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Expert Opinion on Investigational Drugs Volume 26, 2017 - Issue 4
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Original Research

Efficacy of hydralazine and valproate in cutaneous T-cell lymphoma, a phase II study

Jose Ramiro Espinoza-ZamoraDepartment of Hematology, Instituto Nacional de Cancerología, Mexico City, MexicoView further author information
,
Juan Labardini-MéndezDepartment of Hematology, Instituto Nacional de Cancerología, Mexico City, MexicoView further author information
,
Alejandro Sosa-EspinozaDepartment of Hematology, Instituto Nacional de Cancerología, Mexico City, MexicoView further author information
,
Celia López-GonzálezDepartment of Hematology, Instituto Nacional de Cancerología, Mexico City, MexicoView further author information
,
Magnolia Vieyra-GarcíaDepartment of Hematology, Instituto Nacional de Cancerología, Mexico City, MexicoView further author information
,
Myrna CandelariaDivision of Clinical Research, Instituto Nacional de Cancerología, Mexico City, MexicoView further author information
,
Valentin Lozano-ZavaletaDepartment of Hematology, Instituto Nacional de Cancerología, Mexico City, MexicoView further author information
,
Diana Vanesa Toledano-CuevasDepartment of Hematology, Instituto Nacional de Cancerología, Mexico City, MexicoView further author information
,
Nidia Zapata-CantoDepartment of Hematology, Instituto Nacional de Cancerología, Mexico City, MexicoView further author information
,
Eduardo CerveraDepartment of Hematology, Instituto Nacional de Cancerología, Mexico City, MexicoView further author information
&
Alfonso Dueñas-GonzálezUnidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Cancerología, Mexico City, MexicoCorrespondence[email protected]
View further author information
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Pages 481-487 | Received 12 Dec 2016, Accepted 02 Feb 2017, Published online: 15 Feb 2017

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Enrique Pérez-Cárdenas, Lucía Taja-Chayeb, Catalina Trejo-Becerril, José Chanona-Vilchis, Alma Chávez-Blanco, Guadalupe Domínguez-Gómez, Elizabeth Langley, Alejandro García-Carrancá & Alfonso Dueñas-González. (2018) Antimetastatic effect of epigenetic drugs, hydralazine and valproic acid, in Ras-transformed NIH 3T3 cells. OncoTargets and Therapy 11, pages 8823-8833.
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Articles from other publishers (19)

Li Hui, Zhao Ziyue, Liu Chao, Yu Bin, Li Aoyu & Wu Haijing. (2023) Epigenetic Regulations in Autoimmunity and Cancer: from Basic Science to Translational Medicine. European Journal of Immunology 53:4.
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Gabriela Sanchez-Esgua, Juan Reyes-Alvarez & Martin Perez-Santos. (2023) Patenting trends in the pharmaceutical field of Mexican universities. Pharmaceutical Patent Analyst 12:1, pages 37-50.
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Hae Jin Kee, Inkyeom Kim & Myung Ho Jeong. (2022) Zinc-dependent histone deacetylases: Potential therapeutic targets for arterial hypertension. Biochemical Pharmacology 202, pages 115111.
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Wei-Zhi Lin, Chi-Hsiang Chung, Chia-Yang Shaiu, Bing-Heng Yang & Wu-Chien Chien. (2022) Hydralazine Associated With Reduced Therapeutic Phlebotomy Frequency in a Nationwide Cohort Study: Real-World Effectiveness for Drug Repurposing. Frontiers in Pharmacology 13.
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Bing-Heng Yang, Wei-Zhi Lin, Yu-Ting Chiang, Yeu-Chin Chen, Chi-Hsiang Chung, Wu-Chien Chien & Chia-Yang Shiau. (2022) Epigenetics-Associated Risk Reduction of Hematologic Neoplasms in a Nationwide Cohort Study: The Chemopreventive and Therapeutic Efficacy of Hydralazine. Frontiers in Oncology 12.
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Julie Z. Yi, Matthew H. Friedland & Jean S. McGee. 2022. Epigenetics in Precision Medicine. Epigenetics in Precision Medicine 193 221 .
Andrey D. Bondarev, Misty M. Attwood, Jörgen Jonsson, Vladimir N. Chubarev, Vadim V. Tarasov & Helgi B. Schiöth. (2021) Recent developments of HDAC inhibitors: Emerging indications and novel molecules. British Journal of Clinical Pharmacology 87:12, pages 4577-4597.
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Julie Z. Yi & Jean S. McGee. (2021) Epigenetic‐modifying therapies: An emerging avenue for the treatment of inflammatory skin diseases. Experimental Dermatology 30:8, pages 1167-1176.
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Georgia Farrah, Odette Spruijt, Chris McCormack, Odette Buelens, Smaro Lazarakis & Miles Prince. (2021) A systematic review on the management of pruritus in patients with cutaneous T-cell lymphoma. Itch 6:2, pages e55-e55.
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Feng Li, Jing Zhang, Chao Ma, Ziqian Wang, Yinhua Li, Jimin Zhao & Kangdong Liu. (2020) Targeting Epigenetic Aberrations in Esophageal Squamous Cell Carcinoma. Current Pharmacology Reports 6:6, pages 415-428.
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Jelena Dinić, Thomas Efferth, Alfonso T. García-Sosa, Jelena Grahovac, José M. Padrón, Ilza Pajeva, Flavio Rizzolio, Simona Saponara, Gabriella Spengler & Ivanka Tsakovska. (2020) Repurposing old drugs to fight multidrug resistant cancers. Drug Resistance Updates 52, pages 100713.
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Mohamed Abdelaleem, Hossam Ezzat, Muhammed Osama, Adel Megahed, Waleed Alaa, Ahmed Gaber, Ayman Shafei & Alaa Refaat. (2019) Prospects for repurposing CNS drugs for cancer treatment. Oncology Reviews 13:1.
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David M. Vail, Douglas H. Thamm & Julias M. Liptak. 2019. Withrow and MacEwen's Small Animal Clinical Oncology. Withrow and MacEwen's Small Animal Clinical Oncology 251 285 .
Marilia O. Almeida, Adriana A. Lopes, Patricia G. Roberto, Bianca W. Bertoni & Mônica T. Pupo. (2018) Unveiling the fungal biotransformation of hydralazine using 13C-precursor. Phytochemistry Letters 26, pages 55-59.
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Linda Serrano, Maria Estela Martinez-Escala, Xiaolong A. Zhou & Joan Guitart. (2018) Pruritus in Cutaneous T-Cell Lymphoma and Its Management. Dermatologic Clinics 36:3, pages 245-258.
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Myrna Candelaria, Sebastian Burgos, Mayra Ponce, Ramiro Espinoza & Alfonso Dueñas-Gonzalez. (2017) Encouraging results with the compassionate use of hydralazine/valproate (TRANSKRIP™) as epigenetic treatment for myelodysplastic syndrome (MDS). Annals of Hematology 96:11, pages 1825-1832.
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Romina Mancinelli, Guido Carpino, Simonetta Petrungaro, Caterina Loredana Mammola, Luana Tomaipitinca, Antonio Filippini, Antonio Facchiano, Elio Ziparo & Claudia Giampietri. (2017) Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases. Oxidative Medicine and Cellular Longevity 2017, pages 1-14.
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