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Tingxun Lu, Jie Zhang, Jenna M. McCracken & Ken H. Young. (2024) Recent advances in genomics and therapeutics in mantle cell lymphoma. Cancer Treatment Reviews 122, pages 102651.
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Liang Zhang, Chenhai Xia, Yongjun Yang, Fangfang Sun, Yu Zhang, Huan Wang, Rui Liu & Ming Yuan. (2023) DNA methylation and histone post-translational modifications in atherosclerosis and a novel perspective for epigenetic therapy. Cell Communication and Signaling 21:1.
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Zhijie Wang, Donglin Wu, Xiaofei Zhao, Canlin Liu, Siming Jia, Qindi He, Fei Huang, Zitian Cheng, Tao Lu, Yadong Chen, Yun Chen, Pei Yang & Shuai Lu. (2023) Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy. European Journal of Medicinal Chemistry 260, pages 115759.
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Baiyin Zhong, Qicheng Liao, Xin Wang, Xiaonong Wang & Jianhong Zhang. (2023) The roles of epigenetic regulation in cholangiocarcinogenesis. Biomedicine & Pharmacotherapy 166, pages 115290.
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Xin Xie, Nan Zhang, Xiang Li, He Huang, Cheng Peng, Wei Huang, Leonard J. Foster, Gu He & Bo Han. (2023) Small-molecule dual inhibitors targeting heat shock protein 90 for cancer targeted therapy. Bioorganic Chemistry 139, pages 106721.
Crossref
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Tingxun Lu, Jie Zhang, Zijun Y. Xu-Monette & Ken H. Young. (2023) The progress of novel strategies on immune-based therapy in relapsed or refractory diffuse large B-cell lymphoma. Experimental Hematology & Oncology 12:1.
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Mehdi Sanati, Amir R. Afshari, Seyed Sajad Ahmadi, Prashant Kesharwani & Amirhossein Sahebkar. (2023) Aptamers against cancer drug resistance: Small fighters switching tactics in the face of defeat. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1869:6, pages 166720.
Crossref
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Zhe Liu, Jiahui Liu, Wanning Wang, Xingna An, Ling Luo, Dehai Yu & Weixia Sun. (2023) Epigenetic modification in diabetic kidney disease. Frontiers in Endocrinology 14.
Crossref
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Ryuhei Nagata, Makoto Nishiyama & Tomohisa Kuzuyama. (2023) Substrate Recognition Mechanism of a Trichostatin A-Forming Hydroxyamidotransferase. Biochemistry 62:12, pages 1833-1837.
Crossref
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Omnia R Elbatrawy, Moshira A El Deeb, Mohamed Hagras, Fatimah Agili, Maghawry Hegazy, Ahmed A El-Husseiny, Mohamed A Elkady, Ibrahim H Eissa & Samar El-Kalyoubi. (2023) New thiouracil derivatives as histone deacetylase inhibitors and apoptosis inducers: design, synthesis and anticancer evaluation. Future Medicinal Chemistry 15:12, pages 1019-1035.
Crossref
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Jiyong Wu, Jing Nie, Yepeng Luan & Yanjiao Ding. (2023) Hybrid Histone Deacetylase Inhibitor: An Effective Strategy for
Cancer Therapy. Current Medicinal Chemistry 30:20, pages 2267-2311.
Crossref
Crossref
Chen Shen, Mei Li, Yujuan Duan, Xin Jiang, Xiaoming Hou, Fulai Xue, Yinan Zhang & Yao Luo. (2023) HDAC inhibitors enhance the anti-tumor effect of immunotherapies in hepatocellular carcinoma. Frontiers in Immunology 14.
Crossref
Crossref
Dilipkumar Pal, Khushboo Raj, Shyam Sundar Nandi, Surajit Sinha, Abhishek Mishra, Arijit Mondal, Ricardo Lagoa, Jack T. Burcher & Anupam Bishayee. (2023) Potential of Synthetic and Natural Compounds as Novel Histone Deacetylase Inhibitors for the Treatment of Hematological Malignancies. Cancers 15:10, pages 2808.
Crossref
Crossref
Hossein Javid, Alireza Sharbaf Mashhad, Shaghayegh Yazdani, Mahsa Akbari Oryani, Sanaz Akbari, Nastaran Rezagholinejad, Mahboubeh Tajaldini & Mehdi Karimi‐Shahri. (2023) The role of viruses in cancer development versus cancer therapy: An oncological perspective. Cancer Medicine 12:10, pages 11127-11148.
Crossref
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Sun Ju Kong, Gibeom Nam, Pulla Reddy Boggu, Gi Min Park, Ji Eun Kang, Hyun-Ju Park & Young Hoon Jung. (2023) Synthesis and biological evaluation of novel N-benzyltriazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors. Bioorganic & Medicinal Chemistry 79, pages 117154.
Crossref
Crossref
Liping Yang, Shengchuan Chen, Jingyan Xia, Ying Zhou, Linan Peng, Huimin Fan, Yu Han, Lihua Duan, Genhong Cheng, Heng Yang & Feng Xu. (2022) Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection. Cell & Bioscience 12:1.
Crossref
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Liyun Zhao, Qi Liang, Ye He, Maoyu Liu, Rongsheng Tong, Zhongliang Jiang, Wenjing Wang & Jianyou Shi. (2022) HDAC/JAK dual target inhibitors of cancer-related targets: The success of nonclearable linked pharmacophore mode. Bioorganic Chemistry 129, pages 106181.
Crossref
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Swasti Lavania & Bijan Choudhury. (2022) Improvement of amidase production with high specific acyltransferase activity using Bacillus smithii IITR6B2. Biocatalysis and Agricultural Biotechnology, pages 102584.
Crossref
Crossref
Riyun Yang, Jingying Pan, Yankai Wang, Panhui Xia, Mingliang Tai, Zhihao Jiang & Gang Chen. (2022) Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment. Frontiers in Cellular Neuroscience 16.
Crossref
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Md Lutfor Rahman, Mohd Sani Sarjadi, Shaheen M. Sarkar, Daniel J. Walsh & John J. Hannan. (2022) Poly(hydroxamic acid) resins and their applications. Coordination Chemistry Reviews 471, pages 214727.
Crossref
Crossref
Chidvilas Kurapati, Kalyani Paidikondala, Vishnu Nayak Badavath, Sabnam Parveen, Om V. Singh & Rambabu Gundla. (2022)
Design, and synthesis of
N
‐benzyl spiro‐piperidine hydroxamic acid‐based derivatives: Histone deacetylase inhibitory activity and drug‐likeness prediction
. Journal of Heterocyclic Chemistry 59:11, pages 2006-2015.
Crossref
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Benjamin Groth, Chi-Chun Huang & Su-Ju Lin. (2022) The histone deacetylases Rpd3 and Hst1 antagonistically regulate de novo NAD+ metabolism in the budding yeast Saccharomyces cerevisiae. Journal of Biological Chemistry 298:10, pages 102410.
Crossref
Crossref
Jingru Yang, Cong Song & Xianquan Zhan. (2022) The role of protein acetylation in carcinogenesis and targeted drug discovery. Frontiers in Endocrinology 13.
Crossref
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Junru Chen, Xueqing Huang, Zhi Huang & Yu Cao. (2022) Activated Hepatic Stellate Cells Promote the M1 to M2 Macrophage Transformation and Liver Fibrosis by Elevating the Histone Acetylation Level. Disease Markers 2022, pages 1-8.
Crossref
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Yongjie Xu, Haizhi Li, Gang Chen, Liying Zhu, Hairong Lin, Changyudong Huang, Sijia Wei, Tingting Yang, Wen Qian, Xing Li, Shuyun Zhao & Wei Pan. (2022) Radix polygoni multiflori protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting the HDAC4/JNK pathway. Biomedicine & Pharmacotherapy 153, pages 113427.
Crossref
Crossref
Zheng Jian, Yichao Han, Wentian Zhang, Chengqiang Li, Wei Guo, Xijia Feng, Bin Li & Hecheng Li. (2022) Anti-tumor effects of dual PI3K-HDAC inhibitor CUDC-907 on activation of ROS-IRE1α-JNK-mediated cytotoxic autophagy in esophageal cancer. Cell & Bioscience 12:1.
Crossref
Crossref
Margarita E. Neganova, Sergey G. Klochkov, Yulia R. Aleksandrova & Gjumrakch Aliev. (2022) Histone modifications in epigenetic regulation of cancer: Perspectives and achieved progress. Seminars in Cancer Biology 83, pages 452-471.
Crossref
Crossref
Yuefeng Qin, Yang Liang, Guoyun Jiang, Yuhang Peng & Wenli Feng. (2022) ACY-1215 suppresses the proliferation and induces apoptosis of chronic myeloid leukemia cells via the ROS/PTEN/Akt pathway. Cell Stress and Chaperones 27:4, pages 383-396.
Crossref
Crossref
Dóra Laczi, Mark D. Johnstone & Cassandra L. Fleming. (2022) Photoresponsive Small Molecule Inhibitors for the Remote Control of Enzyme Activity. Chemistry – An Asian Journal 17:11.
Crossref
Crossref
Davide Moi, Andrea Citarella, Davide Bonanni, Luca Pinzi, Daniele Passarella, Alessandra Silvani, Clelia Giannini & Giulio Rastelli. (2022) Synthesis of potent and selective HDAC6 inhibitors led to unexpected opening of a quinazoline ring. RSC Advances 12:18, pages 11548-11556.
Crossref
Crossref
Kang‐Nan Wang, Liu‐Yi Liu, Duo Mao, Ming‐Xuan Hou, Cai‐Ping Tan, Zong‐Wan Mao & Bin Liu. (2022) A Nuclear‐Targeted AIE Photosensitizer for Enzyme Inhibition and Photosensitization in Cancer Cell Ablation. Angewandte Chemie International Edition 61:15.
Crossref
Crossref
Kang‐Nan Wang, Liu‐Yi Liu, Duo Mao, Ming‐Xuan Hou, Cai‐Ping Tan, Zong‐Wan Mao & Bin Liu. (2022) A Nuclear‐Targeted AIE Photosensitizer for Enzyme Inhibition and Photosensitization in Cancer Cell Ablation. Angewandte Chemie 134:15.
Crossref
Crossref
Eftiola Pojani & Daniela Barlocco. (2022) Selective Inhibitors of Histone Deacetylase 10 (HDAC-10). Current Medicinal Chemistry 29:13, pages 2306-2321.
Crossref
Crossref
Yukihiro Itoh, Yuri Takada, Yasunobu Yamashita & Takayoshi Suzuki. (2022) Recent progress on small molecules targeting epigenetic complexes. Current Opinion in Chemical Biology 67, pages 102130.
Crossref
Crossref
Davide Bonanni, Andrea Citarella, Davide Moi, Luca Pinzi, Elisa Bergamini & Giulio Rastelli. (2022) Dual Targeting Strategies on Histone Deacetylase 6 (HDAC6) and Heat Shock Protein 90 (Hsp90). Current Medicinal Chemistry 29:9, pages 1474-1502.
Crossref
Crossref
Yongpan Li, Jujia Zheng, Qiang Huo, Zhongchao Chen, Jun Chen & Xiangwei Xu. (2022) Chidamide Suppresses the Growth of Cholangiocarcinoma by Inhibiting HDAC3 and Promoting FOXO1 Acetylation. Stem Cells International 2022, pages 1-15.
Crossref
Crossref
Xingrui He, Zi Hui, Li Xu, Renren Bai, Yuan Gao, Zongcheng Wang, Tian Xie & Xiang-Yang Ye. (2022) Medicinal chemistry updates of novel HDACs inhibitors (2020 to present). European Journal of Medicinal Chemistry 227, pages 113946.
Crossref
Crossref
Hsueh-Yun Lee, Di-Wei Tang, Chi-Yuan Liu & Er-Chieh Cho. (2022) A novel HDAC1/2 inhibitor suppresses colorectal cancer through apoptosis induction and cell cycle regulation. Chemico-Biological Interactions 352, pages 109778.
Crossref
Crossref
Samaneh Zolghadri, Ali Ghanbariasad, Fatemeh Fallahian, Mahdie Rahban, Mahsa Kalavani, Enayatollah Bahman Jahromi, Azizeh Asadzadeh & Maliheh Hajiani. (2021) Anticancer activity of N-heteroaryl acetic acid salts against breast cancer; in silico and in vitro investigation. Molecular Biology Reports 49:1, pages 363-372.
Crossref
Crossref
Wen Li, Feifei Li, Xia Zhang, Hui-Kuan Lin & Chuan Xu. (2021) Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment. Signal Transduction and Targeted Therapy 6:1.
Crossref
Crossref
Giovanni Sandrone, Cyprian D. Cukier, Karol Zrubek, Mattia Marchini, Barbara Vergani, Gianluca Caprini, Gianluca Fossati, Christian Steinkühler & Andrea Stevenazzi. (2021) Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors. ACS Medicinal Chemistry Letters 12:11, pages 1810-1817.
Crossref
Crossref
Ankita Sharma, Rafeeq Mir & Sanjeev Galande. (2021) Epigenetic Regulation of the Wnt/β-Catenin Signaling Pathway in Cancer. Frontiers in Genetics 12.
Crossref
Crossref
Manpreet Kaur, Vikrant Mehta, Aabid Abdullah Wani, Sahil Arora, Prasad V. Bharatam, Ashoke Sharon, Sandeep Singh & Raj Kumar. (2021) Synthesis of 1,4-dihydropyrazolo[4,3-b]indoles via intramolecular C(sp2)-N bond formation involving nitrene insertion, DFT study and their anticancer assessment. Bioorganic Chemistry 114, pages 105114.
Crossref
Crossref
Andrea Citarella, Davide Moi, Luca Pinzi, Davide Bonanni & Giulio Rastelli. (2021) Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications. ACS Omega 6:34, pages 21843-21849.
Crossref
Crossref
Bartosz Bieszczad, Damian Garbicz, Marta Świtalska, Marta K. Dudek, Dawid Warszycki, Joanna Wietrzyk, Elżbieta Grzesiuk & Adam Mieczkowski. (2021) Improved HDAC Inhibition, Stronger Cytotoxic Effect and Higher Selectivity against Leukemias and Lymphomas of Novel, Tricyclic Vorinostat Analogues. Pharmaceuticals 14:9, pages 851.
Crossref
Crossref
Anton Frühauf & Franz-Josef Meyer-Almes. (2021) Non-Hydroxamate Zinc-Binding Groups as Warheads for Histone Deacetylases. Molecules 26:17, pages 5151.
Crossref
Crossref
Qiong Wu, Anders E. Berglund & Arnold B. Etame. (2021) The Impact of Epigenetic Modifications on Adaptive Resistance Evolution in Glioblastoma. International Journal of Molecular Sciences 22:15, pages 8324.
Crossref
Crossref
Annalisa Chianese, Biagio Santella, Annalisa Ambrosino, Debora Stelitano, Luca Rinaldi, Massimiliano Galdiero, Carla Zannella & Gianluigi Franci. (2021) Oncolytic Viruses in Combination Therapeutic Approaches with Epigenetic Modulators: Past, Present, and Future Perspectives. Cancers 13:11, pages 2761.
Crossref
Crossref
Y. Zhang. (2021) Meet Our Editorial Board Member. Anti-Cancer Agents in Medicinal Chemistry 21:9, pages 1057-1057.
Crossref
Crossref
Ghanshyam Teli & Pooja A. Chawla. (2021) Hybridization of Imidazole with Various Heterocycles in Targeting Cancer: A Decade's Work. ChemistrySelect 6:19, pages 4803-4836.
Crossref
Crossref
Olasunkanmi O. Olaoye, Paris R. Watson, Nabanita Nawar, Mulu Geletu, Abootaleb Sedighi, Shazreh Bukhari, Yasir S. Raouf, Pimyupa Manaswiyoungkul, Fettah Erdogan, Ayah Abdeldayem, Aaron D. Cabral, Muhammad Murtaza Hassan, Krimo Toutah, Andrew E. Shouksmith, Justyna M. Gawel, Johan Israelian, Tudor B. Radu, Niyati Kachhiyapatel, Elvin D. de Araujo, David W. Christianson & Patrick T. Gunning. (2021) Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype. Journal of Medicinal Chemistry 64:5, pages 2691-2704.
Crossref
Crossref
Feng Song, Yunqiang Bian, Jing Liu, Zhenghua Li, Li Zhao, Junman Fang, Yonghong Lai & Meng Zhou. (2021) Indole Alkaloids, Synthetic Dimers and Hybrids with Potential In Vivo Anticancer Activity. Current Topics in Medicinal Chemistry 21:5, pages 377-403.
Crossref
Crossref
Alexander E. Kabakov & Anna O. Yakimova. (2021) Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing. Cancers 13:5, pages 1102.
Crossref
Crossref
立园 张. (2021) Progress in the Research of Selective <i>Histone deacetylase</i> Inhibitors. Advances in Material Chemistry 09:01, pages 9-23.
Crossref
Crossref
Maurício T. Tavares, Alan P. Kozikowski & Sida Shen. (2021) Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors. European Journal of Medicinal Chemistry 209, pages 112887.
Crossref
Crossref
Gargi Nikhil Vaidya, Pooja Rana, Ashwini Venkatesh, Deep Rohan Chatterjee, Darshan Contractor, Dinesh Parshuram Satpute, Mithilesh Nagpure, Alok Jain & Dinesh Kumar. (2021) Paradigm shift of “classical” HDAC inhibitors to “hybrid” HDAC inhibitors in therapeutic interventions. European Journal of Medicinal Chemistry 209, pages 112844.
Crossref
Crossref
Jenna L. Carter, Katie Hege, Jay Yang, Hasini A. Kalpage, Yongwei Su, Holly Edwards, Maik Hüttemann, Jeffrey W. Taub & Yubin Ge. (2020) Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy. Signal Transduction and Targeted Therapy 5:1.
Crossref
Crossref
Jiaqi Xiao, Meixiang Gao, Zhou Sun, Qiang Diao, Peng Wang & Feng Gao. (2020) Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010–2020). European Journal of Medicinal Chemistry 208, pages 112830.
Crossref
Crossref
Manpreet Kaur, Loveleen & Raj Kumar. (2020) Inhibition of histone deacetylases, topoisomerases and epidermal growth factor receptor by metal-based anticancer agents: Design & synthetic strategies and their medicinal attributes. Bioorganic Chemistry 105, pages 104396.
Crossref
Crossref
Annalisa Maruca, Roberta Rocca, Raffaella Catalano, Francesco Mesiti, Giosuè Costa, Delia Lanzillotta, Alessandro Salatino, Francesco Ortuso, Francesco Trapasso, Stefano Alcaro & Anna Artese. (2020) Natural Products Extracted from Fungal Species as New Potential Anti-Cancer Drugs: A Structure-Based Drug Repurposing Approach Targeting HDAC7. Molecules 25:23, pages 5524.
Crossref
Crossref
Yuxiang Luo & Huilin Li. (2020) Structure-Based Inhibitor Discovery of Class I Histone Deacetylases (HDACs). International Journal of Molecular Sciences 21:22, pages 8828.
Crossref
Crossref
Terence C. S. Ho, Alex H. Y. Chan & A. Ganesan. (2020) Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight. Journal of Medicinal Chemistry 63:21, pages 12460-12484.
Crossref
Crossref
Wenhua Liu, Yuchen Liang & Xiaoyong Si. (2020) Hydroxamic acid hybrids as the potential anticancer agents: An Overview. European Journal of Medicinal Chemistry 205, pages 112679.
Crossref
Crossref
Shabir Ahmad GanaiShabir Ahmad Ganai. 2020. Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy. Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy
159
171
.
Md Lutfor Rahman, Mohd Sani Sarjadi, Shaheen M. Sarkar, Daniel J. Walsh & John J. Hannan. (2022) Poly(Hydroxamic Acid) Resins and Their Applications. SSRN Electronic Journal.
Crossref
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