang. (2022) Target based structural optimization of substituted pyrazolopyrimidine analogues as inhibitor for IRAK4 by 3D-QSAR and molecular simulation. Structural Chemistry 33:3, pages 921-934.
Crossref
Crossref
Ruyan Wu, Jianfeng Liu, Jimmy Vu, Yufei Huang, David M. Dietz & Jun-Xu Li. (2022) Interleukin-1 receptor-associated kinase 4 (IRAK4) in the nucleus accumbens regulates opioid-seeking behavior in male rats. Brain, Behavior, and Immunity 101, pages 37-48.
Crossref
Crossref
Philip Cohen, Darren Cross & Pasi A. Jänne. (2021) Kinase drug discovery 20 years after imatinib: progress and future directions. Nature Reviews Drug Discovery 20:7, pages 551-569.
Crossref
Crossref
Natalia Garcia-Gonzalez, María A. Nuñez-Sanchez, Miguel Villoria Recio, Natalia Battista, Cormac G. M. Gahan & Aldo Corsetti. (2021) Immunomodulation of J774A.1 Murine Macrophages by Lactiplantibacillus plantarum Strains Isolated From the Human Gastrointestinal Tract and Fermented Foods. Frontiers in Microbiology 11.
Crossref
Crossref
Jing Zhang, Liqiang Fu, Bin Shen, Yingtao Liu, Wenqian Wang, Xin Cai, Linglong Kong, Yilin Yan, Ryan Meng, Zhuming Zhang, Ying-Nan P. Chen, Qian Liu, Zhao-Kui Wan, Tianyuan Zhou, Xiaotao Wang, Paul Gavine, Amanda Del Rosario, Kay Ahn, Ulrike Philippar, Ricardo Attar, Jennifer Yang, Yanping Xu, James P. Edwards & Xuedong Dai. (2020) Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation. Cell Chemical Biology 27:12, pages 1500-1509.e13.
Crossref
Crossref
Bin Pan, Jun Gao, Wei Chen, Cong Liu, Longmei Shang, Mengdi Xu, Chunling Fu, Shengyun Zhu, Mingshan Niu & Kailin Xu. (2020) Selective inhibition of interleukin-1 receptor-associated kinase 1 ameliorates lipopolysaccharide-induced sepsis in mice. International Immunopharmacology 85, pages 106597.
Crossref
Crossref
Gabriel Herrero-Beaumont, Sandra Pérez-Baos, Olga Sánchez-Pernaute, Jorge A. Roman-Blas, Ana Lamuedra & Raquel Largo. (2019) Targeting chronic innate inflammatory pathways, the main road to prevention of osteoarthritis progression. Biochemical Pharmacology 165, pages 24-32.
Crossref
Crossref
Ji-Lin Li, E. Lin, Xiang-Lei Han, Qingjiang Li & Honggen Wang. (2019) Synthesis of α-Fluorinated Imides via Direct Fluorohydroxylation of Ynamides. Organic Letters 21:11, pages 4255-4258.
Crossref
Crossref
Debasis Das & Jian Hong. (2019) Recent advancements of 4-aminoquinazoline derivatives as kinase inhibitors and their applications in medicinal chemistry. European Journal of Medicinal Chemistry 170, pages 55-72.
Crossref
Crossref
Catherine Ropert. (2018) How toll-like receptors reveal monocyte plasticity: the cutting edge of antiinflammatory therapy. Cellular and Molecular Life Sciences 76:4, pages 745-755.
Crossref
Crossref
Katherine R Balka & Dominic De Nardo. (2019) Understanding early TLR signaling through the Myddosome. Journal of Leukocyte Biology 105:2, pages 339-351.
Crossref
Crossref
Stephen W. Wright, Bryan Li, Zhihui Peng, Lulin Wei, Emma McInturff, David Place, David B. Damon & Robert A. Singer. (2018) Improvements to Enable the Large Scale Synthesis of 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833). Organic Process Research & Development 22:12, pages 1835-1845.
Crossref
Crossref
Dominic De Nardo, Katherine R. Balka, Yamel Cardona Gloria, Vikram R. Rao, Eicke Latz & Seth L. Masters. (2018) Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling. Journal of Biological Chemistry 293:39, pages 15195-15207.
Crossref
Crossref
Bryan Li, Steven M. Guinness, Steve Hoagland, Michael Fichtner, Hui Kim, Shelly Li, Robert J. Maguire, J. Christopher McWilliams, Jason Mustakis, Jeffrey Raggon, Dan Campos, Chris. R. Voss, Evan Sohodski, Bryan Feyock, Hannah Murnen, Miguel Gonzalez, Matthew Johnson, Jiangping Lu, Xichun Feng, Xingfang Sun, Songyuan Zheng & Baolin Wu. (2018)
Continuous Production of Anhydrous
tert
-Butyl Hydroperoxide in Nonane Using Membrane Pervaporation and Its Application in Flow Oxidation of a γ-Butyrolactam
. Organic Process Research & Development 22:6, pages 707-720.
Crossref
Crossref
Leah Cushing, Aaron Winkler, Scott A. Jelinsky, Katherine Lee, Wouter Korver, Rachael Hawtin, Vikram R. Rao, Margaret Fleming & Lih-Ling Lin. (2017) IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes. Journal of Biological Chemistry 292:45, pages 18689-18698.
Crossref
Crossref
Rajeev S. Bhide, Alec Keon, Carolyn Weigelt, John S. Sack, Robert J. Schmidt, Shuqun Lin, Hai-Yun Xiao, Steven H. Spergel, James Kempson, William J. Pitts, Julie Carman & Michael A. Poss. (2017) Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors. Bioorganic & Medicinal Chemistry Letters 27:21, pages 4908-4913.
Crossref
Crossref
Nikolay Kuzmich, Konstantin Sivak, Vladimir Chubarev, Yuri Porozov, Tatiana Savateeva-Lyubimova & Francesco Peri. (2017) TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis. Vaccines 5:4, pages 34.
Crossref
Crossref
Katherine L. Lee, Catherine M. Ambler, David R. Anderson, Brian P. Boscoe, Andrea G. Bree, Joanne I. Brodfuehrer, Jeanne S. Chang, Chulho Choi, Seungwon Chung, Kevin J. Curran, Jacqueline E. Day, Christoph M. Dehnhardt, Ken Dower, Susan E. Drozda, Richard K. Frisbie, Lori K. Gavrin, Joel A. Goldberg, Seungil Han, Martin Hegen, David Hepworth, Heidi R. Hope, Satwik Kamtekar, Iain C. Kilty, Arthur Lee, Lih-Ling Lin, Frank E. Lovering, Michael D. Lowe, John P. Mathias, Heidi M. Morgan, Elizabeth A. Murphy, Nikolaos Papaioannou, Akshay Patny, Betsy S. Pierce, Vikram R. Rao, Eddine Saiah, Ivan J. Samardjiev, Brian M. Samas, Marina W. H. Shen, Julia H. Shin, Holly H. Soutter, Joseph W. Strohbach, Peter T. Symanowicz, Jennifer R. Thomason, John D. Trzupek, Richard Vargas, Fabien Vincent, Jiangli Yan, Christoph W. Zapf & Stephen W. Wright. (2017)
Discovery of Clinical Candidate 1-{[(2
S
,3
S
,4
S
)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
. Journal of Medicinal Chemistry 60:13, pages 5521-5542.
Crossref
Crossref
N.E. Genung & K.M. Guckian. 2017.
117
163
.
Mahesh Patra & Sangdun Choi. (2016) Recent Progress in the Molecular Recognition and Therapeutic Importance of Interleukin-1 Receptor-Associated Kinase 4. Molecules 21:11, pages 1529.
Crossref
Crossref