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Expert Opinion on Therapeutic Patents Volume 27, 2017 - Issue 9
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Review

Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006–2016)

Lukas GoreckiDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic;Biomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech RepublicView further author information
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Jan KorabecnyDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic;Biomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech RepublicView further author information
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Kamil MusilekBiomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic;Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech RepublicView further author information
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Eugenie NepovimovaDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic;Biomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech RepublicView further author information
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David MalinakBiomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic;Department of Physiology and Pathophysiology, Faculty of Medicine, University of Ostrava, Ostrava, Czech RepublicView further author information
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Tomas KuceraDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech RepublicView further author information
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Rafael DolezalBiomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic;Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech RepublicView further author information
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Daniel JunDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic;Biomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech RepublicView further author information
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Ondrej SoukupDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic;Biomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech RepublicView further author information
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Kamil KucaBiomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic;Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech RepublicCorrespondence[email protected]
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Pages 971-985 | Received 09 Oct 2016, Accepted 01 Jun 2017, Published online: 06 Jun 2017

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Daniel A. S. Kitagawa, Rafael B. Rodrigues, Thiago N. Silva, Wellington V. dos Santos, Vinicius C. V. da Rocha, Joyce S. F. D. de Almeida, Leandro B. Bernardo, Taynara Carvalho-Silva, Cintia N. Ferreira, Angelo A. T. da Silva, Alessandro B. C. Simas, Eugenie Nepovimova, Kamil Kuča, Tanos C. C. França & Samir F. de A. Cavalcante. (2021) Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1369-1376.
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Parthiban Marimuthu, Yong-Jin Lee, ByungHoon Kim & Seong S. Seo. (2019) In silico approaches to evaluate the molecular properties of organophosphate compounds to inhibit acetylcholinesterase activity in housefly. Journal of Biomolecular Structure and Dynamics 37:2, pages 307-320.
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Nela Váňová, L’ubica Múčková, Tereza Kalíšková, Lukáš Lochman, Petr Bzonek & František Švec. (2023) In Vitro Evaluation of Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in HepG2 Cells. Chemical Research in Toxicology.
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Eliska Prchalova, Zuzana Kohoutova, Karolina Knittelova, David Malinak & Kamil Musilek. (2023) Strategies for enhanced bioavailability of oxime reactivators in the central nervous system. Archives of Toxicology.
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Maciej Noga, Agata Michalska & Kamil Jurowski. (2023) Review of Possible Therapies in Treatment of Novichoks Poisoning and HAZMAT/CBRNE Approaches: State of the Art. Journal of Clinical Medicine 12:6, pages 2221.
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Samir F. de A. Cavalcante, Alessandro B.C. Simas, Marcos C. Barcellos, Kamil Kuča & Tanos Celmar Costa França. 2023. Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects. Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects 659 686 .
Majid Zeinali, Azam Shafaei, Houshang Rafatpanah, Arman Mosavat, Naser Tayebi-Meybodi, Hossein Hosseinzadeh & Seyed Abdolrahim Rezaee. (2022) Potential protective effects of chrysin against immunotoxicity induced by diazinon. Scientific Reports 12:1.
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Guangcai Yu, Yaqian Li, Tianzi Jian, Longke Shi, Siqi Cui, Liwen Zhao, Xiangdong Jian & Baotian Kan. (2022) Clinical Analysis of Acute Organophosphorus Pesticide Poisoning and Successful Cardiopulmonary Resuscitation: A Case Series. Frontiers in Public Health 10.
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Jyothi Dhuguru, Eugene Zviagin & Rachid Skouta. (2022) FDA-Approved Oximes and Their Significance in Medicinal Chemistry. Pharmaceuticals 15:1, pages 66.
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Rauda A. Mohamed, Keat K. Ong, Noor Azilah M. Kasim, Norhana A. Halim, Siti Aminah M. Noor, Victor F. Knight, Nurul Najwa Ab. Rahman & Wan Md Zin W. Yunus. (2021) Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes. Journal of Chemistry 2021, pages 1-16.
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Ruixue Ma, Miao Xu, Chang Liu, Guoyue Shi, Jingjing Deng & Tianshu Zhou. (2020) Stimulus Response of GQD-Sensitized Tb/GMP ICP Nanoparticles with Dual-Responsive Ratiometric Fluorescence: Toward Point-of-Use Analysis of Acetylcholinesterase and Organophosphorus Pesticide Poisoning with Acetylcholinesterase as a Biomarker. ACS Applied Materials & Interfaces 12:37, pages 42119-42128.
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Gisele Lopes Cavalcante, Francislando Nascimento Ferreira, Moisés Tolentino Bento da Silva, Renato Nery Soriano, Antônio Luiz Martins Maia Filho, Daniel Dias Rufino Arcanjo & João Paulo Jacob Sabino. (2020) Acetylcholinesterase inhibition prevents alterations in cardiovascular autonomic control and gastric motility in L-NAME-induced hypertensive rats. Life Sciences 256, pages 117915.
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Martijn C. de Koning, Gabriele Horn, Franz Worek & Marco van Grol. (2020) Synthesis and in vitro evaluation of novel non-oximes for the reactivation of nerve agent inhibited human acetylcholinesterase. Chemico-Biological Interactions 326, pages 109139.
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Maya Kayouka, Pascal Houzé, Marc Lejay, Frédéric J. Baud & Kamil Kuca. (2020) Safety and Efficacy of New Oximes to Reverse Low Dose Diethyl-Paraoxon-Induced Ventilatory Effects in Rats. Molecules 25:13, pages 3056.
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Franz Worek, Horst Thiermann & Timo Wille. (2020) Organophosphorus compounds and oximes: a critical review. Archives of Toxicology 94:7, pages 2275-2292.
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Lijuan Bu, Lei Guo & Jianwei Xie. (2020) An in situ assay of nerve agents enabled by a self-assembled bienzymatic electrochemical biosensor . New Journal of Chemistry 44:18, pages 7460-7466.
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Alexandre A. de Castro, Letícia C. Assis, Flávia V. Soares, Kamil Kuca, Daniel A. Polisel, Elaine F. F. da Cunha & Teodorico C. Ramalho. (2020) Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016–2019). Biomolecules 10:3, pages 436.
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Venkaiah Betapudi, Reena Goswami, Liliya SilayevaDeborah M. DoctorNageswararao Chilukuri. (2020) Gene therapy delivering a paraoxonase 1 variant offers long-term prophylactic protection against nerve agents in mice. Science Translational Medicine 12:527.
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Vyacheslav E. Semenov, Irina V. Zueva, Sofya V. Lushchekina, Oksana A. Lenina, Lilya M. Gubaidullina, Lilya F. Saifina, Marina M. Shulaeva, Ramilya M. Kayumova, Alina F. Saifina, Aidar T. Gubaidullin, Svetlana A. Kondrashova, Shamil K. Latypov, Patrick Masson & Konstantin A. Petrov. (2020) 6-Methyluracil derivatives as peripheral site ligand-hydroxamic acid conjugates: Reactivation for paraoxon-inhibited acetylcholinesterase. European Journal of Medicinal Chemistry 185, pages 111787.
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Kamil Musilek, David Malinak, Eugenie Nepovimova, Rudolf Andrys, Adam Skarka & Kamil Kuca. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 1161 1177 .
Samir F. de A. Cavalcante, Alessandro B. C. Simas & Kamil Kuča. (2019) Nerve Agents’ Surrogates: Invaluable Tools for Development of Acetylcholinesterase Reactivators. Current Organic Chemistry 23:14, pages 1539-1559.
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Lukas Gorecki, Lucie Junova, Tomas Kucera, Vendula Hepnarova, Lukas Prchal, Tereza Kobrlova, Lubica Muckova, Ondrej Soukup & Jan Korabecny. (2019) Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase. Future Medicinal Chemistry 11:20, pages 2625-2634.
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Sandip B. Bharate, Chih-Kai Chao & Charles M. Thompson. (2019) Comparison of the reactivation rates of acetylcholinesterase modified by structurally different organophosphates using novel pyridinium oximes. Environmental Toxicology and Pharmacology 71, pages 103218.
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Tereza Kobrlova, Jan Korabecny & Ondrej Soukup. (2019) Current approaches to enhancing oxime reactivator delivery into the brain. Toxicology 423, pages 75-83.
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Lukas Gorecki, Ondrej Soukup, Tomas Kucera, David Malinak, Daniel Jun, Kamil Kuca, Kamil Musilek & Jan Korabecny. (2018) Oxime K203: a drug candidate for the treatment of tabun intoxication. Archives of Toxicology 93:3, pages 673-691.
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Martijn Constantijn de Koning, Gabriele Horn, Franz Worek & Marco van Grol. (2018) Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase. European Journal of Medicinal Chemistry 157, pages 151-160.
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Hiroyuki Ohbe, Taisuke Jo, Hiroki Matsui, Kiyohide Fushimi & Hideo Yasunaga. (2018) Cholinergic Crisis Caused by Cholinesterase Inhibitors: a Retrospective Nationwide Database Study. Journal of Medical Toxicology 14:3, pages 237-241.
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