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Review

Aquaporin modulators: a patent review (2010–2015)

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Pages 49-62 | Received 04 Jun 2016, Accepted 02 Sep 2016, Published online: 26 Sep 2016

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Ying Bai, Kaier Zhang, Xin Cao & Peng Chen. (2023) Aquaporins in lacrimal glands and their role in dry eye disease. Experimental Eye Research 236, pages 109676.
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Inês Paccetti-Alves, Marta S. P. Batista, Catarina Pimpão, Bruno L. Victor & Graça Soveral. (2023) Unraveling the Aquaporin-3 Inhibitory Effect of Rottlerin by Experimental and Computational Approaches. International Journal of Molecular Sciences 24:6, pages 6004.
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Yaoxing Yi, Guoping Qiu, Hui Liu, Fei Gao, Xueyuan Liu, Yuqing Chen & Mei Yang. (2022) Hypotonic induction of aquaporin5 expression in rat astrocytes through p38 MAPK pathway . Anatomia, Histologia, Embryologia 51:6, pages 769-780.
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Susanna Törnroth-Horsefield, Clara Chivasso, Helin Strandberg, Claudia D’Agostino, Carla V. T. O’Neale, Kevin L. Schey & Christine Delporte. (2022) Insight into the Mammalian Aquaporin Interactome. International Journal of Molecular Sciences 23:17, pages 9615.
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Shu Xu, Shengfu Huang, Daiqiang Li, Qiong Zou, Yuan Yuan & Zhulin Yang. (2022) The expression of Aquaporin-1 and Aquaporin-3 in extrahepatic cholangiocarcinoma and their clinicopathological significance. The American Journal of the Medical Sciences 364:2, pages 181-191.
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Aashis Dutta & Manas Das. (2022) Deciphering the role of aquaporins in metabolic diseases: A mini review. The American Journal of the Medical Sciences 364:2, pages 148-162.
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Kevin L. Schey, Romell B. Gletten, Carla V. T. O’Neale, Zhen Wang, Rosica S. Petrova & Paul J. Donaldson. (2022) Lens Aquaporins in Health and Disease: Location is Everything!. Frontiers in Physiology 13.
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Mingrui Li, Minxin He, Fangshi Xu, Yibing Guan, Juanhua Tian, Ziyan Wan, Haibin Zhou, Mei Gao & Tie Chong. (2022) Abnormal expression and the significant prognostic value of aquaporins in clear cell renal cell carcinoma. PLOS ONE 17:3, pages e0264553.
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Catarina Pimpão, Darren Wragg, Inês V. da Silva, Angela Casini & Graça Soveral. (2022) Aquaglyceroporin Modulators as Emergent Pharmacological Molecules for Human Diseases. Frontiers in Molecular Biosciences 9.
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Aashis Dutta, Swarnali Dutta & Manas Das. (2021) Ameliorative Effect of Boerhavia Diffusa in Adenine-induced CKD Rat and Association of Aquaporin Transcript. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences 91:4, pages 789-797.
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Xier Luo, Kuiqing Cui, Zhiqiang Wang, Zhipeng Li, Zhengjiao Wu, Weiyi Huang, Xing-Quan Zhu, Jue Ruan, Weiyu Zhang & Qingyou Liu. (2021) High-quality reference genome of Fasciola gigantica: Insights into the genomic signatures of transposon-mediated evolution and specific parasitic adaption in tropical regions. PLOS Neglected Tropical Diseases 15:10, pages e0009750.
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Catarina Pimpão, Darren Wragg, Riccardo Bonsignore, Brech Aikman, Per Amstrup Pedersen, Stefano Leoni, Graça Soveral & Angela Casini. (2021) Mechanisms of irreversible aquaporin-10 inhibition by organogold compounds studied by combined biophysical methods and atomistic simulations. Metallomics 13:9.
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Giuseppe Calamita & Christine Delporte. (2021) Involvement of aquaglyceroporins in energy metabolism in health and disease. Biochimie 188, pages 20-34.
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K. V. Basiakova & E. P. Titovets. (2021) Study of the effect of some drugs used in the clinic on the AQP1 activity of the human erythrocyte membrane. Proceedings of the National Academy of Sciences of Belarus, Medical series 18:2, pages 204-211.
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Inês Vieira da Silva, Carlos Cardoso, Helios Martínez-Banaclocha, Angela Casini, Pablo Pelegrín & Graça Soveral. (2020) Aquaporin-3 is involved in NLRP3-inflammasome activation contributing to the setting of inflammatory response. Cellular and Molecular Life Sciences 78:6, pages 3073-3085.
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Angela Tesse, Patrizia Gena, Michael Rützler & Giuseppe Calamita. (2021) Ablation of Aquaporin-9 Ameliorates the Systemic Inflammatory Response of LPS-Induced Endotoxic Shock in Mouse. Cells 10:2, pages 435.
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Inês V. da Silva & Graça Soveral. (2021) Aquaporins in Immune Cells and Inflammation: New Targets for Drug Development. International Journal of Molecular Sciences 22:4, pages 1845.
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Ekta Yadav, Niket Yadav, Ariel Hus & Jagjit S. Yadav. (2020) Aquaporins in lung health and disease: Emerging roles, regulation, and clinical implications. Respiratory Medicine 174, pages 106193.
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Liping Jia, Yuzhu Liu, Yixu Han, Xiaofei Zhou & Fahui Wang. (2020) Differential expression and inhibitory effects of aquaporins on the development of adenomyosis. Molecular Medicine Reports.
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Nuno Cruz, Jacinta Oliveira Pinho, Graça Soveral, Lia Ascensão, Nuno Matela, Catarina Reis & Maria Manuela Gaspar. (2020) A Novel Hybrid Nanosystem Integrating Cytotoxic and Magnetic Properties as a Tool to Potentiate Melanoma Therapy. Nanomaterials 10:4, pages 693.
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Catarina Pimpão, Inês V. da Silva, Andreia F. Mósca, Jacinta O. Pinho, Maria Manuela Gaspar, Nadiia I. Gumerova, Annette Rompel, Manuel Aureliano & Graça Soveral. (2020) The Aquaporin-3-Inhibiting Potential of Polyoxotungstates. International Journal of Molecular Sciences 21:7, pages 2467.
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Katarzyna Krupa, Maria Korabik & Teresa Kowalik-Jankowska. (2019) Coordination properties of Cu(II) ions towards the peptides based on the His-Xaa-His motif from Fusobacterium nucleatum P1 protein. Journal of Inorganic Biochemistry 201, pages 110819.
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Tatjana Arsenijevic, Jason Perret, Jean-Luc Van Laethem & Christine Delporte. (2019) Aquaporins Involvement in Pancreas Physiology and in Pancreatic Diseases. International Journal of Molecular Sciences 20:20, pages 5052.
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Changjun Chen, Songgang Wang, Jiying Chen, Xiaolin Liu, Mengchen Zhang, Xi Wang, Weihua Xu, Yayun Zhang, Hao Li, Xin Pan & Meng Si. (2019) Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells. FEBS Open Bio 9:5, pages 891-900.
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Mohammed Abir-Awan, Philip Kitchen, Mootaz Salman, Matthew Conner, Alex Conner & Roslyn Bill. (2019) Inhibitors of Mammalian Aquaporin Water Channels. International Journal of Molecular Sciences 20:7, pages 1589.
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E. P. Titovets, A. F. Smeyanovich & P. V. Kozich. (2019) Correction of the disorders of the cerebral water metabolism. Proceedings of the National Academy of Sciences of Belarus, Medical series 16:1, pages 99-107.
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Margot N. Wenzel, Andreia F. Mósca, Valentina Graziani, Brech Aikman, Sophie R. Thomas, Andreia de Almeida, James A. Platts, Nazzareno Re, Cecilia Coletti, Alessandro Marrone, Graça Soveral & Angela Casini. (2019) Insights into the Mechanisms of Aquaporin-3 Inhibition by Gold(III) Complexes: the Importance of Non-Coordinative Adduct Formation. Inorganic Chemistry 58:3, pages 2140-2148.
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Jinzhao He & Baoxue Yang. (2019) Aquaporins in Renal Diseases. International Journal of Molecular Sciences 20:2, pages 366.
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Vahid Fadaei Naeini, Masumeh Foroutan, Mina Maddah, Yves Rémond & Majid Baniassadi. (2018) Determinative factors in inhibition of aquaporin by different pharmaceuticals: Atomic scale overview by molecular dynamics simulation. Biochimica et Biophysica Acta (BBA) - General Subjects 1862:12, pages 2815-2823.
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Brech Aikman, Margot Wenzel, Andreia Mósca, Andreia de Almeida, Wim Klooster, Simon Coles, Graça Soveral & Angela Casini. (2018) Gold(III) Pyridine-Benzimidazole Complexes as Aquaglyceroporin Inhibitors and Antiproliferative Agents. Inorganics 6:4, pages 123.
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Andreia Mósca, Andreia de Almeida, Darren Wragg, Ana Martins, Farzana Sabir, Stefano Leoni, Teresa Moura, Catarina Prista, Angela Casini & Graça Soveral. (2018) Molecular Basis of Aquaporin-7 Permeability Regulation by pH. Cells 7:11, pages 207.
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Giuseppe Calamita, Jason Perret & Christine Delporte. (2018) Aquaglyceroporins: Drug Targets for Metabolic Diseases?. Frontiers in Physiology 9.
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André Gomes, Inês V. da Silva, Cecília M. P. Rodrigues, Rui E. Castro & Graça Soveral. (2018) The Emerging Role of microRNAs in Aquaporin Regulation. Frontiers in Chemistry 6.
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Zhengcai Zhu, Lianghe Jiao, Tao Li, Honggang Wang, Wei Wei & Haixin Qian. (2018) Expression of AQP3 and AQP5 as a prognostic marker in triple‑negative breast cancer. Oncology Letters.
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Inês Vieira da Silva, Joana S. Rodrigues, Irene Rebelo, Joana P. G. Miranda & Graça Soveral. (2018) Revisiting the metabolic syndrome: the emerging role of aquaglyceroporins. Cellular and Molecular Life Sciences 75:11, pages 1973-1988.
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Angela Tesse, Elena Grossini, Grazia Tamma, Catherine Brenner, Piero Portincasa, Raul A. Marinelli & Giuseppe Calamita. (2018) Aquaporins as Targets of Dietary Bioactive Phytocompounds. Frontiers in Molecular Biosciences 5.
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Brech Aikman, Andreia de Almeida, Samuel M. Meier-Menches & Angela Casini. (2018) Aquaporins in cancer development: opportunities for bioinorganic chemistry to contribute novel chemical probes and therapeutic agents. Metallomics 10:5, pages 696-712.
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Jianling Xia, Hongqiang Wang, Shi Li, Qinghui Wu, Li Sun, Hongxiang Huang & Ming Zeng. (2017) Ion channels or aquaporins as novel molecular targets in gastric cancer. Molecular Cancer 16:1.
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Valentina Graziani, Alessandro Marrone, Nazzareno Re, Cecilia Coletti, James A. Platts & Angela Casini. (2017) A Multi-Level Theoretical Study to Disclose the Binding Mechanisms of Gold(III)-Bipyridyl Compounds as Selective Aquaglyceroporin Inhibitors. Chemistry - A European Journal 23:55, pages 13802-13813.
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Jessica J. Miller, Luiza M. F. Gomes, Tim Storr & Angela Casini. 2011. Encyclopedia of Inorganic and Bioinorganic Chemistry. Encyclopedia of Inorganic and Bioinorganic Chemistry 1 13 .
Xunwei Huang, Li Huang & Minhua Shao. (2017) Aquaporin 3 facilitates tumor growth in pancreatic cancer by modulating mTOR signaling. Biochemical and Biophysical Research Communications 486:4, pages 1097-1102.
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