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Christian Kretzer, Paul M Jordan, Rossella Bilancia, Antonietta Rossi, Tuğçe Gür Maz, Erden Banoglu, Ulrich S Schubert & Oliver Werz. (2022) Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201. Journal of Inflammation Research 15, pages 911-925.
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Till A Röhn, Shin Numao, Heike Otto, Christian Loesche & Gebhard Thoma. (2021) Drug discovery strategies for novel leukotriene A4 hydrolase inhibitors. Expert Opinion on Drug Discovery 16:12, pages 1483-1495.
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Articles from other publishers (32)
Carmen Cerchia, Laura Küfner, Oliver Werz & Antonio Lavecchia. (2024) Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening. European Journal of Medicinal Chemistry 263, pages 115932.
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Gebhard Thoma, Christian Markert, Rainer Lueoend, Wolfgang Miltz, Carsten Spanka, Birgit Bollbuck, Romain M. Wolf, Honnappa Srinivas, Carlos A. Penno, Michael Kiffe, Monika Gajewska, Dallas Bednarczyk, Grazyna Wieczorek, Amanda Evans, Christian Beerli & Till A. Röhn. (2023) Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase. Journal of Medicinal Chemistry.
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Philipp Dahlke, Lukas K. Peltner, Paul M. Jordan & Oliver Werz. (2023) Differential impact of 5-lipoxygenase-activating protein antagonists on the biosynthesis of leukotrienes and of specialized pro-resolving mediators. Frontiers in Pharmacology 14.
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Mathieu P.A. Hébert, Ayyoub Selka, Andréa A. Lebel, Jérémie A. Doiron, Audrey Isabel Chiasson, Vanessa L. Gauvin, Alexis J. Matthew, Martin J.G. Hébert, Marco S. Doucet, Andrew P. Joy, David A. Barnett, Mohamed Touaibia, Marc E. Surette & Luc H. Boudreau. (2023) Caffeic acid phenethyl ester analogues as selective inhibitors of 12-lipoxygenase product biosynthesis in human platelets. International Immunopharmacology 121, pages 110419.
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Bushra Bashir, Naheed Riaz, Syeda Abida Ejaz, Muhammad Saleem, Ambar Iqbal, Hafiz Mohammad Kashif Mahmood, Samina Ejaz, Muhammad Ashraf, Aziz-ur-Rehman & Keshab Bhattarai. (2023) Parsing p-tolyloxy-1,3,4-oxadiazolepropanamides as 15-lipoxygenase inhibitors prop up by in vitro and in silico profiling including structure determination. Journal of Molecular Structure 1275, pages 134664.
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Jesper Z. HaeggströmMarcia E. Newcomer. (2023) Structures of Leukotriene Biosynthetic Enzymes and Development of New Therapeutics. Annual Review of Pharmacology and Toxicology 63:1, pages 407-428.
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Ferdinando Bruno, Verena Krauth, Seyed Mohamed Nabavi, Veronika Temml, Florinda Fratianni, Giuseppe Spaziano, Filomena Nazzaro, Fiorita Roviezzo, Jianbo Xiao, Haroon Khan, Maria Preziosa Romano, Bruno D'Agostino, Oliver Werz & Rosanna Filosa. (2022) Design and synthesis of functionalized 4-aryl-Catechol derivatives as new antiinflammtory agents with in vivo efficacy. European Journal of Medicinal Chemistry 243, pages 114788.
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Simone Di Micco, Stefania Terracciano, Martina Pierri, Vincenza Cantone, Stefanie Liening, Stefanie König, Ulrike Garscha, Robert Klaus Hofstetter, Andreas Koeberle, Oliver Werz, Ines Bruno & Giuseppe Bifulco. (2022) Identification of 2,4‐Dinitro‐Biphenyl‐Based Compounds as MAPEG Inhibitors. ChemMedChem 17:22.
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Mei Zheng, Panpan Fan, Pu Yang, Junwen Zheng & Dongchi Zhao. (2022) Respiratory Syncytial Virus Nonstructural Protein 1 Promotes 5-Lipoxygenase via miR-19a-3p. Journal of Immunology Research 2022, pages 1-10.
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Ling Wang, Jin-hua Tao, Yi-fan Chen, Yu-meng Shen & Shu Jiang. (2021) Lizhong Decoction (理中汤) Ameliorates Ulcerative Colitis in Mice via Regulation of Plasma and Urine Metabolic Profiling. Chinese Journal of Integrative Medicine.
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Tran Thi Van Anh, Alilou Mostafa, Zhigang Rao, Simona Pace, Stefan Schwaiger, Christian Kretzer, Veronika Temml, Carsten Giesel, Paul M. Jordan, Rossella Bilancia, Christina Weinigel, Silke Rummler, Birgit Waltenberger, Tran Hung, Antonietta Rossi, Hermann Stuppner, Oliver Werz & Andreas Koeberle. (2021) From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution. Acta Pharmaceutica Sinica B 11:6, pages 1629-1647.
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Marcia E. Newcomer, Svetlana Pakhomova & Nathaniel C. Gilbert. 2021. Encyclopedia of Biological Chemistry III. Encyclopedia of Biological Chemistry III
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Blerina Shkodra-Pula, Christian Kretzer, Paul M. Jordan, Paul Klemm, Andreas Koeberle, David Pretzel, Erden Banoglu, Stefan Lorkowski, Maria Wallert, Stephanie Höppener, Steffi Stumpf, Antje Vollrath, Stephanie Schubert, Oliver Werz & Ulrich S. Schubert. (2020) Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity. Journal of Nanobiotechnology 18:1.
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Guiping Tu, Zijian Qin, Donghui Huo, Shengde Zhang & Aixia Yan. (2020) Fingerprint‐based computational models of 5‐lipo‐oxygenase activating protein inhibitors: Activity prediction and structure clustering. Chemical Biology & Drug Design 96:3, pages 931-947.
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Nathaniel C. Gilbert, Jana Gerstmeier, Erin E. Schexnaydre, Friedemann Börner, Ulrike Garscha, David B. Neau, Oliver Werz & Marcia E. Newcomer. (2020) Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. Nature Chemical Biology 16:7, pages 783-790.
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Angela Sester, Lea Winand, Simona Pace, Wolf Hiller, Oliver Werz & Markus Nett. (2019)
Myxochelin- and Pseudochelin-Derived Lipoxygenase Inhibitors from a Genetically Engineered
Myxococcus xanthus
Strain
. Journal of Natural Products 82:9, pages 2544-2549.
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Shweta Sinha, Mukesh Doble & S.L. Manju. (2019) 5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach. Bioorganic & Medicinal Chemistry 27:17, pages 3745-3759.
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Jana Gerstmeier, Julia Seegers, Finja Witt, Birgit Waltenberger, Veronika Temml, Judith M. Rollinger, Hermann Stuppner, Andreas Koeberle, Daniela Schuster & Oliver Werz. (2019) Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis. Frontiers in Pharmacology 10.
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Jana Gerstmeier, Christian Kretzer, Simone Di Micco, Laura Miek, Hannah Butschek, Vincenza Cantone, Rossella Bilancia, Roberta Rizza, Fabiana Troisi, Nunzio Cardullo, Corrado Tringali, Armando Ialenti, Antonietta Rossi, Giuseppe Bifulco, Oliver Werz & Simona Pace. (2019) Novel benzoxanthene lignans that favorably modulate lipid mediator biosynthesis: A promising pharmacological strategy for anti-inflammatory therapy. Biochemical Pharmacology 165, pages 263-274.
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Markus Werner, Paul M. Jordan, Erik Romp, Anna Czapka, Zhigang Rao, Christian Kretzer, Andreas Koeberle, Ulrike Garscha, Simona Pace, Hans‐Erik Claesson, Charles N. Serhan, Oliver Werz & Jana Gerstmeier. (2019) Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome. The FASEB Journal 33:5, pages 6140-6153.
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Stefanie König, Simona Pace, Helmut Pein, Thorsten Heinekamp, Jan Kramer, Erik Romp, Maria Straßburger, Fabiana Troisi, Anna Proschak, Jan Dworschak, Kirstin Scherlach, Antonietta Rossi, Lidia Sautebin, Jesper Z. Haeggström, Christian Hertweck, Axel A. Brakhage, Jana Gerstmeier, Ewgenij Proschak & Oliver Werz. (2019) Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase. Cell Chemical Biology 26:4, pages 524-534.e5.
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Subramani Muthuraman, Shweta Sinha, C.S. Vasavi, Kamran Manzoor Waidha, Biswarup Basu, Punnagai Munussami, M.M. Balamurali, Mukesh Doble & Rajendran Saravana Kumar. (2019) Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies. Bioorganic & Medicinal Chemistry 27:4, pages 604-619.
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Lisa Vieider, Erik Romp, Veronika Temml, Jana Fischer, Christian Kretzer, Martin Schoenthaler, Abdulla Taha, Victor Hernández-Olmos, Sonja Sturm, Daniela Schuster, Oliver Werz, Ulrike Garscha & Barbara Matuszczak. (2018) Synthesis, Biological Evaluation and Structure–Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors. ACS Medicinal Chemistry Letters 10:1, pages 62-66.
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Andreas Koeberle & Oliver Werz. (2018) Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis. Biotechnology Advances 36:6, pages 1709-1723.
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Mayuri Napagoda, Jana Gerstmeier, Hannah Butschek, Sybille Lorenz, Dinusha Kanatiwela, Mallique Qader, Ajith Nagahawatte, Sudhara De Soyza, Gaya Bandara Wijayaratne, Aleš Svatoš, Lalith Jayasinghe, Andreas Koeberle & Oliver Werz. (2018) Lipophilic extracts of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibit key enzymes involved in inflammation and gout. Journal of Ethnopharmacology 224, pages 474-481.
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Helmut Pein, Alexia Ville, Simona Pace, Veronika Temml, Ulrike Garscha, Martin Raasch, Khaled Alsabil, Guillaume Viault, Chau-Phi Dinh, David Guilet, Fabiana Troisi, Konstantin Neukirch, Stefanie König, Rosella Bilancia, Birgit Waltenberger, Hermann Stuppner, Maria Wallert, Stefan Lorkowski, Christina Weinigel, Silke Rummler, Marc Birringer, Fiorentina Roviezzo, Lidia Sautebin, Jean-Jacques Helesbeux, Denis Séraphin, Alexander S. Mosig, Daniela Schuster, Antonietta Rossi, Pascal Richomme, Oliver Werz & Andreas Koeberle. (2018) Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nature Communications 9:1.
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Shuwen Feng, Dongxin Zeng, Junwen Zheng & Dongchi Zhao. (2018) MicroRNAs: Mediators and Therapeutic Targets to Airway Hyper Reactivity After Respiratory Syncytial Virus Infection. Frontiers in Microbiology 9.
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Sun-Yee Cheung, Markus Werner, Lucia Esposito, Fabiana Troisi, Vincenza Cantone, Stefanie Liening, Stefanie König, Jana Gerstmeier, Andreas Koeberle, Rossella Bilancia, Roberta Rizza, Antonietta Rossi, Fiorentina Roviezzo, Veronika Temml, Daniela Schuster, Hermann Stuppner, Manfred Schubert-Zsilavecz, Oliver Werz, Thomas Hanke & Simona Pace. (2018) Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation. European Journal of Medicinal Chemistry 156, pages 815-830.
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Jesper Z. Haeggström. (2018) Leukotriene biosynthetic enzymes as therapeutic targets. Journal of Clinical Investigation 128:7, pages 2680-2690.
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Menachem Rubinstein & Efrat Dvash. (2018) Leukotrienes and kidney diseases. Current Opinion in Nephrology and Hypertension 27:1, pages 42-48.
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Ulrike Garscha, Erik Romp, Simona Pace, Antonietta Rossi, Veronika Temml, Daniela Schuster, Stefanie König, Jana Gerstmeier, Stefanie Liening, Markus Werner, Heiner Atze, Sandra Wittmann, Christina Weinigel, Silke Rummler, Gerhard K. Scriba, Lidia Sautebin & Oliver Werz. (2017) Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. Scientific Reports 7:1.
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ferdinando bruno, Verena Krauth, florinda Fratianni, giuseppe spaziano, Filomena Nazzaro, Fiorentina Roviezzo, Seyed Mohammad Nabavi, Haroon Khan, Maria Preziosa Romano, Bruno D'Agostino, Oliver Werz & rosanna filosa. (2022) Design and Synthesis of Functionalized4-Aryl-Catechol Derivatives as New Anti-Inflammatory Agents with In Vivo Efficacy PART I. SSRN Electronic Journal.
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