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Review

Inhibitory activities of indolizine derivatives: a patent review

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Pages 695-714 | Received 24 Apr 2020, Accepted 16 Jul 2020, Published online: 01 Aug 2020

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Ashraf A. Abbas, Magda H. Abdellattif & Kamal M. Dawood. (2022) Inhibitory activities of bipyrazoles: a patent review. Expert Opinion on Therapeutic Patents 32:1, pages 63-87.
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Katharigatta N. Venugopala, Sandeep Chandrashekharappa, Pran Kishore Deb, Christophe Tratrat, Melendhran Pillay, Deepak Chopra, Nizar A. Al-Shar’i, Wafa Hourani, Lina A. Dahabiyeh, Pobitra Borah, Rahul D. Nagdeve, Susanta K. Nayak, Basavaraj Padmashali, Mohamed A. Morsy, Bandar E. Aldhubiab, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Michelyne Haroun, Sheena Shashikanth, Viresh Mohanlall & Raghuprasad Mailavaram. (2021) Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1471-1486.
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Kyatagani Lakshmikanth, Surbhi Mahender Saini, Sandya Tambi Dorai & Sandeep Chandrashekharappa. (2023) Tandem-Michael-cyclization cascade to make pyridines: Use of electron-deficient acetylenes for the synthesis of indolizines in aqueous media. Tetrahedron 142, pages 133516.
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Priyanka Mundhe, Saqib Kidwai, Surbhi Mahender Saini, Harshada Rambaboo Singh, Ramandeep Singh & Sandeep Chandrashekharappa. (2023) Design, synthesis, characterization, and anti-tubercular activity of novel ethyl-3-benzoyl-6, 8-difluoroindolizine-1-carboxylate analogues: Molecular target identification and molecular docking studies. Journal of Molecular Structure 1284, pages 135359.
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Ferruh Lafzi. (2023) Acetic Acid‐Catalyzed 1,6‐Addition of Indolizine to para ‐Quinone Methides . Asian Journal of Organic Chemistry 12:7.
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Thiago Sabino da Silva, Matheus da Silva Souza, Adriano Defini Andricopulo & Fernando Coelho. (2023) Discovery of indolizine lactones as anticancer agents and their optimization through late-stage functionalization. RSC Advances 13:29, pages 20264-20270.
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Asmita Mondal, Nivedita Acharjee & Debnath Palit. (2023) Unveiling [3 + 2] cycloaddition reactions of pyridinium bis(methoxycarbonyl)methylides and pyridinium dicyanomethylides with cyclooctyne for indolizine synthesis from the molecular electron density theory perspective. Structural Chemistry.
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Delphine Naud‐Martin, Marharyta Kosiuha, Leandro H. Zucolotto Cocca, Pascal Retailleau, Florence Mahuteau‐Betzer, Leonardo De Boni & Sandrine Piguel. (2023) Visible‐Light‐Induced Insertion of Sulfur Dioxide Mediated by Electron Donor–Acceptor Complex: Synthesis and Photophysical Properties of 3‐Sulfonyl Indolizines. European Journal of Organic Chemistry 26:22.
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Roger Monreal‐Corona, Àlex Díaz‐Jiménez, Anna Roglans, Albert Poater & Anna Pla‐Quintana. (2023) Indolizine Synthesis through Annulation of Pyridinium 1,4‐Thiolates and Copper Carbenes: A Predictive Catalysis Approach. Advanced Synthesis & Catalysis 365:5, pages 760-766.
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Kishor D. Mane, Sagar S. Bagwe, Satish G. More & Gurunath Suryavanshi. (2023) Synthesis of 3‑alkyl and 1,3-Bis(alkyl)indolizine amides from α-bromohydroxamates. Tetrahedron Letters 118, pages 154386.
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Changyuan Zhang, Wei Wang, Xuncheng Zhu, Lulu Chen, Hejiang Luo, Mengping Guo, Dan Liu, Fan Liu, Huisheng Zhang, Qi Li & Jianping Lin. (2023) Synthesis of Indolizines via Tf 2 O-Mediated Cascade Reaction of Pyridyl-enaminones with Thiophenols/Thioalcohols . Organic Letters 25:7, pages 1192-1197.
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Rajni Lodhi, Ashvani K. Patel & Sampak Samanta. (2022) AgOTf/Et 3 N Cooperative Catalysis Enabled One‐Pot Access to α‐(Indolizinylethyl)‐Substituted N‐Sulfonyl Ketimines via an Imino‐Alkyne Cyclization . Asian Journal of Organic Chemistry 11:12.
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Feroz Ahmad, Pavit K. Ranga, Yogesh A. Pankhade, Shaheen Fatma, Ashrumochan Gouda & Ramasamy Vijaya Anand. (2022) Pd( ii )-catalyzed annulation of terminal alkynes with 2-pyridinyl-substituted p -quinone methides: direct access to indolizines . Chemical Communications 58:95, pages 13238-13241.
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Rahul Nagarkar & Sudhir Dapurkar. (2022) Dinitro Anacardic Acid Copper(II) Complex—A Bio‐based Catalyst for Room Temperature Synthesis of Indolizine. ChemistrySelect 7:44.
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Ilya V. Nechaev & Georgij V. Cherkaev. (2022) Indolizin-1-ols with Charged Electron Acceptors: A Direct Way to 3 H -Indolizinium-1-olates with Donor Functions . The Journal of Organic Chemistry 87:21, pages 14137-14154.
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Fatma M. Thabet, Kamal M. Dawood, Eman A. Ragab, Mohamed S. Nafie & Ashraf A. Abbas. (2022) Design and synthesis of new bis(1,2,4-triazolo[3,4- b ][1,3,4]thiadiazines) and bis((quinoxalin-2-yl)phenoxy)alkanes as anti-breast cancer agents through dual PARP-1 and EGFR targets inhibition . RSC Advances 12:36, pages 23644-23660.
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Cleisson Schossler Garcia, Evelyn Mianes Besckow, Carlos Natã da Silva Espíndola, Gustavo D’Avila Nunes, Narryman Pinto Zuge, Marcos Pizzatto de Azeredo, Marcia Juciele da Rocha, Luiz Roberto Carraro Junior, Filipe Penteado, Caroline Signorini Gomes, Eder João Lenardão, Cristiani Folharini Bortolatto & César Augusto Brüning. (2022) Antidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5-HT 2A/C Receptors . ACS Chemical Neuroscience 13:12, pages 1746-1755.
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Thoraya A. Farghaly & Kamal M. Dawood. (2022) Inhibitory Activities of Pyrazolo-Oxazine Heterocyclic Derivatives. Mini-Reviews in Medicinal Chemistry 22:9, pages 1256-1267.
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Dorina Amariucai-Mantu, Vasilichia Antoci, Monica Cornelia Sardaru, Cristina Maria Al Matarneh, Ionel Mangalagiu & Ramona Danac. (2022) Fused pyrrolo-pyridines and pyrrolo-(iso)quinoline as anticancer agents. Physical Sciences Reviews 0:0.
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Qijian Ni, Zhiming Zhu, Yanjun Fan, Xiaoyun Chen & Xiaoxiao Song. (2021) Chiral Phosphoric Acid Catalyzed Desymmetrization of Cyclopentendiones via Friedel–Crafts Conjugate Addition of Indolizines. Organic Letters 23:24, pages 9548-9553.
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Chun-Bao Miao, Hong-Rong Guan, YiHan Tang, Kun Wang, Wen-Long Ren, Xinyu Lyu, ChangSheng Yao & Hai-Tao Yang. (2021) Copper-Catalyzed Bisannulations of Malonate-Tethered O -Acyl Oximes with Pyridine, Pyrazine, Pyridazine, and Quinoline Derivatives for the Construction of Dihydroindolizine-Fused Pyrrolidinones and Analogues . Organic Letters 23:22, pages 8699-8704.
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Evgeny Chupakhin, Olga Bakulina, Dmitry Dar'in & Mikhail Krasavin. (2021) Facile entry into the 1H-pyrrolo[3,4-b]indolizine-1,3(2H)-dione scaffold via intramolecular Rh(II) carbene trapping. Tetrahedron Letters 85, pages 153467.
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Guiyun Duan, Hao Liu, Liqing Zhang, Chunhao Yuan, Yongchao Li & Yanqing Ge. (2021) Access to 6-hydroxy indolizines and related imidazo[1,5- a ]pyridines through the S N 2 substitution/condensation/tautomerization cascade process . RSC Advances 11:41, pages 25624-25627.
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Ilya V. Nechaev & Georgij V. Cherkaev. (2021) Radical and Ionic Reactions of Indolizin-1-ols: Synthesis of 3-Arylsulfanyl-, 3-(Tropon-2-yl)- and 3-(Tropolon-5-ylazo)-1-hydroxyindolizines from 3,3-Difluorocyclopropenes. The Journal of Organic Chemistry 86:11, pages 7687-7700.
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Mahanthesha G, Suresh T & Yadav D Bodke. (2021) Synthesis and characterization of (3-Chlorophenyl)(1-(5-phenyl-1,3,4-oxadiazol-2-yl)indolizin-3-yl)methanone derivatives as anticancer and antimicrobial agents. Chemical Data Collections 33, pages 100691.
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Jun-Qi Zhang, Dandan Hu, Jinyu Song & Hongjun Ren. (2021) [3 + 2]-Annulation of gem -Difluoroalkenes and Pyridinium Ylides: Access to Functionalized 2-Fluoroindolizines . The Journal of Organic Chemistry 86:6, pages 4646-4660.
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