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Expert Opinion on Therapeutic Patents Volume 31, 2021 - Issue 8
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Review

Thioredoxin reductase inhibitors: updated patent review (2017-present)

Evgeny Chupakhina Institute of Chemistry, Saint Petersburg State University, Saint PetersburgRussian Federation;b Institute for Living Systems, Immanuel Kant Baltic Federal University, KaliningradRussian FederationView further author information
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Mikhail Krasavina Institute of Chemistry, Saint Petersburg State University, Saint PetersburgRussian Federation;b Institute for Living Systems, Immanuel Kant Baltic Federal University, KaliningradRussian FederationCorrespondence[email protected]
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Pages 745-758 | Received 10 Dec 2020, Accepted 02 Mar 2021, Published online: 22 Mar 2021

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Qianhe Xu & Junmin Zhang. (2022) Novel strategies for targeting the thioredoxin system for cancer therapy. Expert Opinion on Drug Discovery 17:5, pages 437-442.
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Articles from other publishers (14)

Stephen L. DeAngelo, Balázs Győrffy, Markos Koutmos & Yatrik M. Shah. (2023) Selenoproteins and tRNA-Sec: regulators of cancer redox homeostasis. Trends in Cancer 9:12, pages 1006-1018.
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Lihua Xu, Haoyue Guan, Xintong Zhang, Senqiu Qiao, Wenxue Ma, Pinnan Liu, Qiaohan Liu, Yue Sun, Yue Liu, Jingzeng Cai & Ziwei Zhang. (2023) Role of Txnrd3 in NiCl2-induced kidney cell apoptosis in mice: Potential therapeutic effect of melatonin. Ecotoxicology and Environmental Safety 265, pages 115521.
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Zihua Liu, Qiang Ye & Ying Jiang. (2023) Transcriptomic analysis: the protection of over-expression thioredoxin reductase 1 in Parkinson’s disease. Chinese Neurosurgical Journal 9:1.
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Shoujiao Peng, Shaopeng Yu, Junmin Zhang & Jiange Zhang. (2023) 6-Shogaol as a Novel Thioredoxin Reductase Inhibitor Induces Oxidative-Stress-Mediated Apoptosis in HeLa Cells. International Journal of Molecular Sciences 24:5, pages 4966.
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Yi-Lin He, Miao Zhong, Zi-Long Song, Yu-Kai Shen, Lanning Zhao & Jianguo Fang. (2023) Synthesis and discovery of Baylis-Hillman adducts as potent and selective thioredoxin reductase inhibitors for cancer treatment. Bioorganic & Medicinal Chemistry 79, pages 117169.
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A. Nikitjuka, M. Ozola, L. Jackevica, R. Bobrovs & R. Žalubovskis. (2023) Exploration of 3,4-unsubstituted coumarins as thioredoxin reductase 1 inhibitors for cancer therapy. Organic & Biomolecular Chemistry.
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Chunyin Tang, Jieting Liu, Chunsong Yang, Jun Ma, Xuejiao Chen, Dongwen Liu, Yao Zhou, Wei Zhou, Yunzhu Lin & Xiaohuan Yuan. (2022) Curcumin and Its Analogs in Non-Small Cell Lung Cancer Treatment: Challenges and Expectations. Biomolecules 12:11, pages 1636.
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Junmin Zhang, Xinming LiZhengjia ZhaoWenqing CaiJianguo Fang. (2022) Thioredoxin Signaling Pathways in Cancer. Antioxidants & Redox Signaling.
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Xue-Min Shi, Wen-Yan She, Ting-Ting Liu, Lian-Xun Gao, Yu-Jiao Liu & Yi Liu. (2022) 1,3-Benzodioxole Derivatives Improve the Anti-Tumor Efficiency of Arsenicals. International Journal of Molecular Sciences 23:13, pages 6930.
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Junmin Zhang, Yaxiong Chen & Jianguo Fang. (2022) Targeting thioredoxin reductase by micheliolide contributes to radiosensitizing and inducing apoptosis of HeLa cells. Free Radical Biology and Medicine 186, pages 99-109.
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E. G. Chupakhin & M. Yu. Krasavin. (2022) Natural compounds as inhibitors of thioredoxin reductase (TrxR1). Russian Chemical Bulletin 71:3, pages 443-448.
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Israel Pérez-Torres, María Elena Soto, Linaloe Manzano-Pech, Eulises Díaz-Diaz, Elizabeth Soria-Castro, María Esther Rubio-Ruíz & Verónica Guarner-Lans. (2022) Oxidative Stress in Plasma from Patients with Marfan Syndrome Is Modulated by Deodorized Garlic Preliminary Findings. Oxidative Medicine and Cellular Longevity 2022, pages 1-10.
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Pierre Sabatier, Christian M. Beusch, Radosveta Gencheva, Qing Cheng, Roman Zubarev & Elias S.J. Arnér. (2021) Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin. Redox Biology 48, pages 102184.
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Junmin Zhang, Qianhe Xu, Hong-Ying Yang, Minghao Yang, Jianguo Fang & Kun Gao. (2021) Inhibition of Thioredoxin Reductase by Santamarine Conferring Anticancer Effect in HeLa Cells. Frontiers in Molecular Biosciences 8.
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