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Expert Opinion on Investigational Drugs Volume 26, 2017 - Issue 6
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Drug Evaluation

The neurogenic compound, NSI-189 phosphate: a novel multi-domain treatment capable of pro-cognitive and antidepressant effects

Roger S. McIntyreDepartment of Psychiatry, University of Toronto, Toronto, Canada;Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada;Brain and Cognition Discovery Foundation, Toronto, CanadaCorrespondence[email protected]
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,
Karl JoheNeuralstem, 20271 Goldenrod Lane, Germantown, MD20876, USAView further author information
,
Carola RongMood Disorders Psychopharmacology Unit, University Health Network, Toronto, CanadaView further author information
&
Yena LeeMood Disorders Psychopharmacology Unit, University Health Network, Toronto, CanadaView further author information
Pages 767-770 | Received 03 Jan 2017, Accepted 26 Apr 2017, Published online: 08 May 2017

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Theodora Markati, Jessica Duis & Laurent Servais. (2021) Therapies in preclinical and clinical development for Angelman syndrome. Expert Opinion on Investigational Drugs 30:7, pages 709-720.
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Wei-Song Xie, Kiran Shehzadi, Hong-Le Ma & Jian-Hua Liang. (2022) A Potential Strategy for Treatment of Neurodegenerative Disorders by Regulation of Adult Hippocampal Neurogenesis in Human Brain. Current Medicinal Chemistry 29:32, pages 5315-5347.
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C. G. Jolivalt, M. R. Aghanoori, M. C. Navarro-Diaz, M. M. Han, G. Sanchez, L. Guernsey, D. Quach, K. Johe, P. Fernyhough & N. A. Calcutt. (2022) Enhancement of Mitochondrial Function by the Neurogenic Molecule NSI-189 Accompanies Reversal of Peripheral Neuropathy and Memory Impairment in a Rat Model of Type 2 Diabetes. Journal of Diabetes Research 2022, pages 1-12.
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Jessica E. Malberg, René Hen & Torsten M. Madsen. (2021) Adult Neurogenesis and Antidepressant Treatment: The Surprise Finding by Ron Duman and the Field 20 Years Later. Biological Psychiatry 90:2, pages 96-101.
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Ruth Beckervordersandforth & Chiara Rolando. (2020) Untangling human neurogenesis to understand and counteract brain disorders. Current Opinion in Pharmacology 50, pages 67-73.
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Michael J. Parnham & Gerd Geisslinger. (2019) Pharmacological plasticity—How do you hit a moving target?. Pharmacology Research & Perspectives 7:6.
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Corinne G. Jolivalt, Alexandra Marquez, David Quach, Michelle C. Navarro Diaz, Carlos Anaya, Betelhem Kifle, Nabeel Muttalib, Gabriela Sanchez, Lucy Guernsey, Mike Hefferan, Darrel R. Smith, Paul Fernyhough, Karl Johe & Nigel A. Calcutt. (2019) Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189. Diabetes 68:11, pages 2143-2154.
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Weijian Liu, Yanling Zhou, Wei Zheng, Chengyu Wang, Yanni Zhan, Hanqiu Li, Lijian Chen, Cunyou Zhao & Yuping Ning. (2019) Mediating effect of neurocognition between severity of symptoms and social-occupational function in anxious depression. Journal of Affective Disorders 246, pages 667-673.
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Anelia A. Y. Kassi, Anil K. Mahavadi, Angelica Clavijo, Daniela Caliz, Stephanie W. Lee, Aminul I. Ahmed, Shoji Yokobori, Zhen Hu, Markus S. Spurlock, Joseph M Wasserman, Karla N. Rivera, Samuel Nodal, Henry R. Powell, Long Di, Rolando Torres, Lai Yee Leung, Andres Mariano Rubiano, Ross M. Bullock & Shyam Gajavelli. (2019) Enduring Neuroprotective Effect of Subacute Neural Stem Cell Transplantation After Penetrating TBI. Frontiers in Neurology 9.
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Yan Liu, Karl Johe, Jiandong Sun, Xiaoning Hao, Yubin Wang, Xiaoning Bi & Michel Baudry. (2019) Enhancement of synaptic plasticity and reversal of impairments in motor and cognitive functions in a mouse model of Angelman Syndrome by a small neurogenic molecule, NSI-189. Neuropharmacology 144, pages 337-344.
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Melissa D. Bauman, Cynthia M. Schumann, Erin L. Carlson, Sandra L. Taylor, Edwin Vázquez-Rosa, Coral J. Cintrón-Pérez, Min-Kyoo Shin, Noelle S. Williams & Andrew A. Pieper. (2018) Neuroprotective efficacy of P7C3 compounds in primate hippocampus. Translational Psychiatry 8:1.
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F. Caraci, F. Calabrese, R. Molteni, L. Bartova, M. Dold, G. M. Leggio, C. Fabbri, J. Mendlewicz, G. Racagni, S. Kasper, M. A. Riva & F. Drago. (2018) International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets. Pharmacological Reviews 70:3, pages 475-504.
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