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Expert Opinion on Therapeutic Patents Volume 28, 2018 - Issue 2
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Review

Saffron and its derivatives, crocin, crocetin and safranal: a patent review

Maryam RameshradDepartment of Pharmacodynamics and Toxicology, Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranView further author information
,
Bibi Marjan RazaviTargeted Drug Delivery Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranView further author information
&
Hossein HosseinzadehPharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-7755-2204View further author information
ORCID Icon
Pages 147-165 | Received 13 May 2017, Accepted 12 Jul 2017, Published online: 18 Jul 2017

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Xiao-Chun Zhou, Yao-Jun Liang, Long Qin, Guo-Hua Wei & Jian-Qin Wang. (2021) Astragalus–Saffron–Rhubarb Mixture Delays the Progress of Diabetic Nephropathy in db/db Mice. Diabetes, Metabolic Syndrome and Obesity 14, pages 4679-4690.
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Daniel Hill, Chiara Compagnoni & M. Francesca Cordeiro. (2021) Investigational neuroprotective compounds in clinical trials for retinal disease. Expert Opinion on Investigational Drugs 30:5, pages 571-577.
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Arezoo Rajabian, Maryam Rameshrad & Hossein Hosseinzadeh. (2019) Therapeutic potential of Panax ginseng and its constituents, ginsenosides and gintonin, in neurological and neurodegenerative disorders: a patent review. Expert Opinion on Therapeutic Patents 29:1, pages 55-72.
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Sathish Kumar Mungamuri & Yamini Javvadi. 2020. Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers. Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers 261 285 .
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Crossref
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