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Aline T. Marinho, Joana P. Miranda, Umbelina Caixas, Catarina Charneira, Clara Gonçalves-Dias, M. Matilde Marques, Emília C. Monteiro, Alexandra M. M. Antunes & Sofia A. Pereira. (2019) Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity. Drug Metabolism Reviews 51:1, pages 76-90.
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Xiaofang Zuo, Zhipeng Huo, Dongwei Kang, Gaochan Wu, Zhongxia Zhou, Xinyong Liu & Peng Zhan. (2018) Current insights into anti-HIV drug discovery and development: a review of recent patent literature (2014–2017). Expert Opinion on Therapeutic Patents 28:4, pages 299-316.
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Xin Jin, Shuai Wang, Limin Zhao, Wenjuan Huang, Yinxiang Zhang, Christophe Pannecouque, Erik De Clercq, Ge Meng, Huri Piao & Fener Chen. (2023) Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability. Acta Pharmaceutica Sinica B 13:3, pages 1192-1203.
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Ruo-Lan Zhou, Zhiran Ju, Christophe Pannecouque, Erik De Clercq, Shuai Wang & Fen-Er Chen. (2023) Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs. European Journal of Medicinal Chemistry 246, pages 114939.
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Li-Min Zhao, Shuai Wang, Christophe Pannecouque, Erik De Clercq, Hu-Ri Piao & Fen-Er Chen. (2022) Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability. European Journal of Medicinal Chemistry 240, pages 114581.
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Xu Ling, Qing-Qing Hao, Christophe Pannecouque, Erik De Clercq & Fen-Er Chen. (2022) Expansion of the S–CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase. European Journal of Medicinal Chemistry 238, pages 114512.
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Structure-Based Discovery of Novel NH
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Tao Zhang, Zhongxia Zhou, Waleed A. Zalloum, Zhao Wang, Zhipeng Fu, Srinivasulu Cherukupalli, Da Feng, Yanying Sun, Shenghua Gao, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan & Xinyong Liu. (2021) Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP. Bioorganic Chemistry 116, pages 105353.
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Saba Farooq & Zainab Ngaini. (2021)
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Li Ding, Chunlin Zhuang & Fener Chen. (2021) Druggability modification strategies of the diarylpyrimidine‐type non‐nucleoside reverse transcriptase inhibitors. Medicinal Research Reviews 41:3, pages 1255-1290.
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Dongwei Kang, Francesc X. Ruiz, Yanying Sun, Da Feng, Lanlan Jing, Zhao Wang, Tao Zhang, Shenghua Gao, Lin Sun, Erik De Clercq, Christophe Pannecouque, Eddy Arnold, Peng Zhan & Xinyong Liu. (2021) 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies. Journal of Medicinal Chemistry 64:7, pages 4239-4256.
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Dongwei Kang, Da Feng, Yanying Sun, Zengjun Fang, Fenju Wei, Erik De Clercq, Christophe Pannecouque, Xinyong Liu & Peng Zhan. (2020) Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties. Journal of Medicinal Chemistry 63:9, pages 4837-4848.
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Lin Sun, Tianguang Huang, Alexej Dick, Megan E. Meuser, Waleed A. Zalloum, Chin-Ho Chen, Xiao Ding, Ping Gao, Simon Cocklin, Kuo-Hsiung Lee, Peng Zhan & Xinyong Liu. (2020) Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities. European Journal of Medicinal Chemistry 190, pages 112085.
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Dongwei Kang, F. Xavier Ruiz, Da Feng, Alyssa Pilch, Tong Zhao, Fenju Wei, Zhao Wang, Yanying Sun, Zengjun Fang, Erik De Clercq, Christophe Pannecouque, Eddy Arnold, Xinyong Liu & Peng Zhan. (2020) Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. Journal of Medicinal Chemistry 63:3, pages 1298-1312.
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Tong Zhao, Qing Meng, Dongwei Kang, Jianbo Ji, Erik De Clercq, Christophe Pannecouque, Xinyong Liu & Peng Zhan. (2019) Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing. European Journal of Medicinal Chemistry 182, pages 111619.
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Dongwei Kang, Heng Zhang, Zhao Wang, Tong Zhao, Tiziana Ginex, Francisco Javier Luque, Yang Yang, Gaochan Wu, Da Feng, Fenju Wei, Jian Zhang, Erik De Clercq, Christophe Pannecouque, Chin Ho Chen, Kuo-Hsiung Lee, N. Arul Murugan, Thomas A. Steitz, Peng Zhan & Xinyong Liu. (2019)
Identification of Dihydrofuro[3,4-
d
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Zhao Wang, Zhao Yu, Dongwei Kang, Jian Zhang, Ye Tian, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan & Xinyong Liu. (2019) Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs. Bioorganic & Medicinal Chemistry 27:3, pages 447-456.
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Lin Sun, Ping Gao, Guanyu Dong, Xujie Zhang, Xiqiang Cheng, Xiao Ding, Xueshun Wang, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Luis Menéndez-Arias, Peng Zhan & Xinyong Liu. (2018) 5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase. European Journal of Medicinal Chemistry 155, pages 714-724.
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Dongwei Kang, Zhao Wang, Heng Zhang, Gaochan Wu, Tong Zhao, Zhongxia Zhou, Zhipeng Huo, Boshi Huang, Da Feng, Xiao Ding, Jian Zhang, Xiaofang Zuo, Lanlan Jing, Wei Luo, Samuel Guma, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan & Xinyong Liu. (2018) Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery. ACS Medicinal Chemistry Letters 9:4, pages 370-375.
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Xu Ling, Qingqing Hao, Christophe Pannecouque, Erik De Clercq & Fen Er Chen. (2022) Expansion of the <i>S</i>-CN-DABO Scaffold to Exploit the Impact on Inhibitory Activities Against the Non-Nucleoside HIV-1 Reverse Transcriptase. SSRN Electronic Journal.
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