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Review

Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors: an updated patent review (2016-2018)

Pages 243-259 | Received 15 Dec 2018, Accepted 18 Mar 2019, Published online: 29 Mar 2019

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Chao Wang, Yujing Zhang, Tingting Zhang, Lingyu Shi, Zhongmin Geng & Dongming Xing. (2022) Proteolysis-targeting chimaeras (PROTACs) as pharmacological tools and therapeutic agents: advances and future challenges. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1667-1693.
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Andrew B. Benowitz, Katherine L. Jones & John D. Harling. (2021) The therapeutic potential of PROTACs. Expert Opinion on Therapeutic Patents 31:1, pages 1-24.
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Michael D. Wiese, Arkady T. Manning-Bennett & Ahmad Y. Abuhelwa. (2020) Investigational IRAK-4 inhibitors for the treatment of rheumatoid arthritis. Expert Opinion on Investigational Drugs 29:5, pages 475-482.
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Fleur M. Ferguson. (2023) PROTACs reach clinical development in inflammatory skin disease. Nature Medicine.
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Yun Chen, Yi Ning, Zhiwei Chen, Yaping Xue, Qingyun Wu, Wenhu Duan, Jian Ding, Jinpei Zhou, Hua Xie & Huibin Zhang. (2023) Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma. European Journal of Medicinal Chemistry 256, pages 115453.
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Vijayakumar Gosu, Santanu Sasidharan, Prakash Saudagar, Kamalakannan Radhakrishnan, Hak-Kyo Lee & Donghyun Shin. (2023) Deciphering the intrinsic dynamics of unphosphorylated IRAK4 kinase bound to type I and type II inhibitors. Computers in Biology and Medicine 160, pages 106978.
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Yongjin Hao, Jin Wang, Jiawan Ma, Xiaoliang Yu, Zhanhui Li, Shuwei Wu, Sheng Tian, Haikuo Ma, Sudan He & Xiaohu Zhang. (2023) Design, synthesis, evaluation and optimization of potent IRAK4 inhibitors alleviating production of inflammatory cytokines in LPS-induced SIRS model. Bioorganic Chemistry, pages 106584.
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Saynaz A. Choudhary, Debarun Patra, Archana Sinha, Sayani Mazumder, Rajat Pant, Raju Chouhan, Anupam Nath Jha, Biswa Mohan Prusty, Debasis Manna, Sajal K. Das, Kulbhushan Tikoo, Durba Pal & Suman Dasgupta. (2023) A small molecule potent IRAK4 inhibitor abrogates lipopolysaccharide-induced macrophage inflammation in-vitro and in-vivo. European Journal of Pharmacology 944, pages 175593.
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César A. Zapata‐Acevedo, José Manuel Guevara‐Vela, Paul L. A. Popelier & Tomás Rocha‐Rinza. (2022) Binding Energy Partition of Promising IRAK‐4 Inhibitor (Zimlovisertib) for the Treatment of COVID‐19 Pneumonia. ChemPhysChem 23:24.
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Swapnil P. Bhujbal, Weijie He & Jung-Mi Hah. (2022) Design of Novel IRAK4 Inhibitors Using Molecular Docking, Dynamics Simulation and 3D-QSAR Studies. Molecules 27:19, pages 6307.
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Tingting Yao, Heng Xiao, Hong Wang & Xiaowei Xu. (2022) Recent Advances in PROTACs for Drug Targeted Protein Research. International Journal of Molecular Sciences 23:18, pages 10328.
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Qianqian Li, Rui Li, Hanlin Yin, Suli Wang, Bei Liu, Jun Li, Mi Zhou, Qingran Yan & Liangjing Lu. (2022) Oral IRAK4 inhibitor BAY-1834845 prevents acute respiratory distress syndrome. Biomedicine & Pharmacotherapy 153, pages 113459.
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Iain A. Cumming, Sébastien L. Degorce, Anna Aagaard, Erin L. Braybrooke, Nichola L. Davies, Coura R. Diène, Andrew J. Eatherton, Hannah R. Felstead, Sam D. Groombridge, Eva M. Lenz, Yunxia Li, Youfeng Nai, Stuart Pearson, Graeme R. Robb, James S. Scott, Oliver R. Steward, Chengyan Wu, Yafeng Xue, Lanping Zhang & Yanxiu Zhang. (2022) Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors. Bioorganic & Medicinal Chemistry 63, pages 116729.
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Alexander Spasov, Vadim Kosolapov, Denis Babkov, Vladlen Klochkov, Elena Sokolova, Mikhail Miroshnikov, Alexander Borisov, Yulia Velikorodnaya, Alexey Smirnov, Konstantin Savateev, Victor Fedotov, Svetlana Kotovskaya & Vladimir Rusinov. (2022) Discovery of Nitro-azolo[1,5-a]pyrimidines with Anti-Inflammatory and Protective Activity against LPS-Induced Acute Lung Injury. Pharmaceuticals 15:5, pages 537.
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