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Expert Opinion on Therapeutic Patents Volume 31, 2021 - Issue 8
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Review

Targeting the TGF-β signaling pathway for fibrosis therapy: a patent review (2015–2020)

Xuanyi Lia Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4367-3005View further author information
ORCID Icon,
Ziang Dinga Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, ChinaView further author information
,
Zixuan Wua Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, ChinaView further author information
,
Yinqiu Xub Department of Pharmacy, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, ChinaView further author information
,
Hequan Yaoa Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, ChinaView further author information
&
Kejiang Lina Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, ChinaView further author information
Pages 723-743 | Received 22 Oct 2020, Accepted 24 Feb 2021, Published online: 17 May 2021

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Mengying Yao, Dawei Lian, Meizhu Wu, Yuting Zhou, Yi Fang, Siyu Zhang, Wenqiang Zhang, Yanyan Yang, Renfeng Li, Hong Chen, Youqin Chen, Aling Shen & Jun Peng. (2023) Isoliensinine Attenuates Renal Fibrosis and Inhibits TGF-β1/Smad2/3 Signaling Pathway in Spontaneously Hypertensive Rats. Drug Design, Development and Therapy 17, pages 2749-2762.
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Zhihao Gu, Yong Yan, Hequan Yao, Kejiang Lin & Xuanyi Li. (2022) Targeting the LPA1 signaling pathway for fibrosis therapy: a patent review (2010-present). Expert Opinion on Therapeutic Patents 32:10, pages 1097-1122.
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Articles from other publishers (3)

Min Tang, Cheng Guo, Mengxue Sun, Hao Zhou, Xin Peng, Jianli Dai, Qin Ding, Ying Wang & Changqing Yang. (2022) Effective delivery of osteopontin small interference RNA using exosomes suppresses liver fibrosis via TGF-β1 signaling. Frontiers in Pharmacology 13.
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Jian-Li Qiu, Guo-Feng Zhang, Yu-Na Chai, Xiao-Yan Han, Hai-Tao Zheng, Xiang-Feng Li, Fei Duan & Ling-Yan Chen. (2022) Ligustrazine Attenuates Liver Fibrosis by Targeting miR-145 Mediated Transforming Growth Factor- β /Smad Signaling in an Animal Model of Biliary Atresia . Journal of Pharmacology and Experimental Therapeutics 381:3, pages 257-265.
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Vincent Yeung, Sriniwas Sriram, Jennifer A. Tran, Xiaoqing Guo, Audrey E. K. Hutcheon, James D. Zieske, Dimitrios Karamichos & Joseph B. Ciolino. (2021) FAK Inhibition Attenuates Corneal Fibroblast Differentiation In Vitro. Biomolecules 11:11, pages 1682.
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