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Expert Opinion on Investigational Drugs Volume 28, 2019 - Issue 3
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Review

Experimental and investigational phosphodiesterase inhibitors in development for asthma

Polyxeni Ntontsi2nd Respiratory Medicine Department, National and Kapodistrian University of Athens, Medical School, Attikon Hospital, Athens, GreeceView further author information
,
Aggeliki Detta1st Respiratory Medicine Department, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Hospital, Athens, GreeceView further author information
,
Petros Bakakos1st Respiratory Medicine Department, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Hospital, Athens, GreeceView further author information
,
Stelios Loukides2nd Respiratory Medicine Department, National and Kapodistrian University of Athens, Medical School, Attikon Hospital, Athens, GreeceView further author information
&
Georgios Hillas5th Pulmonary Department, “Sotiria” Chest Diseases Hospital, Athens, GreeceCorrespondence[email protected]
View further author information
Pages 261-266 | Received 05 Sep 2018, Accepted 15 Jan 2019, Published online: 24 Jan 2019

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Peng Guo, Rui Li, Tie Hua Piao, Chun Lan Wang, Xiao Lu Wu & Hong Yan Cai. (2022) Pathological Mechanism and Targeted Drugs of COPD. International Journal of Chronic Obstructive Pulmonary Disease 17, pages 1565-1575.
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Maria Gabriella Matera, Josuel Ora, Francesco Cavalli, Paola Rogliani & Mario Cazzola. (2021) New Avenues for Phosphodiesterase Inhibitors in Asthma. Journal of Experimental Pharmacology 13, pages 291-302.
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Ryan Varghese, Gargi Digholkar, Jainam Karsiya, Sahil Salvi, Jeenam Shah, Dileep Kumar & Rohit Sharma. (2023) PDE5 inhibitors: breaking new grounds in the treatment of COVID-19. Drug Metabolism and Personalized Therapy 0:0.
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Mingzhu Xiao, Disheng Lai, Yumin Yu, Qingqing Wu & Caojin Zhang. (2023) Pathogenesis of pulmonary hypertension caused by left heart disease. Frontiers in Cardiovascular Medicine 10.
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Andrey D. Bondarev, Misty M. Attwood, Jörgen Jonsson, Vladimir N. Chubarev, Vadim V. Tarasov, Wen Liu & Helgi B. Schiöth. (2022) Recent developments of phosphodiesterase inhibitors: Clinical trials, emerging indications and novel molecules. Frontiers in Pharmacology 13.
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Salim Megat, Sylvain Hugel, Sarah H. Journée, Yohann Bohren, Adrien Lacaud, Vincent Lelièvre, Stéphane Doridot, Pascal Villa, Jean-Jacques Bourguignon, Eric Salvat, Remy Schlichter, Marie-José Freund-Mercier, Ipek Yalcin & Michel Barrot. (2022) Antiallodynic action of phosphodiesterase inhibitors in a mouse model of peripheral nerve injury. Neuropharmacology 205, pages 108909.
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Mauro Giorgi, Silvia Cardarelli, Federica Ragusa, Michele Saliola, Stefano Biagioni, Giancarlo Poiana, Fabio Naro & Mara Massimi. (2020) Phosphodiesterase Inhibitors: Could They Be Beneficial for the Treatment of COVID-19?. International Journal of Molecular Sciences 21:15, pages 5338.
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Katarzyna Wójcik-Pszczoła, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Marietta Ślusarczyk, Paweł E Ferdek, Agnieszka A Kusiak, Artur Świerczek, Krzysztof Pociecha, Paulina Koczurkiewicz-Adamczyk, Elżbieta Wyska, Elżbieta Pękala & Reinoud Gosens. (2020) A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling. International Journal of Molecular Sciences 21:11, pages 4008.
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