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Expert Opinion on Therapeutic Patents Volume 30, 2020 - Issue 6
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Review

Sirtuin modulators: where are we now? A review of patents from 2015 to 2019

Nicola MautoneDipartimento di Chimica e Tecnologie del Farmaco, “Sapienza” Università di Roma, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-2918-3184View further author information
ORCID Icon,
Clemens ZwergelDipartimento di Chimica e Tecnologie del Farmaco, “Sapienza” Università di Roma, Rome, Italy;Dipartimento di Medicina di Precisione, “Luigi Vanvitelli”, Università della Campania, Naples, ItalyORCID Iconhttps://orcid.org/0000-0002-3097-0003View further author information
ORCID Icon,
Antonello MaiDipartimento di Chimica e Tecnologie del Farmaco, “Sapienza” Università di Roma, Rome, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9176-2382View further author information
ORCID Icon &
Dante RotiliDipartimento di Chimica e Tecnologie del Farmaco, “Sapienza” Università di Roma, Rome, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8428-8763View further author information
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Pages 389-407 | Received 01 Feb 2020, Accepted 26 Mar 2020, Published online: 13 Apr 2020

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Wei Zhang, Yue Qian, Xue Jin, Yixian Wang, Lili Mu & Zhixia Jiang. (2022) SIRT7 is a Prognostic Biomarker in Kidney Renal Clear Cell Carcinoma That is Correlated with Immune Cell Infiltration. International Journal of General Medicine 15, pages 3167-3182.
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Sneha Jos, Snehal Aouti, Sruthi Unni, Vishnupriya Haridass, Hemanga Gogoi, Prashant Deshmukh, Balasundaram Padmanabhan & Sivaraman Padavattan. (2022) In silico screening of small molecule modulators and their binding studies against human sirtuin-6 protein. Journal of Biomolecular Structure and Dynamics 40:20, pages 10033-10044.
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Yan Wang, Chun Jie Wu, Yu Du, Yu Qing Liu, Jing Ran Cai, Xue Qing Wu & Shu Qun Hu. (2021) SIRT2 tyrosine nitration by peroxynitrite in response to renal ischemia/reperfusion injury. Free Radical Research 55:11-12, pages 1104-1118.
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Geetika Garg, Abhishek Kumar Singh, Sandeep Singh & Syed Ibrahim Rizvi. (2021) Promising drug discovery strategies for sirtuin modulators: what lessons have we learnt?. Expert Opinion on Drug Discovery 16:8, pages 915-927.
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Articles from other publishers (29)

Chen-qin Xu, Ji Li, Zhi-qiang Liang, Yi-lang Zhong, Zhi-hui Zhang, Xue-qing Hu, Yong-bing Cao & Jian Chen. (2024) Sirtuins in macrophage immune metabolism: A novel target for cardiovascular disorders. International Journal of Biological Macromolecules 256, pages 128270.
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Francesco Fiorentino, Antonello Mai & Dante Rotili. (2023) The role of structural biology in the design of sirtuin activators. Current Opinion in Structural Biology 82, pages 102666.
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Zhiyuan Zhao, Jintong Du, Yu Du, Yuan Gao, Mingxuan Yu, Yingkai Zhang, Hao Fang & Xuben Hou. (2023) Deciphering the Allosteric Activation Mechanism of SIRT6 Using Molecular Dynamics Simulations. Journal of Chemical Information and Modeling.
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Hany N. Azzam, Marwa O. El-Derany, Sara A. Wahdan, Reham M. Faheim, Gouda K. Helal & Ebtehal El-Demerdash. (2023) The role of mitochondrial/metabolic axis in development of tamoxifen resistance in breast cancer. Human Cell 36:6, pages 1877-1886.
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Clemens Zwergel, Michele Aventaggiato, Sabrina Garbo, Elisabetta Di Bello, Bruno Fassari, Beatrice Noce, Carola Castiello, Chiara Lambona, Federica Barreca, Dante Rotili, Rossella Fioravanti, Thomas Schmalz, Michael Weyand, Amelie Niedermeier, Marco Tripodi, Gianni Colotti, Clemens Steegborn, Cecilia Battistelli, Marco Tafani, Sergio Valente & Antonello Mai. (2023) Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells. Journal of Medicinal Chemistry 66:14, pages 9622-9641.
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María Paula Ceballos, Ariel Darío Quiroga & Nicolás Francisco Palma. (2023) Role of sirtuins in hepatocellular carcinoma progression and multidrug resistance: Mechanistical and pharmacological perspectives. Biochemical Pharmacology 212, pages 115573.
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Maryam Abrishamdar, Maryam Sadat Jalali & Yaghoob Farbood. (2022) Targeting Mitochondria as a Therapeutic Approach for Parkinson’s Disease. Cellular and Molecular Neurobiology 43:4, pages 1499-1518.
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Emanuele Fabbrizi, Francesco Fiorentino, Vincenzo Carafa, Lucia Altucci, Antonello Mai & Dante Rotili. (2023) Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection. Cells 12:6, pages 852.
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Mingxing Teng, Damian W. Young & Zhi Tan. (2022) The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush. Journal of Medicinal Chemistry 65:21, pages 14289-14304.
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Nimisha Lingappa & Harvey N Mayrovitz. (2022) Role of Sirtuins in Diabetes and Age-Related Processes. Cureus.
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Elena Abbotto, Naomi Scarano, Francesco Piacente, Enrico Millo, Elena Cichero & Santina Bruzzone. (2022) Virtual Screening in the Identification of Sirtuins’ Activity Modulators. Molecules 27:17, pages 5641.
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Francesco Fiorentino, Carola Castiello, Antonello Mai & Dante Rotili. (2022) Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5. Journal of Medicinal Chemistry 65:14, pages 9580-9606.
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Francesco Fiorentino, Nicola Mautone, Martina Menna, Francesca D'Acunzo, Antonello Mai & Dante Rotili. (2022) Sirtuin modulators: past, present, and future perspectives. Future Medicinal Chemistry 14:12, pages 915-939.
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Albertas Kriaučiūnas, Rasa Liutkevičienė, Greta Gedvilaitė, Kristė Kaikarytė, Alvita Vilkevičiūtė, Darius Gleiznys, Ingrida Pacauskienė & Gediminas Žekonis. (2022) Value of Serum Sirtuin-1 (SIRT1) Levels and SIRT1 Gene Variants in Periodontitis Patients. Medicina 58:5, pages 653.
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Samanta Taurone, Chiara De Ponte, Dante Rotili, Elena De Santis, Antonello Mai, Francesco Fiorentino, Susanna Scarpa, Marco Artico & Alessandra Micera. (2022) Biochemical Functions and Clinical Characterizations of the Sirtuins in Diabetes-Induced Retinal Pathologies. International Journal of Molecular Sciences 23:7, pages 4048.
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Fatma Sezer Şenol Deniz, Gökçen Eren & Ilkay Erdogan Orhan. (2022) Flavonoids as Sirtuin Modulators. Current Topics in Medicinal Chemistry 22:9, pages 790-805.
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Devaraj Ezhilarasan, Thangavelu Lakshmi, Manoharan Subha, Veeraiyan Deepak Nallasamy & Subramanian Raghunandhakumar. (2021) The ambiguous role of sirtuins in head and neck squamous cell carcinoma. Oral Diseases 28:3, pages 559-567.
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Jefferson A. Leite, Bruno Ghirotto, Vitor P. Targhetta, Jean de Lima & Niels O. S. Câmara. (2021) Sirtuins as pharmacological targets in neurodegenerative and neuropsychiatric disorders. British Journal of Pharmacology 179:8, pages 1496-1511.
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Alberto Zullo, Rosa Guida, Rosaria Sciarrillo & Francesco P. Mancini. (2022) Redox Homeostasis in Cardiovascular Disease: The Role of Mitochondrial Sirtuins. Frontiers in Endocrinology 13.
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Antonino Colloca, Anna Balestrieri, Camilla Anastasio, Maria Luisa Balestrieri & Nunzia D’Onofrio. (2022) Mitochondrial Sirtuins in Chronic Degenerative Diseases: New Metabolic Targets in Colorectal Cancer. International Journal of Molecular Sciences 23:6, pages 3212.
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Eslam Roshdy, Muhamad Mustafa, Abd El-Rahman Shaltout, Mohamed O. Radwan, Mahmoud A.A. Ibrahim, Mahmoud E. Soliman, Mikako Fujita, Masami Otsuka & Taha F.S. Ali. (2021) Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020. European Journal of Medicinal Chemistry 224, pages 113709.
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Fanyun Kong, Qi Li, Fulong Zhang, Xiaocui Li, Hongjuan You, Xiucheng Pan, Kuiyang Zheng & Renxian Tang. (2021) Sirtuins as Potential Therapeutic Targets for Hepatitis B Virus Infection. Frontiers in Medicine 8.
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Pamela Senesi, Anna Ferrulli, Livio Luzi & Ileana Terruzzi. (2021) Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction. International Journal of Molecular Sciences 22:15, pages 7772.
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Gang Liu, Haiying Chen, Hua Liu, Wenbo Zhang & Jia Zhou. (2020) Emerging roles of SIRT6 in human diseases and its modulators. Medicinal Research Reviews 41:2, pages 1089-1137.
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Stacia Rymarchyk, Wenjia Kang & Yana Cen. (2021) Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition. Biomolecules 11:2, pages 312.
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Jannik Prasuhn, Ryan L. Davis & Kishore R. Kumar. (2021) Targeting Mitochondrial Impairment in Parkinson's Disease: Challenges and Opportunities. Frontiers in Cell and Developmental Biology 8.
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Jia-lin Shang, Shao-bo Ning, Ying-yi Chen, Tian-xiang Chen & Jian Zhang. (2020) MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer. Acta Pharmacologica Sinica 42:1, pages 120-131.
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George N. Chaldakov, Luigi Aloe, Gorana Rancic, Rouzha Z. Pancheva, Marcia Hiriart, Marco Fiore & Stanislav Yanev. 2021. Cellular and Biochemical Mechanisms of Obesity. Cellular and Biochemical Mechanisms of Obesity 297 312 .
Belgin Sever, Gülşen Akalın Çiftçi & Mehlika Dilek Altıntop. (2020) A new series of benzoxazole‐based SIRT1 modulators for targeted therapy of non‐small‐cell lung cancer. Archiv der Pharmazie 354:1, pages 2000235.
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