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Expert Opinion on Therapeutic Patents Volume 27, 2017 - Issue 1
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Patent Evaluation

Novel diaryltriazines with a picolinonitrile moiety as potent HIV-1 RT inhibitors: a patent evaluation of WO2016059647(A2)

Boshi HuangDepartment of Medicinal Chemistry, Key laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. ChinaView further author information
,
Zhongxia ZhouDepartment of Medicinal Chemistry, Key laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. ChinaView further author information
,
Dongwei KangDepartment of Medicinal Chemistry, Key laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. ChinaView further author information
,
Wanzhuo LiDepartment of Medicinal Chemistry, Key laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. ChinaView further author information
,
Zihui ChenDepartment of Medicinal Chemistry, Key laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. ChinaView further author information
,
Peng ZhanDepartment of Medicinal Chemistry, Key laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. ChinaCorrespondence[email protected]
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&
Xinyong LiuDepartment of Medicinal Chemistry, Key laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. ChinaCorrespondence[email protected]
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Pages 9-15 | Received 31 Jul 2016, Accepted 15 Nov 2016, Published online: 25 Nov 2016

Citations (7)

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Xiaofang Zuo, Zhipeng Huo, Dongwei Kang, Gaochan Wu, Zhongxia Zhou, Xinyong Liu & Peng Zhan. (2018) Current insights into anti-HIV drug discovery and development: a review of recent patent literature (2014–2017). Expert Opinion on Therapeutic Patents 28:4, pages 299-316.
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Articles from other publishers (6)

Xiangyi Jiang, Boshi Huang, Shawn Rumrill, David Pople, Waleed A. Zalloum, Dongwei Kang, Fabao Zhao, Xiangkai Ji, Zhen Gao, Lide Hu, Zhao Wang, Minghui Xie, Erik De Clercq, Francesc X. Ruiz, Eddy Arnold, Christophe Pannecouque, Xinyong Liu & Peng Zhan. (2023) Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors. Communications Chemistry 6:1.
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Shuang-Xi Gu, Jiong Chen, Yuan-Yuan Zhu, Wei Ming, Shuang-Shuang Zhang & Jin-Xu Cao. 2023. Privileged Scaffolds in Drug Discovery. Privileged Scaffolds in Drug Discovery 513 542 .
Boshi Huang, Tiziana Ginex, F. Javier Luque, Xiangyi Jiang, Ping Gao, Jian Zhang, Dongwei Kang, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan & Xinyong Liu. (2021) Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies. Journal of Medicinal Chemistry 64:18, pages 13604-13621.
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Shuang-Xi Gu, Yuan-Yuan Zhu, Chao Wang, Hai-Feng Wang, Gen-Yan Liu, Shuang Cao & Lu Huang. (2020) Recent discoveries in HIV-1 reverse transcriptase inhibitors. Current Opinion in Pharmacology 54, pages 166-172.
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Shuang-Xi Gu, Huan-Huan Lu, Gen-Yan Liu, Xiu-Lian Ju & Yuan-Yuan Zhu. (2018) Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors. European Journal of Medicinal Chemistry 158, pages 371-392.
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Boshi Huang, Xinhao Liu, Ye Tian, Dongwei Kang, Zhongxia Zhou, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan & Xinyong Liu. (2018) First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain. Bioorganic & Medicinal Chemistry Letters 28:8, pages 1348-1351.
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