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Expert Opinion on Therapeutic Patents Volume 31, 2021 - Issue 5
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Review

Acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease – a patent review (2016–present)

Martina Bortolamia Department of Scienze Di Base E Applicate per l’Ingegneria, Sapienza University of Rome, Rome, ItalyView further author information
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Daniele Roccoa Department of Scienze Di Base E Applicate per l’Ingegneria, Sapienza University of Rome, Rome, ItalyView further author information
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Antonella Messoreb Department of Chimica E Tecnologia Del Farmaco, Dipartimento Di Eccellenza 2018−2022, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, ItalyView further author information
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Roberto Di Santob Department of Chimica E Tecnologia Del Farmaco, Dipartimento Di Eccellenza 2018−2022, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-4279-7666View further author information
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Roberta Costib Department of Chimica E Tecnologia Del Farmaco, Dipartimento Di Eccellenza 2018−2022, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-1314-9029View further author information
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Valentina Noemi Madiab Department of Chimica E Tecnologia Del Farmaco, Dipartimento Di Eccellenza 2018−2022, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, ItalyView further author information
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Luigi Scipioneb Department of Chimica E Tecnologia Del Farmaco, Dipartimento Di Eccellenza 2018−2022, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2006-7005View further author information
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Fabiana Pandolfia Department of Scienze Di Base E Applicate per l’Ingegneria, Sapienza University of Rome, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-5972-851XView further author information
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Pages 399-420 | Received 21 Sep 2020, Accepted 07 Jan 2021, Published online: 14 Jan 2021

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Roque Spinelli, Álvaro Rietmann, Ivan Sanchis & Álvaro Sebastián Siano. (2022) Natural multi-target modulators of pathological pathways in Alzheimer's disease isolated from the Rhinella arenarum skin. Natural Product Research 36:12, pages 3193-3197.
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Yan Bai, Duo Ren, Xinlei Xue, Weixian Gao, Jiangchun Hu & Huaqi Pan. (2024) Structurally diverse brefeldin A derivatives as potent and selective acetylcholinesterase inhibitors from an endophytic fungus Penicillium brefeldianum F4a. Arabian Journal of Chemistry 17:1, pages 105388.
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Guoxing Wang, Jiyu Du, Jie Ma, Peipei Liu, Siqi Xing, Jucheng Xia, Shuanghong Dong & Zeng Li. (2023) Discovery of Novel Tryptanthrin Derivatives with Benzenesulfonamide Substituents as Multi-Target-Directed Ligands for the Treatment of Alzheimer’s Disease. Pharmaceuticals 16:10, pages 1468.
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Md. Yousof Ali, Sumera Zaib, Susoma Jannat & Imtiaz Khan. (2022) Discovery of potent and selective dual cholinesterases and β-secretase inhibitors in pomegranate as a treatment for Alzheimer’s disease. Bioorganic Chemistry 129, pages 106137.
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Roque Spinelli, Ma. Verónica Humpola, Ivan Sanchís, Emilse de los Angeles Méndez & Alvaro Siano. (2022) Biological Characterization of Natural Peptide BcI-1003 from Boana cordobae (anura): Role in Alzheimer’s Disease and Microbial Infections. International Journal of Peptide Research and Therapeutics 29:1.
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Sarra Chortani, Amel Hajlaoui, Salma Jlizi, Abdel Halim Harrath, Hichem Ben Jannet & Anis Romdhane. (2022) Access to new phosphonate- and imidazolidine-benzopyrimidinone derivatives as antityrosinase and anti-acetylcholinesterase agents: Design, synthesis and molecular docking. Journal of Molecular Structure 1268, pages 133693.
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R. Cuciniello, D. Luongo, A. Ferramosca, P. Lunetti, V. Rotondi-Aufiero, S. Crispi, V. Zara, F. Maurano, S. Filosa & P. Bergamo. (2022) Conjugated linoleic acid downregulates Alzheimer's hallmarks in aluminum mouse model through an Nrf2-mediated adaptive response and increases brain glucose transporter levels. Free Radical Biology and Medicine 191, pages 48-58.
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Samar O. El-Ganainy, Omar A. Soliman, Aya A. Ghazy, Maram Allam, Aya I. Elbahnasi, Amira M. Mansour & Mennatallah A. Gowayed. (2022) Intranasal Oxytocin Attenuates Cognitive Impairment, β-Amyloid Burden and Tau Deposition in Female Rats with Alzheimer’s Disease: Interplay of ERK1/2/GSK3β/Caspase-3. Neurochemical Research 47:8, pages 2345-2356.
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Karanvir Singh, Rohit Bhatia, Bhupinder Kumar, Gurpreet Singh & Vikramdeep Monga. (2022) Design Strategies, Chemistry and Therapeutic Insights of Multi-target Directed Ligands as Antidepressant Agents. Current Neuropharmacology 20:7, pages 1329-1358.
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Andreea L. Turcu, Júlia Companys-Alemany, Matthew B. Phillips, Dhilon S. Patel, Christian Griñán-Ferré, M. Isabel Loza, José M. Brea, Belén Pérez, David Soto, Francesc X. Sureda, Maria G. Kurnikova, Jon W. Johnson, Mercè Pallàs & Santiago Vázquez. (2022) Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease. European Journal of Medicinal Chemistry 236, pages 114354.
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Adnan Ahmad & Krishan Pal. (2022) Therapeutic Efficacy of Natural Phytochemicals as Acetylcholinesterase Inhibitors Against Alzheimer’s Disease. Journal of Ecophysiology and Occupational Health 22:1, pages 39.
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Yongmei Zhao, Yeshu Mu, Wen Luo & Zhiyong Tian. (2022) Synthesis of Naphthalimide Derivatives as Cholinesterase Inhibitors with Aggregation Induced Emission Properties. Chinese Journal of Organic Chemistry 42:3, pages 819.
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