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Drug Evaluation

Filgotinib for the treatment of rheumatoid arthritis

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Pages 1181-1187 | Received 13 Jun 2017, Accepted 24 Aug 2017, Published online: 29 Aug 2017

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Xinyu Ge, Sheng Ma, Shu Yan, Yali Wu, Chong Chen, Chongzhuang Tang, Yan Zhan, Yi-cong Bian, Kai Shen, Sheng Feng, Xuehu Gao, Dafang Zhong, Hua Zhang, Li-yan Miao & Xing-xing Diao. (2023) Mass balance study of [14C]SHR0302, a selective and potent JAK1 inhibitor in humans. Xenobiotica 53:2, pages 69-83.
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Yeke Wu, Yi Liu, Lele Zhang, Lan Wen & Yunfei Xie. (2022) Aconiti lateralis radix praeparata total alkaloids exert anti-RA effects by regulating NF-κB and JAK/STAT signaling pathways and promoting apoptosis. Frontiers in Pharmacology 13.
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Md Fulbabu Sk, Nisha Amarnath Jonniya, Rajarshi Roy & Parimal Kar. (2022) Unraveling the Molecular Mechanism of Recognition of Selected Next-Generation Antirheumatoid Arthritis Inhibitors by Janus Kinase 1. ACS Omega 7:7, pages 6195-6209.
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Yasmin Adel, Mohamed Sabry, Amr Mohamed El-Sabbagh & Yousra Sadeq. (2021) JAK2 mutation may predict response and guide first line treatment in rheumatoid arthritis. The Egyptian Journal of Internal Medicine 33:1.
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Peter Nash. (2021) Clinical use of Jak 1 inhibitors for rheumatoid arthritis. Rheumatology 60:Supplement_2, pages ii31-ii38.
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Fabiola Atzeni, Javier Rodríguez-Carrio, Călin D. Popa, Michael T. Nurmohamed, Gabriella Szűcs & Zoltán Szekanecz. (2021) Cardiovascular effects of approved drugs for rheumatoid arthritis. Nature Reviews Rheumatology 17:5, pages 270-290.
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Rebecca Begley, Kacey Anderson, Timothy R. Watkins, Winnie Weng, Lorraine Ampaw, Ann Qin, Brian P. Kearney & Anita Mathias. (2020) Lack of Drug‐Drug Interaction Between Filgotinib, a Selective JAK1 Inhibitor, and Oral Hormonal Contraceptives Levonorgestrel/Ethinyl Estradiol in Healthy Volunteers. Clinical Pharmacology in Drug Development 10:4, pages 376-383.
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Y. H. Lee & G. G. Song. (2019) Comparison of the efficacy and safety of tofacitinib and filgotinib in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trialsVergleich der Wirksamkeit und Sicherheit von Tofacitinib und Filgotinib bei Patienten mit aktiver rheumatoider Arthritis: eine Bayes-Netzwerk-Metaanalyse randomisierter kontrollierter Studien. Zeitschrift für Rheumatologie 79:6, pages 590-603.
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Ping Xin, Xiaoyun Xu, Chengjie Deng, Shuang Liu, Youzhi Wang, Xuegang Zhou, Hongxing Ma, Donghua Wei & Shiqin Sun. (2020) The role of JAK/STAT signaling pathway and its inhibitors in diseases. International Immunopharmacology 80, pages 106210.
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Qing Zhang, Wei Peng, Shujun Wei, Daneng Wei, Ruolan Li, Jia Liu, Lanyu Peng, Shuang Yang, Yongxiang Gao, Chunjie Wu & Xufeng Pu. (2019) Guizhi-Shaoyao-Zhimu decoction possesses anti-arthritic effects on type II collagen-induced arthritis in rats via suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblasts. Biomedicine & Pharmacotherapy 118, pages 109367.
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Katie Bechman, Mark Yates & James B. Galloway. (2019) The new entries in the therapeutic armamentarium: The small molecule JAK inhibitors. Pharmacological Research 147, pages 104392.
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Feng Jiang, Linghe Zang, Xiuqi Miao, Fang Jia, Jie Wang, Minglin Zhu, Ping Gong, Nan Jiang & Xin Zhai. (2019) Design, synthesis and anti-inflammatory evaluation of novel pyrrolo[2,3-d]pyrimidin derivatives as potent JAK inhibitors. Bioorganic & Medicinal Chemistry 27:18, pages 4089-4100.
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Francesca Musumeci, Chiara Greco, Ilaria Giacchello, Anna Lucia Fallacara, Munjed M. Ibrahim, Giancarlo Grossi, Chiara Brullo & Silvia Schenone. (2019) An Update on JAK Inhibitors. Current Medicinal Chemistry 26:10, pages 1806-1832.
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Anja Dullius, Claudia Monfroni Rocha, Stefan Laufer, Claucia Fernanda Volken de Souza & Márcia Inês Goettert. (2019) Are peptides a solution for the treatment of hyperactivated JAK3 pathways?. Inflammopharmacology 27:3, pages 433-452.
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Agnès Fernández-Clotet, Jesús Castro-Poceiro & Julián Panés. (2019) JAK Inhibition: The Most Promising Agents in the IBD Pipeline?. Current Pharmaceutical Design 25:1, pages 32-40.
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V. Chemes, O. Abrahamovych, U. Abrahamovych, L. Tsyhanyk & S. Guta. (2019) Peculiarities of Calcium-Phosphorus Metabolism and Bone State in Patients with Rheumatoid Arthritis: Pathogenesis, Diagnosis and Principles of Differential Treatment (Literature Review and Clinical Case Description). Lviv clinical bulletin 1:25, pages 51-62.
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Florence Namour, Liesbeth Fagard, Annegret Van der Aa, Pille Harrison, Yan Xin & Chantal Tasset. (2018) Influence of age and renal impairment on the steady state pharmacokinetics of filgotinib, a selective JAK1 inhibitor. British Journal of Clinical Pharmacology 84:12, pages 2779-2789.
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Katherine R Tuttle, Frank C BrosiusIIIIII, Sharon G Adler, Matthias Kretzler, Ravindra L Mehta, James A Tumlin, Yoshiya Tanaka, Masakazu Haneda, Jiajun Liu, Maria E Silk, Tracy E Cardillo, Kevin L Duffin, Joseph V Haas, William L Macias, Fabio P Nunes & Jonathan M Janes. (2018) JAK1/JAK2 inhibition by baricitinib in diabetic kidney disease: results from a Phase 2 randomized controlled clinical trial. Nephrology Dialysis Transplantation 33:11, pages 1950-1959.
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Charles J. Malemud. (2018) The role of the JAK/STAT signal pathway in rheumatoid arthritis. Therapeutic Advances in Musculoskeletal Disease 10:5-6, pages 117-127.
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