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Giulio Poli, Margherita Lapillo, Vibhu Jha, Nayla Mouawad, Isabella Caligiuri, Marco Macchia, Filippo Minutolo, Flavio Rizzolio, Tiziano Tuccinardi & Carlotta Granchi. (2019) Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 589-596.
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Yingfang He, Uwe Grether, Marco F. Taddio, Carla Meier, Claudia Keller, Martin R. Edelmann, Michael Honer, Sylwia Huber, Matthias B. Wittwer, Dominik Heer, Hans Richter, Ludovic Collin, Melanie N. Hug, Manuel Hilbert, Annemarieke G.J. Postmus, Anna Floor Stevens, Mario van der Stelt, Stefanie D. Krämer, Roger Schibli, Linjing Mu & Luca C. Gobbi. (2022) Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain. European Journal of Medicinal Chemistry, pages 114750.
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Francesca Galvani, Laura Scalvini, Silvia Rivara, Alessio Lodola & Marco Mor. (2022) Mechanistic Modeling of Monoglyceride Lipase Covalent Modification Elucidates the Role of Leaving Group Expulsion and Discriminates Inhibitors with High and Low Potency. Journal of Chemical Information and Modeling 62:11, pages 2771-2787.
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Dongming Lan, Shu Li, Wei Tang, Zexin Zhao, Mupeng Luo, Shuguang Yuan, Jun Xu & Yonghua Wang. (2021) Glycerol is Released from a New Path in MGL Lipase Catalytic Process. Journal of Chemical Information and Modeling 62:9, pages 2248-2256.
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Jing Wang, Hongwei Xu, Tianjie Chen, Changqin Xu, Xiaohua Zhang & Shulei Zhao. (2022) Effect of Monoacylglycerol Lipase Inhibition on Intestinal Permeability of Rats With Severe Acute Pancreatitis. Frontiers in Pharmacology 13.
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Shivanshu Bajaj, Saima Zameer, Shreshta Jain, Vaishali Yadav & Divya Vohora. (2022) Effect of the MAGL/FAAH Dual Inhibitor JZL-195 on Streptozotocin-Induced Alzheimer’s Disease-like Sporadic Dementia in Mice with an Emphasis on Aβ, HSP-70, Neuroinflammation, and Oxidative Stress. ACS Chemical Neuroscience 13:7, pages 920-932.
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Yingfang He, Matthias Schild, Uwe Grether, Jörg Benz, Lea Leibrock, Dominik Heer, Andreas Topp, Ludovic Collin, Bernd Kuhn, Matthias Wittwer, Claudia Keller, Luca C. Gobbi, Roger Schibli & Linjing Mu. (2022) Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging. Journal of Medicinal Chemistry 65:3, pages 2191-2207.
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Shuhei Ikeda, Hideyuki Sugiyama, Hidekazu Tokuhara, Masataka Murakami, Minoru Nakamura, Yuya Oguro, Jumpei Aida, Nao Morishita, Satoshi Sogabe, Douglas R. Dougan, Sean C. Gay, Ling Qin, Naoto Arimura, Yasuko Takahashi, Masako Sasaki, Yusuke Kamada, Kazunobu Aoyama, Kouya Kimoto & Makoto Kamata. (2021)
Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2
H
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Giulia Bononi, Tiziano Tuccinardi, Flavio Rizzolio & Carlotta Granchi. (2021) α/β-Hydrolase Domain (ABHD) Inhibitors as New Potential Therapeutic Options against Lipid-Related Diseases. Journal of Medicinal Chemistry 64:14, pages 9759-9785.
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