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Expert Opinion on Therapeutic Patents Volume 27, 2017 - Issue 2
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Review

Recent advances in therapeutics and drug delivery for the treatment of inner ear diseases: a patent review (2011-2015)

Kim NguyenDepartment of Chemistry, University of Southern California, Los Angeles, CA, USAView further author information
,
Judith S. KempfleDepartment of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA;Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA;Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USAView further author information
,
David H. JungDepartment of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA;Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA;Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USAView further author information
&
Charles E. McKennaDepartment of Chemistry, University of Southern California, Los Angeles, CA, USACorrespondence[email protected]
View further author information
Pages 191-202 | Received 09 May 2016, Accepted 21 Oct 2016, Published online: 18 Nov 2016

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Xu Liu, Mingshuang Li, Hugh Smyth & Feng Zhang. (2018) Otic drug delivery systems: formulation principles and recent developments. Drug Development and Industrial Pharmacy 44:9, pages 1395-1408.
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Daniel Bodmer. (2017) An update on drug design strategies to prevent acquired sensorineural hearing loss. Expert Opinion on Drug Discovery 12:11, pages 1161-1167.
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Jie Zhang, Ru Chen, Shuainan Chen, Die Yu, Dalia H. Elkamchouchi, Mohammed S. Alqahtani, Hamid Assilzadeh, Zhongguan Huang & Yideng Huang. (2023) Application of lipid and polymeric-based nanoparticles for treatment of inner ear infections via XGBoost. Environmental Research 239, pages 117115.
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Masoud Mohseni-Dargah, Zahra Falahati, Christopher Pastras, Khosro Khajeh, Payal Mukherjee, Amir Razmjou, Sebastian Stefani & Mohsen Asadnia. (2023) Meniere's disease: Pathogenesis, treatments, and emerging approaches for an idiopathic bioenvironmental disorder. Environmental Research 238, pages 116972.
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Pierre Reynard & Hung Thai-Van. (2023) Drug-induced hearing loss: Listening to the latest advances. Therapies.
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Yousuf Mohammed, Amy Holmes, Philip Chi Lip Kwok, Tushar Kumeria, Sarika Namjoshi, Mohammad Imran, Lana Matteucci, Masood Ali, Waiting Tai, Heather A.E. Benson & Michael S. Roberts. (2022) Advances and future perspectives in epithelial drug delivery. Advanced Drug Delivery Reviews 186, pages 114293.
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Zipei Zhang, Xiyu Li, Wei Zhang & Daniel S. Kohane. (2020) Drug Delivery across Barriers to the Middle and Inner Ear. Advanced Functional Materials 31:44.
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Christin Geissler, Miriam Blumenstock, Jennis Gabrielpillai, Leon Guchlerner, Timo Stöver & Marc Diensthuber. (2021) Simultaneous treatment with pentoxifylline does not adversely affect the neurotrophic effects of brain-derived neurotrophic factor on spiral ganglion neurons. NeuroReport 32:13, pages 1134-1139.
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Anne G.M. Schilder, Matthew P. Su, Rishi Mandavia, Caroline R. Anderson, Evie Landry, Tanjinah Ferdous & Helen Blackshaw. (2019) Early phase trials of novel hearing therapeutics: Avenues and opportunities. Hearing Research 380, pages 175-186.
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Helena Wichova, Sameer Alvi, Christine Boatright, Luke Ledbetter, Hinrich Staecker & James Lin. (2019) High-Resolution Computed Tomography of the Inner Ear: Effect of Otosclerosis on Cochlear Aqueduct Dimensions. Annals of Otology, Rhinology & Laryngology 128:8, pages 749-754.
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Verena Scheper, Andrea Hoffmann, Michael M. Gepp, André Schulz, Anika Hamm, Christoph Pannier, Peter Hubka, Thomas Lenarz & Jana Schwieger. (2019) Stem Cell Based Drug Delivery for Protection of Auditory Neurons in a Guinea Pig Model of Cochlear Implantation. Frontiers in Cellular Neuroscience 13.
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Jinsong Hao & S. Kevin Li. (2019) Inner ear drug delivery: Recent advances, challenges, and perspective. European Journal of Pharmaceutical Sciences 126, pages 82-92.
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R. Glueckert, L. Johnson Chacko, H. Rask-Andersen, W. Liu, S. Handschuh & A. Schrott-Fischer. (2018) Anatomical basis of drug delivery to the inner ear. Hearing Research 368, pages 10-27.
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David H. Jung & Steven D. Rauch. (2018) Clinical trials for inner ear drugs: Design and execution challenges. Hearing Research 368, pages 123-126.
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Alec N. Salt & Stefan K. Plontke. (2018) Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications. Hearing Research 368, pages 28-40.
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Judith S. Kempfle, Kim Nguyen, Christine Hamadani, Nicholas Koen, Albert S. Edge, Boris A. Kashemirov, David H. Jung & Charles E. McKenna. (2018) Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss. Bioconjugate Chemistry 29:4, pages 1240-1250.
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Umberto M. Musazzi, Silvia Franzé & Francesco Cilurzo. (2017) Innovative pharmaceutical approaches for the management of inner ear disorders. Drug Delivery and Translational Research 8:2, pages 436-449.
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