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Review

A patent review of immunoproteasome inhibitors

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Pages 517-540 | Received 20 Mar 2018, Accepted 22 May 2018, Published online: 14 Jun 2018

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Yu Cao, Huajian Zhu, Ruoyu He, Limin Kong, Jiaan Shao, Rangxiao Zhuang, Jianjun Xi & Jiankang Zhang. (2020) Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer. Drug Design, Development and Therapy 14, pages 4327-4342.
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Yunxuan Li, Guanglei Nan, Xianxin Hou, Yechao Yan, Yajun Yang, Ying Yang, Ke Li & Zhiyan Xiao. (2023) Non-peptidic immunoproteasome β5i-selective inhibitor as potential treatment for idiopathic pulmonary fibrosis: Virtual screening, hit evolution and lead identification. European Journal of Medicinal Chemistry 261, pages 115856.
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Grazia R. Tundo, Paolo Cascio, Danilo Milardi, Anna Maria Santoro, Grazia Graziani, Pedro Miguel Lacal, Alessio Bocedi, Francesco Oddone, Mariacristina Parravano, Andrea Coletta, Massimo Coletta & Diego Sbardella. (2023) Targeting immunoproteasome in neurodegeneration: A glance to the future. Pharmacology & Therapeutics 241, pages 108329.
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Po-Wen Tu, Jie-Siang Chiu, Chih Lin, Chih-Cheng Chien, Feng-Chia Hsieh, Ming-Che Shih & Yu-Liang Yang. (2022) Evaluation of the Antifungal Activities of Photorhabdus akhurstii and Its Secondary Metabolites against Phytopathogenic Colletotrichum gloeosporioides. Journal of Fungi 8:4, pages 403.
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Guanglei Nan, Lei Huang, Yunxuan Li, Yajun Yang, Ying Yang, Ke Li, Fangfang Lai, Xiaoguang Chen & Zhiyan Xiao. (2022) Identification of N, C-capped di- and tripeptides as selective immunoproteasome inhibitors. European Journal of Medicinal Chemistry 234, pages 114252.
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Vasudha TandonRuturajsinh M. Vala, Albert ChenRobert L. SahHitendra M. Patel, Michael C. PirrungSourav Banerjee. (2022) Syrbactin-class dual constitutive- and immuno-proteasome inhibitor TIR-199 impedes myeloma-mediated bone degeneration in vivo . Bioscience Reports 42:2.
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Grazia R. Tundo, Diego Sbardella, Francesco Oddone, Anna A. Kudriaeva, Pedro M. Lacal, Alexey A. BelogurovJr.Jr., Grazia Graziani & Stefano Marini. (2021) At the Cutting Edge against Cancer: A Perspective on Immunoproteasome and Immune Checkpoints Modulation as a Potential Therapeutic Intervention. Cancers 13:19, pages 4852.
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Min Jae Lee, Deepak Bhattarai, Hyeryung Jang, Ahreum Baek, In Jun Yeo, Seongsoo Lee, Zachary Miller, Sukyeong Lee, Jin Tae Hong, Dong-Eun Kim, Wooin Lee & Kyung Bo Kim. (2021) Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer’s Disease. Journal of Medicinal Chemistry 64:15, pages 10934-10950.
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Levente Kollár, Martina Gobec, Bence Szilágyi, Matic Proj, Damijan Knez, Péter Ábrányi-Balogh, László Petri, Tímea Imre, Dávid Bajusz, György G. Ferenczy, Stanislav Gobec, György M. Keserű & Izidor Sosič. (2021) Discovery of selective fragment-sized immunoproteasome inhibitors. European Journal of Medicinal Chemistry 219, pages 113455.
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Eva Shannon Schiffrer, Matic Proj, Martina Gobec, Luka Rejc, Andrej Šterman, Janez Mravljak, Stanislav Gobec & Izidor Sosič. (2021) Synthesis and Biochemical Evaluation of Warhead-Decorated Psoralens as (Immuno)Proteasome Inhibitors. Molecules 26:2, pages 356.
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Piotr Karabowicz, Adam Wroński, Halina Ostrowska, Georg Waeg, Neven Zarkovic & Elżbieta Skrzydlewska. (2020) Reduced Proteasome Activity and Enhanced Autophagy in Blood Cells of Psoriatic Patients. International Journal of Molecular Sciences 21:20, pages 7608.
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Deepak Bhattarai, Min Jae Lee, Ahruem Baek, In Jun Yeo, Zachary Miller, Yu Mi Baek, Sukyeong Lee, Dong-Eun Kim, Jin Tae Hong & Kyung Bo Kim. (2020) LMP2 Inhibitors as a Potential Treatment for Alzheimer’s Disease. Journal of Medicinal Chemistry 63:7, pages 3763-3783.
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Kaja Rožman, Evan M. Alexander, Eva Ogorevc, Krištof Bozovičar, Izidor Sosič, Courtney C. Aldrich & Stanislav Gobec. (2020) Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome. Molecules 25:6, pages 1305.
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Jianjun Xi, Rangxiao Zhuang, Limin Kong, Ruoyu He, Huajian Zhu & Jiankang Zhang. (2019) Immunoproteasome-selective inhibitors: An overview of recent developments as potential drugs for hematologic malignancies and autoimmune diseases. European Journal of Medicinal Chemistry 182, pages 111646.
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Nicolas Albornoz, Hianara Bustamante, Andrea Soza & Patricia Burgos. (2019) Cellular Responses to Proteasome Inhibition: Molecular Mechanisms and Beyond. International Journal of Molecular Sciences 20:14, pages 3379.
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Daqiang Li, Xiaotuan Zhang, Xiaodong Ma, Lei Xu, Jianjun Yu, Lixin Gao, Xiaobei Hu, Jiankang Zhang, Xiaowu Dong, Jia Li, Tao Liu, Yubo Zhou & Yongzhou Hu. (2018) Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors. Journal of Medicinal Chemistry 61:20, pages 9177-9204.
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Deepak Bhattarai, Min Jae Lee, Ahruem Baek, Zi Soo Yoo, Zachary Miller, Yu Mi Baek, In Jun Yeo, Jin Tae Hong, Sukyeong Lee, Wooin Lee, Dong-Eun Kim & Kyung Bo Kim. (2019) CNS-penetrant LMP2 Inhibitors as Potential Therapies for Age-related Macular Degeneration. SSRN Electronic Journal.
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