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Expert Opinion on Therapeutic Patents Volume 26, 2016 - Issue 9
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Review

Pleiotropic mechanisms of action of perhexiline in heart failure

Christopher H. GeorgeWales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, UKCorrespondence[email protected]
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,
Alice N. MitchellWales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, UKView further author information
,
Ryan PreeceWales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, UKView further author information
,
Mark L. BannisterWales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, UKView further author information
&
Zaheer YousefWales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, UKView further author information
Pages 1049-1059 | Received 15 Feb 2016, Accepted 06 Jul 2016, Published online: 25 Jul 2016

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Gary A. Gintant & Christopher H. George. (2018) Introduction to biological complexity as a missing link in drug discovery. Expert Opinion on Drug Discovery 13:8, pages 753-763.
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Xianfeng Liu, Xinmei Xu, Tao Zhang, Lei Xu, Honglin Tao, Yue Liu, Yi Zhang & Xianli Meng. (2023) Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases. Phytotherapy Research 37:11, pages 4976-4998.
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Miaosen Liu, Jialan Lv, Zhicheng Pan, Dongfei Wang, Liding Zhao & Xiaogang Guo. (2022) Mitochondrial dysfunction in heart failure and its therapeutic implications. Frontiers in Cardiovascular Medicine 9.
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Mark L. Bannister, Kenneth T. MacLeod & Christopher H. George. (2021) Moving in the right direction: elucidating the mechanisms of interaction between flecainide and the cardiac ryanodine receptor. British Journal of Pharmacology 179:11, pages 2558-2563.
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Vasco Sequeira. (2021) When fat meets the engine: implications of dietary rumenic acid on myosin‐targeting therapies in heart failure. The Journal of Physiology 599:15, pages 3635-3636.
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Zeyad D. Nassar, Chui Yan Mah, Margaret M. Centenera, Swati Irani, Martin C. Sadowski, Julia S. Scott, Elizabeth V. Nguyen, Shilpa R. Nagarajan, Max Moldovan, David J. Lynn, Roger J. Daly, Andrew J. Hoy & Lisa M. Butler. (2020) Fatty Acid Oxidation Is an Adaptive Survival Pathway Induced in Prostate Tumors by HSP90 Inhibition. Molecular Cancer Research 18:10, pages 1500-1511.
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Alessandra Guidi, A Prasanth Saraswati, Nicola Relitti, Roberto Gimmelli, Fulvio Saccoccia, Carmina Sirignano, Orazio Taglialatela-Scafati, Giuseppe Campiani, Giovina Ruberti & Sandra Gemma. (2020) (+)-(R)- and (−)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages. Bioorganic Chemistry 102, pages 104067.
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Shiva Kant, Pravin Kesarwani, Anthony R. Guastella, Praveen Kumar, Stewart F. Graham, Katie L. Buelow, Ichiro Nakano & Prakash Chinnaiyan. (2020) Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma. Molecular Cancer Therapeutics 19:7, pages 1415-1422.
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Vicente Benavides-Cordoba. (2020) Drug Repositioning for COVID-19. Colombia Medica.
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Claudia Sacchetto, Vasco Sequeira, Edoardo Bertero, Jan Dudek, Christoph Maack & Martina Calore. (2019) Metabolic Alterations in Inherited Cardiomyopathies. Journal of Clinical Medicine 8:12, pages 2195.
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Rong TianWilson S. ColucciZoltan AranyMarkus M. BachschmidScott W. BallingerSihem BoudinaJames E. BruceDavid W. BusijaSergey DikalovGerald W. DornIIIIZorina S. GalisRoberta A. GottliebDaniel P. KellyRichard N. KitsisMark J. KohrDaniel LevyE. Douglas LewandowskiJoseph M. McClungDaria Mochly-RosenKevin D. O’BrienBrian O’RourkeJoon-Young ParkPeipei PingMichael N. SackShey-Shing SheuYang ShiSruti ShivaDouglas C. WallaceRobert G. WeissHilary J. VernonRenee WongLisa Schwartz LongacreScarlet Shi. (2019) Unlocking the Secrets of Mitochondria in the Cardiovascular System. Circulation 140:14, pages 1205-1216.
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Santo Dellegrottaglie, Alessandra Scatteia, Carmine Emanuele Pascale, Francesco Renga & Pasquale Perrone-Filardi. (2019) Evaluation of Cardiac Metabolism by Magnetic Resonance Spectroscopy in Heart Failure. Heart Failure Clinics 15:3, pages 421-433.
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Bo Zhou & Rong Tian. (2018) Mitochondrial dysfunction in pathophysiology of heart failure. Journal of Clinical Investigation 128:9, pages 3716-3726.
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Jolanda van der Velden, Carlo G Tocchetti, Gilda Varricchi, Anna Bianco, Vasco Sequeira, Denise Hilfiker-Kleiner, Nazha Hamdani, Adelino F Leite-Moreira, Manuel Mayr, Ines Falcão-Pires, Thomas Thum, Dana K Dawson, Jean-Luc Balligand & Stephane Heymans. (2018) Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovascular Research 114:10, pages 1273-1280.
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Chih-Chung TsengHannah NoordaliMonica Sani, Melanie MadhaniDenis M. Grant, Michael P. FrenneauxMatteo Zanda & Iain R. Greig. (2017) Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy. Journal of Medicinal Chemistry 60:7, pages 2780-2789.
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