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Review

Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents

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Pages 1239-1256 | Received 14 Jun 2016, Accepted 25 Aug 2016, Published online: 08 Sep 2016

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Philip A. Harris. (2021) Inhibitors of RIP1 kinase: a patent review (2016–present). Expert Opinion on Therapeutic Patents 31:2, pages 137-151.
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Christopher R. Gardner, Katherine A. Davies, Ying Zhang, Martin Brzozowski, Peter E. Czabotar, James M. Murphy & Guillaume Lessene. (2023) From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors. Journal of Medicinal Chemistry 66:4, pages 2361-2385.
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Kathleen Weisel, Scott Berger, Kim Papp, Catherine Maari, James G. Krueger, Nicola Scott, Debra Tompson, Susanne Wang, Monica Simeoni, John Bertin & Paul Peter Tak. (2020) Response to Inhibition of Receptor‐Interacting Protein Kinase 1 (RIPK1) in Active Plaque Psoriasis: A Randomized Placebo‐Controlled Study. Clinical Pharmacology & Therapeutics 108:4, pages 808-816.
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Xuehui Li, Xiaoying Yao, Yuzhen Zhu, Hui Zhang, Haiyan Wang, Qun Ma, Fenglian Yan, Yonghong Yang, Junfeng Zhang, Hui Shi, Zhaochen Ning, Jun Dai, Zhihua Li, Chunxia Li, Fei Su, Yin Xue, Xiangzhi Meng, Guanjun Dong & Huabao Xiong. (2019) The Caspase Inhibitor Z-VAD-FMK Alleviates Endotoxic Shock via Inducing Macrophages Necroptosis and Promoting MDSCs-Mediated Inhibition of Macrophages Activation. Frontiers in Immunology 10.
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Natalia F. Smirnova & Oliver Eickelberg. (2019) Three Is Better than One: An Improved Multiple-Hit Model of Primary Graft Dysfunction. American Journal of Respiratory Cell and Molecular Biology 61:2, pages 141-142.
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Wen SunJie YuHongwei GaoXiaxia WuSheng WangYing HouJin-Jian LuXiuping Chen. (2019) Inhibition of Lung Cancer by 2-Methoxy-6-Acetyl-7-Methyljuglone Through Induction of Necroptosis by Targeting Receptor-Interacting Protein 1. Antioxidants & Redox Signaling 31:2, pages 93-108.
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Robert F. Schwabe & Tom Luedde. (2018) Apoptosis and necroptosis in the liver: a matter of life and death. Nature Reviews Gastroenterology & Hepatology 15:12, pages 738-752.
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Eun-Jung In, Yuno Lee, Sushruta Koppula, Tae-Yeon Kim, Jun-Hyuk Han, Kwang-Ho Lee & Tae-Bong Kang. (2018) Identification and Characterization of NTB451 as a Potential Inhibitor of Necroptosis. Molecules 23:11, pages 2884.
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Walter Gottlieb LandWalter Gottlieb Land. 2018. Damage-Associated Molecular Patterns in Human Diseases. Damage-Associated Molecular Patterns in Human Diseases 427 466 .
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Fabienne Le Cann, Claire Delehouzé, Sabrina Leverrier-Penna, Aveline Filliol, Arnaud Comte, Olivier Delalande, Nathalie Desban, Blandine Baratte, Isabelle Gallais, Claire Piquet-Pellorce, Florence Faurez, Marion Bonnet, Yvette Mettey, Peter Goekjian, Michel Samson, Peter Vandenabeele, Stéphane Bach & Marie-Thérèse Dimanche-Boitrel. (2017) Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis. The FEBS Journal 284:18, pages 3050-3068.
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Yao-Li Cui, Li-Hua Qiu, Shi-Yong Zhou, Lan-Fang Li, Zheng-Zi Qian, Xian-Ming Liu, Hui-Lai Zhang, Xiu-Bao Ren & Yong-Qiang Wang. (2017) Necroptosis as a potential therapeutic target in multiple organ dysfunction syndrome. Oncotarget 8:34, pages 56980-56990.
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