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Expert Opinion on Therapeutic Patents Volume 30, 2020 - Issue 4

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Review

A patent review of apelin receptor (APJR) modulators (2014-2019)

Conrad FischerDepartment of Chemistry, University of Alberta, Edmonton, Alberta, CanadaCorrespondence[email protected]
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Pages 251-261 | Received 12 Jan 2020, Accepted 14 Feb 2020, Published online: 20 Feb 2020

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https://doi.org/10.1080/13543776.2020.1731473
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Fiona A Chapman, Janet J Maguire, David E Newby, Anthony P Davenport & Neeraj Dhaun. (2023) Targeting the apelin system for the treatment of cardiovascular diseases. Cardiovascular Research.
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Roberto Monastero, Daniele Magro, Marika Venezia, Calogera Pisano & Carmela Rita Balistreri. (2023) A promising therapeutic peptide and preventive/diagnostic biomarker for age-related diseases: The Elabela/Apela/Toddler peptide. Ageing Research Reviews 91, pages 102076.
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Béatrice Louis, Vincent Nail, Oriane Nachar, Ahlem Bouhlel, Anaïs Moyon, Laure Balasse, Stéphanie Simoncini, Adrien Chabert, Samantha Fernandez, Pauline Brige, Guillaume Hache, Aura Tintaru, Clément Morgat, Françoise Dignat-George, Philippe Garrigue & Benjamin Guillet. (2023) Design and preclinical evaluation of a novel apelin-based PET radiotracer targeting APJ receptor for molecular imaging of angiogenesis. Angiogenesis 26:3, pages 463-475.
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Bo Pang, Yin-Ru Jiang, Jia-Yao Xu, Dong-Xue Shao & Li-Ying Hao. (2023) Apelin/ELABELA-APJ system in cardiac hypertrophy: Regulatory mechanisms and therapeutic potential. European Journal of Pharmacology, pages 175727.
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Jui-Chieh Chen, Hsun-Chang Shih, Chih-Yang Lin, Jeng-Hung Guo, Cheng Huang, Hsiu-Chen Huang, Zhi-Yong Chong & Chih-Hsin Tang. (2023) MicroRNA-631 Resensitizes Doxorubicin-Resistant Chondrosarcoma Cells by Targeting Apelin. International Journal of Molecular Sciences 24:1, pages 839.
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Peter Janssens, Jean-Paul Decuypere, Bert Bammens, Catherine Llorens-Cortes, Rudi Vennekens & Djalila Mekahli. (2022) The emerging role of the apelinergic system in kidney physiology and disease. Nephrology Dialysis Transplantation 37:12, pages 2314-2326.
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Martin N. Ivanov, Dimo S. Stoyanov, Stoyan P. Pavlov & Anton. B. Tonchev. (2022) Distribution, Function, and Expression of the Apelinergic System in the Healthy and Diseased Mammalian Brain. Genes 13:11, pages 2172.
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Jeremy M. Richter, J. Alex Bates, Peter Gargalovic, Joelle M. Onorato, Claudia Generaux, Tao Wang, David A. Gordon, Ruth R. Wexler & Heather J. Finlay. (2022) Design and preparation of N-linked hydroxypyridine-based APJ agonists. Bioorganic & Medicinal Chemistry Letters 73, pages 128882.
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Jiawei Song, Jianqiong Tang, Zhenzhou Zhang, Ying Liu & Jiuchang Zhong. (2022) Targeting the elabela/apelin-apelin receptor axis as a novel therapeutic approach for hypertension. Chinese Medical Journal 135:9, pages 1019-1026.
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Wei Meng, Zulan Pi, Robert Brigance, Karen A. Rossi, William A. Schumacher, Jeffrey S. Bostwick, Peter S. Gargalovic, Joelle M. Onorato, Chiuwa E. Luk, Claudia N. Generaux, Tao Wang, Ruth R. Wexler & Heather J. Finlay. (2021) Identification of a Hydroxypyrimidinone Compound ( 21 ) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure . Journal of Medicinal Chemistry 64:24, pages 18102-18113.
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Zulan Pi, James A. Johnson, Wei Meng, Monique Phillips, William A. Schumacher, Jeffrey S. Bostwick, Peter S. Gargalovic, Joelle M. Onorato, Claudia N. Generaux, Tao Wang, Yan He, David A. Gordon, Ruth R. Wexler & Heather J. Finlay. (2021) Identification of 6-Hydroxypyrimidin-4(1 H )-one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists . ACS Medicinal Chemistry Letters 12:11, pages 1766-1772.
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Laura C. E. Manoliu, Eliza C. Martin, Adina L. Milac & Laurentiu Spiridon. (2021) Effective Use of Empirical Data for Virtual Screening against APJR GPCR Receptor. Molecules 26:16, pages 4894.
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I. Castan-Laurell, C. Dray & P. Valet. (2021) The therapeutic potentials of apelin in obesity-associated diseases. Molecular and Cellular Endocrinology 529, pages 111278.
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Kien Trân, Robin Van Den Hauwe, Xavier Sainsily, Pierre Couvineau, Jérôme Côté, Louise Simard, Marco Echevarria, Alexandre Murza, Alexandra Serre, Léa Théroux, Sabrina Saibi, Lounès Haroune, Jean-Michel Longpré, Olivier Lesur, Mannix Auger-Messier, Claude Spino, Michel Bouvier, Philippe Sarret, Steven Ballet & Éric Marsault. (2021) Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile. Journal of Medicinal Chemistry 64:9, pages 5345-5364.
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Anthony Estienne, Alice Bongrani, Pascal Froment & Joëlle Dupont. (2021) Apelin and chemerin receptors are G protein-coupled receptors involved in metabolic as well as reproductive functions: Potential therapeutic implications?. Current Opinion in Endocrine and Metabolic Research 16, pages 86-95.
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