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Expert Opinion on Therapeutic Patents Volume 29, 2019 - Issue 1
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Review

Current state on tryptophan 2,3-dioxygenase inhibitors: a patent review

Arina KozlovaMedicinal Chemistry Research Group (CMFA), Louvain Drug Research Institute (LDRI), Université Catholique de Louvain (UCLouvain), Brussels, BelgiumView further author information
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Raphaël FrédérickMedicinal Chemistry Research Group (CMFA), Louvain Drug Research Institute (LDRI), Université Catholique de Louvain (UCLouvain), Brussels, BelgiumCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-8119-1272View further author information
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Pages 11-23 | Received 09 Oct 2018, Accepted 04 Dec 2018, Published online: 16 Jan 2019

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Fanni Annamária Boros & László Vécsei. (2021) Tryptophan 2,3-dioxygenase, a novel therapeutic target for Parkinson’s disease. Expert Opinion on Therapeutic Targets 25:10, pages 877-888.
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Michele Coluccia, Daniela Secci & Paolo Guglielmi. 2024. Metalloenzymes. Metalloenzymes 485 519 .
Pengbo Yang & Junhua Zhang. (2023) Indoleamine 2,3-Dioxygenase (IDO) Activity: A Perspective Biomarker for Laboratory Determination in Tumor Immunotherapy. Biomedicines 11:7, pages 1988.
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Chengcao Sun, Youqiong Ye, Zhi Tan, Yuan Liu, Yajuan Li, Wei HuKe LiangSergey D. EgranovLisa Angela HuangZhao Zhang, Yaohua Zhang, Jun Yao, Tina K. NguyenZilong Zhao, Andrew Wu, Jeffrey R. Marks, Abigail S. CaudleAysegul A. SahinJianjun Gao, Seth T. Gammon, David Piwnica-Worms, Jian Hu, Paul J. ChiaoDihua Yu, Mien-Chie Hung, Michael A. Curran, George A. CalinHaoqiang Ying, Leng Han, Chunru Lin & Liuqing Yang. (2023) Tumor-associated nonmyelinating Schwann cell–expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion . Science Advances 9:5.
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Cui Huo, Zongyuan Luo, Xiangli Ning, Xin Kang, Qin Yan, Yuying Guo, Guobo Li, Zhouyu Wang, Yuzhi Li & Shan Qian. (2022) 4,6-Disubstituted-1H-Indazole-4-Amine derivatives with immune-chemotherapy effect and in vivo antitumor activity. European Journal of Medicinal Chemistry 241, pages 114625.
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Andrea Mammoli, Alessandra Riccio, Elisa Bianconi, Alice Coletti, Emidio Camaioni & Antonio Macchiarulo. (2021) One Key and Multiple Locks: Substrate Binding in Structures of Tryptophan Dioxygenases and Hydroxylases. ChemMedChem 16:18, pages 2732-2743.
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Arina Kozlova, Léopold Thabault, Maxime Liberelle, Simon Klaessens, Julien R. C. Prévost, Caroline Mathieu, Luc Pilotte, Vincent Stroobant, Benoît Van den Eynde & Raphaël Frédérick. (2021) Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase. Journal of Medicinal Chemistry 64:15, pages 10967-10980.
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Xiang-Li Ning, Yu-Zhi Li, Cui Huo, Ji Deng, Cheng Gao, Kai-Rong Zhu, Miao Wang, Yu-Xiang Wu, Jun-Lin Yu, Ya-Li Ren, Zong-Yuan Luo, Gen Li, Yang Chen, Si-Yao Wang, Cheng Peng, Ling-Ling Yang, Zhou-Yu Wang, Yong Wu, Shan Qian & Guo-Bo Li. (2021) X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson’s Disease. Journal of Medicinal Chemistry 64:12, pages 8303-8332.
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Małgorzata Kiluk, Janina Lewkowicz, Dariusz Pawlak & Anna Tankiewicz-Kwedlo. (2021) Crosstalk between Tryptophan Metabolism via Kynurenine Pathway and Carbohydrate Metabolism in the Context of Cardio-Metabolic Risk—Review. Journal of Clinical Medicine 10:11, pages 2484.
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Flóra John, Sharon K. Michelhaugh, Geoffrey R. Barger, Sandeep Mittal & Csaba Juhász. (2020) Depression and tryptophan metabolism in patients with primary brain tumors: Clinical and molecular imaging correlates. Brain Imaging and Behavior 15:2, pages 974-985.
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Marta Cecchi, Sara Paccosi, Angela Silvano, Ali Hussein Eid & Astrid Parenti. (2021) Dexamethasone Induces the Expression and Function of Tryptophan-2-3-Dioxygenase in SK-MEL-28 Melanoma Cells. Pharmaceuticals 14:3, pages 211.
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Minah Kim & Petr Tomek. (2021) Tryptophan: A Rheostat of Cancer Immune Escape Mediated by Immunosuppressive Enzymes IDO1 and TDO. Frontiers in Immunology 12.
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Sara Paccosi, Marta Cecchi, Angela Silvano, Sergio Fabbri & Astrid Parenti. (2020) Different effects of tryptophan 2,3-dioxygenase inhibition on SK-Mel-28 and HCT-8 cancer cell lines. Journal of Cancer Research and Clinical Oncology 146:12, pages 3155-3163.
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Shanbao Li, Junyong Weng, Fangbin Song, Lei Li, Chao Xiao, Weiqiang Yang & Junming Xu. (2020) Circular RNA circZNF566 promotes hepatocellular carcinoma progression by sponging miR-4738-3p and regulating TDO2 expression. Cell Death & Disease 11:6.
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Christiane A. Opitz, Luis F. Somarribas Patterson, Soumya R. Mohapatra, Dyah L. Dewi, Ahmed Sadik, Michael Platten & Saskia Trump. (2019) The therapeutic potential of targeting tryptophan catabolism in cancer. British Journal of Cancer 122:1, pages 30-44.
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